L-selectin and intercellular adhesion molecule-1 regulate the development of Concanavalin A-induced liver injury.

abstract：:Dendritic cell (DC) and DC-derived exosomes (EXO) have been used extensively for tumor vaccination. However, its therapeutic efficiency is limited to only production of prophylactic immunity against tumors. T cells can uptake DC-released EXO. However, the functional effect of transferred exosomal molecules on T cells ...

journal_title：Journal of leukocyte biology

authors： Hao S,Yuan J,Xiang J

更新日期：2007-10-01 00:00:00

abstract：:IL-17 has been associated with selected inflammatory and autoimmune diseases. We characterized the expression of this proinflammatory cytokine following HSV-1 corneal infection and investigated whether IL-17R signaling modulated the host response to the viral pathogen at early time-points postinfection. IL-17 was elev...

journal_title：Journal of leukocyte biology

authors： Molesworth-Kenyon SJ,Yin R,Oakes JE,Lausch RN

更新日期：2008-02-01 00:00:00

abstract：:Regulation of macrophage PCD plays an important role in pathogenesis of leishmaniasis. However, the precise involvement of any parasite molecule in this process remains uncertain. In the current study, in silico wide analysis demonstrated that genes in the Leishmania donovani genome are highly enriched for CpG motifs,...

journal_title：Journal of leukocyte biology

authors： Das S,Ghosh AK,Singh S,Saha B,Ganguly A,Das P

更新日期：2015-02-01 00:00:00

abstract：:The success of using immune checkpoint inhibitors to treat cancers implies that inhibiting an immunosuppressive cytokine, such as TGF-β2, could be a strategy to develop novel adjuvants for microbial vaccines. To develop nucleic acid based TGF-β2 inhibitors, we designed three antisense oligonucleotides, designated as T...

journal_title：Journal of leukocyte biology

authors： Tu L,Sun X,Yang L,Zhang T,Zhang X,Li X,Dong B,Liu Y,Yang M,Wang L,Yu Y

更新日期：2020-11-01 00:00:00

abstract：:Granulocyte apoptosis and subsequent clearance by phagocytes are critical for the resolution of inflammation. However, no studies have addressed how the resolution proceeds in the inflammatory site. We studied the time course of neutrophil apoptosis and the following ingestion by mononuclear leukocytes in rat carragee...

journal_title：Journal of leukocyte biology

authors： Murai N,Nagai K,Fujisawa H,Hatanaka K,Kawamura M,Harada Y

更新日期：2003-04-01 00:00:00

abstract：:In vivo, dendritic cells (DC) form a network comprising different populations. In particular, Langerhans cells (LC) appear as a unique population of cells dependent on transforming growth factor beta(TGF-beta) for its development. In this study, we show that endogenous TGF-beta is required for the development of both ...

journal_title：Journal of leukocyte biology

authors： Caux C,Massacrier C,Dubois B,Valladeau J,Dezutter-Dambuyant C,Durand I,Schmitt D,Saeland S

更新日期：1999-11-01 00:00:00

abstract：:Although the immune system may provide early protection against cancer, tumors may exploit the healing arm of the immune system to enhance their growth and metastasis. For example, myeloid derived suppressor cells (MDSCs) are thought to promote tumor growth by several mechanisms, including the suppression of T cell ac...

journal_title：Journal of leukocyte biology

authors： Abad C,Nobuta H,Li J,Kasai A,Yong WH,Waschek JA

更新日期：2014-02-01 00:00:00

abstract：:Leukocytes have been implicated to be involved in the pathogenesis of IgA nephropathy (IgAN). To clarify the precise molecular mechanism of recruitment and activation of leukocytes in the subgroups of IgAN, latent, acute, and chronic types, we studied monocyte chemotactic and activating factor (MCAF/MCP-1) and interle...

journal_title：Journal of leukocyte biology

authors： Yokoyama H,Wada T,Furuichi K,Segawa C,Shimizu M,Kobayashi K,Su S,Mukaida N,Matsushima K

更新日期：1998-04-01 00:00:00

abstract：:The lineage-specific Charcot-Leyden crystal (CLC) protein is found in human eosinophils and basophils where it comprises 7-10% of the cellular protein content. Previous work from our laboratory has identified the motif GGAGA[A/G] as a powerful enhancer of gene transcription ill two eosinophil ribonuclease genes. To ev...

journal_title：Journal of leukocyte biology

authors： Dyer KD,Rosenberg HF

更新日期：2000-05-01 00:00:00

abstract：:Respiratory complications occur frequently in individuals living with human immunodeficiency-1 virus (HIV) infection, and there is evidence that HIV-related oxidative stress impairs alveolar macrophage immune function. We hypothesized that nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a master transcription fact...

journal_title：Journal of leukocyte biology

authors： Staitieh BS,Ding L,Neveu WA,Spearman P,Guidot DM,Fan X

更新日期：2017-08-01 00:00:00

abstract：:Cytokines and chemokines play an essential role in recruiting leukocytes from the circulation to the peripheral sites of inflammation by modulating cellular interactions with endothelial cell ligands and extracellular matrix (ECM). Herein, we examined regulation of T cell adhesion to ECM ligands by two major proinflam...

