Diminishment of alpha-MSH anti-inflammatory activity in MC1r siRNA-transfected RAW264.7 macrophages.

abstract：:Rats were injected with phenylhydrazine (PHZ) for periods of up to 6 months, during which time a marked leukocytosis was induced. The highest leukocyte counts occurred within 4-5 days following injection. An initial injection of 4 mg/100 gm body weight evoked a mean total leukocyte count of 129 X 10(3) cells/microlite...

journal_title：Journal of leukocyte biology

authors： Dornfest BS,Lapin DM,Naughton BA,Adu S,Korn L,Gordon AS

更新日期：1986-01-01 00:00:00

abstract：:The influence of ethanol (EtOH) on multiple dendritic cell (DC) subsets, in the steady state or following their mobilization in vivo, has not been characterized. Herein, generation of mouse bone marrow-derived DC (BMDC) in response to fms-like tyrosine kinase 3 ligand was inhibited by physiologically relevant concentr...

journal_title：Journal of leukocyte biology

authors： Lau AH,Abe M,Thomson AW

更新日期：2006-05-01 00:00:00

abstract：:Absence of lymph nodes in nonmammalian species, expression of MHCII by APCs in the periphery, and the recent findings that T cells can change their polarization status after presentation in the lymph nodes imply a role for MHCII-mediated presentation outside the organized lymphoid tissue. This study shows that MHCII(+...

journal_title：Journal of leukocyte biology

authors： Inman CF,Singha S,Lewis M,Bradley B,Stokes C,Bailey M

更新日期：2010-09-01 00:00:00

abstract：:In this study, we demonstrate that freshly adherent bovine monocytes release tumor necrosis factor-alpha (TNF-alpha) in response to stimulation with bacterial lipopolysaccharide (LPS). TNF-alpha was detected using actinomycin D-treated WEHI-164 murine fibrosarcoma cells as targets in an 18 hr cytotoxicity assay. Doses...

journal_title：Journal of leukocyte biology

authors： Adams JL,Czuprynski CJ

更新日期：1990-12-01 00:00:00

abstract：:Microbicidal activity of neutrophils is usually measured by colony-counting techniques after cell lysis in distilled water. While studying the effect of the reduced nicotinamide adenine dinucleotide phosphate-oxidase inhibitor diphenyleneiodonium (DPI) on the staphylocidal activity of neutrophils, we obtained inconsis...

journal_title：Journal of leukocyte biology

authors： Decleva E,Menegazzi R,Busetto S,Patriarca P,Dri P

更新日期：2006-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive, neurodegenerative disease characterized by the presence of multiple senile plaques in the brain tissue, which are also associated with considerable inflammatory infiltrates. Although the precise mechanisms of the pathogenesis of AD remain to be determined, the overproduction ...

journal_title：Journal of leukocyte biology

authors： Cui Y,Le Y,Yazawa H,Gong W,Wang JM

更新日期：2002-10-01 00:00:00

abstract：:The human activation antigen CD69 is an early inducible surface glycoprotein acquired by T cells in the thymus at the stage of positive selection and during activation of mature lymphoid cells both in vivo and in vitro. We have studied the regulatory influence of CD69 activation pathway on the glycolytic process and t...

journal_title：Journal of leukocyte biology

authors： Conde M,Montaño R,Moreno-Aurioles VR,Ramirez R,Sanchez-Mateos P,Sanchez-Madrid F,Sobrino F

更新日期：1996-08-01 00:00:00

abstract：:There is vast body of evidence that the insulin-like growth factor (IGF)-I exerts immunomodulatory effects in vitro and in vivo. In vitro studies indicate that stimulatory effects of IGF-I may be exerted through augmentation of inflammatory cytokine production. To further explore the immunomodulatory effects of IGF-I ...

journal_title：Journal of leukocyte biology

authors： Kooijman R,Coppens A

更新日期：2004-10-01 00:00:00

abstract：:We have studied two key stages of CD4 development that serve as important checkpoints in determining whether a response will occur, how big it will be, and how long it will last. The response of naive CD4 cells is strictly regulated by the requirement for interaction of the potential precursor with an antigen-presenti...

journal_title：Journal of leukocyte biology

authors： Swain SL

更新日期：1995-05-01 00:00:00

abstract：:Primitive macrophages emerged in the sinusoidal lumen of the fetal mouse liver at 10 days of gestation before the initiation of hepatic hematopoiesis and matured into fetal macrophages. In the culture of cell suspensions from the fetal liver with LP3-conditioned medium, monocyte colonies were formed, but monocytopoies...

