Osteopontin augments CD3-mediated interferon-gamma and CD40 ligand expression by T cells, which results in IL-12 production from peripheral blood mononuclear cells.

abstract：:Structurally, the monocyte chemotactic proteins MCP-1, -2, and -3 form a subfamily of the C-C or beta-chemokines. Like other chemokines, MCPs are produced by a variety of cells on stimulation with cytokines (interleukin-1, tumor necrosis factor-alpha, interferon-gamma), bacterial and viral products or mitogens. MCP-1 ...

journal_title：Journal of leukocyte biology

authors： Proost P,Wuyts A,Van Damme J

更新日期：1996-01-01 00:00:00

abstract：:Endotoxin tolerance is characterized by diminished expression of inflammatory cytokines after sequential exposure to Toll-like receptor stimuli. Many mechanisms contribute to tolerance; however, chromatin remodeling appears to be the most significant regulator. The type II interferon, IFN-γ, has been recognized as bei...

journal_title：Journal of leukocyte biology

authors： Shi L,Song L,Maurer K,Sharp J,Zhang Z,Sullivan KE

更新日期：2015-10-01 00:00:00

abstract：:The ellipsoid-associated cells (EAC) localize on the surface of the ellipsoid. They bind the IV injected horseradish peroxidase (HRP) and bovine serum albumin (BSA), migrate to the red pulp and then enter the systemic circulation. After protein injection, the number of white blood cells increased above the normal leve...

journal_title：Journal of leukocyte biology

authors： Oláh I,Glick B,Taylor RL Jr

更新日期：1984-05-01 00:00:00

abstract：:Application of exogenous Abs targeting cell surface Ags has been widely used as an experimental approach to induce cell depletion or to inhibit receptor functionality. Moreover, Ab therapy is emerging as one of the mainstream strategies for cancer treatment. Previous studies on the mechanisms of Ab-mediated cell deple...

journal_title：Journal of leukocyte biology

authors： Sun D,Sun P,He S,Shi M

更新日期：2020-03-01 00:00:00

abstract：:We have identified three distinct cell phenotypes with respect to the conditions under which cells became susceptible to TNF-mediated lysis. These conditions include: 1) treatment with the protein synthesis inhibitor, cycloheximide; 2) contact with activated macrophages, and 3) infection with vaccinia virus. Whereas v...

journal_title：Journal of leukocyte biology

authors： Woods KM,Chapes SK

更新日期：1993-01-01 00:00:00

abstract：:We have shown previously that PCNA, a nuclear factor involved in DNA replication and repair in proliferating cells, is localized exclusively in the cytoplasm of neutrophils, where it regulates their survival. Nuclear PCNA functions are tightly linked to its ring-shaped structure, which allows PCNA to bind to numerous ...

journal_title：Journal of leukocyte biology

authors： De Chiara A,Pederzoli-Ribeil M,Mocek J,Candalh C,Mayeux P,Millet A,Witko-Sarsat V

更新日期：2013-10-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is a potent natural adjuvant, commonly used to amplify Th1 responses. Here, we report that systemic immunization using LPS generates large numbers of specific Th17 cells in murine small intestinal lamina propria. The priming of these Th17 cells required IL-23p19 production by bone marrow-deriv...

journal_title：Journal of leukocyte biology

authors： McAleer JP,Liu B,Li Z,Ngoi SM,Dai J,Oft M,Vella AT

更新日期：2010-07-01 00:00:00

abstract：:Secretory leukocyte proteinase inhibitor (SLPI) is the main neutrophil elastase (HLE) inhibitor found in the upper airways during pulmonary inflammation. It has been shown to be synthesized and secreted in vitro by epithelial cells and has been localized in tracheal glands and bronchiolar epithelial cells by immunocyt...

journal_title：Journal of leukocyte biology

authors： Sallenave JM,Si Tahar M,Cox G,Chignard M,Gauldie J

更新日期：1997-06-01 00:00:00

abstract：:Although class A type I/II scavenger receptor (SR-A) is involved in numerous macrophage functions, its signaling ability remains uncertain. We used monoclonal antibodies (mAb) to specifically stimulate receptors on mouse alveolar (AMs) and peritoneal macrophages (PMs). Immobilized anti-SR-A (2F8) and anti-FcgammaR II/...

journal_title：Journal of leukocyte biology

authors： Józefowski S,Kobzik L

更新日期：2004-11-01 00:00:00

abstract：:Mono-Mac-6 (MM6) human monocytes ingest IgG-opsonized particles better than other human cell lines. We compared the phagocytic signaling pathway in MM6 with human monocytes. MM6 expressed FcgammaRI at levels similar to monocytes, whereas FcRgammaII expression was approximately double. MM6 ingested IgG-opsonized erythr...