journal_title：Journal of leukocyte biology

authors： Ariel A,Novick D,Rubinstein M,Dinarello CA,Lider O,Hershkoviz R

更新日期：2002-07-01 00:00:00

abstract：:Protein kinase B (Akt) is known to be involved in proinflammatory and chemotactic events in response to injury. Akt activation also leads to the induction of heme oxygenase (HO)-1. Up-regulation of HO-1 mediates potent, anti-inflammatory effects and attenuates organ injury. Although studies have shown that 17beta-estr...

journal_title：Journal of leukocyte biology

authors： Hsu JT,Kan WH,Hsieh CH,Choudhry MA,Schwacha MG,Bland KI,Chaudry IH

更新日期：2007-10-01 00:00:00

abstract：:CD8(+) T cells must detect foreign antigens and differentiate into effector cells to eliminate infections. But, when self-antigen is recognized instead, mechanisms of peripheral tolerance prevent acquisition of effector function to avoid autoimmunity. These distinct responses are influenced by inflammatory and regulat...

journal_title：Journal of leukocyte biology

authors： Jackson SR,Yuan J,Berrien-Elliott MM,Chen CL,Meyer JM,Donlin MJ,Teague RM

更新日期：2014-09-01 00:00:00

abstract：:GM-CSF is well recognized as a proliferative agent for hematopoietic cells and exerts a priming function on neutrophils. The aim of this study was to determine if GM-CSF has a role as a neutrophil chemoattractant in vivo and if it can contribute to recruitment during intestinal inflammation. Initial studies in vitro, ...

journal_title：Journal of leukocyte biology

authors： Khajah M,Millen B,Cara DC,Waterhouse C,McCafferty DM

更新日期：2011-06-01 00:00:00

abstract：:Given the variable protective efficacy provided by Mycobacterium bovis bacillus Calmette-Guérin (BCG), there is an urgent need to develop new vaccines against tuberculosis. As dendritic cells (DC) play a critical role in initiating and regulating a protective T cell response against the pathogens, the comprehension of...

journal_title：Journal of leukocyte biology

authors： Giacomini E,Remoli ME,Gafa V,Pardini M,Fattorini L,Coccia EM

更新日期：2009-03-01 00:00:00

abstract：:Pulmonary fibrosis is the end point of a chronic inflammatory process characterized by leukocyte recruitment and activation, fibroblast proliferation, and increased extracellular matrix production. Previous studies of models of pulmonary fibrosis have investigated the role of cytokines in the evolution of the fibrotic...

journal_title：Journal of leukocyte biology

authors： Smith RE,Strieter RM,Zhang K,Phan SH,Standiford TJ,Lukacs NW,Kunkel SL

更新日期：1995-05-01 00:00:00

abstract：:The production of IL-12 by macrophages/dendritic cells (Mphi/DC) is mediated either by a T cell-dependent pathway that is induced primarily by the interaction of CD40 ligand (CD40L) on activated T cells with CD40 on IL-12-producing cells or by a T cell-independent pathway that is induced by bacteria or bacterial produ...

journal_title：Journal of leukocyte biology

authors： Takenaka H,Maruo S,Yamamoto N,Wysocka M,Ono S,Kobayashi M,Yagita H,Okumura K,Hamaoka T,Trinchieri G,Fujiwara H

更新日期：1997-01-01 00:00:00

abstract：:Polymorphonuclear leukocytes (PMNs) exert most of their physiological functions while adherent to surfaces rather than in suspension. PMN adhesion is largely dependent on the function of the beta 2 integrins, CD11a,b,c/CD18. We mimicked engagement of beta 2 integrins by antibody cross-linking of CD18 on isolated human...

journal_title：Journal of leukocyte biology

authors： Walzog B,Seifert R,Zakrzewicz A,Gaehtgens P,Ley K

更新日期：1994-11-01 00:00:00

abstract：:Leukocytes are a large population of cells spread within most tissues in the body. These cells may be either sessile (called as resident cells) or circulating leukocytes, which travel long journeys inside the vessels during their lifespan. Although production and maturation of these leukocytes in adults primarily occu...

journal_title：Journal of leukocyte biology

authors： Mafra K,Nakagaki BN,Castro Oliveira HM,Rezende RM,Antunes MM,Menezes GB

更新日期：2019-09-01 00:00:00

abstract：:The pathogenesis of CRC remains to be further understood. This study was designed to elucidate the role of Foxp3+IL-17+ T cells in the pathogenesis of CRC. Surgically removed CRC tissue was collected from 12 patients with CRC. The frequency and cytokine profile of Foxp3+IL-17+ T cells in CRC were examined by flow cyto...

