Survival and function of human thymic dendritic cells are dependent on autocrine Hedgehog signaling.

abstract：:We examined the relationship of I-A expression by normal murine macrophages to their immunoregulatory role on natural killer cell activity. Macrophages were isolated on the basis of plastic adherence; characterized on the basis of conventional markers such as phagocytic ability, cytoplasmic non-specific esterase activ...

journal_title：Journal of leukocyte biology

authors： Nelson JA,Parhar RS,Scodras JM,Lala PK

更新日期：1990-11-01 00:00:00

abstract：:Murine reconstitution assays were used to investigate the effects of recombinant human interleukin-7 (rhIL-7) on myeloid and lymphoid precursors and on bone marrow engraftment. Reconstitution with bone marrow from rhIL-7-treated mice results in a 3.4-fold decrease in total colony-forming unit-spleen (CFU-S) activity (...

journal_title：Journal of leukocyte biology

authors： Boerman OC,Gregorio TA,Grzegorzewski KJ,Faltynek CR,Kenny JJ,Wiltrout RH,Komschlies KL

更新日期：1995-08-01 00:00:00

abstract：:Leukocytes are a large population of cells spread within most tissues in the body. These cells may be either sessile (called as resident cells) or circulating leukocytes, which travel long journeys inside the vessels during their lifespan. Although production and maturation of these leukocytes in adults primarily occu...

journal_title：Journal of leukocyte biology

authors： Mafra K,Nakagaki BN,Castro Oliveira HM,Rezende RM,Antunes MM,Menezes GB

更新日期：2019-09-01 00:00:00

abstract：:Although mouse models of inflammatory skin diseases such as psoriasis and atopic dermatitis fail to completely phenocopy disease in humans, they provide invaluable tools to examine the molecular and cellular mechanisms responsible for the epidermal hyperplasia, inflammation, and excess angiogenesis observed in human d...

journal_title：Journal of leukocyte biology

authors： Voskas D,Babichev Y,Ling LS,Alami J,Shaked Y,Kerbel RS,Ciruna B,Dumont DJ

更新日期：2008-07-01 00:00:00

abstract：:Previous work has demonstrated that bleomycin can directly stimulate alveolar macrophage secretion of fibroblast growth factors and monocyte chemotactic factors. In this study, rat alveolar macrophages obtained by bronchoalveolar lavage were examined for the presence of bleomycin binding sites, which might mediate thi...

journal_title：Journal of leukocyte biology

authors： Denholm EM,Phan SH

更新日期：1990-12-01 00:00:00

abstract：:Cathelicidin LL-37 is a multifunctional, immunomodulatory and antimicrobial host-defense peptide of the human immune system. Here, we identified the role of SFKs in mediating the chemokine induction activity of LL-37 in monocytic cells. LL-37 induced SFK phosphorylation; and chemical inhibitors of SFKs suppressed chem...

journal_title：Journal of leukocyte biology

authors： Nijnik A,Pistolic J,Cho P,Filewod NC,Falsafi R,Ramin A,Harder KW,Hancock RE

更新日期：2012-04-01 00:00:00

abstract：:Autoreactive CD4+ and CD8+ T cells directed against CNS autoantigens may play a role in the development of multiple sclerosis (MS). Identical twins share the same genetic background but not the TCR repertoire that is shaped by the encounter with self or foreign antigens. To gain insights into the interplay between MS ...

journal_title：Journal of leukocyte biology

authors： Somma P,Ristori G,Battistini L,Cannoni S,Borsellino G,Diamantini A,Salvetti M,Sorrentino R,Fiorillo MT

更新日期：2007-03-01 00:00:00

abstract：:Absence of lymph nodes in nonmammalian species, expression of MHCII by APCs in the periphery, and the recent findings that T cells can change their polarization status after presentation in the lymph nodes imply a role for MHCII-mediated presentation outside the organized lymphoid tissue. This study shows that MHCII(+...

journal_title：Journal of leukocyte biology

authors： Inman CF,Singha S,Lewis M,Bradley B,Stokes C,Bailey M

更新日期：2010-09-01 00:00:00

abstract：:We show that interleukin-18 is constitutively produced by dendritic cells; synthesis and secretion are poorly affected by maturative stimuli. Challenge of dendritic cells with autologous anti-tetanus toxoid T lymphocytes results in a secretory switch, with induction of secretion of biologically active interleukin-18 a...

journal_title：Journal of leukocyte biology

authors： Gardella S,Andrei C,Costigliolo S,Poggi A,Zocchi MR,Rubartelli A

更新日期：1999-08-01 00:00:00

abstract：:HIV infection causes rapid and lasting defects in the population of Vgamma2Vdelta2 T cells. To fully describe the impact of HIV, we examined PBMC samples from HIV+ patients receiving highly active antiretroviral therapy, who had displayed prolonged viral control and CD4 counts above 300 cells/mm3. We observed lower fr...

