Different patterns of deactivation of chemotaxis and haptotaxis of human peripheral blood mononuclear leukocytes by soluble and surface-bound attractants.

abstract：:Asthma is a chronic inflammatory disease of the airways that afflicts over 30 million individuals in the United States and over 300 million individuals worldwide. The inflammatory response in the airways is often characterized by the analysis of sputum, which contains multiple types of cells including neutrophils, mac...

journal_title：Journal of leukocyte biology

authors： Stewart E,Wang X,Chupp GL,Montgomery RR

更新日期：2020-11-01 00:00:00

abstract：:The RAGE binds multiple ligand families linked to hyperglycemia, aging, inflammation, neurodegeneration, and cancer. Activation of RAGE by its ligands stimulates diverse signaling cascades. The recent observation that the cytoplasmic domain of RAGE interacts with diaphanous or mDia-1 links RAGE signal transduction to ...

journal_title：Journal of leukocyte biology

authors： Ramasamy R,Yan SF,Schmidt AM

更新日期：2009-09-01 00:00:00

abstract：:Virulent Legionella pneumophila replicate readily in thioglycollate-elicited peritoneal macrophages from genetically permissive A/J mice, but avirulent L. pneumophila do not. The production of cytokines by macrophages infected with L. pneumophila has been studied, but the correlation of bacterial virulence with immune...

journal_title：Journal of leukocyte biology

authors： McHugh SL,Yamamoto Y,Klein TW,Friedman H

更新日期：2000-06-01 00:00:00

abstract：:The dynamics of immune cell populations during acute HIV-1 infection are not fully deciphered, especially for non-T cells. In this study, we tested whether specific cellular subsets of the innate arm of the immune response are affected early after HIV-1 infection. Using a cohort of HIV-1-infected individuals, we have ...

journal_title：Journal of leukocyte biology

authors： Centlivre M,Legrand N,Steingrover R,van der Sluis R,Grijsen ML,Bakker M,Jurriaans S,Berkhout B,Paxton WA,Prins JM,Pollakis G

更新日期：2011-05-01 00:00:00

abstract：:Using a panel of vaccines that provided different degrees of protection, we previously identified the IL-12 receptor subunit β2 as a mediator, whose relative expression correlated with strength of protection against secondary lethal challenge of vaccinated mice with an intracellular bacterium, the LVS of Francisella t...

journal_title：Journal of leukocyte biology

authors： Melillo AA,Foreman O,Elkins KL

更新日期：2013-05-01 00:00:00

abstract：:Leukocytes have been implicated to be involved in the pathogenesis of IgA nephropathy (IgAN). To clarify the precise molecular mechanism of recruitment and activation of leukocytes in the subgroups of IgAN, latent, acute, and chronic types, we studied monocyte chemotactic and activating factor (MCAF/MCP-1) and interle...

journal_title：Journal of leukocyte biology

authors： Yokoyama H,Wada T,Furuichi K,Segawa C,Shimizu M,Kobayashi K,Su S,Mukaida N,Matsushima K

更新日期：1998-04-01 00:00:00

abstract：:Rats were injected with phenylhydrazine (PHZ) for periods of up to 6 months, during which time a marked leukocytosis was induced. The highest leukocyte counts occurred within 4-5 days following injection. An initial injection of 4 mg/100 gm body weight evoked a mean total leukocyte count of 129 X 10(3) cells/microlite...

journal_title：Journal of leukocyte biology

authors： Dornfest BS,Lapin DM,Naughton BA,Adu S,Korn L,Gordon AS

更新日期：1986-01-01 00:00:00

abstract：:The current results provide direct evidence for a role of tissue macrophages (M phi) in natural immunity and support the use of immunomodulators to enhance antiviral resistance in immunocompromised individuals. In this study, macrophages (M phi) in the spleen and liver were eliminated by intravenous (i.v.) injection o...

journal_title：Journal of leukocyte biology

authors： Pinto AJ,Stewart D,van Rooijen N,Morahan PS

更新日期：1991-06-01 00:00:00

abstract：:An important mediator of inflammation is prostaglandin E2 (PGE2 ), whose levels are determined by the activity of the enzyme cyclooxygenase (COX). Of the two isoforms of the enzyme, COX-2 has been shown to be induced in macrophages during inflammation. Although general COX inhibitors, belonging to the class of nonster...

journal_title：Journal of leukocyte biology

authors： Akter S,Sharma RK,Sharma S,Rastogi S,Fiebich BL,Akundi RS

更新日期：2021-01-13 00:00:00

abstract：:In the absence of IL-10, colonic inflammation ensues, which is characterized by high levels of IL-17. Here, we demonstrate a direct correlation between ICOS expression and IL-17 production in cIELs. IL-10(-/-) mice had increased numbers of cIELs and greater colon weight. Although the CD69 early activation antigen was ...

