Decidual macrophages: key regulators of vascular remodeling in human pregnancy.

Abstract:

:Successful remodeling of the uterine spiral arteries is essential for a complication-free pregnancy and is best described in terms of its morphologic features. The molecular mediators and cellular sources of spiral artery remodeling are not known, although a role for uterine leukocytes has been proposed. Immunohistochemical assessment of placental bed biopsies demonstrated uterine NK cells, macrophages, and T lymphocytes in the wall and adventitia of spiral arteries at different stages of remodeling, regardless of the presence of extravillous trophoblast cells. Leukocytes were more prevalent in vessel adventitia than wall, and macrophages were the most abundant leukocyte population. Macrophages, separated from early pregnancy decidua, did not alter extravillous trophoblast cells invasion or vascular smooth muscle cell organization or differentiation status but did induce extracellular matrix breakdown (reduced immunostaining of laminin, P = 0.05; fibronectin, P = 0.02) and were able to phagocytose apoptotic vascular smooth muscle cells. Decidual macrophages were shown to secrete a wide range of cytokines (IL-1β, -2, -4, -5, -6, -8, -10, and -13 and TNF-α), proteases (matrix metalloproteinase-1, -2, -7, -9, and -10), and angiogenic growth factors (angiogenin, keratinocyte growth factor, fibroblast growth factor B, vascular endothelial growth factor A, and angiopoietin-1 and -2). We conclude that spiral artery remodeling involves the coordinated activity of a range of cell types, including extravillous trophoblast cells, decidual uterine NK cells, and macrophages in a carefully, spatiotemporally regulated manner.

journal_name

J Leukoc Biol

authors

Lash GE,Pitman H,Morgan HL,Innes BA,Agwu CN,Bulmer JN

doi

10.1189/jlb.1A0815-351R

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

315-25

issue

2

eissn

0741-5400

issn

1938-3673

pii

jlb.1A0815-351R

journal_volume

100

pub_type

杂志文章
  • New dog and new tricks: evolving roles for IL-33 in type 2 immunity.

    abstract::IL-33 is a more recently identified member of the IL-1 cytokine family, expressed in the nucleus of epithelial cells and released into the extracellular space following tissue damage. The impact of IL-33 as a regulator of the adaptive immune response has been studied extensively, with an understood role for IL-33 in t...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1189/jlb.3RI1214-595R

    authors: Lott JM,Sumpter TL,Turnquist HR

    更新日期:2015-06-01 00:00:00

  • Modulation of IL-1 alpha, IL-1 beta, and 25K Mr non-IL-1 activity released by human mononuclear cells.

    abstract::To determine if the release of IL-1 alpha and IL-1 beta by cultured PBMC could be independently modulated by different exogenous stimuli, we examined the effect of LPS, IFN gamma, latex beads, and indomethacin on the release of IL-1 alpha and IL-1 beta. PBMC culture supernatants were fractionated by Sephacryl-S-200 co...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.46.5.417

    authors: Sandborg CI,Berman MA,Imfeld KL,Zaldivar F Jr,Masada MP,Kenney JS

    更新日期:1989-11-01 00:00:00

  • Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson's disease.

    abstract::Progressive loss of dopaminergic neurons in the substantia nigra pars compacta and their terminal connections in the striatum are central features in Parkinson's disease (PD). Emerging evidence supports the notion that microglia neuroinflammatory responses speed neurodegenerative events. We demonstrated previously tha...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0507296

    authors: Reynolds AD,Banerjee R,Liu J,Gendelman HE,Mosley RL

    更新日期:2007-11-01 00:00:00

  • From top to bottom: midkine and pleiotrophin as emerging players in immune regulation.

    abstract::Cytokines are pivotal in the generation and resolution of the inflammatory response. The midkine/pleiotrophin (MK/PTN) family of cytokines, composed of just two members, was discovered as heparin-binding neurite outgrowth-promoting factors. Since their discovery, expression of this cytokine family has been reported in...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1189/jlb.3MR1116-475R

    authors: Sorrelle N,Dominguez ATA,Brekken RA

    更新日期:2017-08-01 00:00:00

  • Tissue distribution of CD6 and CD6 ligand in cattle: expression of the CD6 ligand (CD166) in the autonomic nervous system of cattle and the human.

    abstract::We studied the tissue distribution of CD6(+) lymphocytes and cells expressing the CD6 ligand (also known as activated leukocyte cell adhesion molecule CD166) in calves by immunohistochemistry using an anti-bovine CD6 monoclonal antibody (mAb), a human CD6 (huCD6)-immunoglobulin G1 fusion protein (huCD6-Ig), and an ant...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:

    authors: Konno A,Ahn JS,Kitamura H,Hamilton MJ,Gebe JA,Aruffo A,Davis WC

    更新日期:2001-06-01 00:00:00

  • IL-17 receptor signaling influences virus-induced corneal inflammation.