journal_title：Journal of leukocyte biology

authors： Cummings JS,Cairo C,Armstrong C,Davis CE,Pauza CD

更新日期：2008-08-01 00:00:00

abstract：:This study addresses the role of (pro)MMP-9 overexpression in CLL cell migration. We have used primary CLL cells and CLL-derived MEC-1 cells transfected with empty (mock cells) or proMMP-9-encoding (MMP-9 cells) lentiviral vectors. The constitutive (pro)MMP-9 expression in mock cells and primary CLL cells was similar,...

journal_title：Journal of leukocyte biology

authors： Bailón E,Ugarte-Berzal E,Amigo-Jiménez I,Van den Steen P,Opdenakker G,García-Marco JA,García-Pardo A

更新日期：2014-03-11 00:00:00

abstract：:The objective of this study was to find the role of LncRNA SNHG12 in the regulation of hypertensive vascular endothelial injury. LncRNA SNHG12 and miR-25-3p expression were detected by quantitative RT-PCR. Protein levels of Sirtuin 6 (SIRT6), endothelial cell (EC) senescence markers p16 and p21, and EC marker CD31 wer...

journal_title：Journal of leukocyte biology

authors： Qian W,Zheng ZQ,Nie JG,Liu LJ,Meng XZ,Sun H,Xiao FM,Kang T

更新日期：2021-01-19 00:00:00

abstract：:Bacterial and viral infections cause high rates of morbidity and mortality in premature newborns. In the setting of viral infection, pDCs play a key role as strong producers of IFN-α upon TLR9 activation. We analyzed pDC frequency, phenotype, morphology, and function in CB of preterm and term newborns in comparison wi...

journal_title：Journal of leukocyte biology

authors： Schüller SS,Sadeghi K,Wisgrill L,Dangl A,Diesner SC,Prusa AR,Klebermasz-Schrehof K,Greber-Platzer S,Neumüller J,Helmer H,Husslein P,Pollak A,Spittler A,Förster-Waldl E

更新日期：2013-05-01 00:00:00

abstract：:Cyclophilin A (CypA), a peptidylprolyl cis-trans isomerase, is a ubiquitous and multifunctional protein. In addition to its role as a host-cell receptor for cyclosporine A, CypA has diverse functions in inflammatory conditions and diseases. CypA secreted in response to inflammatory stimuli binds to the cell surface vi...

journal_title：Journal of leukocyte biology

authors： Dawar FU,Xiong Y,Khattak MNK,Li J,Lin L,Mei J

更新日期：2017-10-01 00:00:00

abstract：:IL-32 is a proinflammatory cytokine associated with infections, autoimmune diseases, and allergic asthma. In the present study, we elucidated the synergistic effect of IL-32γ and NOD ligand on the activation of human eosinophils, principal effector cells for allergic inflammation, and the underlying mechanisms. Specif...

journal_title：Journal of leukocyte biology

authors： Wong CK,Dong J,Lam CW

更新日期：2014-04-01 00:00:00

abstract：:Traumatic brain injury (TBI) is often accompanied by an acute inflammatory reaction mediated initially by neutrophils. Adhesion molecules expressed on vascular endothelium are requisite elements during recruitment of leukocytes at sites of inflammation. In a rat model of TBI the induction and persistent expression of ...

journal_title：Journal of leukocyte biology

authors： Carlos TM,Clark RS,Franicola-Higgins D,Schiding JK,Kochanek PM

更新日期：1997-03-01 00:00:00

abstract：:Membrane rafts are microdomains of the plasma membrane that have multiple biological functions. The involvement of these structures in the biology of T cells, namely in signal transduction by the TCR, has been widely studied. However, the role of membrane rafts in immunoreceptor signaling in NK cells is less well know...

journal_title：Journal of leukocyte biology

authors： Serrano-Pertierra E,Cernuda-Morollón E,Brdička T,Hoøejši V,López-Larrea C

更新日期：2014-09-01 00:00:00

abstract：:Subcutaneous injection of recombinant human interleukin-2 (rhuIL-2) at 10(2)-10(4) U/mouse induced delayed (48 h) accumulation of mononuclear leukocytes with diffuse granulocytes, including eosinophils. Subcutaneous local infusion of rhuIL-2 or recombinant murine IL-2 (10(2)-10(4) U/mouse) via implanted Alzet miniosmo...

journal_title：Journal of leukocyte biology

authors： Dunn CJ,Hardee MM,Fidler SF,Shields SK,Chosay JG

更新日期：1996-07-01 00:00:00

abstract：:LPS has been widely used to induce inflammatory pain, attributing to production of inflammatory cytokines and sensitization of nociceptors. Paeoniflorin (PF) possesses anti-nociceptive property, but its effect on LPS-induced inflammatory pain has not been investigated. In this study, we aimed to investigate the analge...

journal_title：Journal of leukocyte biology

authors： Yin N,Gao Q,Tao W,Chen J,Bi J,Ding F,Wang Z

更新日期：2020-07-01 00:00:00

abstract：:Chemokines play a crucial role in combating microbial infection by recruiting blood neutrophils to infected tissue. In mice, the chemokines Cxcl1/KC and Cxcl2/MIP2 fulfill this role. Cxcl1 and Cxcl2 exist as monomers and dimers, and exert their function by activating the Cxcr2 receptor and binding glycosaminoglycans (...

