The inflammatory potential of IL-2: local induction of a specific chronic granulomatous lesion in mice.

abstract：:Maturation of cells of the mononuclear phagocyte lineage from bone marrow precursors to tissue macrophages (MAC) via circulating blood monocytes (MO) is a multistep process only partially understood. Similarly, MAC differentiation can be observed if MO are cultured in vitro. In an attempt to further characterize molec...

journal_title：Journal of leukocyte biology

authors： Krause SW,Rehli M,Kreutz M,Schwarzfischer L,Paulauskis JD,Andreesen R

更新日期：1996-10-01 00:00:00

abstract：:The immune system modulates a number of biological processes to properly defend against pathogens. Here, we review how crosstalk between nuclear hormone receptors and the innate immune system may influence multiple biological functions during an immune response. Although nuclear hormone receptor repression of innate i...

journal_title：Journal of leukocyte biology

authors： Chow EK,Razani B,Cheng G

更新日期：2007-08-01 00:00:00

abstract：:We have investigated the role of the purinergic P2X7 receptor in the formation of multinucleated giant cells in human monocyte/macrophage cultures stimulated with either concanavalin A or phytohemagglutinin. Macrophage fusion can be blocked by a P2X7-selective pharmacological antagonist or by a mAb directed against th...

journal_title：Journal of leukocyte biology

authors： Di Virgilio F,Falzoni S,Chiozzi P,Sanz JM,Ferrari D,Buell GN

更新日期：1999-11-01 00:00:00

abstract：:Recent studies have shown that proinflammatory cytokines damage rodent neural precursor cells (NPCs), a source of self-renewing, multipotent cells that play an important role in the developing as well as adult brain. In this study, the effects of tumor necrosis factor alpha (TNF-alpha) on cytokine and chemokine produc...

journal_title：Journal of leukocyte biology

authors： Sheng WS,Hu S,Ni HT,Rowen TN,Lokensgard JR,Peterson PK

更新日期：2005-12-01 00:00:00

abstract：:Cytokines are pivotal in the generation and resolution of the inflammatory response. The midkine/pleiotrophin (MK/PTN) family of cytokines, composed of just two members, was discovered as heparin-binding neurite outgrowth-promoting factors. Since their discovery, expression of this cytokine family has been reported in...

journal_title：Journal of leukocyte biology

authors： Sorrelle N,Dominguez ATA,Brekken RA

更新日期：2017-08-01 00:00:00

abstract：:IL-1β is an important mediator of innate inflammatory responses and has been shown to contribute to liver injury in a number of etiologies. HIV patients have increased necroinflammation and more rapid fibrosis progression in chronic liver injury compared to non-HIV-infected patients. As the resident liver macrophage i...

journal_title：Journal of leukocyte biology

authors： Zhang L,Mosoian A,Schwartz ME,Florman SS,Gunasekaran G,Schiano T,Fiel MI,Jiang W,Shen Q,Branch AD,Bansal MB

更新日期：2019-04-01 00:00:00

abstract：:TLR agonists such as LPS and poly(I:C) induce expression of type I IFNs, such as IFN-α and -β, by macrophages. To examine the role of IFN-β in the induction of ISGs by LPS, we compared the ability of LPS to induce ISGF3 activity and ISG expression in bone marrow-derived macrophages from WT and Ifnb1(-/-) mice. We foun...

journal_title：Journal of leukocyte biology

authors： Sheikh F,Dickensheets H,Gamero AM,Vogel SN,Donnelly RP

更新日期：2014-10-01 00:00:00

abstract：:The objective of this study was to find the role of LncRNA SNHG12 in the regulation of hypertensive vascular endothelial injury. LncRNA SNHG12 and miR-25-3p expression were detected by quantitative RT-PCR. Protein levels of Sirtuin 6 (SIRT6), endothelial cell (EC) senescence markers p16 and p21, and EC marker CD31 wer...

journal_title：Journal of leukocyte biology

authors： Qian W,Zheng ZQ,Nie JG,Liu LJ,Meng XZ,Sun H,Xiao FM,Kang T

更新日期：2021-01-19 00:00:00

abstract：:Many tumor cells are resistant to Fas-mediated killing, which has been primarily used as a mechanism to evade immune attack. In this study, we found a new action of Fas on tumors where activation of the Fas signal may force tumor cells to produce survival factors for neutrophils. Human peripheral circulating neutrophi...

journal_title：Journal of leukocyte biology

authors： Hor WS,Huang WL,Lin YS,Yang BC

更新日期：2003-03-01 00:00:00

abstract：:The absence or reduction of CFTR function causes CF and results in a pulmonary milieu characterized by bacterial colonization and unresolved inflammation. The ineffectiveness at controlling infection by species such as Pseudomonas aeruginosa suggests defects in innate immunity. Macrophages, neutrophils, and DCs have a...

