The secretion of HMGB1 is required for the migration of maturing dendritic cells.

abstract：:A cell resistant to concentrations of mitomycin-C associated with the inactivation of many in vitro immune responses is described. This cell is responsive to concanavalin A (Con A), poorly adherent to nylon wool, present in relatively greater numbers in lymph node than other lymphoid tissues, and is relatively radiose...

journal_title：Journal of leukocyte biology

authors： Anderson RE,Standefer JC,Troup GM,Pogue LE

更新日期：1987-01-01 00:00:00

abstract：:TNF is a pleiotropic cytokine involved in a variety of inflammatory processes and immune responses. TNF effects are mediated via two distinct membrane receptors: TNFR1 and TNFR2. Investigations concerning regulation and function of TNFR2 revealed a novel TNFR2 isoform in human and mouse cells, termed icp75TNFR, with m...

journal_title：Journal of leukocyte biology

authors： Bäumel M,Lechner A,Hehlgans T,Männel DN

更新日期：2008-07-01 00:00:00

abstract：:Monocyte chemoattractant protein 1 (MCP-1) is likely to contribute to the macrophage infiltrate in human ovarian carcinomas. Although MCP-1 is predominantly expressed by the tumor parenchyma, macrophages accumulate at highest density in necrotic regions, which are associated with low oxygen tensions. Tumor necrosis fa...

journal_title：Journal of leukocyte biology

authors： Negus RP,Turner L,Burke F,Balkwill FR

更新日期：1998-06-01 00:00:00

abstract：:GenBank entries for mouse Il33 reveal the existence of two transcripts, Il33a and Il33b, with different 5'UTRs but coding for the same protein. We investigated expression of these transcripts in different mouse organs and cell types in basal and inflammatory conditions. Il33a and Il33b mRNAs start with different nonco...

journal_title：Journal of leukocyte biology

authors： Talabot-Ayer D,Calo N,Vigne S,Lamacchia C,Gabay C,Palmer G

更新日期：2012-01-01 00:00:00

abstract：:Mast cells and MDSCs are increased by parasitic infection and tumor growth. We previously demonstrated that enhanced MDSC development in ADAM10 transgenic mice yielded resistance to Nb infection and that coculturing MDSCs and mast cells enhanced cytokine production. In the current work, we show that MDSC-mast cell coc...

journal_title：Journal of leukocyte biology

authors： Morales JK,Saleem SJ,Martin RK,Saunders BL,Barnstein BO,Faber TW,Pullen NA,Kolawole EM,Brooks KB,Norton SK,Sturgill J,Graham L,Bear HD,Urban JF Jr,Lantz CS,Conrad DH,Ryan JJ

更新日期：2014-04-01 00:00:00

abstract：:A simple and rapid method for the purification of morphologically and functionally intact eosinophils from human blood of both normal and eosinophilic subjects is described. The method is based on a single centrifugation of total blood leukocytes suspended in Percoll with specific gravity 1.0853 g/ml, after erythrocyt...

journal_title：Journal of leukocyte biology

authors： Cramer R,Dri P,Zabucchi G,Patriarca P

更新日期：1992-09-01 00:00:00

abstract：:The recognition of pathogen-associated molecular patterns by TLRs triggers the activation of innate and adaptive immune responses. Flagellin, the agonist of TLR5, is expressed by prokaryotes and eukaryotes, and DNA sequences containing unmethylated CpG dinucleotides, agonists of TLR9, are present essentially in prokar...

journal_title：Journal of leukocyte biology

authors： Merlo A,Calcaterra C,Mènard S,Balsari A

更新日期：2007-09-01 00:00:00

abstract：:Transition metals, including zinc, are essential to all living organisms. They are also toxic in high amounts, and their intracellular concentration must be tightly regulated. In this edition of JLB, Stocks et al. report that the zinc transporter, ZnT1 (SLC30A1) is induced by TLR4 activation in Mϕs, in which it contri...

journal_title：Journal of leukocyte biology

authors： Neyrolles O

更新日期：2021-02-01 00:00:00

abstract：:Antibody-facilitated macrophage (MP) destruction of Trypanosoma musculi involves ingestion and intracellular degradation of the parasites. It is likely, however, as we show here, that death of the trypanosomes is extracellular and it is the corpses that are ingested by MPs. We have utilized both peritoneal MPs and a c...

journal_title：Journal of leukocyte biology

authors： Albright JW,Stewart MJ,Latham PS,Albright JF

更新日期：1994-11-01 00:00:00

abstract：:Interleukin-15 (IL-15) is a cytokine that possesses interesting, potential therapeutic properties. However, based on several parameters including activation of neutrophils, it is also recognized as a proinflammatory cytokine. The mechanisms by which IL-15 activates human neutrophil functions are not fully understood. ...

