Charcot-Leyden crystal protein in the degranulation and recovery of activated basophils.

abstract：:To test whether reduced immune responsiveness in early life may be related to the immaturity of neonatal antigen-presenting cells, we comparatively assessed the phenotypic and functional characteristics of dendritic epidermal leukocytes (DEL) and epidermal Langerhans cells (LC) in newborn (NB) and adult mice, respecti...

journal_title：Journal of leukocyte biology

authors： Chang-Rodriguez S,Ecker R,Stingl G,Elbe-Bürger A

更新日期：2004-09-01 00:00:00

abstract：:Tumor necrosis factor (TNF) and interleukin-1 (IL-1) are cytokines with pleiotropic biological activities, exerting a broad range of overlapping biological functions. The redundancy of TNF and IL-1 activities may be based on the utilization of shared key components of intracellular signaling pathways. Two lipid second...

journal_title：Journal of leukocyte biology

authors： Schütze S,Machleidt T,Krönke M

更新日期：1994-11-01 00:00:00

abstract：:Osteoarticular complications are common in human brucellosis, but the pathogenic mechanisms involved are largely unknown. In this manuscript, we described an immune mechanism for inflammatory bone loss in response to infection by Brucella abortus. We established a requirement for MyD88 and TLR2 in TNF-α-elicited osteo...

journal_title：Journal of leukocyte biology

authors： Delpino MV,Barrionuevo P,Macedo GC,Oliveira SC,Genaro SD,Scian R,Miraglia MC,Fossati CA,Baldi PC,Giambartolomei GH

更新日期：2012-02-01 00:00:00

abstract：:A murine anti-rat intercellular adhesion molecule 1 (ICAM-1) monoclonal antibody (mAb), 1A29, was used to investigate the importance of blood leukocyte-associated beta 2-integrin (CD11/CD18) vascular endothelium-associated ICAM-1 adhesive interactions in the reversed passive Arthus reaction (RPAR) in rats. An Arthus p...

journal_title：Journal of leukocyte biology

authors： Smith RJ,Chosay JG,Dunn CJ,Manning AM,Justen JM

更新日期：1996-03-01 00:00:00

abstract：:Type I IFNs display multiple biological effects. They have a strong antiviral action, not only directly but also indirectly through activation of the immune system. They may also have actions that are deleterious for the host. The cells that produce type I IFN are mostly plasmacytoid dendritic cells (pDC), but this de...

journal_title：Journal of leukocyte biology

authors： Hosmalin A,Lebon P

更新日期：2006-11-01 00:00:00

abstract：:We have studied two key stages of CD4 development that serve as important checkpoints in determining whether a response will occur, how big it will be, and how long it will last. The response of naive CD4 cells is strictly regulated by the requirement for interaction of the potential precursor with an antigen-presenti...

journal_title：Journal of leukocyte biology

authors： Swain SL

更新日期：1995-05-01 00:00:00

abstract：:We have shown previously that the cellular proteins 47b and 71/73 could be used to construct phenotypes that distinguish among bone marrow culture-derived (BMCD) macrophages that were either unstimulated or primed by gamma interferon or fully activated for tumor cell killing by gamma interferon in combination with lip...

journal_title：Journal of leukocyte biology

authors： MacKay RJ,Russell SW

更新日期：1987-09-01 00:00:00

abstract：:The scavenger receptor CD163 is exclusively expressed by monocyte/macrophages and is shed by matrix metalloproteinases (MMPs) and neutrophil elastase (ELA2) as soluble CD163 (sCD163). Monocyte phenotype is altered in diabetes, but the relationship among monocyte CD163, sCD163, and diabetic complications is not known a...

journal_title：Journal of leukocyte biology

authors： Min D,Brooks B,Wong J,Aamidor S,Seehoo R,Sutanto S,Harrisberg B,Yue DK,Twigg SM,McLennan SV

更新日期：2016-12-01 00:00:00

abstract：:Many tumor cells are resistant to Fas-mediated killing, which has been primarily used as a mechanism to evade immune attack. In this study, we found a new action of Fas on tumors where activation of the Fas signal may force tumor cells to produce survival factors for neutrophils. Human peripheral circulating neutrophi...

journal_title：Journal of leukocyte biology

authors： Hor WS,Huang WL,Lin YS,Yang BC

更新日期：2003-03-01 00:00:00

abstract：:Blocking monoclonal antibodies (mAbs) specific to mouse interleukin-1 receptor antagonist (IL-1ra) were prepared by immunizing Armenian hamsters with recombinant mouse IL-1ra. A sensitive and specific ELISA against mouse IL-1ra was also established. In Propionibacterium acnes-induced liver injury, P. acnes induced tra...

