Role of YopH in the suppression of tyrosine phosphorylation and respiratory burst activity in murine macrophages infected with Yersinia enterocolitica.

abstract：:HIV infection causes rapid and lasting defects in the population of Vgamma2Vdelta2 T cells. To fully describe the impact of HIV, we examined PBMC samples from HIV+ patients receiving highly active antiretroviral therapy, who had displayed prolonged viral control and CD4 counts above 300 cells/mm3. We observed lower fr...

journal_title：Journal of leukocyte biology

authors： Cummings JS,Cairo C,Armstrong C,Davis CE,Pauza CD

更新日期：2008-08-01 00:00:00

abstract：:Human neutrophils generate oxygen reduction products as a consequence of membrane interactions with a number of stimuli. One oxygen-centered free radical (superoxide) has been unequivocally shown to result from this "respiratory burst," and some experimental evidence for another (hydroxyl radical) has been published, ...

journal_title：Journal of leukocyte biology

authors： Britigan BE,Cohen MS,Rosen GM

更新日期：1987-04-01 00:00:00

abstract：:Neutrophils kill invading pathogens by AMPs, including cathelicidins, ROS, and NETs. The human pathogen Staphylococcus aureus exhibits enhanced resistance to neutrophil AMPs, including the murine cathelicidin CRAMP, in part, as a result of alanylation of teichoic acids by the dlt operon. In this study, we took advanta...

journal_title：Journal of leukocyte biology

authors： Jann NJ,Schmaler M,Kristian SA,Radek KA,Gallo RL,Nizet V,Peschel A,Landmann R

更新日期：2009-11-01 00:00:00

abstract：:The kinetics and regulatory mechanisms of T cell migration through the endothelium have not been fully defined. In experimental, filter-based assays in vitro, transmigration of lymphocytes takes hours, compared with minutes, in vivo. We cultured endothelial cell (EC) monolayers on filters, solid substrates, or collage...

journal_title：Journal of leukocyte biology

authors： McGettrick HM,Hunter K,Moss PA,Buckley CD,Rainger GE,Nash GB

更新日期：2009-01-01 00:00:00

abstract：:When mouse peritoneal cells in early phase-inflammatory exudates were cultured in vitro, the number of polymorphonuclear leukocytes (PMNs) rapidly decreased, whereas the number of macrophages gradually increased during culture. Macrophage growth was also induced by addition of effete PMNs or their debris to macrophage...

journal_title：Journal of leukocyte biology

authors： Yui S,Yamazaki M

更新日期：1986-05-01 00:00:00

abstract：:Freeze-fracture analysis has shown that treatment of cells with phorbol myristate acetate (PMA) results in a loss of intramembranous particles (IMP) associated with the external leaflet of their plasma membranes. It has also been demonstrated that phorbol esters markedly enhance the sensitivity of tumor targets to nat...

journal_title：Journal of leukocyte biology

authors： Nabi ZF,Zucker-Franklin D,Baten A

更新日期：1989-03-01 00:00:00

abstract：:Evidence that gamma/delta T cells play a broad, immunoregulatory role has been accumulating steadily. We show here that myeloid cells are disregulated after peritoneal infection with Listeria monocytogenes in mice lacking gamma/delta T cells. Inflammatory populations of neutrophils and monocytes recruited to the site ...

journal_title：Journal of leukocyte biology

authors： Skeen MJ,Freeman MM,Ziegler HK

更新日期：2004-07-01 00:00:00

abstract：:The human polyomavirus JCV lytically infects oligodendrocytes of immunosuppressed individuals leading to the fatal demyelinating disease termed progressive multifocal leukoencephalopathy (PML). Dementia, hemiparesis, and hemianopsia are the predominant presenting signs of PML. Asymptomatic JCV infection is common worl...

journal_title：Journal of leukocyte biology

authors： Jensen PN,Major EO

更新日期：1999-04-01 00:00:00

abstract：:Previous work indicated that macrophages and a lymphoid dendritic cell-like tumor line, P388AD.2, possessed a differential ability to present a haptenated immunoglobulin (tolerogen) in vitro. Macrophages presented fluorescein-conjugated sheep gamma globulin (FL-SGG) and elicited B-cell unresponsiveness. In contrast, P...

journal_title：Journal of leukocyte biology

authors： Phipps RP,Illig K,Schad V,Bhimani K

更新日期：1988-03-01 00:00:00

abstract：:We have shown previously that the cellular proteins 47b and 71/73 could be used to construct phenotypes that distinguish among bone marrow culture-derived (BMCD) macrophages that were either unstimulated or primed by gamma interferon or fully activated for tumor cell killing by gamma interferon in combination with lip...

