Unmethylated CpG motifs in the L. donovani DNA regulate TLR9-dependent delay of programmed cell death in macrophages.

abstract：:During inflammation the balance between cell activation and cell death is determined by the tight regulation of multiple intracellular enzyme cascades. Key regulatory steps often involve protein kinases. We show that the prototypical pro-inflammatory molecule, bacterial lipopolysaccharide, activates multiple protein k...

journal_title：Journal of leukocyte biology

authors： Lee J,Mira-Arbibe L,Ulevitch RJ

更新日期：2000-12-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) is one of the recently defined damage-associated molecular pattern molecules, passively released from necrotic cells and secreted by activated macrophage/monocytes. Whether cytolytic cells induce HMGB1 release from tumor cells is not known. We developed a highly sensitive method for d...

journal_title：Journal of leukocyte biology

authors： Ito N,DeMarco RA,Mailliard RB,Han J,Rabinowich H,Kalinski P,Stolz DB,Zeh HJ 3rd,Lotze MT

更新日期：2007-01-01 00:00:00

abstract：:Nucleotide receptors serve as sensors of extracellular ATP and are important for immune function. The nucleotide receptor P2RX7 is a cell-surface, ligand-gated cation channel that has been implicated in many diseases, including arthritis, granuloma formation, sepsis, and tuberculosis. These disorders are often exacerb...

journal_title：Journal of leukocyte biology

authors： Gavala ML,Pfeiffer ZA,Bertics PJ

更新日期：2008-10-01 00:00:00

abstract：:The human lysozyme (LZM) gene is highly methylated in LZM-nonexpressor immature myeloid and in nonmyeloid cells and unmethylated only in LZM-expressing cells. Extended methylation analyses of the CpG-poor 5' flanking region and of the exon 4 CpG island (both containing Alu elements) of the LZM gene were now performed....

journal_title：Journal of leukocyte biology

authors： Claus R,Fliegauf M,Stock M,Duque JA,Kolanczyk M,Lübbert M

更新日期：2006-12-01 00:00:00

abstract：:Absence of lymph nodes in nonmammalian species, expression of MHCII by APCs in the periphery, and the recent findings that T cells can change their polarization status after presentation in the lymph nodes imply a role for MHCII-mediated presentation outside the organized lymphoid tissue. This study shows that MHCII(+...

journal_title：Journal of leukocyte biology

authors： Inman CF,Singha S,Lewis M,Bradley B,Stokes C,Bailey M

更新日期：2010-09-01 00:00:00

abstract：:The recently cloned ligand binding component of the type I human interferon-alpha/beta receptor (IFN-alpha/beta R) and its soluble analogue (p40) were characterized. p40 is a potent inhibitor of type I IFNs and antibodies directed against p40 completely block the activity of type I IFNs in human cells. These antibodie...

journal_title：Journal of leukocyte biology

authors： Novick D,Cohen B,Tal N,Rubinstein M

更新日期：1995-05-01 00:00:00

abstract：:Throughout evolution, mammals have developed an elaborate network of positive and negative regulatory mechanisms, which provide balance between defensive measures against bacterial and viral pathogens and protective measures against unwarranted destruction of the host by the activated immune system. Kinases and phosph...

journal_title：Journal of leukocyte biology

authors： Salojin K,Oravecz T

更新日期：2007-04-01 00:00:00

abstract：:In this study, we test the hypothesis that cAMP, acting as an extracellular mediator, affects the physiology and function of human myeloid cells. The cAMP is a second messenger recognized as a universal regulator of several cellular functions in different organisms. Many studies have shown that extracellular cAMP exer...

journal_title：Journal of leukocyte biology

authors： Sciaraffia E,Riccomi A,Lindstedt R,Gesa V,Cirelli E,Patrizio M,De Magistris MT,Vendetti S

更新日期：2014-07-01 00:00:00

abstract：:Polymorphonuclear leukocytes (PMNs) exert most of their physiological functions while adherent to surfaces rather than in suspension. PMN adhesion is largely dependent on the function of the beta 2 integrins, CD11a,b,c/CD18. We mimicked engagement of beta 2 integrins by antibody cross-linking of CD18 on isolated human...

journal_title：Journal of leukocyte biology

authors： Walzog B,Seifert R,Zakrzewicz A,Gaehtgens P,Ley K

更新日期：1994-11-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) encodes the MHC class I-like molecule UL18, which binds with high affinity to the leukocyte Ig-like receptor-1 (LIR-1), an inhibitory receptor commonly expressed on myeloid cells and subsets of NK and T cells. The exact role of UL18 is not known, in particular in relation to its proposed r...

journal_title：Journal of leukocyte biology

authors： Wagner CS,Walther-Jallow L,Buentke E,Ljunggren HG,Achour A,Chambers BJ

更新日期：2008-01-01 00:00:00

abstract：:Neutrophils are important mediators of the innate immune defense and of the host response to a physical trauma. Because aberrant infiltration of injured sites by neutrophils was shown to cause adverse effects after trauma, we investigated how neutrophil infiltration could be modulated at the cellular level. Our data i...

