Characterization of cytosolic proliferating cell nuclear antigen (PCNA) in neutrophils: antiapoptotic role of the monomer.

abstract：:Multiple mechanisms are used by the human immunodeficiency virus type 1 (HIV-1) to interfere with host-cell immune effector functions. The 27-kD Nef protein has been shown to down-modulate specific genes of the major histocompatibility complex class I (MHC-I) on the surface of infected primary T cells, facilitating th...

journal_title：Journal of leukocyte biology

authors： Brown A,Gartner S,Kawano T,Benoit N,Cheng-Mayer C

更新日期：2005-09-01 00:00:00

abstract：:Previous work has demonstrated that bleomycin can directly stimulate alveolar macrophage secretion of fibroblast growth factors and monocyte chemotactic factors. In this study, rat alveolar macrophages obtained by bronchoalveolar lavage were examined for the presence of bleomycin binding sites, which might mediate thi...

journal_title：Journal of leukocyte biology

authors： Denholm EM,Phan SH

更新日期：1990-12-01 00:00:00

abstract：:Osteoarticular complications are common in human brucellosis, but the pathogenic mechanisms involved are largely unknown. In this manuscript, we described an immune mechanism for inflammatory bone loss in response to infection by Brucella abortus. We established a requirement for MyD88 and TLR2 in TNF-α-elicited osteo...

journal_title：Journal of leukocyte biology

authors： Delpino MV,Barrionuevo P,Macedo GC,Oliveira SC,Genaro SD,Scian R,Miraglia MC,Fossati CA,Baldi PC,Giambartolomei GH

更新日期：2012-02-01 00:00:00

abstract：:Live, but not dead Bacillus Calmette-Guérin (BCG) is partially protective against infection by Mycobacterium tuberculosis, which causes a disease with high mortality in immune compromised individuals. We have shown that uptake of BCG induces maturation of immature dendritic cells (DCs) regardless of the viability of t...

journal_title：Journal of leukocyte biology

authors： Tsunetsugu-Yokota Y,Tamura H,Tachibana M,Ogata K,Honda M,Takemori T

更新日期：2002-07-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) infection is characterized by viral entry into the central nervous system (CNS), which is mediated, in part, by the transmigration of HIV-infected monocytes into the brain. The elaboration of chemokines and other factors by these infected cells contributes to CNS inflammation and cog...

journal_title：Journal of leukocyte biology

authors： Eugenin EA,Gamss R,Buckner C,Buono D,Klein RS,Schoenbaum EE,Calderon TM,Berman JW

更新日期：2006-03-01 00:00:00

abstract：:Feline peritoneal cells were collected by lavage with isotonic saline without the use of irritants or need for euthanasia of the cats. Macrophages were purified by centrifugation on Percoll followed by selective adherence. Although few macrophages could be obtained from an initial lavage, a second lavage performed on ...

journal_title：Journal of leukocyte biology

authors： Stoddart CA,Scott FW

更新日期：1988-11-01 00:00:00

abstract：:The liver contains a unique repertoire of immune cells and a particular abundance of NK cells. We have found that CD11c defines a distinct subset of NK cells (NK1.1(+)CD3(-)) in the murine liver whose function was currently unknown. In naïve animals, CD11c(+) liver NK cells displayed an activated phenotype and possess...

journal_title：Journal of leukocyte biology

authors： Burt BM,Plitas G,Stableford JA,Nguyen HM,Bamboat ZM,Pillarisetty VG,DeMatteo RP

更新日期：2008-10-01 00:00:00

abstract：:Lysophosphatidylcholines (lysoPCs) are effective polymorphonuclear neutrophil (PMN) priming agents implicated in transfusion-related acute lung injury (TRALI). LysoPCs cause ligation of the G2A receptor, cytosolic Ca2+ flux, and activation of Hck. We hypothesize that lysoPCs induce Hck-dependent activation of protein ...

journal_title：Journal of leukocyte biology

authors： Kelher MR,McLaughlin NJ,Banerjee A,Elzi DJ,Gamboni F,Khan SY,Meng X,Mitra S,Silliman CC

更新日期：2017-01-01 00:00:00

abstract：:We provide new information on how apoptosis regulates the expansion and survival of dendritic cell (DC) elements during in vitro hematopoiesis. Functionally distinct apoptotic schedules were associated with different phases of DC development when multipotent CD34+ progenitor cells were treated with GM-CSF + TNF +/- SC...

journal_title：Journal of leukocyte biology

authors： Santiago-Schwarz F,Borrero M,Tucci J,Palaia T,Carsons SE

更新日期：1997-10-01 00:00:00

abstract：:Recent studies have shown that proinflammatory cytokines damage rodent neural precursor cells (NPCs), a source of self-renewing, multipotent cells that play an important role in the developing as well as adult brain. In this study, the effects of tumor necrosis factor alpha (TNF-alpha) on cytokine and chemokine produc...

