Monomeric bovine IgG2 is a potent stimulus for bovine neutrophils.

abstract：:When mouse peritoneal cells in early phase-inflammatory exudates were cultured in vitro, the number of polymorphonuclear leukocytes (PMNs) rapidly decreased, whereas the number of macrophages gradually increased during culture. Macrophage growth was also induced by addition of effete PMNs or their debris to macrophage...

journal_title：Journal of leukocyte biology

authors： Yui S,Yamazaki M

更新日期：1986-05-01 00:00:00

abstract：:Immune and inflammatory cells play a critical role in the pathogenesis of atherosclerotic plaques. We have demonstrated that A2ARs inhibit foam cell formation and stimulate production of ABCA1, the primary transporter of lipoproteins. We asked whether the effects of A2ARs on foam cell formation in vitro are mediated b...

journal_title：Journal of leukocyte biology

authors： Bingham TC,Fisher EA,Parathath S,Reiss AB,Chan ES,Cronstein BN

更新日期：2010-04-01 00:00:00

abstract：:We have identified three distinct cell phenotypes with respect to the conditions under which cells became susceptible to TNF-mediated lysis. These conditions include: 1) treatment with the protein synthesis inhibitor, cycloheximide; 2) contact with activated macrophages, and 3) infection with vaccinia virus. Whereas v...

journal_title：Journal of leukocyte biology

authors： Woods KM,Chapes SK

更新日期：1993-01-01 00:00:00

abstract：:NLRP3 is the most crucial member of the NLR family, as it detects the existence of pathogen invasion and self-derived molecules associated with cellular damage. Several studies have reported that excessive NLRP3 inflammasome-mediated caspase-1 activation is a key factor in the development of diseases. Recent studies h...

journal_title：Journal of leukocyte biology

authors： Lin YC,Huang DY,Wang JS,Lin YL,Hsieh SL,Huang KC,Lin WW

更新日期：2015-05-01 00:00:00

abstract：:In an analysis of nitric oxide (.NO) production and toxicity, chicken macrophage-generated .NO inhibited mitochondrial activity in both .NO-producing macrophages themselves and lymphoid tumor targets. However, differences in targeting of mitochondrial toxicity were observed among these cells. Two chicken macrophage ce...

journal_title：Journal of leukocyte biology

authors： Sung YJ,Dietert RR

更新日期：1994-07-01 00:00:00

abstract：:Mice with a naturally occurring Csfm(op)/Csfm(op) (op/op) gene mutation lack functional macrophage-colony stimulating factor (M-CSF) and are deficient of M-CSF-derived macrophages. They are severely monocytopenic, and their remaining M-CSF-independent macrophages were shown to differ in differentiation and distinct fu...

journal_title：Journal of leukocyte biology

authors： Schönlau F,Schlesiger C,Ehrchen J,Grabbe S,Sorg C,Sunderkötter C,Ehrehen J

更新日期：2003-05-01 00:00:00

abstract：:Lipopolysaccharide-induced necrosis of grafted tumors was potentiated by several hydrophilic and lipophilic muramyl dipeptide (MDP) derivatives administered a few hours prior to small amounts of lipopolysaccharide (LPS) in spite of low titers of induced circulating tumor necrosis factor (TNF). However, pretreatment wi...

journal_title：Journal of leukocyte biology

authors： Parant M,Parant F,Vinit MA,Jupin C,Noso Y,Chedid L

更新日期：1990-02-01 00:00:00

abstract：:TNF-α is a proinflammatory cytokine, dramatically elevated during pathogenic infection and often responsible for inflammation-induced disease pathology. SOCS proteins are inhibitors of cytokine signaling and regulators of inflammation. In this study, we found that both SOCS1 and SOCS3 were transiently induced by TNF-α...

journal_title：Journal of leukocyte biology

authors： Collins AS,Ahmed S,Napoletano S,Schroeder M,Johnston JA,Hegarty JE,O'Farrelly C,Stevenson NJ

更新日期：2014-08-01 00:00:00

abstract：:The adhesion and degranulation promoting adaptor protein (ADAP) is a multifunctional scaffold involved in many different signaling pathways that are important for the function of T cells, including the inside-out and outside-in signaling of integrins, the activation of NF-κB, and the subsequent production of proinflam...

journal_title：Journal of leukocyte biology

authors： Parzmair GP,Gereke M,Haberkorn O,Annemann M,Podlasly L,Kliche S,Reinhold A,Schraven B,Bruder D

更新日期：2017-02-01 00:00:00

abstract：:Zinc is an essential element important for growth, the nervous system, and especially the immune system. Zinc deficiency as well as levels well above normal, due to high-dose treatment, showed an impaired immune function. This review summarizes the current status of zinc's significance for leukocyte biology and health...