journal_title：Journal of leukocyte biology

authors： Wille C,Eiseler T,Langenberger ST,Richter J,Mizuno K,Radermacher P,Knippschild U,Huber-Lang M,Seufferlein T,Paschke S

更新日期：2018-09-01 00:00:00

abstract：:We provide new information on how apoptosis regulates the expansion and survival of dendritic cell (DC) elements during in vitro hematopoiesis. Functionally distinct apoptotic schedules were associated with different phases of DC development when multipotent CD34+ progenitor cells were treated with GM-CSF + TNF +/- SC...

journal_title：Journal of leukocyte biology

authors： Santiago-Schwarz F,Borrero M,Tucci J,Palaia T,Carsons SE

更新日期：1997-10-01 00:00:00

abstract：:The cytosolic adaptor molecule SKAP-HOM, similar to the T cell-specific homologue SKAP55, interacts directly with ADAP, and both molecules are involved in inside-out signaling. Previous studies have shown that in the absence of SKAP-HOM, antigen receptor-triggered integrin-mediated adhesion is impaired severely in B c...

journal_title：Journal of leukocyte biology

authors： Reinhold A,Reimann S,Reinhold D,Schraven B,Togni M

更新日期：2009-07-01 00:00:00

abstract：:MRL/fas(lpr) mice, which undergo a systemic autoimmune disease with similarities to systemic lupus erythematosus (SLE), display reduced pathology and prolonged survival if rendered deficient in ICAM-1. However, it remains unclear whether this is a result of the ability of ICAM-1 to promote the immune response or media...

journal_title：Journal of leukocyte biology

authors： Norman MU,James WG,Hickey MJ

更新日期：2008-07-01 00:00:00

abstract：:Successful remodeling of the uterine spiral arteries is essential for a complication-free pregnancy and is best described in terms of its morphologic features. The molecular mediators and cellular sources of spiral artery remodeling are not known, although a role for uterine leukocytes has been proposed. Immunohistoch...

journal_title：Journal of leukocyte biology

authors： Lash GE,Pitman H,Morgan HL,Innes BA,Agwu CN,Bulmer JN

更新日期：2016-08-01 00:00:00

abstract：:Neutrophil-induced damage to the protective epithelium has been implicated in mucosal disorders associated with hypoxia, and such damage may be initiated by epithelial-derived chemokines. Because chemokines can bind to membrane proteoglycans, we hypothesized that chemokines may associate with epithelial surfaces and a...

journal_title：Journal of leukocyte biology

authors： Furuta GT,Dzus AL,Taylor CT,Colgan SP

更新日期：2000-08-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) has been shown to induce the production of interstitial collagenase by fibroblasts and chondrocytes. We investigated the role of TNF-alpha in collagenase gene expression by U937 monocyte/macrophage cells. Transcription of the TNF-alpha gene was observed after 0.5 h of phorbol my...

journal_title：Journal of leukocyte biology

authors： Callaghan MM,Lovis RM,Rammohan C,Lu Y,Pope RM

更新日期：1996-01-01 00:00:00

abstract：:Previously, we demonstrated the stimulus-specific ability of platelet lysate or release products to inhibit neutrophil functions in response to f-met-leu-phe (fMLP) or phorbol myristate acetate (PMA). The present study further characterizes these activities and identifies one of the platelet inhibitors of neutrophil s...

journal_title：Journal of leukocyte biology

authors： McGarrity ST,Stephenson AH,Hyers TM,Webster RO

更新日期：1988-11-01 00:00:00

abstract：:Chemokines play a crucial role in combating microbial infection by recruiting blood neutrophils to infected tissue. In mice, the chemokines Cxcl1/KC and Cxcl2/MIP2 fulfill this role. Cxcl1 and Cxcl2 exist as monomers and dimers, and exert their function by activating the Cxcr2 receptor and binding glycosaminoglycans (...

journal_title：Journal of leukocyte biology

authors： Sawant KV,Sepuru KM,Lowry E,Penaranda B,Frevert CW,Garofalo RP,Rajarathnam K

更新日期：2020-09-02 00:00:00

abstract：:Neutrophil extracellular traps (NETs), web-like DNA structures, provide efficient means of eliminating invading microorganisms but can also present a potential threat to its host because it is a likely source of autoantigens or by promoting bystander tissue damage. Therefore, it is important to identify mechanisms tha...

journal_title：Journal of leukocyte biology

authors： Zabieglo K,Majewski P,Majchrzak-Gorecka M,Wlodarczyk A,Grygier B,Zegar A,Kapinska-Mrowiecka M,Naskalska A,Pyrc K,Dubin A,Wahl SM,Cichy J