journal_title：Journal of leukocyte biology

authors： Karimi K,Gemmill TR,Lennartz MR

更新日期：1999-06-01 00:00:00

abstract：:In previous studies, macrophages have been shown to influence in vitro colony formation by erythroid progenitors (CFU-E). To determine whether the origin of the macrophages influences their effects on in vitro erythropoiesis, plasma clot cultures of CFU-E were grown over adherent monolayers of macrophages from various...

journal_title：Journal of leukocyte biology

authors： Johnson CS,Furmanski P

更新日期：1984-11-01 00:00:00

abstract：:Overexpression of CD95 (Fas/Apo-1) ligand (CD95L) has been shown to induce T cell tolerance but also, neutrophilic inflammation and rejection of allogeneic tissue. We explored the capacity of dendritic cells (DCs) genetically engineered to overexpress CD95L to induce an antitumor response. We first found that DCs over...

journal_title：Journal of leukocyte biology

authors： Buonocore S,Haddou NO,Moore F,Florquin S,Paulart F,Heirman C,Thielemans K,Goldman M,Flamand V

更新日期：2008-09-01 00:00:00

abstract：:Macrophages and dendritic cells are in the front line of host defense. When they sense host invasion, they produce cytokines that alert other innate immune cells and also abet the development of an adaptive immune response. Although lipolysaccharide (LPS), peptidoglycan, unmethylated DNA, and other microbial products ...

journal_title：Journal of leukocyte biology

authors： Beutler B,Hoebe K,Du X,Ulevitch RJ

更新日期：2003-10-01 00:00:00

abstract：:To elucidate the differentiation mechanisms of macrophages in the murine omentum, we studied the repopulation of these cells and the expression of macrophage colony-stimulating factor (M-CSF) in the milky spots and omental tissues in mice depleted of macrophages following administration of liposome-encapsulated dichlo...

journal_title：Journal of leukocyte biology

authors： Zhu H,Naito M,Umezu H,Moriyama H,Takatsuka H,Takahashi K,Shultz LD

更新日期：1997-04-01 00:00:00

abstract：:Hepatic Macs, consisting of resident KCs and infiltrating monocytes/IMs, are thought to play an important role in the pathogenesis of ALD. Previous work has focused on KCs or studied hepatic Macs as one cell population. The aim of the current study is to distinguish IMs from KCs and to compare their phenotypes and fun...

journal_title：Journal of leukocyte biology

authors： Wang M,You Q,Lor K,Chen F,Gao B,Ju C

更新日期：2014-10-01 00:00:00

abstract：:Individuals with T2D and PD suffer significantly from the ability of one disease to intensify the other. Disease-associated inflammation is one mechanism thought to fuel this pathogenic feed-forward loop. Several lines of evidence indicate that proinflammatory B cells promote T2D and PD; thus, B cells are top candidat...

journal_title：Journal of leukocyte biology

authors： Zhu M,Belkina AC,DeFuria J,Carr JD,Van Dyke TE,Gyurko R,Nikolajczyk BS

更新日期：2014-08-01 00:00:00

abstract：:Antibody-facilitated macrophage (MP) destruction of Trypanosoma musculi involves ingestion and intracellular degradation of the parasites. It is likely, however, as we show here, that death of the trypanosomes is extracellular and it is the corpses that are ingested by MPs. We have utilized both peritoneal MPs and a c...

journal_title：Journal of leukocyte biology

authors： Albright JW,Stewart MJ,Latham PS,Albright JF

更新日期：1994-11-01 00:00:00

abstract：:TLR agonists such as LPS and poly(I:C) induce expression of type I IFNs, such as IFN-α and -β, by macrophages. To examine the role of IFN-β in the induction of ISGs by LPS, we compared the ability of LPS to induce ISGF3 activity and ISG expression in bone marrow-derived macrophages from WT and Ifnb1(-/-) mice. We foun...

journal_title：Journal of leukocyte biology

authors： Sheikh F,Dickensheets H,Gamero AM,Vogel SN,Donnelly RP

更新日期：2014-10-01 00:00:00

abstract：:An epithelial cell line, IT-45R1, has been established from a thymus of normal Wistar rat and was found to produce growth factor which stimulated the proliferation of bone marrow cells. This growth factor induced the formation of colonies composed of macrophages, granulocytes, or both, in semi-solid medium and stimula...

journal_title：Journal of leukocyte biology

authors： Nanno M,Takahashi T,Sakata T,Horikawa T,Sako T,Suzuki R,Itoh T,Kumagai K

更新日期：1991-12-01 00:00:00

abstract：:The actual level of circulating estrogen (17β-estradiol, E2) has a serious impact on regulation of diverse immune cell functions, where their classical cytoplasmic receptors, ERα and ERβ, act as nuclear transcriptional regulators of multiple target genes. There is growing evidence, however, for rapid, "non-nuclear" re...

journal_title：Journal of leukocyte biology

authors： Schneider AE,Kárpáti E,Schuszter K,Tóth EA,Kiss E,Kulcsár M,László G,Matko J