journal_title：Journal of leukocyte biology

authors： Ratthé C,Girard D

更新日期：2004-07-01 00:00:00

abstract：:Nitric oxide (NO(.-)) contributes to vascular collapse in septic shock and regulates inflammation. Here, we demonstrate in lipopolysaccharide (LPS)-stimulated human THP-1 cells and monocytes that NO(.-) regulates interleukin (IL)-8 and tumor necrosis factor alpha (TNF-alpha) by distinct mechanisms. Dibutyryl-cyclic gu...

journal_title：Journal of leukocyte biology

authors： Ma P,Cui X,Wang S,Zhang J,Nishanian EV,Wang W,Wesley RA,Danner RL

更新日期：2004-07-01 00:00:00

abstract：:A previously unsuspected, considerable proportion of newly synthesized polypeptides are hydrolyzed rapidly by proteasomes, possibly competing with endogenous substrates and altering proteostasis. In view of the anti-cancer effects of PIs, we set out to achieve a quantitative assessment of proteasome workload in cells ...

journal_title：Journal of leukocyte biology

authors： Cenci S,Oliva L,Cerruti F,Milan E,Bianchi G,Raule M,Mezghrani A,Pasqualetto E,Sitia R,Cascio P

更新日期：2012-11-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that accumulate during pathologic conditions, such as cancer. Patients diagnosed with advanced metastatic cancers have an average survival of 12-24 mo, a survival time that hasn't changed significantly in the past 30 yr. ...

journal_title：Journal of leukocyte biology

authors： Chesney JA,Mitchell RA,Yaddanapudi K

更新日期：2017-09-01 00:00:00

abstract：:In the present work, we demonstrate that interleukin (IL)-4 is able to rescue B cells from Trypanosoma cruzi-infected mice, counteracting the strong apoptotic signals that these cells received in vivo. We have observed that IL-4 restrains the apoptosis of immunoglobulin (Ig)M(+) and IgG(+) B cells from infected and no...

journal_title：Journal of leukocyte biology

authors： Acosta Rodriguez EV,Zuñiga E,Montes CL,Gruppi A

更新日期：2003-01-01 00:00:00

abstract：:PI3Ks have been identified as key signaling proteins involved in many basic biologic processes in health and disease. Transgenic animals have been essential tools to study the underlying molecular mechanisms in this context and therefore, have been widely used to elucidate the role of these factors in many different s...

journal_title：Journal of leukocyte biology

authors： Schneider C,Nobs SP,Heer AK,Hirsch E,Penninger J,Siggs OM,Kopf M

更新日期：2017-02-01 00:00:00

abstract：:Brucella abortus is a Gram-negative intracellular bacterial pathogen that causes a zoonosis of worldwide occurrence, leading to undulant fever in humans and abortion in domestic animals. B. abortus is recognized by several pattern-recognition receptors triggering pathways during the host innate immune response. Theref...

journal_title：Journal of leukocyte biology

authors： Gomes MT,Campos PC,Pereira Gde S,Bartholomeu DC,Splitter G,Oliveira SC

更新日期：2016-05-01 00:00:00

abstract：:DCs orchestrate immune responses contributing to the pattern of response developed. In cancer, DCs may play a dysfunctional role in the induction of CD4(+)CD25(+)Foxp3(+) Tregs, contributing to immune evasion. We show here that Mo-DCs from breast cancer patients show an altered phenotype and induce preferentially Treg...

journal_title：Journal of leukocyte biology

authors： Ramos RN,Chin LS,Dos Santos AP,Bergami-Santos PC,Laginha F,Barbuto JA

更新日期：2012-09-01 00:00:00

abstract：:Engagement of 2B4 (CD244) with CD48 results in activation, costimulation, or inhibition of NK cell activities, depending on the cell types and the stage of differentiation. In vivo, 2B4+ NK cells can interact with CD48+ NK cells and also with surrounding CD48+ hematopoietic cells. Similarly, CD48+ NK cells may be trig...

journal_title：Journal of leukocyte biology

authors： Kim EO,Kim N,Kim TJ,Kim K,Kim TW,Kumar V,Lee KM

更新日期：2010-10-01 00:00:00

abstract：:Human immunodeficiency virus infects different cell types including CD4+ lymphocytes and monocyte-derived macrophages (MDMs). We have examined the activity of the HIV-1 Tat inhibitors Ro-5-3335 and Ro-24-7429 in cultured human peripheral MDMs. Monocytes were isolated from HIV-seronegative donors by gradient centrifuga...

journal_title：Journal of leukocyte biology

authors： Dunne AL,Siregar H,Mills J,Crowe SM

更新日期：1994-09-01 00:00:00

abstract：:The high-affinity receptor for the constant region of immunoglobulin G IgG (Fc gamma RI; CD64) is virtually undetectable on mature polymorphonuclear neutrophils (PMNs) in healthy individuals but is expressed on PMNs in patients with certain infections and in patients treated with recombinant human granulocyte colony-s...