journal_title：Journal of leukocyte biology

authors： Schaefer JS,Montufar-Solis D,Vigneswaran N,Klein JR

更新日期：2010-02-01 00:00:00

abstract：:A previously unsuspected, considerable proportion of newly synthesized polypeptides are hydrolyzed rapidly by proteasomes, possibly competing with endogenous substrates and altering proteostasis. In view of the anti-cancer effects of PIs, we set out to achieve a quantitative assessment of proteasome workload in cells ...

journal_title：Journal of leukocyte biology

authors： Cenci S,Oliva L,Cerruti F,Milan E,Bianchi G,Raule M,Mezghrani A,Pasqualetto E,Sitia R,Cascio P

更新日期：2012-11-01 00:00:00

abstract：:4-1BB is a member of the TNFR superfamily, which contributes to the activation of signaling pathways required for the survival of activated and memory T cells. We have shown previously that TRAF1, an adaptor protein recruited to 4-1BB, is required for 4-1BB-mediated CD8 T cell survival in vivo. With the use of a prote...

journal_title：Journal of leukocyte biology

authors： Sabbagh L,Andreeva D,Laramée GD,Oussa NA,Lew D,Bisson N,Soumounou Y,Pawson T,Watts TH

更新日期：2013-05-01 00:00:00

abstract：:Glucocorticoids, such as dexamethasone (Dex), are used clinically in the treatment of various inflammatory diseases. Dex acts by inhibiting the expression of inflammatory mediators, such as tumor necrosis factor alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1). It is surprising that Dex enhances bacter...

journal_title：Journal of leukocyte biology

authors： Reddy KV,Bhattacharjee G,Schabbauer G,Hollis A,Kempf K,Tencati M,O'Connell M,Guha M,Mackman N

更新日期：2004-07-01 00:00:00

abstract：:Neutrophils showed a rapid and transient adhesion to immunoglobulin G (IgG)-coated plates compared with their adhesion to bovine serum albumin (BSA)-coated plates: the adhesion reached a peak after 15 min of incubation and then gradually returned to almost the basal state in 60 min. The addition of monomeric IgG or an...

journal_title：Journal of leukocyte biology

authors： Kusunoki T,Tsuruta S,Higashi H,Hosoi S,Hata D,Sugie K,Mayumi M,Mikawa H

更新日期：1994-06-01 00:00:00

abstract：:NLRP3 is the most crucial member of the NLR family, as it detects the existence of pathogen invasion and self-derived molecules associated with cellular damage. Several studies have reported that excessive NLRP3 inflammasome-mediated caspase-1 activation is a key factor in the development of diseases. Recent studies h...

journal_title：Journal of leukocyte biology

authors： Lin YC,Huang DY,Wang JS,Lin YL,Hsieh SL,Huang KC,Lin WW

更新日期：2015-05-01 00:00:00

abstract：:The pathogenesis of CRC remains to be further understood. This study was designed to elucidate the role of Foxp3+IL-17+ T cells in the pathogenesis of CRC. Surgically removed CRC tissue was collected from 12 patients with CRC. The frequency and cytokine profile of Foxp3+IL-17+ T cells in CRC were examined by flow cyto...

journal_title：Journal of leukocyte biology

authors： Yang S,Wang B,Guan C,Wu B,Cai C,Wang M,Zhang B,Liu T,Yang P

更新日期：2011-01-01 00:00:00

abstract：:Individuals with T2D and PD suffer significantly from the ability of one disease to intensify the other. Disease-associated inflammation is one mechanism thought to fuel this pathogenic feed-forward loop. Several lines of evidence indicate that proinflammatory B cells promote T2D and PD; thus, B cells are top candidat...

journal_title：Journal of leukocyte biology

authors： Zhu M,Belkina AC,DeFuria J,Carr JD,Van Dyke TE,Gyurko R,Nikolajczyk BS

更新日期：2014-08-01 00:00:00

abstract：:Neonatal humans and rodents are susceptible to infection with encapsulated bacteria as a result of an inability to make antibodies to capsular polysaccharides. This is partly a result of decreased production of proinflammatory cytokines by splenic macrophages (MPhi) from neonates. In this study, we show that when stim...

journal_title：Journal of leukocyte biology

authors： Chelvarajan L,Popa D,Liu Y,Getchell TV,Stromberg AJ,Bondada S

更新日期：2007-08-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a multifunctional cytokine that plays a pivotal role in mediating neovascularization as well as other endothelial cell alterations during inflammation. In this study, we demonstrate that human neutrophils are a source of VEGF. We observed that isolated blood neutrophils rel...

journal_title：Journal of leukocyte biology

authors： Taichman NS,Young S,Cruchley AT,Taylor P,Paleolog E

更新日期：1997-09-01 00:00:00

abstract：:LPS induces dendritic cell (DC) activation, but the precise in vivo mechanism is unclear since DCs express low levels of TLR4. Here, it is shown that DCs can be activated in response to LPS through a bystander mechanism. This result was obtained using chimeric mice reconstituted with LPS-responsive and nonresponsive b...

