The polysaccharide capsule of Cryptococcus neoformans interferes with human dendritic cell maturation and activation.

abstract：:CD4(+) T cell help contributes critically to DC-induced CD8(+) CTL immunity. However, precisely how these three cell populations interact and how CD4(+) T cell signals are delivered to CD8(+) T cells in vivo have been unclear. In this study, we developed a novel, two-step approach, wherein CD4(+) T cells and antigen-p...

journal_title：Journal of leukocyte biology

authors： Ahmed KA,Wang L,Munegowda MA,Mulligan SJ,Gordon JR,Griebel P,Xiang J

更新日期：2012-08-01 00:00:00

abstract：:Resting microglia comprise up to 13% of the cells in human central nervous system (CNS) white matter. Their large number and dendritic morphology make them ideally suited to survey the CNS for noxious stimuli. Upon activation microglia gradually lose dendritic processes and transform into typical phagocytic macrophage...

journal_title：Journal of leukocyte biology

authors： Ulvestad E,Williams K,Bjerkvig R,Tiekotter K,Antel J,Matre R

更新日期：1994-12-01 00:00:00

abstract：:Notch signaling plays a preeminent role during development in not only regulating cell fate decisions, but it can also influence growth and survival of progenitor cells. In the immune system, Notch is required for the maintenance of hematopoietic stem cells and in directing T- versus B-lineage commitment. In this revi...

journal_title：Journal of leukocyte biology

authors： Hoyne GF

更新日期：2003-12-01 00:00:00

abstract：:The heterotrimeric guanine nucleotide-binding protein Galphai2 is involved in regulation of immune responses against microbial and nonmicrobial stimuli. Galphai2-/- mice have a selectively impaired IgM response consistent with a disorder in B cell development yet have augmented T cell effector function associated with...

journal_title：Journal of leukocyte biology

authors： Padigel UM,Stein L,Redding K,Lee JJ,Nolan TJ,Schad GA,Birnbaumer L,Abraham D

更新日期：2007-04-01 00:00:00

abstract：:Cytokines and chemokines play an essential role in recruiting leukocytes from the circulation to the peripheral sites of inflammation by modulating cellular interactions with endothelial cell ligands and extracellular matrix (ECM). Herein, we examined regulation of T cell adhesion to ECM ligands by two major proinflam...

journal_title：Journal of leukocyte biology

authors： Ariel A,Novick D,Rubinstein M,Dinarello CA,Lider O,Hershkoviz R

更新日期：2002-07-01 00:00:00

abstract：:The adhesion and degranulation promoting adaptor protein (ADAP) is a multifunctional scaffold involved in many different signaling pathways that are important for the function of T cells, including the inside-out and outside-in signaling of integrins, the activation of NF-κB, and the subsequent production of proinflam...

journal_title：Journal of leukocyte biology

authors： Parzmair GP,Gereke M,Haberkorn O,Annemann M,Podlasly L,Kliche S,Reinhold A,Schraven B,Bruder D

更新日期：2017-02-01 00:00:00

abstract：:Neutrophils are important mediators of the innate immune defense and of the host response to a physical trauma. Because aberrant infiltration of injured sites by neutrophils was shown to cause adverse effects after trauma, we investigated how neutrophil infiltration could be modulated at the cellular level. Our data i...

journal_title：Journal of leukocyte biology

authors： Wille C,Eiseler T,Langenberger ST,Richter J,Mizuno K,Radermacher P,Knippschild U,Huber-Lang M,Seufferlein T,Paschke S

更新日期：2018-09-01 00:00:00

abstract：:The synthesis and secretion of prostaglandins and leukotrienes by mouse peritoneal macrophages is under several regulatory controls. Arachidonic acid must first be released from phospholipid stores by the action of phospholipases. Macrophages have the capacity to deacylate arachidonic acid directly from the SN2 positi...

journal_title：Journal of leukocyte biology

authors： Bonney RJ,Humes JL

更新日期：1984-01-01 00:00:00

abstract：:Neutrophils, an essential component of the innate immune system, are produced at a rate 10(11) cells/day and are consequently the most abundant leukocyte in the blood. These granulocytes have a relatively short half-life (6-8 h) in the blood, and as a result of the cytotoxic nature of their contents, it is critical th...

journal_title：Journal of leukocyte biology

authors： Rankin SM

更新日期：2010-08-01 00:00:00

abstract：:Colostrum plays an important role in protecting newborn infants against acute gastrointestinal and respiratory infections. IgA antibodies have been considered the major effector component; however, the role of their receptors on colostral phagocytes, especially neutrophils, has not been studied. Here, we demonstrate t...

journal_title：Journal of leukocyte biology

authors： Honorio-França AC,Launay P,Carneiro-Sampaio MM,Monteiro RC

更新日期：2001-02-01 00:00:00

abstract：:Type I IFNs are used for treating viral, neoplastic, and inflammatory disorders. The protein products encoded by IFN-stimulated genes (ISGs) likely mediate clinical effects of IFN in patients. Macroarray assays, used for studying ISG induction in IFN-treated patients, comprise genes identified predominantly through an...