journal_title：Journal of leukocyte biology

authors： Naito M,Takahashi K,Nishikawa S

更新日期：1990-07-01 00:00:00

abstract：:Tumor necrosis factor (TNF) and interleukin-1 (IL-1) are cytokines with pleiotropic biological activities, exerting a broad range of overlapping biological functions. The redundancy of TNF and IL-1 activities may be based on the utilization of shared key components of intracellular signaling pathways. Two lipid second...

journal_title：Journal of leukocyte biology

authors： Schütze S,Machleidt T,Krönke M

更新日期：1994-11-01 00:00:00

abstract：:Successful remodeling of the uterine spiral arteries is essential for a complication-free pregnancy and is best described in terms of its morphologic features. The molecular mediators and cellular sources of spiral artery remodeling are not known, although a role for uterine leukocytes has been proposed. Immunohistoch...

journal_title：Journal of leukocyte biology

authors： Lash GE,Pitman H,Morgan HL,Innes BA,Agwu CN,Bulmer JN

更新日期：2016-08-01 00:00:00

abstract：:CXCL8 is the principal human neutrophil-attracting chemokine and a major mediator of inflammation. The chemokine exerts its neutrophil-chemotactic and neutrophil-activating activities via interaction with glycosaminoglycans (GAGs) and activation of the G protein-coupled receptors (GPCRs) CXCR1 and CXCR2. Natural CXCL8...

journal_title：Journal of leukocyte biology

authors： Metzemaekers M,Vandendriessche S,Berghmans N,Gouwy M,Proost P

更新日期：2020-06-01 00:00:00

abstract：:We report the systematic use of large-scale cDNA microarrays to study the gene expression profiles of primary human peripheral blood monocytes (MONO) in comparison with in vitro-differentiated, M-CSF-induced MONO-derived macrophages (MAC) and primary human alveolar MAC (AM), obtained by bronchoalveolar lavage from the...

journal_title：Journal of leukocyte biology

authors： Li J,Pritchard DK,Wang X,Park DR,Bumgarner RE,Schwartz SM,Liles WC

更新日期：2007-01-01 00:00:00

abstract：:Mice with a naturally occurring Csfm(op)/Csfm(op) (op/op) gene mutation lack functional macrophage-colony stimulating factor (M-CSF) and are deficient of M-CSF-derived macrophages. They are severely monocytopenic, and their remaining M-CSF-independent macrophages were shown to differ in differentiation and distinct fu...

journal_title：Journal of leukocyte biology

authors： Schönlau F,Schlesiger C,Ehrchen J,Grabbe S,Sorg C,Sunderkötter C,Ehrehen J

更新日期：2003-05-01 00:00:00

abstract：:Transition metals, including zinc, are essential to all living organisms. They are also toxic in high amounts, and their intracellular concentration must be tightly regulated. In this edition of JLB, Stocks et al. report that the zinc transporter, ZnT1 (SLC30A1) is induced by TLR4 activation in Mϕs, in which it contri...

journal_title：Journal of leukocyte biology

authors： Neyrolles O

更新日期：2021-02-01 00:00:00

abstract：:TLR agonists such as LPS and poly(I:C) induce expression of type I IFNs, such as IFN-α and -β, by macrophages. To examine the role of IFN-β in the induction of ISGs by LPS, we compared the ability of LPS to induce ISGF3 activity and ISG expression in bone marrow-derived macrophages from WT and Ifnb1(-/-) mice. We foun...

journal_title：Journal of leukocyte biology

authors： Sheikh F,Dickensheets H,Gamero AM,Vogel SN,Donnelly RP

更新日期：2014-10-01 00:00:00

abstract：:Inflammation is deeply entangled with redox modulation. Triggering of PRRs on inflammatory cells induces ROS generation. As a consequence, activated cells mount antioxidant responses to counteract the possible harmful effects of oxidation. Therefore, when repair is completed, homeostasis is restored. Here, we describe...

journal_title：Journal of leukocyte biology

authors： Carta S,Castellani P,Delfino L,Tassi S,Venè R,Rubartelli A

更新日期：2009-09-01 00:00:00

abstract：:It has been reported recently that granulocyte-colony stimulating factor (G-CSF) is degraded upon exposure to human neutrophil elastase (HNE), and this has a negative effect on the ability of the cytokine to promote the in vitro proliferation and maturation of CD34+ cells. This has important implications on the possib...

journal_title：Journal of leukocyte biology

authors： Carter CR,Whitmore KM,Thorpe R

更新日期：2004-03-01 00:00:00

abstract：:The immune system in early life is regarded as immature. However, the IL-12 family member IL-23 is highly produced upon TLR stimulation by neonatal DCs. Human adult Vγ9Vδ2 T cells can be stimulated specifically via their TCR by phosphoantigens (as the pathogen-derived HMB-PP) or agents and infections that lead to thei...