journal_title：Journal of leukocyte biology

authors： Sheng WS,Hu S,Ni HT,Rowen TN,Lokensgard JR,Peterson PK

更新日期：2005-12-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) has been shown to induce the production of interstitial collagenase by fibroblasts and chondrocytes. We investigated the role of TNF-alpha in collagenase gene expression by U937 monocyte/macrophage cells. Transcription of the TNF-alpha gene was observed after 0.5 h of phorbol my...

journal_title：Journal of leukocyte biology

authors： Callaghan MM,Lovis RM,Rammohan C,Lu Y,Pope RM

更新日期：1996-01-01 00:00:00

abstract：:Exacerbations of asthma are most commonly triggered by viral infections, which amplify allergic inflammation. Cytokines released by virus-infected AECs may be important in driving this response. This review focuses on accumulating evidence in support of a role for epithelial cytokines, including IL-33, IL-25, and TSLP...

journal_title：Journal of leukocyte biology

authors： Kumar RK,Foster PS,Rosenberg HF

更新日期：2014-09-01 00:00:00

abstract：:Recognition of Gram-positive bacteria by Toll-like receptor 2 (TLR2) induces activation of proinflammatory pathways. In mice, sensitization with the Gram-positive Propionibacterium acnes followed by a challenge with the TLR4 ligand, lipopolysaccharide (LPS), results in fulminant hepatic failure. Here, we investigated ...

journal_title：Journal of leukocyte biology

authors： Romics L Jr,Dolganiuc A,Velayudham A,Kodys K,Mandrekar P,Golenbock D,Kurt-Jones E,Szabo G

更新日期：2005-12-01 00:00:00

abstract：:It has been shown recently that MCs are required for differential regulation of the immune response by granulocytic versus monocytic MDSCs. Granulocytic MDSCs promoted parasite clearance, whereas monocytic MDSCs enhanced tumor progression; both activities were abrogated in MC-deficient mice. Herein, we demonstrate tha...

journal_title：Journal of leukocyte biology

authors： Martin RK,Saleem SJ,Folgosa L,Zellner HB,Damle SR,Nguyen GK,Ryan JJ,Bear HD,Irani AM,Conrad DH

更新日期：2014-07-01 00:00:00

abstract：:The present study was initiated to identify the antigen recognized by the monoclonal antibody (MAb) MAC387 which is widely used for phenotypical characterization of myelomonocytic cells in situ. MAC387 has been described to show a similar reaction pattern as antisera to a complex formed by the calcium-binding proteins...

journal_title：Journal of leukocyte biology

authors： Goebeler M,Roth J,Teigelkamp S,Sorg C

更新日期：1994-02-01 00:00:00

abstract：:The expression of beta 2-integrins on gammadelta T cells in naïve mice or those with experimental autoimmune encephalomyelitis (EAE) remains poorly characterized. We compared beta 2-integrin expression and cytokine production between gammadelta and alphabeta T cells over the acute course of EAE. We observed that unlik...

journal_title：Journal of leukocyte biology

authors： Smith SS,Barnum SR

更新日期：2008-01-01 00:00:00

abstract：:Human promyelocytic cells (HL-60) were labeled with 35S-sulfate and either 3H-glucosamine or 3H-serine as precursors. Accumulation of 35S-labeled macromolecules was approximately linear for up to 96 h, with a mean cell:medium ratio of 5.5:1, although activity/10(5) viable cells reached a plateau level after 24 h. Virt...

journal_title：Journal of leukocyte biology

authors： Bentley SA,Kirby SL

更新日期：1989-01-01 00:00:00

abstract：:Alcohol use has been shown to decrease monocyte antigen presentation capacity and inflammatory cytokine production, thereby increasing susceptibility to infections. Here, we demonstrate that in vitro acute treatment of normal monocytes with pharmacological doses of ethanol can decrease superantigen [Staphylococcus ent...

journal_title：Journal of leukocyte biology

authors： Szabo G,Mandrekar P,Catalano D

更新日期：1995-09-01 00:00:00

abstract：:Growth hormone controls somatic growth in mammals by regulating the production of IGF-1, which is predominantly made by the liver. The development of cells within the MPS is controlled by the lineage-specific growth factor M-CSF (CSF-1). In this review, we summarize the role of CSF-1-dependent macrophages in somatic g...

journal_title：Journal of leukocyte biology

authors： Gow DJ,Sester DP,Hume DA

更新日期：2010-09-01 00:00:00

abstract：:Studies on the mechanism of interferon-induced gene expression revealed a direct signaling pathway from cell surface receptors to transcription factors. In this pathway, signal transduction is mediated by a new class of transcription factor STAT (signal transducer and activator of transcription). We have shown that ST...