journal_title：Journal of leukocyte biology

authors： Bonfield TL,Hodges CA,Cotton CU,Drumm ML

更新日期：2012-11-01 00:00:00

abstract：:Chemokine-chemokine receptor (CKR) interactions are traditionally described by a two-step/two-site mechanism that details the major contact points between chemokine ligands and CKRs leading to ligand recognition and receptor activation. Chemokine recognition site 1 (CRS1) encompasses interactions between the CKR N-ter...

journal_title：Journal of leukocyte biology

authors： Riutta SJ,Larsen O,Getschman AE,Rosenkilde MM,Hwang ST,Volkman BF

更新日期：2018-08-01 00:00:00

abstract：:In mammals, macrophages are multifunctional cells. Apart from their scavenger role in the clearance of non-self materials such as microorganisms and altered-self materials such as apoptotic cells, senescent erythrocytes, immune complexes, and inflammatory products, they play a crucial role in the regulation of both in...

journal_title：Journal of leukocyte biology

authors： van Rooijen N,Sanders A

更新日期：1997-12-01 00:00:00

abstract：:It is well established that the cytokine IL-12 and the transcription factor STAT4, an essential part of the IL-12 signaling pathway, are critical components of the Th1 differentiation process in T cells. In response to pathogenic stimuli, this process causes T cells to proliferate rapidly and secrete high amounts of t...

journal_title：Journal of leukocyte biology

authors： Schaller M,Ito T,Allen RM,Kroetz D,Kittan N,Ptaschinski C,Cavassani K,Carson WF 4th,Godessart N,Grembecka J,Cierpicki T,Dou Y,Kunkel SL

更新日期：2015-10-01 00:00:00

abstract：:Although a number of chemokine receptors display coreceptor activities in vitro, chemokine receptor 5 (CCR5) and CXC chemokine receptor 4 (CXCR4) remain the major coreceptors used by the human immunodeficiency virus type 1 (HIV-1). In this study, we used an envelope-mediated fusion assay to demonstrate low CCR4 corece...

journal_title：Journal of leukocyte biology

authors： Agrawal L,Vanhorn-Ali Z,Alkhatib G

更新日期：2002-11-01 00:00:00

abstract：:This study was initiated to identify and characterize thyroid fibrosis in a murine model of granulomatous experimental autoimmune thyroiditis (G-EAT) and determine if TGF-beta1 might be involved in fibrosis. G-EAT was induced by transfer of mouse thyroglobulin-sensitized spleen cells activated in vitro with thyroglobu...

journal_title：Journal of leukocyte biology

authors： Chen K,Wei Y,Sharp GC,Braley-Mullen H

更新日期：2000-12-01 00:00:00

abstract：:The ability of encapsulated and acapsular strains of Cryptococcus neoformans to activate dendritic cells (DC) derived from monocytes stimulated with granulocyte macrophage-colony stimulating factor and interleukin-4 was evaluated. Profound differences in DC response to encapsulated and acapsular C. neoformans strains ...

journal_title：Journal of leukocyte biology

authors： Vecchiarelli A,Pietrella D,Lupo P,Bistoni F,McFadden DC,Casadevall A

更新日期：2003-09-01 00:00:00

abstract：:Workshop cluster 1 (WC1) is a member of the scavenger receptor cysteine-rich (SRCR) superfamily that includes CD5, CD6, CD163, and M160. Bovine WC1 consists of 11 SRCR domains, a unique domain 1, and two homologous 5 SRCR domain cassettes, WC1 domains 2-6 and 7-11. The porcine orthologue of WC1 contains five SRCR doma...

journal_title：Journal of leukocyte biology

authors： Ahn JS,Konno A,Gebe JA,Aruffo A,Hamilton MJ,Park YH,Davis WC

更新日期：2002-08-01 00:00:00

abstract：:Stimulation of the respiratory burst in phagocytes induces the formation of mixed disulfides between sulfhydryl groups of proteins and low-molecular-weight thiols. We hypothesized that this process (S-thiolation) might be involved in turning off the respiratory burst. However, induction of S-thiolation by pretreatment...

journal_title：Journal of leukocyte biology

authors： Moriguchi T,Seres T,Ravichandran V,Sasada M,Johnston RB Jr

更新日期：1996-08-01 00:00:00

abstract：:Chemokines regulate the migration and the maturation of dendritic cells (DC) licensed by microbial constituents. We have recently found that the function of DC, including their ability to activate naïve, allogeneic CD4+ T cells, requires the autocrine/paracrine release of the nuclear protein high mobility group box 1 ...

journal_title：Journal of leukocyte biology

authors： Dumitriu IE,Bianchi ME,Bacci M,Manfredi AA,Rovere-Querini P

更新日期：2007-01-01 00:00:00

abstract：:The oxidative burst of polymorphonuclear neutrophils (PMN) and their ability to inhibit Paracoccidioides brasiliensis growth was studied in susceptible (B10.A) and resistant (A/J) mice. The cells were obtained after subcutaneous inoculation in air pouches, yielding highly pure PMN preparations; the number of cells was...