journal_title：Journal of leukocyte biology

authors： Yang S,Wang B,Guan C,Wu B,Cai C,Wang M,Zhang B,Liu T,Yang P

更新日期：2011-01-01 00:00:00

abstract：:DC maturation and functions are influenced by microbial and environmental stimuli, which could contribute to immune dysfunction. Here, we have investigated the role of enterobacteria (Escherichia coli CBL2 and Shigella CBD8) isolated from CD patients, bifidobacteria (Bifidobacterium longum CECT 7347 and Bifidobacteriu...

journal_title：Journal of leukocyte biology

authors： De Palma G,Kamanova J,Cinova J,Olivares M,Drasarova H,Tuckova L,Sanz Y

更新日期：2012-11-01 00:00:00

abstract：:The neuropathogenesis of HIV-1 encephalitis and its associated dementia revolves around sustained viral replication in cells of mononuclear phagocyte origin (brain macrophages, multinucleated giant cells, and microglia). Macrophage secretory factors play important roles in facilitating monocyte trafficking into the br...

journal_title：Journal of leukocyte biology

authors： Persidsky Y,Gendelman HE

更新日期：1997-07-01 00:00:00

abstract：:The adjuvant effect of gamma-inulin, a strong activator of the alternative complement pathway, is well-known, but its exact mechanism is not revealed yet. Here, we show that macrophages, isolated from the peritoneal cavity of gamma-inulin-injected mice and used as antigen-presenting cells, enhance the proliferation of...

journal_title：Journal of leukocyte biology

authors： Kerekes K,Cooper PD,Prechl J,Józsi M,Bajtay Z,Erdei A

更新日期：2001-01-01 00:00:00

abstract：:Developmental delays, which impair antibacterial host defense, are present in the neutrophil system of human preterm neonates. We hypothesized that diminished production of interleukin-8 (IL-8), a neutrophil chemotactic peptide, might in part be responsible for these defects. To test this, monocytes from the blood of ...

journal_title：Journal of leukocyte biology

authors： Schibler KR,Trautman MS,Liechty KW,White WL,Rothstein G,Christensen RD

更新日期：1993-04-01 00:00:00

abstract：:IL-18 has a potential to up-regulate the Th1 and Th2 immune responses. It is known that IL-18, in synergy with IL-12, augments the Th1 response to bacterial infections, but it also augments the Th2 response to allergic disorders in the absence of IL-12. Although the Th1 and Th2 immune responses cross-regulate each oth...

journal_title：Journal of leukocyte biology

authors： Kinoshita M,Miyazaki H,Ono S,Seki S

更新日期：2013-05-01 00:00:00

abstract：:M-CSF is a pleiotropic cytokine involved in the survival, proliferation, and differentiation of cells of the monocyte/macrophage lineage. M-CSF is produced by numerous cells including CD3-activated T cells. M-CSF serum levels are increased during acute graft rejection. We tested the in vitro production of M-CSF, GM-CS...

journal_title：Journal of leukocyte biology

authors： Frétier S,Besse A,Delwail A,Garcia M,Morel F,Leprivey-Lorgeot V,Wijdenes J,Praloran V,Lecron JC

更新日期：2002-02-01 00:00:00

abstract：:Cytosolic RIG-I-like helicases (RLR) are PRRs involved in type I IFN production and antiviral immunity. This study focuses to the comparison of the expression, function, and signaling cascades associated to RLR in the previously identified CD14(-)DC-SIGN(+)PPARγ(low)CD1a(+) and CD14(low)DC-SIGN(+)PPARγ(high)CD1a(-) hu...

journal_title：Journal of leukocyte biology

authors： Szabo A,Bene K,Gogolák P,Réthi B,Lányi Á,Jankovich I,Dezső B,Rajnavölgyi E

更新日期：2012-07-01 00:00:00

abstract：:The expression of beta 2-integrins on gammadelta T cells in naïve mice or those with experimental autoimmune encephalomyelitis (EAE) remains poorly characterized. We compared beta 2-integrin expression and cytokine production between gammadelta and alphabeta T cells over the acute course of EAE. We observed that unlik...

journal_title：Journal of leukocyte biology

authors： Smith SS,Barnum SR

更新日期：2008-01-01 00:00:00

abstract：:Increasing the dietary alpha-linolenate (18:3n - 3)/linoleate (18:2n - 6) ratio results in an increase in lipopolysaccharide (LPS)-stimulated tumor necrosis factor (TNF) production in mouse resident and casein-induced peritoneal macrophages [3]. We found that prostaglandin E2 (PGE2) production is inversely related to ...

journal_title：Journal of leukocyte biology

authors： Watanabe S,Onozaki K,Yamamoto S,Okuyama H

更新日期：1993-02-01 00:00:00

abstract：:A role for the dietary trace mineral element selenium in the reduction of cancer incidence has been documented in numerous epidemiological and experimental studies. The precise mechanism of this antitumor effect is not well understood, but published data suggest that both inhibition of tumor cell growth and enhancemen...

journal_title：Journal of leukocyte biology

authors： Petrie HT,Klassen LW,Kay HD

更新日期：1989-03-01 00:00:00