journal_title：Journal of leukocyte biology

authors： Fujioka N,Mukaida N,Harada A,Akiyama M,Kasahara T,Kuno K,Ooi A,Mai M,Matsushima K

更新日期：1995-07-01 00:00:00

abstract：:Several members of the cytokine network play an important role in controlling the replication of the human immunodeficiency virus (HIV) in several experimental systems. Their effects can be categorized in the following three functional groups: (1) HIV-inductive cytokines; (2) HIV-suppressive cytokines; (3) cytokines w...

journal_title：Journal of leukocyte biology

authors： Vicenzi E,Biswas P,Mengozzi M,Poli G

更新日期：1997-07-01 00:00:00

abstract：:Human neutrophils generate oxygen reduction products as a consequence of membrane interactions with a number of stimuli. One oxygen-centered free radical (superoxide) has been unequivocally shown to result from this "respiratory burst," and some experimental evidence for another (hydroxyl radical) has been published, ...

journal_title：Journal of leukocyte biology

authors： Britigan BE,Cohen MS,Rosen GM

更新日期：1987-04-01 00:00:00

abstract：:Inbred mouse strains have been known for many years to vary in their degree of susceptibility to different types of infectious diseases. The genetic basis of these interstrain differences is sometimes simple but often complex. In a few cases, positional cloning has been used successfully to identify single gene effect...

journal_title：Journal of leukocyte biology

authors： Fortier A,Min-Oo G,Forbes J,Lam-Yuk-Tseung S,Gros P

更新日期：2005-06-01 00:00:00

abstract：:Human immunodeficiency virus infects different cell types including CD4+ lymphocytes and monocyte-derived macrophages (MDMs). We have examined the activity of the HIV-1 Tat inhibitors Ro-5-3335 and Ro-24-7429 in cultured human peripheral MDMs. Monocytes were isolated from HIV-seronegative donors by gradient centrifuga...

journal_title：Journal of leukocyte biology

authors： Dunne AL,Siregar H,Mills J,Crowe SM

更新日期：1994-09-01 00:00:00

abstract：:Fetal alcohol spectrum disorder (FASD), which results from ethanol exposure during pregnancy, and alcohol use disorder (AUD), which includes both binge and chronic alcohol abuse, are strikingly common and costly at personal and societal levels. These disorders are associated with significant pathology, including that ...

journal_title：Journal of leukocyte biology

authors： Kane CJ,Drew PD

更新日期：2016-11-01 00:00:00

abstract：:The key role of TRAF6 in TLR signaling pathways is well known. More recent evidence has implicated TRAF3 as another TRAF family member important to certain TLR responses of myeloid cells. Previous studies demonstrate that TRAF3 functions are highly context-dependent, displaying receptor and cell-type specificity. We t...

journal_title：Journal of leukocyte biology

authors： Xie P,Poovassery J,Stunz LL,Smith SM,Schultz ML,Carlin LE,Bishop GA

更新日期：2011-12-01 00:00:00

abstract：:The magnitude and efficacy of CD8(+) T cell memory may notably regress, especially if immune induction occurs in the absence of adequate CD4(+) help. This report demonstrates that this CD8(+) memory malfunction could be remedied if a source of cognate antigen-recognizing helper cells were provided during recall. The i...

journal_title：Journal of leukocyte biology

authors： Kumaraguru U,Banerjee K,Rouse BT

更新日期：2005-10-01 00:00:00

abstract：:In the pathogenesis of chronic inflammatory periodontal disease, neutrophils are recognized as a major cellular component from the histopathology of the periodontal lesion around teeth and from clinical cases where absence or dysfunction of neutrophils results in major periodontal destruction. Neutrophils are recruite...

journal_title：Journal of leukocyte biology

authors： Galicia JC,Benakanakere MR,Stathopoulou PG,Kinane DF

更新日期：2009-07-01 00:00:00

abstract：:Inflammation alters hematopoiesis, often by decreasing erythropoiesis and enhancing myeloid output. The mechanisms behind these changes and how the BM stroma contributes to this process are active areas of research. In this study, we examine these questions in the setting of murine Toxoplasma gondii infection. Our dat...

journal_title：Journal of leukocyte biology

authors： Chou DB,Sworder B,Bouladoux N,Roy CN,Uchida AM,Grigg M,Robey PG,Belkaid Y

更新日期：2012-07-01 00:00:00

abstract：:Expression of phosphatidylserine (PS) on the surface of both macrophages and their apoptotic targets is required for efficient phagocytosis. Monocytes, the precursors of macrophages, do not express PS on their surface and do not efficiently phagocytose apoptotic cells. We report here that PS appears on the surface of ...