journal_title：Journal of leukocyte biology

authors： MacKay RJ,Russell SW

更新日期：1987-09-01 00:00:00

abstract：:Exposure of humans to beryllium dusts can induce a specific form of chronic pneumonitis that consists mainly of noncaseating granulomas in the lungs. Multiple studies have documented both genetic and immune components of chronic berylliosis. Much work has focused on T cells and their reactivity in berylliosis, but les...

journal_title：Journal of leukocyte biology

authors： Misra UK,Gawdi G,Pizzo SV,Lewis JG

更新日期：1999-06-01 00:00:00

abstract：:The magnitude and efficacy of CD8(+) T cell memory may notably regress, especially if immune induction occurs in the absence of adequate CD4(+) help. This report demonstrates that this CD8(+) memory malfunction could be remedied if a source of cognate antigen-recognizing helper cells were provided during recall. The i...

journal_title：Journal of leukocyte biology

authors： Kumaraguru U,Banerjee K,Rouse BT

更新日期：2005-10-01 00:00:00

abstract：:Azurocidin is a multifunctional endotoxin-binding serine protease homolog synthesized during the promyelocytic stage of neutrophil development. To characterize the biosynthesis and processing of azurocidin, cDNA encoding human preproazurocidin was stably transfected to the rat basophilic leukemia cell line RBL-1 and t...

journal_title：Journal of leukocyte biology

authors： Lindmark A,Garwicz D,Rasmussen PB,Flodgaard H,Gullberg U

更新日期：1999-10-01 00:00:00

abstract：:TKs are intracellular signaling molecules essential for cell homeostasis. Inhibition of TKs is used in treatment of malignancies and diabetes mellitus. The present study evaluated the role of Flt3 in antigen-induced arthritis. Mice were immunized with mBSA, and arthritis was induced by an i.a. injection of mBSA. Treat...

journal_title：Journal of leukocyte biology

authors： Dehlin M,Andersson S,Erlandsson M,Brisslert M,Bokarewa M

更新日期：2011-10-01 00:00:00

abstract：:HIV infection results in depletion and dysfunction of naïve CD4(+) T cells. The mechanisms underlying these deficiencies are not understood. We investigated the frequencies of CD4(+) naïve subsets in HIV disease as defined by expression of CD25 and/or FoxP3 and the relationship of these frequencies to naïve T cell pro...

journal_title：Journal of leukocyte biology

authors： Rodriguez B,Bazdar DA,Funderburg N,Asaad R,Luciano AA,Yadavalli G,Kalayjian RC,Lederman MM,Sieg SF

更新日期：2011-09-01 00:00:00

abstract：:Macrophages and dendritic cells are in the front line of host defense. When they sense host invasion, they produce cytokines that alert other innate immune cells and also abet the development of an adaptive immune response. Although lipolysaccharide (LPS), peptidoglycan, unmethylated DNA, and other microbial products ...

journal_title：Journal of leukocyte biology

authors： Beutler B,Hoebe K,Du X,Ulevitch RJ

更新日期：2003-10-01 00:00:00

abstract：:Neutrophils are the first cells arriving at sites of tissue injury or infection to combat invading pathogens. Successful neutrophil recruitment to sites of inflammation highly depends on specific molecular mechanisms, fine-tuning the received information into signaling pathways and converting them into well-described ...

journal_title：Journal of leukocyte biology

authors： Begandt D,Thome S,Sperandio M,Walzog B

更新日期：2017-09-01 00:00:00

abstract：:Recruitment of leukocytes from bloodstream to extrahematic sites is tightly regulated by a variety of adhesion molecules that are expressed on the leukocytes and the vessel walls. In this manuscript, we describe the interactions between natural killer (NK) cells and activated, autologous platelets under physiologic fl...

journal_title：Journal of leukocyte biology

authors： Sheikh S,Parhar RS,Bakheet R,Saleh S,Collison K,Al-Mohanna F

更新日期：2004-09-01 00:00:00

abstract：:The synthesis and secretion of prostaglandins and leukotrienes by mouse peritoneal macrophages is under several regulatory controls. Arachidonic acid must first be released from phospholipid stores by the action of phospholipases. Macrophages have the capacity to deacylate arachidonic acid directly from the SN2 positi...

journal_title：Journal of leukocyte biology

authors： Bonney RJ,Humes JL

更新日期：1984-01-01 00:00:00

abstract：:In an analysis of nitric oxide (.NO) production and toxicity, chicken macrophage-generated .NO inhibited mitochondrial activity in both .NO-producing macrophages themselves and lymphoid tumor targets. However, differences in targeting of mitochondrial toxicity were observed among these cells. Two chicken macrophage ce...

