From top to bottom: midkine and pleiotrophin as emerging players in immune regulation.

Abstract:

:Cytokines are pivotal in the generation and resolution of the inflammatory response. The midkine/pleiotrophin (MK/PTN) family of cytokines, composed of just two members, was discovered as heparin-binding neurite outgrowth-promoting factors. Since their discovery, expression of this cytokine family has been reported in a wide array of inflammatory diseases and cancer. In this minireview, we will discuss the emerging appreciation of the functions of the MK/PTN family in the immune system, which include promoting lymphocyte survival, sculpting myeloid cell phenotype, driving immune cell chemotaxis, and maintaining hematopoiesis.

journal_name

J Leukoc Biol

authors

Sorrelle N,Dominguez ATA,Brekken RA

doi

10.1189/jlb.3MR1116-475R

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

277-286

issue

2

eissn

0741-5400

issn

1938-3673

pii

jlb.3MR1116-475R

journal_volume

102

pub_type

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