journal_title：Journal of leukocyte biology

authors： Rani MR,Shrock J,Appachi S,Rudick RA,Williams BR,Ransohoff RM

更新日期：2007-11-01 00:00:00

abstract：:Severe injury can initiate an exaggerated systemic inflammatory response and multiple organ failure (MOF) if a subsequent immune stimulus, "second hit", occurs. Using a mouse thermal injury model, we tested whether changes in innate immune cell reactivity following injury can contribute to the development of heightene...

journal_title：Journal of leukocyte biology

authors： Murphy TJ,Paterson HM,Kriynovich S,Zang Y,Kurt-Jones EA,Mannick JA,Lederer JA

更新日期：2005-01-01 00:00:00

abstract：:We have developed a method that enables the rates of phagocytosis and killing of bacteria by neutrophils to be measured in a single assay. Neutrophils were incubated with bacteria, and at specific intervals were separated from uningested bacteria by low speed centrifugation. Rates of phagocytosis and killing were calc...

journal_title：Journal of leukocyte biology

authors： Hampton MB,Vissers MC,Winterbourn CC

更新日期：1994-02-01 00:00:00

abstract：:The absence or reduction of CFTR function causes CF and results in a pulmonary milieu characterized by bacterial colonization and unresolved inflammation. The ineffectiveness at controlling infection by species such as Pseudomonas aeruginosa suggests defects in innate immunity. Macrophages, neutrophils, and DCs have a...

journal_title：Journal of leukocyte biology

authors： Bonfield TL,Hodges CA,Cotton CU,Drumm ML

更新日期：2012-11-01 00:00:00

abstract：:Workshop cluster 1 (WC1) is a member of the scavenger receptor cysteine-rich (SRCR) superfamily that includes CD5, CD6, CD163, and M160. Bovine WC1 consists of 11 SRCR domains, a unique domain 1, and two homologous 5 SRCR domain cassettes, WC1 domains 2-6 and 7-11. The porcine orthologue of WC1 contains five SRCR doma...

journal_title：Journal of leukocyte biology

authors： Ahn JS,Konno A,Gebe JA,Aruffo A,Hamilton MJ,Park YH,Davis WC

更新日期：2002-08-01 00:00:00

abstract：:NLRs are cytoplasmic proteins that sense cellular stress and intracellular damage resulting from pathogen uptake. To date, the role of NLRs has been studied using combinations of NLR and TLR agonists, but the interplay between two different NLRs remains uncharacterized. In this study, we employed microarrays to invest...

journal_title：Journal of leukocyte biology

authors： Conforti-Andreoni C,Beretta O,Licandro G,Qian HL,Urbano M,Vitulli F,Ricciardi-Castagnoli P,Mortellaro A

更新日期：2010-12-01 00:00:00

abstract：:Both humoral and cellular immune responses are inducible by inoculation of naked plasmid DNA encoding a polypeptide antigen. This new vaccination protocol, known as genetic immunization, has been used to initiate protective immunity against a variety of infectious pathogens and tumors in experimental animals. Dendriti...

journal_title：Journal of leukocyte biology

authors： Takashima A,Morita A

更新日期：1999-08-01 00:00:00

abstract：:The production of IL-12 by macrophages/dendritic cells (Mphi/DC) is mediated either by a T cell-dependent pathway that is induced primarily by the interaction of CD40 ligand (CD40L) on activated T cells with CD40 on IL-12-producing cells or by a T cell-independent pathway that is induced by bacteria or bacterial produ...

journal_title：Journal of leukocyte biology

authors： Takenaka H,Maruo S,Yamamoto N,Wysocka M,Ono S,Kobayashi M,Yagita H,Okumura K,Hamaoka T,Trinchieri G,Fujiwara H

更新日期：1997-01-01 00:00:00

abstract：:DCs orchestrate immune responses contributing to the pattern of response developed. In cancer, DCs may play a dysfunctional role in the induction of CD4(+)CD25(+)Foxp3(+) Tregs, contributing to immune evasion. We show here that Mo-DCs from breast cancer patients show an altered phenotype and induce preferentially Treg...

journal_title：Journal of leukocyte biology

authors： Ramos RN,Chin LS,Dos Santos AP,Bergami-Santos PC,Laginha F,Barbuto JA

更新日期：2012-09-01 00:00:00

abstract：:The ganglioside composition of endotoxin-responsive C3H/HeN murine peritoneal macrophages is known to undergo dramatic changes in vivo in response to intraperitoneal lipopolysaccharides (LPS), unlike endotoxin-hyporesponsive C3H/HeJ macrophages. To better investigate the mechanism behind LPS-induced macrophage ganglio...