journal_title：Journal of leukocyte biology

authors： Callahan MK,Halleck MS,Krahling S,Henderson AJ,Williamson P,Schlegel RA

更新日期：2003-11-01 00:00:00

abstract：:Previous work indicated that macrophages and a lymphoid dendritic cell-like tumor line, P388AD.2, possessed a differential ability to present a haptenated immunoglobulin (tolerogen) in vitro. Macrophages presented fluorescein-conjugated sheep gamma globulin (FL-SGG) and elicited B-cell unresponsiveness. In contrast, P...

journal_title：Journal of leukocyte biology

authors： Phipps RP,Illig K,Schad V,Bhimani K

更新日期：1988-03-01 00:00:00

abstract：:Exposure of humans to beryllium dusts can induce a specific form of chronic pneumonitis that consists mainly of noncaseating granulomas in the lungs. Multiple studies have documented both genetic and immune components of chronic berylliosis. Much work has focused on T cells and their reactivity in berylliosis, but les...

journal_title：Journal of leukocyte biology

authors： Misra UK,Gawdi G,Pizzo SV,Lewis JG

更新日期：1999-06-01 00:00:00

abstract：:Tumor necrosis factor (TNF)-stimulated gene 14 (TSG-14, also termed PTX3) encodes a secreted glycoprotein whose carboxy-terminal half shares sequence similarity with the pentraxin family of acute phase proteins (C-reactive protein and serum amyloid P component). We compared TSG-14 mRNA expression in cultures of murine...

journal_title：Journal of leukocyte biology

authors： Goodman AR,Levy DE,Reis LF,Vilcek J

更新日期：2000-03-01 00:00:00

abstract：:TTP is an anti-inflammatory protein that acts by binding to AREs in its target mRNAs, such as Tnf mRNA, and promoting their deadenylation and decay. TNF released from inflammatory cells can then stimulate gene expression in tissue cells, such as fibroblasts. To determine whether TTP could affect the decay of TNF-induc...

journal_title：Journal of leukocyte biology

authors： Qiu LQ,Lai WS,Bradbury A,Zeldin DC,Blackshear PJ

更新日期：2015-04-01 00:00:00

abstract：:In this study, we test the hypothesis that cAMP, acting as an extracellular mediator, affects the physiology and function of human myeloid cells. The cAMP is a second messenger recognized as a universal regulator of several cellular functions in different organisms. Many studies have shown that extracellular cAMP exer...

journal_title：Journal of leukocyte biology

authors： Sciaraffia E,Riccomi A,Lindstedt R,Gesa V,Cirelli E,Patrizio M,De Magistris MT,Vendetti S

更新日期：2014-07-01 00:00:00

abstract：:An anti-macrophage monoclonal antibody designated TRPM-3 was produced using thioglycollate-elicited rat peritoneal macrophages as immunogen. By the immunoperoxidase method, TRPM-3 was found to be specific for certain macrophage populations, such as marginal zone macrophages and marginal metallophils of the spleen, sin...

journal_title：Journal of leukocyte biology

authors： Takeya M,Hsiao L,Takahashi K

更新日期：1987-03-01 00:00:00

abstract：:Hepatic lymphocytes are enriched in NK and NKT cells that play important roles in antiviral and antitumor defenses and in the pathogenesis of chronic liver disease. In this review, we discuss the differential distribution of NK and NKT cells in mouse, rat, and human livers, the ultrastructural similarities and differe...

journal_title：Journal of leukocyte biology

authors： Gao B,Radaeva S,Park O

更新日期：2009-09-01 00:00:00

abstract：:Hematopoietic cell differentiation takes place in phenotypically recognizable stages characterized by morphology as well as by the expression of enzymes and surface markers. It is recognized that differentiation results from an interaction of environmental cues, such as cytokines and hormones, with internal cellular p...

journal_title：Journal of leukocyte biology

authors： Chen F,Rao J,Studzinski GP

更新日期：2000-04-01 00:00:00

abstract：:In the present study, we investigated the expression of human CD1d antigen on activated mature T cells. Expression of this glycoprotein was found to be highly regulated and dependent on PHA stimulation. Flow cytometry studies using the NOR3.2 antibody, which recognized CD1d under denaturing conditions, showed a clear ...

journal_title：Journal of leukocyte biology

authors： Salamone MC,Rabinovich GA,Mendiguren AK,Salamone GV,Fainboim L

更新日期：2001-02-01 00:00:00

abstract：:Interactions between chemokines and their specific receptors are important for leukocyte trafficking. The CC-chemokine monocyte chemoattractant protein-1 (MCP-1) and its specific receptor CCR2 are essential in monocytic infiltration and have been associated with several inflammatory diseases. It has been reported that...

journal_title：Journal of leukocyte biology

authors： Zhou Y,Yang Y,Warr G,Bravo R

更新日期：1999-02-01 00:00:00