journal_title：Journal of leukocyte biology

authors： Fu XY

更新日期：1995-04-01 00:00:00

abstract：:The viral CC chemokines MC148, encoded by the poxvirus molluscum contagiosum, and viral macrophage inflammatory protein (vMIP)-I and vMIP-II, encoded by human herpesvirus 8, were probed on the murine CC receptor (CCR) 8 in parallel with human CCR8. In calcium mobilization assays, vMIP-I acted as a high-affinity agonis...

journal_title：Journal of leukocyte biology

authors： Lüttichau HR,Gerstoft J,Schwartz TW

更新日期：2001-08-01 00:00:00

abstract：:IL-1 receptor-associated kinase (IRAK) 4 is a central enzyme of the TLR pathways. This study tested the hypothesis that IRAK4 kinase activity is prerequisite for regulating innate immunity during infections with intracellular bacteria. To this end, we analyzed responses of macrophages obtained from mice expressing wil...

journal_title：Journal of leukocyte biology

authors： Pattabiraman G,Murphy M,Agliano F,Karlinsey K,Medvedev AE

更新日期：2018-10-01 00:00:00

abstract：:Scaffolding molecules bind simultaneously and link together various components of signal-transduction pathways. Grb2-associated binder 2 (Gab2) is a scaffolding protein required for FcgammaR-initiated allergic responses in mast cells and FcgammaR-mediated phagocytosis in macrophages, where it links IgE and IgG recepto...

journal_title：Journal of leukocyte biology

authors： Zompi S,Gu H,Colucci F

更新日期：2004-10-01 00:00:00

abstract：:Discussion on Tregs that have anti-inflammatory and anti-atherogenic properties as an ideal therapeutic target to reduce fatal cardiovascular deaths following major noncardiac surgery. ...

journal_title：Journal of leukocyte biology

authors： Kyaw T,Bobik A

更新日期：2020-05-01 00:00:00

abstract：:We recently demonstrated that the arachidonate metabolite 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) is converted by a highly specific dehydrogenase in human neutrophils to 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE), which is a potent stimulator of these cells. The objective of this study was to dete...

journal_title：Journal of leukocyte biology

authors： Zhang Y,Styhler A,Powell WS

更新日期：1996-06-01 00:00:00

abstract：:Compared with CD4+25+ regulatory T cells (Tregs), the mechanisms for natural, polyclonal CD8+25+ Treg immune suppression have been significantly less studied. We previously showed that polyclonal T cells can acquire antigen-specific targeting activity through arming with exosomal peptide-MHC (pMHC). In this study, we ...

journal_title：Journal of leukocyte biology

authors： Mu C,Zhang X,Wang L,Xu A,Ahmed KA,Pang X,Chibbar R,Freywald A,Huang J,Zhu Y,Xiang J

更新日期：2017-05-01 00:00:00

abstract：:Stimulation of phagocytic leukocytes with chemotactic factors results in transient acidification, followed by alkalinization of the cytosol. Human monocytes are known to alter their functional responses to the chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (fMLP) in a complex fashion as they mature in vitr...

journal_title：Journal of leukocyte biology

authors： Bernardo J,Brennan L,Brink HF,Ortiz MF,Newburger PE,Simons ER

更新日期：1993-06-01 00:00:00

abstract：:In previous studies, macrophages have been shown to influence in vitro colony formation by erythroid progenitors (CFU-E). To determine whether the origin of the macrophages influences their effects on in vitro erythropoiesis, plasma clot cultures of CFU-E were grown over adherent monolayers of macrophages from various...

journal_title：Journal of leukocyte biology

authors： Johnson CS,Furmanski P

更新日期：1984-11-01 00:00:00

abstract：:CD4(+) T cell help contributes critically to DC-induced CD8(+) CTL immunity. However, precisely how these three cell populations interact and how CD4(+) T cell signals are delivered to CD8(+) T cells in vivo have been unclear. In this study, we developed a novel, two-step approach, wherein CD4(+) T cells and antigen-p...

journal_title：Journal of leukocyte biology

authors： Ahmed KA,Wang L,Munegowda MA,Mulligan SJ,Gordon JR,Griebel P,Xiang J

更新日期：2012-08-01 00:00:00

abstract：:TLRs mediate host defense against microbial pathogens by eliciting production of inflammatory mediators and activating expression of MHC, adhesion, and costimulatory molecules. Endotoxin tolerance limits excessive TLR-driven inflammation during sepsis and reprograms macrophage responses to LPS, decreasing expression o...

journal_title：Journal of leukocyte biology

authors： Xiong Y,Medvedev AE

更新日期：2011-12-01 00:00:00