journal_title：Journal of leukocyte biology

authors： Sung YJ,Dietert RR

更新日期：1994-07-01 00:00:00

abstract：:Glucocorticoids (GC) are potent anti-inflammatory and immunosuppressive agents that act on a variety of immune cells, including T cells, monocytes/macrophages, osteoclasts, and dendritic cells (DC). However, the mechanism(s) by which GC exert anti-inflammatory effects is still largely unknown. It is already well known...

journal_title：Journal of leukocyte biology

authors： Kim KD,Choe YK,Choe IS,Lim JS

更新日期：2001-03-01 00:00:00

abstract：:The transcription factor nuclear factor (NF)-kappaB controls the expression of genes involved in inflammation, cell proliferation, apoptosis, and differentiation. Impaired regulation of NF-kappaB has been associated with many diseases; thus, there is significant interest in therapeutic approaches based on modulation o...

journal_title：Journal of leukocyte biology

authors： Diatchenko L,Romanov S,Malinina I,Clarke J,Tchivilev I,Li X,Makarov SS

更新日期：2005-12-01 00:00:00

abstract：:Recently identified, angiopoietin-1 (Ang1) and -2 (Ang2) bind to the tyrosine kinase receptor Tie2 and contribute to orchestrate blood vessel formation during angiogenesis. Ang1 mediates vessel maturation and integrity by favoring the recruitment of pericytes and smooth muscle cells. Ang2, initially identified as a Ti...

journal_title：Journal of leukocyte biology

authors： Maliba R,Brkovic A,Neagoe PE,Villeneuve LR,Sirois MG

更新日期：2008-02-01 00:00:00

abstract：:Macrophage activation by IFN-gamma results in a cascade of gene expression. To identify genes activated in mouse peritoneal macrophages by IFN-gamma, we created a cDNA subtraction library of IFN-gamma-induced genes. We have isolated from this subtraction library a novel cDNA clone, called Mg21, whose mRNA is absent in...

journal_title：Journal of leukocyte biology

authors： Lafuse WP,Brown D,Castle L,Zwilling BS

更新日期：1995-03-01 00:00:00

abstract：:Blood leukocyte count alterations induced by PAF-acether in anesthetized and nonanesthetized rats were investigated. Intravenous injection of increasing amounts of PAF-acether (1.5-8 micrograms/kg) in nonanesthetized animals induced dose-dependent hemoconcentration and leukocytosis. The former was apparent within 10 m...

journal_title：Journal of leukocyte biology

authors： Bozza PT,Silva PM,Castro-Faria-Neto HC,Martins MA,Cordeiro RS

更新日期：1992-02-01 00:00:00

abstract：:TNF is a pleiotropic cytokine involved in a variety of inflammatory processes and immune responses. TNF effects are mediated via two distinct membrane receptors: TNFR1 and TNFR2. Investigations concerning regulation and function of TNFR2 revealed a novel TNFR2 isoform in human and mouse cells, termed icp75TNFR, with m...

journal_title：Journal of leukocyte biology

authors： Bäumel M,Lechner A,Hehlgans T,Männel DN

更新日期：2008-07-01 00:00:00

abstract：:Although tumor growth enhances macrophage (m phi) cytotoxic activity by increasing their tumor necrosis factor-alpha (TNF-alpha) production, increased prostaglandin E2 (PGE2) synthesis reduces most immune responses during tumor growth. Macrophages that do not express major histocompatibility complex class II molecules...

journal_title：Journal of leukocyte biology

authors： Alleva DG,Burger CJ,Elgert KD

更新日期：1993-05-01 00:00:00

abstract：:We investigated the pathogenesis of lung injury in sepsis (septic adult respiratory distress syndrome) by focusing on the functional changes of alveolar macrophages (AMs). Sepsis was induced in male WK rats by cecal ligation and puncture. Histological examination of the lungs from this experimental model revealed edem...

journal_title：Journal of leukocyte biology

authors： Goya T,Abe M,Shimura H,Torisu M

更新日期：1992-08-01 00:00:00

abstract：:IL-32 is a proinflammatory cytokine associated with infections, autoimmune diseases, and allergic asthma. In the present study, we elucidated the synergistic effect of IL-32γ and NOD ligand on the activation of human eosinophils, principal effector cells for allergic inflammation, and the underlying mechanisms. Specif...

journal_title：Journal of leukocyte biology

authors： Wong CK,Dong J,Lam CW

更新日期：2014-04-01 00:00:00

abstract：:Lymphocyte development is initiated from hematopoietic stem cells and can be divided into multiple phenotypically distinct stages. Transcription factors play important roles in programming the developmental process of lymphocytes. Recent studies have identified key roles of several orphan nuclear receptors in T lympho...

journal_title：Journal of leukocyte biology

authors： He YW

更新日期：2002-09-01 00:00:00