Abstract:
:A cell resistant to concentrations of mitomycin-C associated with the inactivation of many in vitro immune responses is described. This cell is responsive to concanavalin A (Con A), poorly adherent to nylon wool, present in relatively greater numbers in lymph node than other lymphoid tissues, and is relatively radiosensitive. In part, the resistance of this T cell appears to relate to a reduced activity of a microsomal reductase responsible for converting mitomycin-C to its more active form. Discrepancies in reductase activity may represent a way to differentiate among subsets of lymphocytes.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Anderson RE,Standefer JC,Troup GM,Pogue LEdoi
10.1002/jlb.41.1.33subject
Has Abstractpub_date
1987-01-01 00:00:00pages
33-9issue
1eissn
0741-5400issn
1938-3673journal_volume
41pub_type
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