Partial characterization of a mitomycin-C resistant T cell.

Abstract:

:A cell resistant to concentrations of mitomycin-C associated with the inactivation of many in vitro immune responses is described. This cell is responsive to concanavalin A (Con A), poorly adherent to nylon wool, present in relatively greater numbers in lymph node than other lymphoid tissues, and is relatively radiosensitive. In part, the resistance of this T cell appears to relate to a reduced activity of a microsomal reductase responsible for converting mitomycin-C to its more active form. Discrepancies in reductase activity may represent a way to differentiate among subsets of lymphocytes.

journal_name

J Leukoc Biol

authors

Anderson RE,Standefer JC,Troup GM,Pogue LE

doi

10.1002/jlb.41.1.33

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

33-9

issue

1

eissn

0741-5400

issn

1938-3673

journal_volume

41

pub_type

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