journal_title：Journal of leukocyte biology

authors： Gericke GH,Ericson SG,Pan L,Mills LE,Guyre PM,Ely P

更新日期：1995-03-01 00:00:00

abstract：:Granulocyte apoptosis and subsequent clearance by phagocytes are critical for the resolution of inflammation. However, no studies have addressed how the resolution proceeds in the inflammatory site. We studied the time course of neutrophil apoptosis and the following ingestion by mononuclear leukocytes in rat carragee...

journal_title：Journal of leukocyte biology

authors： Murai N,Nagai K,Fujisawa H,Hatanaka K,Kawamura M,Harada Y

更新日期：2003-04-01 00:00:00

abstract：:The ability of encapsulated and acapsular strains of Cryptococcus neoformans to activate dendritic cells (DC) derived from monocytes stimulated with granulocyte macrophage-colony stimulating factor and interleukin-4 was evaluated. Profound differences in DC response to encapsulated and acapsular C. neoformans strains ...

journal_title：Journal of leukocyte biology

authors： Vecchiarelli A,Pietrella D,Lupo P,Bistoni F,McFadden DC,Casadevall A

更新日期：2003-09-01 00:00:00

abstract：:Eosinophils were isolated from peritoneal lavages of repeated horse serum-injected guinea pigs or rhesus monkeys and from peripheral blood of normal human donors. Eicosanoid metabolism and chemotaxis by these cells were studied by in vitro techniques. Upon calcium ionophore stimulation guinea pig eosinophils released ...

journal_title：Journal of leukocyte biology

authors： Sun FF,Crittenden NJ,Czuk CI,Taylor BM,Stout BK,Johnson HG

更新日期：1991-08-01 00:00:00

abstract：:Given the variable protective efficacy provided by Mycobacterium bovis bacillus Calmette-Guérin (BCG), there is an urgent need to develop new vaccines against tuberculosis. As dendritic cells (DC) play a critical role in initiating and regulating a protective T cell response against the pathogens, the comprehension of...

journal_title：Journal of leukocyte biology

authors： Giacomini E,Remoli ME,Gafa V,Pardini M,Fattorini L,Coccia EM

更新日期：2009-03-01 00:00:00

abstract：:Patients with head and neck squamous cell carcinoma (HNSCC) have increased levels of immune-suppressive peripheral blood CD34+ cells. This study showed that the peripheral blood CD34+ cells of HNSCC patients are capable of differentiating into dendritic cells. Because CD34+ cells can differentiate through several path...

journal_title：Journal of leukocyte biology

authors： Lathers DM,Lubbers E,Wright MA,Young MR

更新日期：1999-05-01 00:00:00

abstract：:The immune system modulates a number of biological processes to properly defend against pathogens. Here, we review how crosstalk between nuclear hormone receptors and the innate immune system may influence multiple biological functions during an immune response. Although nuclear hormone receptor repression of innate i...

journal_title：Journal of leukocyte biology

authors： Chow EK,Razani B,Cheng G

更新日期：2007-08-01 00:00:00

abstract：:Constitutive expression of cell-associated, but not secreted, interleukin-1alpha (IL-1alpha) by oncogene-transformed fibrosarcoma cells induced regressing tumors in mice, a phenomenon that was abrogated by the IL-1 inhibitor, the IL-1 receptor antagonist (IL-1Ra). On the contrary, non-IL-1alpha-expressing tumor cells ...

journal_title：Journal of leukocyte biology

authors： Dvorkin T,Song X,Argov S,White RM,Zoller M,Segal S,Dinarello CA,Voronov E,Apte RN

更新日期：2006-07-01 00:00:00

abstract：:We have demonstrated previously that binding of ephrin-A1 to EphA receptors on human CD4(+) and CD8(+) T cells stimulates migration. Two EphA receptors have been reported in T cells: EphA1 at the protein level and EphA4 at the mRNA level. In this study, we wanted to investigate the expression profile of these receptor...

journal_title：Journal of leukocyte biology

authors： Holen HL,Nustad K,Aasheim HC

更新日期：2010-06-01 00:00:00

abstract：:Emerging evidence suggests that the innate immune system, comprised of Toll-like receptors (TLRs) and their associated molecules, plays a pivotal role in the regulation of intestinal inflammation and in the response to invading pathogens. Although TLRs are thought to have predominantly beneficial effects in pathogen r...

journal_title：Journal of leukocyte biology

authors： Gribar SC,Anand RJ,Sodhi CP,Hackam DJ

更新日期：2008-03-01 00:00:00

abstract：:Osteoarticular complications are common in human brucellosis, but the pathogenic mechanisms involved are largely unknown. In this manuscript, we described an immune mechanism for inflammatory bone loss in response to infection by Brucella abortus. We established a requirement for MyD88 and TLR2 in TNF-α-elicited osteo...

journal_title：Journal of leukocyte biology

authors： Delpino MV,Barrionuevo P,Macedo GC,Oliveira SC,Genaro SD,Scian R,Miraglia MC,Fossati CA,Baldi PC,Giambartolomei GH

更新日期：2012-02-01 00:00:00