journal_title：Journal of leukocyte biology

authors： Moens E,Brouwer M,Dimova T,Goldman M,Willems F,Vermijlen D

更新日期：2011-05-01 00:00:00

abstract：:The agent(s) and mechanism(s) responsible for suppression of neutrophil chemotaxis in association with major thermal injury have not been identified. We have proposed that the reduced random motility characterizing patients' cells may contribute to their generalized chemotactic dysfunction. Here we report that actin p...

journal_title：Journal of leukocyte biology

authors： Hasslen SR,Ahrenholz DH,Solem LD,Nelson RD

更新日期：1992-11-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that accumulate during pathologic conditions, such as cancer. Patients diagnosed with advanced metastatic cancers have an average survival of 12-24 mo, a survival time that hasn't changed significantly in the past 30 yr. ...

journal_title：Journal of leukocyte biology

authors： Chesney JA,Mitchell RA,Yaddanapudi K

更新日期：2017-09-01 00:00:00

abstract：:Previous work indicated that macrophages and a lymphoid dendritic cell-like tumor line, P388AD.2, possessed a differential ability to present a haptenated immunoglobulin (tolerogen) in vitro. Macrophages presented fluorescein-conjugated sheep gamma globulin (FL-SGG) and elicited B-cell unresponsiveness. In contrast, P...

journal_title：Journal of leukocyte biology

authors： Phipps RP,Illig K,Schad V,Bhimani K

更新日期：1988-03-01 00:00:00

abstract：:Intracellular zinc homeostasis is strictly regulated by zinc binding proteins and zinc transporters. In the present study, we quantified in a first global view the expression of all characterized human zinc exporters (hZnT-1-9) in different leukocyte subsets in response to zinc supplementation and depletion and analyz...

journal_title：Journal of leukocyte biology

authors： Overbeck S,Uciechowski P,Ackland ML,Ford D,Rink L

更新日期：2008-02-01 00:00:00

abstract：:In the present work, we demonstrate that interleukin (IL)-4 is able to rescue B cells from Trypanosoma cruzi-infected mice, counteracting the strong apoptotic signals that these cells received in vivo. We have observed that IL-4 restrains the apoptosis of immunoglobulin (Ig)M(+) and IgG(+) B cells from infected and no...

journal_title：Journal of leukocyte biology

authors： Acosta Rodriguez EV,Zuñiga E,Montes CL,Gruppi A

更新日期：2003-01-01 00:00:00

abstract：:The pathogenesis of CRC remains to be further understood. This study was designed to elucidate the role of Foxp3+IL-17+ T cells in the pathogenesis of CRC. Surgically removed CRC tissue was collected from 12 patients with CRC. The frequency and cytokine profile of Foxp3+IL-17+ T cells in CRC were examined by flow cyto...

journal_title：Journal of leukocyte biology

authors： Yang S,Wang B,Guan C,Wu B,Cai C,Wang M,Zhang B,Liu T,Yang P

更新日期：2011-01-01 00:00:00

abstract：:The neutrophil is a key player in immunity, and its activities are essential for the resolution of infections. Neutrophil-pathogen interactions usually trigger a large arsenal of antimicrobial measures that leads to the highly efficient killing of pathogens. In neutrophils, the phagocytic process, including the format...

journal_title：Journal of leukocyte biology

authors： Nordenfelt P,Tapper H

更新日期：2011-08-01 00:00:00

abstract：:LPS induces dendritic cell (DC) activation, but the precise in vivo mechanism is unclear since DCs express low levels of TLR4. Here, it is shown that DCs can be activated in response to LPS through a bystander mechanism. This result was obtained using chimeric mice reconstituted with LPS-responsive and nonresponsive b...

journal_title：Journal of leukocyte biology

authors： Yadav R,Zammit DJ,Lefrancois L,Vella AT

更新日期：2006-12-01 00:00:00

abstract：:A continuing theme of work done in our laboratory involves regulation of adaptive immune response by innate cells, in general, and immuneregulation by natural killer (NK) and NKT cells, in particular. Studies include work with the lung and the eye. In addition to immune surveillance of tumor cells, the NK cell is ofte...

journal_title：Journal of leukocyte biology

authors： Stein-Streilein J,Sonoda KH,Faunce D,Zhang-Hoover J

更新日期：2000-04-01 00:00:00

abstract：:Corynebacterium parvum-treated mice produce large amounts of circulating nitrogen oxides and develop a severe liver injury in response to lipopolysaccharide (LPS). Concurrent administration of NG-monomethyl-L-arginine not only suppresses nitric oxide synthesis in these animals but also profoundly increases the hepatic...

journal_title：Journal of leukocyte biology

authors： Harbrecht BG,Billiar TR,Stadler J,Demetris AJ,Ochoa J,Curran RD,Simmons RL

更新日期：1992-10-01 00:00:00