journal_title：Journal of leukocyte biology

authors： Wellinghausen N,Rink L

更新日期：1998-11-01 00:00:00

abstract：:Neutrophils phagocytize high-valency immune complexes (HIC) by an Fc gamma receptor-mediated mechanism, activating an oxidative burst and initiating degranulation. In contrast, neutrophils exhibit chemotaxis to N-formylated peptides [e.g., N-formyl-methionyl-leucyl-phenylalanine (fMLP)] and secrete far fewer oxidants ...

journal_title：Journal of leukocyte biology

authors： Gewirtz AT,Simons ER

更新日期：1997-04-01 00:00:00

abstract：:Increased concentrations of eicosanoids are found in synovial fluids (SF) from patients with rheumatoid arthritis (RA). SF polymorphonuclear leukocytes (PMN), which derive from peripheral blood, usually account for approximately 90% of the cells in RA SF. Since eicosanoid precursor fatty acids (FA) are liberated by ph...

journal_title：Journal of leukocyte biology

authors： Bomalaski JS,Clark MA,Douglas SD,Zurier RB

更新日期：1985-11-01 00:00:00

abstract：:An epithelial cell line, IT-45R1, has been established from a thymus of normal Wistar rat and was found to produce growth factor which stimulated the proliferation of bone marrow cells. This growth factor induced the formation of colonies composed of macrophages, granulocytes, or both, in semi-solid medium and stimula...

journal_title：Journal of leukocyte biology

authors： Nanno M,Takahashi T,Sakata T,Horikawa T,Sako T,Suzuki R,Itoh T,Kumagai K

更新日期：1991-12-01 00:00:00

abstract：:The immune system is armed with a broad range of receptors to detect and initiate the elimination of bacterial pathogens. Inflammasomes are molecular platforms that sense a diverse range of microbial insults to develop appropriate host response. In that context, noncanonical inflammasome arose as a sensor for Gram-neg...

journal_title：Journal of leukocyte biology

authors： Gomes MTR,Cerqueira DM,Guimarães ES,Campos PC,Oliveira SC

更新日期：2019-09-01 00:00:00

abstract：:Regulation of macrophage PCD plays an important role in pathogenesis of leishmaniasis. However, the precise involvement of any parasite molecule in this process remains uncertain. In the current study, in silico wide analysis demonstrated that genes in the Leishmania donovani genome are highly enriched for CpG motifs,...

journal_title：Journal of leukocyte biology

authors： Das S,Ghosh AK,Singh S,Saha B,Ganguly A,Das P

更新日期：2015-02-01 00:00:00

abstract：:The role of JNK in neutrophil chemotaxis and killing of microbial pathogens remains unclear. Using a recently described cell-permeable peptide inhibitor of the JNK pathway, based on the JBD of JIP-1, coupled to the protein transduction domain of HIV-TAT (TAT-JIP), in association with control peptides, we demonstrate t...

journal_title：Journal of leukocyte biology

authors： Yeh MC,Mukaro V,Hii CS,Ferrante A

更新日期：2010-05-01 00:00:00

abstract：:GCs are widely prescribed to treat inflammatory disorders and autoimmune and allergic diseases. Their anti-inflammatory and immunosuppressive effects may be related, in part, to their ability to control the maturation and functions of DCs. Here, we report that GCs inhibit the maturation of human CD34-DCs induced by th...

journal_title：Journal of leukocyte biology

authors： Larangé A,Antonios D,Pallardy M,Kerdine-Römer S

更新日期：2012-01-01 00:00:00

abstract：:The role of PI-3K in leukocyte function has been studied extensively. However, the specific role of the p110gamma isoform of PI- 3K in CD4 T lymphocyte function has yet to be defined explicitly. In this study, we report that although p110gamma does not regulate antigen-dependent CD4 T cell activation and proliferation...

journal_title：Journal of leukocyte biology

authors： Thomas MS,Mitchell JS,DeNucci CC,Martin AL,Shimizu Y

更新日期：2008-09-01 00:00:00

abstract：:To assess the effect of hypoxemia on the responses of polymorphonuclear neutrophils (PMN) during an inflammatory response, rats were maintained in a low F1O2 atmosphere (9% O2) or room air for 12 h before intrathoracic injection of carrageenin or intradermal injections of agonists. After 4 h, hypoxemic rats had 50% mo...

journal_title：Journal of leukocyte biology

authors： Tremblay PB,Macari DM,Martel D,du Souich P,Barja-Fidalgo C,Marleau S

更新日期：2000-06-01 00:00:00

abstract：:Intracellular zinc homeostasis is strictly regulated by zinc binding proteins and zinc transporters. In the present study, we quantified in a first global view the expression of all characterized human zinc exporters (hZnT-1-9) in different leukocyte subsets in response to zinc supplementation and depletion and analyz...

journal_title：Journal of leukocyte biology

authors： Overbeck S,Uciechowski P,Ackland ML,Ford D,Rink L

更新日期：2008-02-01 00:00:00

abstract：:The Fanconi anemia proteins participate in a canonical pathway that repairs cross-linking agent-induced DNA damage. Cells with inactivated Fanconi anemia genes are universally hypersensitive to such agents. Fanconi anemia-deficient hematopoietic stem cells are also hypersensitive to inflammatory cytokines, and, as imp...