journal_title：Journal of leukocyte biology

authors： Berenson CS,Yohe HC,Ryan JL

更新日期：1989-03-01 00:00:00

abstract：:CXCL8 is the principal human neutrophil-attracting chemokine and a major mediator of inflammation. The chemokine exerts its neutrophil-chemotactic and neutrophil-activating activities via interaction with glycosaminoglycans (GAGs) and activation of the G protein-coupled receptors (GPCRs) CXCR1 and CXCR2. Natural CXCL8...

journal_title：Journal of leukocyte biology

authors： Metzemaekers M,Vandendriessche S,Berghmans N,Gouwy M,Proost P

更新日期：2020-06-01 00:00:00

abstract：:During the development of immune responses to pathogens, self-antigens, or environmental allergens, naive CD4(+) T cells differentiate into subsets of effector cells including Th1, Th2, and Th17 cells. The differentiation into these subsets is controlled by specific transcription factors. The activity of these effecto...

journal_title：Journal of leukocyte biology

authors： Chapoval S,Dasgupta P,Dorsey NJ,Keegan AD

更新日期：2010-06-01 00:00:00

abstract：:Interleukin-1beta is a secreted protein that accumulates in the cytosol as an inactive precursor (pIL-1beta) before processing and release of biologically active protein. To understand the impact of this property on IL-1beta production, we examined the intracellular stability of pIL-1beta in lipopolysaccharide (LPS)-s...

journal_title：Journal of leukocyte biology

authors： Moors MA,Mizel SB

更新日期：2000-07-01 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a naturally occurring growth factor produced by several cell types in response to a variety of stimuli. GM-CSF has potent stimulatory effects on the growth and maturation of hematopoietic cells and has profound effects on mature circulating effector cells. C...

journal_title：Journal of leukocyte biology

authors： Hill AD,Naama HA,Calvano SE,Daly JM

更新日期：1995-12-01 00:00:00

abstract：:Osteoarticular complications are common in human brucellosis, but the pathogenic mechanisms involved are largely unknown. In this manuscript, we described an immune mechanism for inflammatory bone loss in response to infection by Brucella abortus. We established a requirement for MyD88 and TLR2 in TNF-α-elicited osteo...

journal_title：Journal of leukocyte biology

authors： Delpino MV,Barrionuevo P,Macedo GC,Oliveira SC,Genaro SD,Scian R,Miraglia MC,Fossati CA,Baldi PC,Giambartolomei GH

更新日期：2012-02-01 00:00:00

abstract：:Carcinoembryonic antigen (CEA), a member of the immunoglobulin supergene family, is recognized by a specific 80-kd receptor on Kupffer cells and alveolar macrophages. Peritoneal macrophages were harvested from male Sprague-Dawley rats 72 h after intraperitoneal injection with thioglycolate broth and from unstimulated ...

journal_title：Journal of leukocyte biology

authors： Toth CA

更新日期：1992-05-01 00:00:00

abstract：:The neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) is a powerful suppressor of inflammation mediated by macrophages, which express at least two receptors, melanocortin 1 and 3 receptors (MC1r and MC3r) that bind alpha-MSH. Albeit, the anti-inflammatory activity of alpha-MSH has been well documented in m...

journal_title：Journal of leukocyte biology

authors： Li D,Taylor AW

更新日期：2008-07-01 00:00:00

abstract：:A sensitive in vitro assay for generation of human leukocytic pyrogen has been used to study the pathogenesis of fever accompanying administration of human alpha-interferon. Unlike other potent pyrogens, two recombinant interferon preparations tested over a wide concentration range did not stimulate release of leukocy...

journal_title：Journal of leukocyte biology

authors： Ackerman SK,Hochstein HD,Zoon K,Browne W,Rivera E,Elisberg B

更新日期：1984-07-01 00:00:00

abstract：:Sexual transmission is the primary route of HIV-1 infection, and DC subsets are thought to be involved in viral dissemination to T cells. In the genital mucosa, two main subsets of DCs are present: epithelial LCs capture and degrade HIV-1 through C-type lectin Langerin, whereas subepithelial DCs express DC-SIGN, which...

journal_title：Journal of leukocyte biology

authors： de Jong MA,de Witte L,Santegoets SJ,Fluitsma D,Taylor ME,de Gruijl TD,Geijtenbeek TB

更新日期：2010-04-01 00:00:00

abstract：:4-1BB is a member of the TNFR superfamily, which contributes to the activation of signaling pathways required for the survival of activated and memory T cells. We have shown previously that TRAF1, an adaptor protein recruited to 4-1BB, is required for 4-1BB-mediated CD8 T cell survival in vivo. With the use of a prote...

journal_title：Journal of leukocyte biology

authors： Sabbagh L,Andreeva D,Laramée GD,Oussa NA,Lew D,Bisson N,Soumounou Y,Pawson T,Watts TH

更新日期：2013-05-01 00:00:00