journal_title：Journal of leukocyte biology

authors： Meloni-Bruneri LH,Campa A,Abdalla DS,Calich VL,Lenzi HL,Burger E

更新日期：1996-04-01 00:00:00

abstract：:A lethal human septic shock model, mouse generalized Shwartzman reaction (GSR), was elicited by two consecutive lippolysaccharide (LPS) injections (24 h apart) in which interferon-gamma (IFN-gamma) induced by interleukin (IL)-12 played a critical role in the priming phase, and tumor necrosis factor (TNF) was an import...

journal_title：Journal of leukocyte biology

authors： Motegi A,Kinoshita M,Sato K,Shinomiya N,Ono S,Nonoyama S,Hiraide H,Seki S

更新日期：2006-03-01 00:00:00

abstract：:TNF is a pleiotropic cytokine involved in a variety of inflammatory processes and immune responses. TNF effects are mediated via two distinct membrane receptors: TNFR1 and TNFR2. Investigations concerning regulation and function of TNFR2 revealed a novel TNFR2 isoform in human and mouse cells, termed icp75TNFR, with m...

journal_title：Journal of leukocyte biology

authors： Bäumel M,Lechner A,Hehlgans T,Männel DN

更新日期：2008-07-01 00:00:00

abstract：:There is accumulating evidence that omega-3 fatty acids may modulate immune responses. When monocytes were differentiated to dendritic cells (DCs) in the presence of docosahexaenoic acid (DHA), the expression of costimulatory and antigen presentation markers was altered in a concentration-dependent way, positively or ...

journal_title：Journal of leukocyte biology

authors： Zapata-Gonzalez F,Rueda F,Petriz J,Domingo P,Villarroya F,Diaz-Delfin J,de Madariaga MA,Domingo JC

更新日期：2008-10-01 00:00:00

abstract：:Lipopolysaccharide-induced CXC chemokine (LIX) is a novel murine neutrophil-chemoattractant CXC chemokine cloned as a glucocorticoid-attenuated response gene. We investigated LIX message expression in an acute endotoxemia model. LIX message peaks later than KC or macrophage inflammatory protein-2 (MIP-2) and remains e...

journal_title：Journal of leukocyte biology

authors： Rovai LE,Herschman HR,Smith JB

更新日期：1998-10-01 00:00:00

abstract：:IL-10 is a key immune-regulatory cytokine, and its gene polymorphisms correlate with severity of clinical GVHD. IL-10 is made by a variety of donor and host cells, but the functional relevance of its source and its role in the biology of acute GVHD are not well understood. We used preclinical models to examine the rel...

journal_title：Journal of leukocyte biology

authors： Tawara I,Sun Y,Liu C,Toubai T,Nieves E,Evers R,Alrubaie M,Mathewson N,Tamaki H,Reddy P

更新日期：2012-04-01 00:00:00

abstract：:Developmental delays, which impair antibacterial host defense, are present in the neutrophil system of human preterm neonates. We hypothesized that diminished production of interleukin-8 (IL-8), a neutrophil chemotactic peptide, might in part be responsible for these defects. To test this, monocytes from the blood of ...

journal_title：Journal of leukocyte biology

authors： Schibler KR,Trautman MS,Liechty KW,White WL,Rothstein G,Christensen RD

更新日期：1993-04-01 00:00:00

abstract：:Underlying acquired immunity to the fungus Candida albicans is usually present in adult immunocompetent individuals and is presumed to prevent mucosal colonization progressing to symptomatic infection. Exploration of immunological events leading to Candida resistance or susceptibility has indicated the central role of...

journal_title：Journal of leukocyte biology

authors： Romani L

更新日期：2000-08-01 00:00:00

abstract：:The Charcot-Leyden crystal (CLC) protein, a prominent cell constituent unique to eosinophils and basophils, possesses lysophospholipase activity. This activity and the extracellular deposition and formation of CLC in tissues and body fluids in association with eosinophils suggest an extracellular function for this pro...

journal_title：Journal of leukocyte biology

authors： Golightly LM,Thomas LL,Dvorak AM,Ackerman SJ

更新日期：1992-04-01 00:00:00

abstract：:Human immunodeficiency virus infects different cell types including CD4+ lymphocytes and monocyte-derived macrophages (MDMs). We have examined the activity of the HIV-1 Tat inhibitors Ro-5-3335 and Ro-24-7429 in cultured human peripheral MDMs. Monocytes were isolated from HIV-seronegative donors by gradient centrifuga...

journal_title：Journal of leukocyte biology

authors： Dunne AL,Siregar H,Mills J,Crowe SM

更新日期：1994-09-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) has been shown to induce the production of interstitial collagenase by fibroblasts and chondrocytes. We investigated the role of TNF-alpha in collagenase gene expression by U937 monocyte/macrophage cells. Transcription of the TNF-alpha gene was observed after 0.5 h of phorbol my...

journal_title：Journal of leukocyte biology

authors： Callaghan MM,Lovis RM,Rammohan C,Lu Y,Pope RM

更新日期：1996-01-01 00:00:00