journal_title：Journal of leukocyte biology

authors： Garbati MR,Hays LE,Rathbun RK,Jillette N,Chin K,Al-Dhalimy M,Agarwal A,Newell AE,Olson SB,Bagby GC Jr

更新日期：2016-03-01 00:00:00

abstract：:We reported previously that N-myc downstream-regulated gene 2 (NDRG2), a member of a new family of differentiation-related genes, is expressed specifically in dendritic cells (DC) differentiated from monocytes, CD34(+) progenitor cells, and the myelomonocytic leukemic cell line. In this study, we demonstrate that NDRG...

journal_title：Journal of leukocyte biology

authors： Choi SC,Kim KD,Kim JT,Kim JW,Lee HG,Kim JM,Jang YS,Yoon DY,Kim KI,Yang Y,Cho DH,Lim JS

更新日期：2008-01-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is a potent natural adjuvant, commonly used to amplify Th1 responses. Here, we report that systemic immunization using LPS generates large numbers of specific Th17 cells in murine small intestinal lamina propria. The priming of these Th17 cells required IL-23p19 production by bone marrow-deriv...

journal_title：Journal of leukocyte biology

authors： McAleer JP,Liu B,Li Z,Ngoi SM,Dai J,Oft M,Vella AT

更新日期：2010-07-01 00:00:00

abstract：:The signaling adapters MyD88 and TRIF are engaged by TLRs and/or receptors of the IL-1 family and are considered important for innate immune responses that combat bacterial infections. Here, the consequences of a combined MyD88 and TRIF deficiency for the innate immune response against severe septic peritonitis was ex...

journal_title：Journal of leukocyte biology

authors： Reim D,Rossmann-Bloeck T,Jusek G,Prazeres da Costa O,Holzmann B

更新日期：2011-09-01 00:00:00

abstract：:Lymphocyte development is initiated from hematopoietic stem cells and can be divided into multiple phenotypically distinct stages. Transcription factors play important roles in programming the developmental process of lymphocytes. Recent studies have identified key roles of several orphan nuclear receptors in T lympho...

journal_title：Journal of leukocyte biology

authors： He YW

更新日期：2002-09-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) is one of the recently defined damage-associated molecular pattern molecules, passively released from necrotic cells and secreted by activated macrophage/monocytes. Whether cytolytic cells induce HMGB1 release from tumor cells is not known. We developed a highly sensitive method for d...

journal_title：Journal of leukocyte biology

authors： Ito N,DeMarco RA,Mailliard RB,Han J,Rabinowich H,Kalinski P,Stolz DB,Zeh HJ 3rd,Lotze MT

更新日期：2007-01-01 00:00:00

abstract：:In a DNA immunization against Herpes simplex virus (HSV), we examined the ability of plasmid-encoded interleukin-15 (pIL-15) to induce and maintain the mucosal B and T cell immune response. pIL-15 generated memory CD8(+) T cell responses that were threefold higher and mainly maintained in the spleen, but high levels o...

journal_title：Journal of leukocyte biology

authors： Toka FN,Rouse BT

更新日期：2005-07-01 00:00:00

abstract：:Scaffolding molecules bind simultaneously and link together various components of signal-transduction pathways. Grb2-associated binder 2 (Gab2) is a scaffolding protein required for FcgammaR-initiated allergic responses in mast cells and FcgammaR-mediated phagocytosis in macrophages, where it links IgE and IgG recepto...

journal_title：Journal of leukocyte biology

authors： Zompi S,Gu H,Colucci F

更新日期：2004-10-01 00:00:00

abstract：:IL-7R, FLT3, and CD43 are surface antigens expressed during the transition from pro-B to pre-B cells in BM. To understand interactions between their signaling pathways, we analyzed spontaneous mouse B-LBLs with dual MLV integration into Stat5a and Fiz1 or Stat5a and Hipk2. MLV integration resulted in up-regulation of ...

journal_title：Journal of leukocyte biology

authors： Tsuruyama T,Imai Y,Takeuchi H,Hiratsuka T,Maruyama Y,Kanaya K,Kaszynski R,Jin G,Okuno T,Ozeki M,Nakamura T,Takakuwa T,Manabe T,Tamaki K,Hiai H

更新日期：2010-07-01 00:00:00

abstract：:Life stress is a major risk factor in the onset and exacerbation of mast cell-associated diseases, including allergy/anaphylaxis, asthma, and irritable bowel syndrome. Although it is known that mast cells are highly activated upon stressful events, the mechanisms by which stress modulates mast cell function and diseas...

journal_title：Journal of leukocyte biology

authors： Ayyadurai S,Gibson AJ,D'Costa S,Overman EL,Sommerville LJ,Poopal AC,Mackey E,Li Y,Moeser AJ

更新日期：2017-12-01 00:00:00