The macrophage scavenger receptor CD163: endocytic properties of cytoplasmic tail variants.

abstract：:The high-affinity receptor for the constant region of immunoglobulin G IgG (Fc gamma RI; CD64) is virtually undetectable on mature polymorphonuclear neutrophils (PMNs) in healthy individuals but is expressed on PMNs in patients with certain infections and in patients treated with recombinant human granulocyte colony-s...

journal_title：Journal of leukocyte biology

authors： Gericke GH,Ericson SG,Pan L,Mills LE,Guyre PM,Ely P

更新日期：1995-03-01 00:00:00

abstract：:The dynamics of immune cell populations during acute HIV-1 infection are not fully deciphered, especially for non-T cells. In this study, we tested whether specific cellular subsets of the innate arm of the immune response are affected early after HIV-1 infection. Using a cohort of HIV-1-infected individuals, we have ...

journal_title：Journal of leukocyte biology

authors： Centlivre M,Legrand N,Steingrover R,van der Sluis R,Grijsen ML,Bakker M,Jurriaans S,Berkhout B,Paxton WA,Prins JM,Pollakis G

更新日期：2011-05-01 00:00:00

abstract：:Breaking the long-held paradigm that primary B cells are not phagocytic, several studies have demonstrated recently that B cells from fish, amphibians, and reptilians have a significant phagocytic capacity. Whether such capacity has remained conserved in certain mammalian B cell subsets is presently an enigma. Here, w...

journal_title：Journal of leukocyte biology

authors： Parra D,Rieger AM,Li J,Zhang YA,Randall LM,Hunter CA,Barreda DR,Sunyer JO

更新日期：2012-04-01 00:00:00

abstract：:Female BDF1 mice were immunized with virulent Listeria monocytogenes, which resulted in the generation of a long-lived state of protective immunological memory for this facultative intracellular bacterial pathogen. The influence of antiorthostatic suspension, a ground-based model employed to simulate certain aspects o...

journal_title：Journal of leukocyte biology

authors： Miller ES,Sonnenfeld G

更新日期：1993-12-01 00:00:00

abstract：:The ability of an individual to mount defense responses to infection depend in part on the capacity to produce cytokines such as interleukin 1 (IL-1) and tumor necrosis factor (TNF). The specialized equipment, labor intensity, and sterile practice required for the standard in vitro evaluation of cytokine production ca...

journal_title：Journal of leukocyte biology

authors： Nerad JL,Griffiths JK,Van der Meer JW,Endres S,Poutsiaka DD,Keusch GT,Bennish M,Salam MA,Dinarello CA,Cannon JG

更新日期：1992-12-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a multifunctional cytokine that plays a pivotal role in mediating neovascularization as well as other endothelial cell alterations during inflammation. In this study, we demonstrate that human neutrophils are a source of VEGF. We observed that isolated blood neutrophils rel...

journal_title：Journal of leukocyte biology

authors： Taichman NS,Young S,Cruchley AT,Taylor P,Paleolog E

更新日期：1997-09-01 00:00:00

abstract：:The interaction between CD40 on dendritic cells (DC) and its ligand CD154 has been recognized to be an important feature in the maturation of DC. Here, we were interested in the role of CD44 a surface receptor shown to mediate cell-cell adhesion and binding to Hyaluronic acid (HA). Western blot analysis of human DC st...

journal_title：Journal of leukocyte biology

authors： Termeer C,Johannsen H,Braun T,Renkl A,Ahrens T,Denfeld RW,Lappin MB,Weiss JM,Simon JC

更新日期：2001-11-01 00:00:00

abstract：:The recognition of pathogen-associated molecular patterns by TLRs triggers the activation of innate and adaptive immune responses. Flagellin, the agonist of TLR5, is expressed by prokaryotes and eukaryotes, and DNA sequences containing unmethylated CpG dinucleotides, agonists of TLR9, are present essentially in prokar...

journal_title：Journal of leukocyte biology

authors： Merlo A,Calcaterra C,Mènard S,Balsari A

更新日期：2007-09-01 00:00:00

abstract：:Macrophages play an important role in effector mechanisms of various chronic inflammatory diseases. We studied the effect of gluten, the agent inducing celiac disease, and other food antigens on the activation of macrophages. Nitric oxide (NO) and cytokine production were followed as markers of activation, using cultu...

journal_title：Journal of leukocyte biology

authors： Tucková L,Flegelová Z,Tlaskalová-Hogenová H,Zídek Z

更新日期：2000-03-01 00:00:00

abstract：:The aim of the study was to elucidate the effect of lipopolysaccharide (LPS) administration in vivo (Escherichia coli endotoxin, 1 mg/kg body weight) on the expression and cellular activity of glucose-6-phosphate dehydrogenase (G6PDH, EC 1.1.1.49), the rate-limiting enzyme of the hexose monophosphate shunt in hepatic ...