更新日期：2015-07-01 00:00:00

abstract：:An in vitro system allowing the culture of ovine bone marrow-derived macrophages (BMMs) is described. Bone marrow (BM) cells from the sternum of 4- to 9-month-old sheep were cultured in liquid suspension in hydrophobic bags with medium containing 20% autologous serum and 20% fetal calf serum (FCS). Cells with macropha...

journal_title：Journal of leukocyte biology

authors： Francey T,Jungi TW,Rey O,Peterhans E

更新日期：1992-06-01 00:00:00

abstract：:Secreted IgM (sIgM) is a multifunctional evolutionary conserved antibody that is critical for the maintenance of tissue homeostasis as well as the development of fully protective humoral responses to pathogens. Constitutive secretion of self- and polyreactive natural IgM, produced mainly by B-1 cells, provides a circu...

journal_title：Journal of leukocyte biology

authors： Blandino R,Baumgarth N

更新日期：2019-11-01 00:00:00

abstract：:Membrane rafts are microdomains of the plasma membrane that have multiple biological functions. The involvement of these structures in the biology of T cells, namely in signal transduction by the TCR, has been widely studied. However, the role of membrane rafts in immunoreceptor signaling in NK cells is less well know...

journal_title：Journal of leukocyte biology

authors： Serrano-Pertierra E,Cernuda-Morollón E,Brdička T,Hoøejši V,López-Larrea C

更新日期：2014-09-01 00:00:00

abstract：:The last 10-15 years have witnessed a revolution in treating multiple myeloma, an incurable cancer of Ab-producing plasma cells. Advances in myeloma therapy were ushered in by novel agents that remodel the myeloma immune microenvironment. The first generation of novel agents included immunomodulatory drugs (thalidomid...

journal_title：Journal of leukocyte biology

authors： Asimakopoulos F,Hope C,Johnson MG,Pagenkopf A,Gromek K,Nagel B

更新日期：2017-08-01 00:00:00

abstract：:Neutrophils, an essential component of the innate immune system, are produced at a rate 10(11) cells/day and are consequently the most abundant leukocyte in the blood. These granulocytes have a relatively short half-life (6-8 h) in the blood, and as a result of the cytotoxic nature of their contents, it is critical th...

journal_title：Journal of leukocyte biology

authors： Rankin SM

更新日期：2010-08-01 00:00:00

abstract：:This study investigated the expression of MUC5B by AMs in the lungs of cigarette smokers and nonsmokers. We analyzed MUC5B expression by measuring the levels of apomucin and mRNA in human BALF cells from 50 subjects (20 nonsmokers, 17 patients with CB, and 13 patients with COPD). apoMUC5B was observed in BALF mononucl...

journal_title：Journal of leukocyte biology

authors： Sepper R,Prikk K,Metsis M,Sergejeva S,Pugatsjova N,Bragina O,Marran S,Fehniger TE

更新日期：2012-08-01 00:00:00

abstract：:Low density lipoprotein receptor-related protein (LRP) is a major receptor for multiple ligands, including chylomicron and VLDL remnants, bacterial toxins, viruses, proteinases, lipoprotein lipase, and activated alpha2-macroglobulin (alpha2M). In this study, we used Northern blot analyses and nuclear run-on experiment...

journal_title：Journal of leukocyte biology

authors： Hussaini IM,LaMarre J,Lysiak JJ,Karns LR,VandenBerg SR,Gonias SL

更新日期：1996-05-01 00:00:00

abstract：:Tyrosine phosphorylation is an important component of the signaling pathways responsible for the activation of the macrophage respiratory burst. Because the virulence plasmid of Yersinia enterocolitica encodes a phosphotyrosine phosphatase, YopH, it is possible that the pathogenic strategy of Y. enterocolitica involve...

journal_title：Journal of leukocyte biology

authors： Green SP,Hartland EL,Robins-Browne RM,Phillips WA

更新日期：1995-06-01 00:00:00

abstract：:The in vitro effects of 17 alpha AED, the isomer of 5-androstene-3 beta,17 beta diol (17 beta AED) on the basal growth of murine RAW 264.7, P388D1, and human HL-60 cells were investigated. 17 alpha AED treatment of RAW cells for 48 h reduced total cell number without increasing cell death as detected by trypan blue ex...

journal_title：Journal of leukocyte biology

authors： Huynh PN,Loria RM

更新日期：1997-08-01 00:00:00

abstract：:T helper cell type 1 (Th1)-polarizing cytokines are induced by Legionella pneumophila infection and are suppressed by pretreatment with marijuana cannabinoids (CB). Glucocorticoids and prostaglandin E2(PGE2) are also reported to suppress Th1 polarization and are induced by Delta9-tetrahydrocannabinol (THC), so their r...

journal_title：Journal of leukocyte biology

authors： Newton CA,Lu T,Nazian SJ,Perkins I,Friedman H,Klein TW

更新日期：2004-10-01 00:00:00