    abstract::IL-17 has been associated with selected inflammatory and autoimmune diseases. We characterized the expression of this proinflammatory cytokine following HSV-1 corneal infection and investigated whether IL-17R signaling modulated the host response to the viral pathogen at early time-points postinfection. IL-17 was elev...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0807571

    authors: Molesworth-Kenyon SJ,Yin R,Oakes JE,Lausch RN

    更新日期:2008-02-01 00:00:00

  • The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system.

    abstract::The human cathelicidin LL-37 is a cationic host defense peptide (antimicrobial peptide) expressed primarily by neutrophils and epithelial cells. This peptide, up-regulated under conditions of inflammation, has immunomodulatory and antimicrobial functions. We demonstrate that LL-37 is a potent inhibitor of human neutro...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.1005560

    authors: Barlow PG,Li Y,Wilkinson TS,Bowdish DM,Lau YE,Cosseau C,Haslett C,Simpson AJ,Hancock RE,Davidson DJ

    更新日期:2006-09-01 00:00:00

  • Activation of the sympathetic nervous system modulates neutrophil function.

    abstract::Emerging evidence has revealed that noradrenaline (NA), the main neurotransmitter of the sympathetic nervous system (SNS), regulates a variety of immune functions via binding to adrenergic receptors present on immune cells. In this study, we examined the role of NA in the regulation of neutrophil functions. Neutrophil...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/JLB.3MA0517-194RR

    authors: Nicholls AJ,Wen SW,Hall P,Hickey MJ,Wong CHY

    更新日期:2018-02-01 00:00:00

  • Statins alter neutrophil migration by modulating cellular Rho activity--a potential mechanism for statins-mediated pleotropic effects?

    abstract::The ability of neutrophils to sense and migrate toward damaged tissue is a vital component of the innate immune response. Paradoxically, this same migration serves as the hallmark of a number of inflammatory conditions, including ischemic reperfusion injury, atherosclerosis, arthritis, and Crohn's disease. More recent...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0608382

    authors: Maher BM,Dhonnchu TN,Burke JP,Soo A,Wood AE,Watson RW

    更新日期:2009-01-01 00:00:00

  • Relationship between chemical composition and biological function of Pseudomonas aeruginosa lipopolysaccharide: effect on human neutrophil chemotaxis and oxidative burst.

    abstract::There are conflicting data on the effect of bacterial lipopolysaccharides (LPS) on the function of human neutrophils. The present study was designed to examine the relationship between chemical composition and the modulatory effect of LPS on human neutrophil function. LPS was extracted from five strains of Pseudomonas...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.49.1.15

    authors: Kharazmi A,Fomsgaard A,Conrad RS,Galanos C,Høiby N

    更新日期:1991-01-01 00:00:00

  • Regulation of T cell-dependent and -independent IL-12 production by the three Th2-type cytokines IL-10, IL-6, and IL-4.

    abstract::The production of IL-12 by macrophages/dendritic cells (Mphi/DC) is mediated either by a T cell-dependent pathway that is induced primarily by the interaction of CD40 ligand (CD40L) on activated T cells with CD40 on IL-12-producing cells or by a T cell-independent pathway that is induced by bacteria or bacterial produ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.61.1.80

    authors: Takenaka H,Maruo S,Yamamoto N,Wysocka M,Ono S,Kobayashi M,Yagita H,Okumura K,Hamaoka T,Trinchieri G,Fujiwara H

    更新日期:1997-01-01 00:00:00

  • CD137 is expressed by follicular dendritic cells and costimulates B lymphocyte activation in germinal centers.

    abstract::CD137, a member of the TNF receptor family, and its ligand are expressed on T lymphocytes and antigen-presenting cells (APC), respectively. During interaction with APC, T lymphocytes receive a potent, costimulatory signal through CD137. Reverse signaling has been demonstrated for the CD137 ligand, which causes activat...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:

    authors: Pauly S,Broll K,Wittmann M,Giegerich G,Schwarz H

    更新日期:2002-07-01 00:00:00

  • Activity and subcellular distribution of cathepsins in primary human monocytes.

    abstract::Cathepsins (Cat) in antigen presenting cells (APC) control antigen processing as well as major histocompatibility complex class II transport and function. The set of active Cat and the subcellular architecture of the class II antigen presentation compartment are largely unknown in primary human APC, including peripher...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0802398

    authors: Greiner A,Lautwein A,Overkleeft HS,Weber E,Driessen C

    更新日期:2003-02-01 00:00:00

  • Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice.