更新日期：2014-11-01 00:00:00

abstract：:Besides their growth-inhibiting and differentiation-inducing properties, retinoids have been shown to exert immunomodulatory and anti-inflammatory functions by mechanisms that are not well understood. Tumor necrosis factor-alpha (TNF), a cytokine produced by mononuclear phagocytes, has been shown to be an important me...

journal_title：Journal of leukocyte biology

authors： Mehta K,McQueen T,Tucker S,Pandita R,Aggarwal BB

更新日期：1994-03-01 00:00:00

abstract：:The role of PI-3K in leukocyte function has been studied extensively. However, the specific role of the p110gamma isoform of PI- 3K in CD4 T lymphocyte function has yet to be defined explicitly. In this study, we report that although p110gamma does not regulate antigen-dependent CD4 T cell activation and proliferation...

journal_title：Journal of leukocyte biology

authors： Thomas MS,Mitchell JS,DeNucci CC,Martin AL,Shimizu Y

更新日期：2008-09-01 00:00:00

abstract：:Protein synthetic patterns of murine peritoneal macrophages were analyzed by two-dimensional polyacrylamide gel electrophoresis (2D PAGE) of 35S methionine-labeled proteins. While the protein synthetic patterns exhibited by resident, inflammatory, and activated macrophages had numerous common features that distinguish...

journal_title：Journal of leukocyte biology

authors： Tannenbaum CS,Nurmi-McKernan L,Largen MT

更新日期：1987-06-01 00:00:00

abstract：:The human cathelicidin LL-37 is a cationic host defense peptide (antimicrobial peptide) expressed primarily by neutrophils and epithelial cells. This peptide, up-regulated under conditions of inflammation, has immunomodulatory and antimicrobial functions. We demonstrate that LL-37 is a potent inhibitor of human neutro...

journal_title：Journal of leukocyte biology

authors： Barlow PG,Li Y,Wilkinson TS,Bowdish DM,Lau YE,Cosseau C,Haslett C,Simpson AJ,Hancock RE,Davidson DJ

更新日期：2006-09-01 00:00:00

abstract：:We have shown that low-dose UVB radiation converts Langerhans cells (LC) from immunogenic to tolerogenic APC. Therefore, we questioned whether low-dose UVB irradiation of bone marrow-derived dendritic cells (DC) alters their APC function, thereby inducing tolerance in T cells. To address this issue, cocultures of DC; ...

journal_title：Journal of leukocyte biology

authors： Denfeld RW,Hara H,Tesmann JP,Martin S,Simon JC

更新日期：2001-04-01 00:00:00

abstract：:Human promyelocytic cells (HL-60) were labeled with 35S-sulfate and either 3H-glucosamine or 3H-serine as precursors. Accumulation of 35S-labeled macromolecules was approximately linear for up to 96 h, with a mean cell:medium ratio of 5.5:1, although activity/10(5) viable cells reached a plateau level after 24 h. Virt...

journal_title：Journal of leukocyte biology

authors： Bentley SA,Kirby SL

更新日期：1989-01-01 00:00:00

abstract：:To become competent killer cells, CD8(+) T cells require stimulation through signal transduction pathways associated with the T-cell receptor, costimulatory molecules such as CD28, and cytokine receptors such as the interleukin (IL)-2 receptor. We used wortmannin and LY294002, two inhibitors of phosphatidylinositol 3-...

journal_title：Journal of leukocyte biology

authors： Phu T,Haeryfar SM,Musgrave BL,Hoskin DW

更新日期：2001-05-01 00:00:00

abstract：:Thimerosal is an organic mercury compound that is used as a preservative in vaccines and pharmaceutical products. Recent studies have shown a TH2-skewing effect of mercury, although the underlying mechanisms have not been identified. In this study, we investigated whether thimerosal can exercise a TH2-promoting effect...

journal_title：Journal of leukocyte biology

authors： Agrawal A,Kaushal P,Agrawal S,Gollapudi S,Gupta S

更新日期：2007-02-01 00:00:00

abstract：:CD163 is the monocyte/macrophage-specific receptor for haptoglobin-hemoglobin (Hp-Hb) complexes. The cytoplasmic tail of human CD163 exists as a short tail variant and two long tail variants. Reverse transcriptase-polymerase chain reaction analysis indicated that all three CD163 variants are substantially expressed in...

journal_title：Journal of leukocyte biology

authors： Nielsen MJ,Madsen M,Møller HJ,Moestrup SK

更新日期：2006-04-01 00:00:00

abstract：:The in vitro effects of 17 alpha AED, the isomer of 5-androstene-3 beta,17 beta diol (17 beta AED) on the basal growth of murine RAW 264.7, P388D1, and human HL-60 cells were investigated. 17 alpha AED treatment of RAW cells for 48 h reduced total cell number without increasing cell death as detected by trypan blue ex...

journal_title：Journal of leukocyte biology

authors： Huynh PN,Loria RM

更新日期：1997-08-01 00:00:00