journal_title：Journal of leukocyte biology

authors： Spolarics Z,Navarro L

更新日期：1994-10-01 00:00:00

abstract：:The human activation antigen CD69 is an early inducible surface glycoprotein acquired by T cells in the thymus at the stage of positive selection and during activation of mature lymphoid cells both in vivo and in vitro. We have studied the regulatory influence of CD69 activation pathway on the glycolytic process and t...

journal_title：Journal of leukocyte biology

authors： Conde M,Montaño R,Moreno-Aurioles VR,Ramirez R,Sanchez-Mateos P,Sanchez-Madrid F,Sobrino F

更新日期：1996-08-01 00:00:00

abstract：:Previously, we described a novel glycosylphosphatidyl inositol (GPI)-anchored glycoprotein (designated GPI-80) on human neutrophils and monocytes that may regulate beta(2) integrin-dependent neutrophil adherence and migration. However, the mechanism regulating beta(2) integrin remains to be clarified. To study this, w...

journal_title：Journal of leukocyte biology

authors： Yoshitake H,Takeda Y,Nitto T,Sendo F

更新日期：2002-02-01 00:00:00

abstract：:Bovine plasma contains factors that can stimulate bovine neutrophils. Bovine plasma at 1:1,000,000-1:1,000 dilution induced a dose-dependent superoxide production in bovine neutrophils. When bovine plasma was fractionated with a protein G column, only the IgG fraction contained induction activity. At similar concentra...

journal_title：Journal of leukocyte biology

authors： Tao W,Corbett MJ,Pickett W

更新日期：1995-08-01 00:00:00

abstract：:Successful remodeling of the uterine spiral arteries is essential for a complication-free pregnancy and is best described in terms of its morphologic features. The molecular mediators and cellular sources of spiral artery remodeling are not known, although a role for uterine leukocytes has been proposed. Immunohistoch...

journal_title：Journal of leukocyte biology

authors： Lash GE,Pitman H,Morgan HL,Innes BA,Agwu CN,Bulmer JN

更新日期：2016-08-01 00:00:00

abstract：:Progressive loss of dopaminergic neurons in the substantia nigra pars compacta and their terminal connections in the striatum are central features in Parkinson's disease (PD). Emerging evidence supports the notion that microglia neuroinflammatory responses speed neurodegenerative events. We demonstrated previously tha...

journal_title：Journal of leukocyte biology

authors： Reynolds AD,Banerjee R,Liu J,Gendelman HE,Mosley RL

更新日期：2007-11-01 00:00:00

abstract：:Newborns are highly susceptible to viral infections. We hypothesized that this susceptibility could be due to a dysregulated expression of innate virus-sensing receptors, i.e., TLR3, TLR7, TLR8, and TLR9 and the cytosolic receptors retinoic acid-inducible gene I, melanoma differentiation-associated protein 5, protein ...

journal_title：Journal of leukocyte biology

authors： Slavica L,Nordström I,Karlsson MN,Valadi H,Kacerovsky M,Jacobsson B,Eriksson K

更新日期：2013-11-01 00:00:00

abstract：:The last 10-15 years have witnessed a revolution in treating multiple myeloma, an incurable cancer of Ab-producing plasma cells. Advances in myeloma therapy were ushered in by novel agents that remodel the myeloma immune microenvironment. The first generation of novel agents included immunomodulatory drugs (thalidomid...

journal_title：Journal of leukocyte biology

authors： Asimakopoulos F,Hope C,Johnson MG,Pagenkopf A,Gromek K,Nagel B

更新日期：2017-08-01 00:00:00

abstract：:The T-box transcription factor Eomes is expressed in cytotoxic immune cells and plays an important role in development, maintenance, and function of these cell types. Identification and separation of cells with differential Eomes expression would allow for better understanding of the transcriptional program governing ...

journal_title：Journal of leukocyte biology

authors： Paley MA,Gordon SM,Bikoff EK,Robertson EJ,Wherry EJ,Reiner SL

更新日期：2013-02-01 00:00:00

abstract：:How regulatory T (TR) cells dampen T cell responses remains unclear. Multiple modes of action have been proposed, including cell contact-dependent and/or cytokine-dependent mechanisms. Suppression may involve direct contact between TR cells and responder T cells. Alternatively, TR cells may act on dendritic cells to r...

journal_title：Journal of leukocyte biology

authors： Bodor J,Fehervari Z,Diamond B,Sakaguchi S

更新日期：2007-01-01 00:00:00

abstract：:T-cell recognition of foreign antigen and migration to specific anatomic sites in vivo involves transient adhesive contacts between beta1 integrins expressed on T cells and cell surface proteins or extracellular-matrix components. Engagement of the CD3-T-cell receptor (CD3-TCR) complex initiates a complex signaling ca...

journal_title：Journal of leukocyte biology

authors： Woods ML,Shimizu Y

更新日期：2001-06-01 00:00:00

abstract：:Hybridoma cell lines were produced by fusion of SP2/0 murine myeloma cell line with the spleen cells of Wister rats which were immunized with IgG2a-binding protein isolated from the detergent lysate of a murine macrophagelike cell line, P388D1, by affinity chromatography on IgG-Sepharose 4B. A monoclonal clone (design...

