Abstract:
:Glycoprotein 130 (gp130) is a shared receptor utilized by several related cytokines, including IL-6, IL-11, IL-27, Leukemia Inhibitory Factor (LIF), Oncostatin M (OSM), Ciliary Neurotrophic Factor (CNTF), Cardiotrophin 1 (CT-1) and Cardiotrophin-like Cytokine (CLC). Gp130 plays critical roles during development and gp130-deficient mice are embryonically lethal. However, the best characterized facet of this receptor and its associated cytokines is the ability to promote or suppress inflammation. The aim of this review is to discuss the role of gp130 in promoting or preventing the development of autoimmunity and cancer, two processes that are associated with aberrant inflammatory responses.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Silver JS,Hunter CAdoi
10.1189/jlb.0410217subject
Has Abstractpub_date
2010-12-01 00:00:00pages
1145-56issue
6eissn
0741-5400issn
1938-3673pii
jlb.0410217journal_volume
88pub_type
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