journal_title：Journal of leukocyte biology

authors： Yadav R,Zammit DJ,Lefrancois L,Vella AT

更新日期：2006-12-01 00:00:00

abstract：:Alcohol use has been shown to decrease monocyte antigen presentation capacity and inflammatory cytokine production, thereby increasing susceptibility to infections. Here, we demonstrate that in vitro acute treatment of normal monocytes with pharmacological doses of ethanol can decrease superantigen [Staphylococcus ent...

journal_title：Journal of leukocyte biology

authors： Szabo G,Mandrekar P,Catalano D

更新日期：1995-09-01 00:00:00

abstract：:Concanavalin A (Con A)-induced hepatitis is a model for human T cell-mediated hepatitis. We evaluated the role of L-selectin and intercellular adhesion molecule-1 (ICAM-1) in this model by injecting Con A intravenously in mice lacking L-selectin (L-selectin-/-), ICAM-1 (ICAM-1-/-), or both (L-selectin/ICAM-1-/-). Bloo...

journal_title：Journal of leukocyte biology

authors： Kawasuji A,Hasegawa M,Horikawa M,Fujita T,Matsushita Y,Matsushita T,Fujimoto M,Steeber DA,Tedder TF,Takehara K,Sato S

更新日期：2006-04-01 00:00:00

abstract：:Primitive macrophages emerged in the sinusoidal lumen of the fetal mouse liver at 10 days of gestation before the initiation of hepatic hematopoiesis and matured into fetal macrophages. In the culture of cell suspensions from the fetal liver with LP3-conditioned medium, monocyte colonies were formed, but monocytopoies...

journal_title：Journal of leukocyte biology

authors： Naito M,Takahashi K,Nishikawa S

更新日期：1990-07-01 00:00:00

abstract：:Freeze-fracture analysis has shown that treatment of cells with phorbol myristate acetate (PMA) results in a loss of intramembranous particles (IMP) associated with the external leaflet of their plasma membranes. It has also been demonstrated that phorbol esters markedly enhance the sensitivity of tumor targets to nat...

journal_title：Journal of leukocyte biology

authors： Nabi ZF,Zucker-Franklin D,Baten A

更新日期：1989-03-01 00:00:00

abstract：:Extracellular vesicles (EVs) are nanosized particles that have emerged as mediators for intercellular communication in physiologic and pathologic conditions. EVs carry signaling information on their bilipid membrane as well as cargo within, allowing them to perform a wide range of biologic processes and contribute to ...

journal_title：Journal of leukocyte biology

authors： Lam KCK,Lam MKN,Chim CS,Chan GCF,Li JCB

更新日期：2020-11-01 00:00:00

abstract：:Leucocyte-endothelial cell interactions are important in the inflammatory response. In this study, the effect of peripheral blood mononuclear cell (PBMC) products on endothelial cell (EC) shape was examined and quantified. PBMC were obtained from normal donors by Ficoll-Hypaque separation of heparinized whole blood an...

journal_title：Journal of leukocyte biology

authors： FitzGerald OM,Hess EV,Chance A,Highsmith RF

更新日期：1987-05-01 00:00:00

abstract：:Mono-Mac-6 (MM6) human monocytes ingest IgG-opsonized particles better than other human cell lines. We compared the phagocytic signaling pathway in MM6 with human monocytes. MM6 expressed FcgammaRI at levels similar to monocytes, whereas FcRgammaII expression was approximately double. MM6 ingested IgG-opsonized erythr...

journal_title：Journal of leukocyte biology

authors： Karimi K,Gemmill TR,Lennartz MR

更新日期：1999-06-01 00:00:00

abstract：:Previous studies about basophils and mast cells identified the ability of IgE to up-regulate FcepsilonRI expression by a process that depends on stabilization of the surface receptor by IgE. However, the mechanism of loss from the cell surface, when unoccupied, is not known. The current studies have examined whether u...

journal_title：Journal of leukocyte biology

authors： MacGlashan DW Jr

更新日期：2007-10-01 00:00:00

abstract：:Although HDPs were originally hypothesized to act as antimicrobial agents, they also have been shown to broadly modulate the immune response through the activation of different cell types. We recently developed a series of novel, synthetic peptides, termed IDRs, which are conceptually based on a natural HDP, bovine ba...

journal_title：Journal of leukocyte biology

authors： Niyonsaba F,Madera L,Afacan N,Okumura K,Ogawa H,Hancock RE

更新日期：2013-07-01 00:00:00

abstract：:The mechanisms by which concanavalin A (Con A), a lectin, activates T cells are poorly studied. A low dose of Con A is stimulatory for T cells, whereas a high dose of Con A results in suppression of proliferation and enhanced T cell death. The expression and functional roles of costimulatory receptors, CD28 and cytoto...

journal_title：Journal of leukocyte biology

authors： Mukherjee S,Ahmed A,Nandi D

更新日期：2005-07-01 00:00:00