journal_title：Journal of leukocyte biology

authors： Kagami M,Funatsu Y,Suzuki T

更新日期：1989-04-01 00:00:00

abstract：:TLR are primary triggers of the innate immune system by recognizing various microorganisms through conserved pathogen-associated molecular patterns. TLR2 is the receptor for a functional recognition of bacterial lipopeptides (LP) and is up-regulated during various disorders such as chronic obstructive pulmonary diseas...

journal_title：Journal of leukocyte biology

authors： Farhat K,Riekenberg S,Heine H,Debarry J,Lang R,Mages J,Buwitt-Beckmann U,Röschmann K,Jung G,Wiesmüller KH,Ulmer AJ

更新日期：2008-03-01 00:00:00

abstract：:Monocyte chemoattractant protein-1 (MCP-1, CCL2) is a mediator of inflammation that has been implicated in the pathogenesis of a wide variety of human diseases. CCR2, a heterotrimeric G-coupled receptor, is the only known receptor that functions at physiologic concentrations of MCP-1. Despite the importance of CCR2 in...

journal_title：Journal of leukocyte biology

authors： Schecter AD,Berman AB,Yi L,Ma H,Daly CM,Soejima K,Rollins BJ,Charo IF,Taubman MB

更新日期：2004-06-01 00:00:00

abstract：:Impairments in the respiratory burst and stimulus-response coupling were studied with respect to the increased rate of cell replication that occurred in HL60 cells during repetitive passages in cell culture. During a 45-week period of culture, HL60 cells developed a progressive increase in rate of replication. Concomi...

journal_title：Journal of leukocyte biology

authors： Hadjokas N,Bayer C,Nielson CP

更新日期：1992-08-01 00:00:00

abstract：:IL-1β is an important mediator of innate inflammatory responses and has been shown to contribute to liver injury in a number of etiologies. HIV patients have increased necroinflammation and more rapid fibrosis progression in chronic liver injury compared to non-HIV-infected patients. As the resident liver macrophage i...

journal_title：Journal of leukocyte biology

authors： Zhang L,Mosoian A,Schwartz ME,Florman SS,Gunasekaran G,Schiano T,Fiel MI,Jiang W,Shen Q,Branch AD,Bansal MB

更新日期：2019-04-01 00:00:00

abstract：:G-CSF and GM-CSF play important roles in regulating neutrophil production, survival, differentiation, and function. However, we have shown previously that G-CSF/GM-CSF double-deficient [knockout (KO)] mice still develop a profound neutrophilia in bone marrow and blood after infection with Candida albicans. This findin...

journal_title：Journal of leukocyte biology

authors： Zhang HH,Basu S,Wu F,Begley CG,Saris CJ,Dunn AR,Burgess AW,Walker F

更新日期：2007-10-01 00:00:00

abstract：:The human lysozyme (LZM) gene is highly methylated in LZM-nonexpressor immature myeloid and in nonmyeloid cells and unmethylated only in LZM-expressing cells. Extended methylation analyses of the CpG-poor 5' flanking region and of the exon 4 CpG island (both containing Alu elements) of the LZM gene were now performed....

journal_title：Journal of leukocyte biology

authors： Claus R,Fliegauf M,Stock M,Duque JA,Kolanczyk M,Lübbert M

更新日期：2006-12-01 00:00:00

abstract：:Endotoxin (lipopolysaccharide, LPS) is known to induce inflammatory responses, such as monocyte/macrophage adherence, migration, and accumulation. Recruitment and accumulation of macrophages during infection and inflammation are regulated by integrin-mediated cell-extracellular matrix interactions. In the present repo...

journal_title：Journal of leukocyte biology

authors： Kang YH,Lee CH,Brummel SE,Newball HH,Forrester J

更新日期：1995-04-01 00:00:00

abstract：:The mannose receptor is a macrophage surface receptor that mediates both endocytosis and phagocytosis. Previous work has demonstrated that the prototypical Th 2 cytokine, interleukin-4 (IL-4), increases both cell-surface receptor expression and mannose receptor-mediated endocytosis, whereas the prototypical Th 1 cytok...

journal_title：Journal of leukocyte biology

authors： Raveh D,Kruskal BA,Farland J,Ezekowitz RAB

更新日期：1998-07-01 00:00:00

abstract：:Low density lipoprotein receptor-related protein (LRP) is a major receptor for multiple ligands, including chylomicron and VLDL remnants, bacterial toxins, viruses, proteinases, lipoprotein lipase, and activated alpha2-macroglobulin (alpha2M). In this study, we used Northern blot analyses and nuclear run-on experiment...

journal_title：Journal of leukocyte biology

authors： Hussaini IM,LaMarre J,Lysiak JJ,Karns LR,VandenBerg SR,Gonias SL

更新日期：1996-05-01 00:00:00