Abstract:
:In the present work, we demonstrate that interleukin (IL)-4 is able to rescue B cells from Trypanosoma cruzi-infected mice, counteracting the strong apoptotic signals that these cells received in vivo. We have observed that IL-4 restrains the apoptosis of immunoglobulin (Ig)M(+) and IgG(+) B cells from infected and normal mice without inducing them to proliferate. In addition, IL-4 does not modify the quantity or quality of the antibodies secreted by B cells from infected mice, as it blocks their terminal differentiation to plasma cells and favors memory pathway. It is interesting that the protective effect of IL-4 over B cells from infected mice is mediated, at least partly, by the down-regulation of Fas ligand (FasL) expression, which leads to interference in the apoptosis executed by these B cells through the Fas/FasL death pathway. Accordingly, a marked up-regulation of the "FasL gene repressor" class II transactivator was observed, suggesting that this would be one mechanism underlying the IL-4-mediated FasL down-regulation.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Acosta Rodriguez EV,Zuñiga E,Montes CL,Gruppi Adoi
10.1189/jlb.0702353subject
Has Abstractpub_date
2003-01-01 00:00:00pages
127-36issue
1eissn
0741-5400issn
1938-3673journal_volume
73pub_type
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