    abstract::Hepatic Macs, consisting of resident KCs and infiltrating monocytes/IMs, are thought to play an important role in the pathogenesis of ALD. Previous work has focused on KCs or studied hepatic Macs as one cell population. The aim of the current study is to distinguish IMs from KCs and to compare their phenotypes and fun...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.6A0114-004RR

    authors: Wang M,You Q,Lor K,Chen F,Gao B,Ju C

    更新日期:2014-10-01 00:00:00

  • The phenotype of murine wound macrophages.

    abstract::The phenotype of wound macrophages has not been studied by direct examination of these cells, yet macrophages recruited to sites of injury are described as alternatively activated macrophages, requiring IL-4 or IL-13 for phenotypic expression. This study characterized wound macrophage phenotype in the PVA sponge wound...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0409236

    authors: Daley JM,Brancato SK,Thomay AA,Reichner JS,Albina JE

    更新日期:2010-01-01 00:00:00

  • CD40 ligation and phagocytosis differently affect the differentiation of monocytes into dendritic cells.

    abstract::That monocytes can differentiate into macrophages or dendritic cells (DCs) makes them an essential link between innate and adaptive immunity. However, little is known about how interactions with pathogens or T cells influence monocyte engagement toward DCs. We approached this point in cultures where granulocyte macrop...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:

    authors: Rosenzwajg M,Jourquin F,Tailleux L,Gluckman JC

    更新日期:2002-12-01 00:00:00

  • AGE-modified albumin containing infusion solutions boosts septicaemia and inflammation in experimental peritonitis.

    abstract::HSA preparations for i.v. use are administered in critically ill patients. Although increasing intravascular osmotic pressure seems to be a pathophysiologically orientated treatment, clinical trials do not indicate a benefit for mortality in HSA-treated patients. Instead, there is evidence for inflammatory reactions u...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.1008646

    authors: Humpert PM,Lukic IK,Thorpe SR,Hofer S,Awad EM,Andrassy M,Deemer EK,Kasper M,Schleicher E,Schwaninger M,Weigand MA,Nawroth PP,Bierhaus A

    更新日期:2009-09-01 00:00:00

  • Liposome-encapsulated dichloromethylene diphosphonate induces macrophage apoptosis in vivo and in vitro.

    abstract::Dichloromethylene diphosphonate (MDPCl2) encapsulated in multilamellar liposomes was selectively incorporated by macrophages, immediately transferred to lysosomes, then released from liposomes into lysosomes by enzymatic digestion of the liposomal lipid layers. From 4 h after ingesting liposome-encapsulated MDPCL2 mur...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.60.3.337

    authors: Naito M,Nagai H,Kawano S,Umezu H,Zhu H,Moriyama H,Yamamoto T,Takatsuka H,Takei Y

    更新日期:1996-09-01 00:00:00

  • Leukocyte-specific protein 1 links TNF receptor-associated factor 1 to survival signaling downstream of 4-1BB in T cells.

    abstract::4-1BB is a member of the TNFR superfamily, which contributes to the activation of signaling pathways required for the survival of activated and memory T cells. We have shown previously that TRAF1, an adaptor protein recruited to 4-1BB, is required for 4-1BB-mediated CD8 T cell survival in vivo. With the use of a prote...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.1112579

    authors: Sabbagh L,Andreeva D,Laramée GD,Oussa NA,Lew D,Bisson N,Soumounou Y,Pawson T,Watts TH

    更新日期:2013-05-01 00:00:00

  • IL-10 receptor dysfunction in macrophages during chronic inflammation.

    abstract::The immunosuppressive activity of interleukin-10 (IL-10) makes this cytokine a potentially important clinical tool to reduce inflammatory responses in various diseases. Its efficacy as a therapeutic modality is dependent on the responsiveness of immune cells. We report that macrophages from mice chronically infected w...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:

    authors: Avdiushko R,Hongo D,Lake-Bullock H,Kaplan A,Cohen D

    更新日期:2001-10-01 00:00:00

  • Potential roles of galectins in myeloid differentiation into three different lineages.

    abstract::Little is known about the roles of galectins, a family of beta-galactoside-binding lectins, in myeloid cell differentiation. In the present experiments, we used HL-60 cells as a model of myeloid cell differentiation. The HL-60 cells were differentiated into eosinophil-, monocyte-, and neutrophil-like cells by cocultur...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0402163

    authors: Abedin MJ,Kashio Y,Seki M,Nakamura K,Hirashima M

    更新日期:2003-05-01 00:00:00

  • Phagocytosis by receptors for C3b (CR1), iC3b (CR3), and IgG (Fc) on human peritoneal macrophages.

    abstract::Human peritoneal macrophages (HPM) obtained via laparoscopy were examined for the presence and functional capacity of complement and Fc receptors. Between 5 and 20 ml of peritoneal fluid containing 1-2 X 10(6) macrophages/ml was available for each study. Macrophages made up 80-95% of the cells in the fluid. Fc and C3 ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.38.2.267

    authors: Newman SL,Becker S,Halme J

    更新日期:1985-08-01 00:00:00

  • Direct in vivo evidence of CD4+ T cell requirement for CTL response and memory via pMHC-I targeting and CD40L signaling.