journal_title：Journal of leukocyte biology

authors： Sawant KV,Sepuru KM,Lowry E,Penaranda B,Frevert CW,Garofalo RP,Rajarathnam K

更新日期：2020-09-02 00:00:00

abstract：:Type I IFNs display multiple biological effects. They have a strong antiviral action, not only directly but also indirectly through activation of the immune system. They may also have actions that are deleterious for the host. The cells that produce type I IFN are mostly plasmacytoid dendritic cells (pDC), but this de...

journal_title：Journal of leukocyte biology

authors： Hosmalin A,Lebon P

更新日期：2006-11-01 00:00:00

abstract：:Recruitment of leukocytes from bloodstream to extrahematic sites is tightly regulated by a variety of adhesion molecules that are expressed on the leukocytes and the vessel walls. In this manuscript, we describe the interactions between natural killer (NK) cells and activated, autologous platelets under physiologic fl...

journal_title：Journal of leukocyte biology

authors： Sheikh S,Parhar RS,Bakheet R,Saleh S,Collison K,Al-Mohanna F

更新日期：2004-09-01 00:00:00

abstract：:Phagocytosis is the process whereby cells engulf large particles, usually over 0.5 micro m in diameter. Phagocytosis is triggered by the interaction of opsonins that cover the particle to be internalized with specific receptors on the surface of the phagocyte. The best-studied phagocytic receptors include the Fc recep...

journal_title：Journal of leukocyte biology

authors： García-García E,Rosales C

更新日期：2002-12-01 00:00:00

abstract：:IL-10 is a key immune-regulatory cytokine, and its gene polymorphisms correlate with severity of clinical GVHD. IL-10 is made by a variety of donor and host cells, but the functional relevance of its source and its role in the biology of acute GVHD are not well understood. We used preclinical models to examine the rel...

journal_title：Journal of leukocyte biology

authors： Tawara I,Sun Y,Liu C,Toubai T,Nieves E,Evers R,Alrubaie M,Mathewson N,Tamaki H,Reddy P

更新日期：2012-04-01 00:00:00

abstract：:Neutrophil-induced damage to the protective epithelium has been implicated in mucosal disorders associated with hypoxia, and such damage may be initiated by epithelial-derived chemokines. Because chemokines can bind to membrane proteoglycans, we hypothesized that chemokines may associate with epithelial surfaces and a...

journal_title：Journal of leukocyte biology

authors： Furuta GT,Dzus AL,Taylor CT,Colgan SP

更新日期：2000-08-01 00:00:00

abstract：:Cytosolic RIG-I-like helicases (RLR) are PRRs involved in type I IFN production and antiviral immunity. This study focuses to the comparison of the expression, function, and signaling cascades associated to RLR in the previously identified CD14(-)DC-SIGN(+)PPARγ(low)CD1a(+) and CD14(low)DC-SIGN(+)PPARγ(high)CD1a(-) hu...

journal_title：Journal of leukocyte biology

authors： Szabo A,Bene K,Gogolák P,Réthi B,Lányi Á,Jankovich I,Dezső B,Rajnavölgyi E

更新日期：2012-07-01 00:00:00

abstract：:Monocyte chemoattractant protein-1 (MCP-1, CCL2) is a mediator of inflammation that has been implicated in the pathogenesis of a wide variety of human diseases. CCR2, a heterotrimeric G-coupled receptor, is the only known receptor that functions at physiologic concentrations of MCP-1. Despite the importance of CCR2 in...

journal_title：Journal of leukocyte biology

authors： Schecter AD,Berman AB,Yi L,Ma H,Daly CM,Soejima K,Rollins BJ,Charo IF,Taubman MB

更新日期：2004-06-01 00:00:00

abstract：:Increasing the dietary alpha-linolenate (18:3n - 3)/linoleate (18:2n - 6) ratio results in an increase in lipopolysaccharide (LPS)-stimulated tumor necrosis factor (TNF) production in mouse resident and casein-induced peritoneal macrophages [3]. We found that prostaglandin E2 (PGE2) production is inversely related to ...

journal_title：Journal of leukocyte biology

authors： Watanabe S,Onozaki K,Yamamoto S,Okuyama H

更新日期：1993-02-01 00:00:00

abstract：:Macrophages in brain, lung, and lymphatics constitute a major HIV reservoir during subclinical infection and disease. During HIV transmission macrophages are seemingly one of the first cells infected, being as efficient as T cells in supporting productive viral replication. Macrophages control a myriad of cell-mediate...

journal_title：Journal of leukocyte biology

authors： Stevenson M,Gendelman HE

更新日期：1994-09-01 00:00:00

abstract：:THP-1-derived cell lines were stably transfected with constructs encoding glycophosphatidylinositol (GPI)-anchored or transmembrane forms of human CD14. CD14 expression was associated with enhanced phagocytosis of serum (heat-inactivated)-opsonized Escherichia coli (opEc). Both the GPI-anchored and transmembrane forms...

journal_title：Journal of leukocyte biology

authors： Schiff DE,Kline L,Soldau K,Lee JD,Pugin J,Tobias PS,Ulevitch RJ

更新日期：1997-12-01 00:00:00