    abstract::CD4(+) T cell help contributes critically to DC-induced CD8(+) CTL immunity. However, precisely how these three cell populations interact and how CD4(+) T cell signals are delivered to CD8(+) T cells in vivo have been unclear. In this study, we developed a novel, two-step approach, wherein CD4(+) T cells and antigen-p...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.1211631

    authors: Ahmed KA,Wang L,Munegowda MA,Mulligan SJ,Gordon JR,Griebel P,Xiang J

    更新日期:2012-08-01 00:00:00

  • Rabbit vascular endothelial adhesion molecules: ELAM-1 is most elevated in acute inflammation, whereas VCAM-1 and ICAM-1 predominate in chronic inflammation.

    abstract::Activation of the microvasculature is a major component of the inflammatory response. During inflammation the vascular endothelium not only becomes more permeable to plasma proteins but also develops adhesion molecules that initiate the local immigration of leukocytes. We describe herein the in vivo changes in the thr...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.60.6.692

    authors: Abe Y,Sugisaki K,Dannenberg AM Jr

    更新日期:1996-12-01 00:00:00

  • Macrophage-elicited osteoclastogenesis in response to Brucella abortus infection requires TLR2/MyD88-dependent TNF-α production.

    abstract::Osteoarticular complications are common in human brucellosis, but the pathogenic mechanisms involved are largely unknown. In this manuscript, we described an immune mechanism for inflammatory bone loss in response to infection by Brucella abortus. We established a requirement for MyD88 and TLR2 in TNF-α-elicited osteo...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.04111185

    authors: Delpino MV,Barrionuevo P,Macedo GC,Oliveira SC,Genaro SD,Scian R,Miraglia MC,Fossati CA,Baldi PC,Giambartolomei GH

    更新日期:2012-02-01 00:00:00

  • Diminished transcription of interleukin-8 by monocytes from preterm neonates.

    abstract::Developmental delays, which impair antibacterial host defense, are present in the neutrophil system of human preterm neonates. We hypothesized that diminished production of interleukin-8 (IL-8), a neutrophil chemotactic peptide, might in part be responsible for these defects. To test this, monocytes from the blood of ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.53.4.399

    authors: Schibler KR,Trautman MS,Liechty KW,White WL,Rothstein G,Christensen RD

    更新日期:1993-04-01 00:00:00

  • IL-4 and a glucocorticoid up-regulate CXCR4 expression on human CD4+ T lymphocytes and enhance HIV-1 replication.

    abstract::CXCR4 is a key co-receptor required for the infection of T-tropic HIV-1 strain of CD4+ T lymphocytes. The regulation of this chemokine receptor was therefore studied. Th2 polarized cells expressed more CXCR4 than Th1 cells. Among a panel of cytokines and stimulants, a Th2 type cytokine interleukin-4 (IL-4) selectively...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.64.5.642

    authors: Wang J,Harada A,Matsushita S,Matsumi S,Zhang Y,Shioda T,Nagai Y,Matsushima K

    更新日期:1998-11-01 00:00:00

  • MERTK as negative regulator of human T cell activation.

    abstract::The aim of this study was to test the hypothesis whether MERTK, which is up-regulated in human DCs treated with immunosuppressive agents, is directly involved in modulating T cell activation. MERTK is a member of the TAM family and contributes to regulating innate immune response to ACs by inhibiting DC activation in ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.3A0714-334R

    authors: Cabezón R,Carrera-Silva EA,Flórez-Grau G,Errasti AE,Calderón-Gómez E,Lozano JJ,España C,Ricart E,Panés J,Rothlin CV,Benítez-Ribas D

    更新日期:2015-04-01 00:00:00

  • Transmembrane proteases in focus: diversity and redundancy?

    abstract::Recent advances have led to the identification and characterization of an array of transmembrane proteases that mediate the proteolysis of various substrates (including bioactive peptides, components of the extracellular matrix, and integral proteins) and cell-cell or cell-matrix adhesion. The membrane proteases known...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:

    authors: Bauvois B

    更新日期:2001-07-01 00:00:00

  • Dendritic cells interact with CD4 T cells in intestinal mucosa.

    abstract::Absence of lymph nodes in nonmammalian species, expression of MHCII by APCs in the periphery, and the recent findings that T cells can change their polarization status after presentation in the lymph nodes imply a role for MHCII-mediated presentation outside the organized lymphoid tissue. This study shows that MHCII(+...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0310161

    authors: Inman CF,Singha S,Lewis M,Bradley B,Stokes C,Bailey M

    更新日期:2010-09-01 00:00:00