Inhibition of glucocorticoid-mediated, caspase-independent dendritic cell death by CD40 activation.

abstract：:Interactions between chemokines and their specific receptors are important for leukocyte trafficking. The CC-chemokine monocyte chemoattractant protein-1 (MCP-1) and its specific receptor CCR2 are essential in monocytic infiltration and have been associated with several inflammatory diseases. It has been reported that...

journal_title：Journal of leukocyte biology

authors： Zhou Y,Yang Y,Warr G,Bravo R

更新日期：1999-02-01 00:00:00

abstract：:Microbicidal activity of neutrophils is usually measured by colony-counting techniques after cell lysis in distilled water. While studying the effect of the reduced nicotinamide adenine dinucleotide phosphate-oxidase inhibitor diphenyleneiodonium (DPI) on the staphylocidal activity of neutrophils, we obtained inconsis...

journal_title：Journal of leukocyte biology

authors： Decleva E,Menegazzi R,Busetto S,Patriarca P,Dri P

更新日期：2006-01-01 00:00:00

abstract：:Seventy-kilodalton amino-terminal and 180-kDa cell-binding fibronectin fragments were used to determine which fibronectin domains support soluble gelatin interactions with macrophages. At each time measured, intact and 180-kDa fibronectin supported significantly larger quantities of cell-associated gelatin than contro...

journal_title：Journal of leukocyte biology

authors： Penc SF,Blumenstock FA,Kaplan JE

更新日期：1995-11-01 00:00:00

abstract：:Carcinoembryonic antigen (CEA), a member of the immunoglobulin supergene family, is recognized by a specific 80-kd receptor on Kupffer cells and alveolar macrophages. Peritoneal macrophages were harvested from male Sprague-Dawley rats 72 h after intraperitoneal injection with thioglycolate broth and from unstimulated ...

journal_title：Journal of leukocyte biology

authors： Toth CA

更新日期：1992-05-01 00:00:00

abstract：:Thimerosal is an organic mercury compound that is used as a preservative in vaccines and pharmaceutical products. Recent studies have shown a TH2-skewing effect of mercury, although the underlying mechanisms have not been identified. In this study, we investigated whether thimerosal can exercise a TH2-promoting effect...

journal_title：Journal of leukocyte biology

authors： Agrawal A,Kaushal P,Agrawal S,Gollapudi S,Gupta S

更新日期：2007-02-01 00:00:00

abstract：:Postnatal stem cells regulate the homeostasis of the majority of our tissues. They continuously generate new progenitors and mature, functional cells to replace old cells, which cannot assume the tissue function anymore and are eliminated. Blood, skin, gut mucosa, muscle, cartilage, nerves, cornea, retina, liver, and ...

journal_title：Journal of leukocyte biology

authors： Kindler V

更新日期：2005-10-01 00:00:00

abstract：:Asthma is a chronic inflammatory disease of the airways that afflicts over 30 million individuals in the United States and over 300 million individuals worldwide. The inflammatory response in the airways is often characterized by the analysis of sputum, which contains multiple types of cells including neutrophils, mac...

journal_title：Journal of leukocyte biology

authors： Stewart E,Wang X,Chupp GL,Montgomery RR

更新日期：2020-11-01 00:00:00

abstract：:Multiple mechanisms are used by the human immunodeficiency virus type 1 (HIV-1) to interfere with host-cell immune effector functions. The 27-kD Nef protein has been shown to down-modulate specific genes of the major histocompatibility complex class I (MHC-I) on the surface of infected primary T cells, facilitating th...

journal_title：Journal of leukocyte biology

authors： Brown A,Gartner S,Kawano T,Benoit N,Cheng-Mayer C

更新日期：2005-09-01 00:00:00

abstract：:p67(phox) is the paramount cytosolic regulator of the superoxide-generating Nox of phagocytes, by controlling the conformation of the catalytic component, Nox2. The initiating event of this process is a protein-protein interaction between p67(phox) and the part of Nox2 protruding into the cytosol, known as the dehydro...

journal_title：Journal of leukocyte biology

authors： Dahan I,Smith SM,Pick E

更新日期：2015-11-01 00:00:00

abstract：:The mannose receptor is a macrophage surface receptor that mediates both endocytosis and phagocytosis. Previous work has demonstrated that the prototypical Th 2 cytokine, interleukin-4 (IL-4), increases both cell-surface receptor expression and mannose receptor-mediated endocytosis, whereas the prototypical Th 1 cytok...

journal_title：Journal of leukocyte biology

authors： Raveh D,Kruskal BA,Farland J,Ezekowitz RAB

更新日期：1998-07-01 00:00:00

abstract：:The aim of the study was to elucidate the effect of lipopolysaccharide (LPS) administration in vivo (Escherichia coli endotoxin, 1 mg/kg body weight) on the expression and cellular activity of glucose-6-phosphate dehydrogenase (G6PDH, EC 1.1.1.49), the rate-limiting enzyme of the hexose monophosphate shunt in hepatic ...

journal_title：Journal of leukocyte biology

authors： Spolarics Z,Navarro L

更新日期：1994-10-01 00:00:00

abstract：:Human peripheral blood monocytes were incubated with free or liposome-encapsulated human lymphokines containing macrophage-activating factor (MAF) and tested for their effect on herpes simplex virus (HSV)-infected target cells. Activated monocytes lysed allogeneic HSV type 2 (HSV-2)-infected whole human embryo cells a...

journal_title：Journal of leukocyte biology

authors： Koff WC,Showalter SD,Chakrabarty MK,Hampar B,Ceccorulli LM,Kleinerman ES

更新日期：1985-04-01 00:00:00

abstract：:The germinal center (GC) is a dynamic structure formed by proliferating B cells in the follicles of secondary lymphoid organs during T cell-dependent antibody responses to exogenous antigens. GC is composed by a dark zone, enriched in proliferating centroblasts (CBs), and a light zone where CBs migrate and transform i...

journal_title：Journal of leukocyte biology

authors： Ferretti E,Ponzoni M,Doglioni C,Pistoia V

更新日期：2016-11-01 00:00:00

abstract：:We identified fresh human leukocytes as an abundant source of the candidate epithelial tumor suppressor gene, Ecrg4, an epigenetically regulated gene, which unlike other tumor suppressor genes, encodes an orphan-secreted, ligand-like protein. In human cell lines, Ecrg4 gene expression was low, Ecrg4 protein undetectab...

journal_title：Journal of leukocyte biology

authors： Baird A,Coimbra R,Dang X,Lopez N,Lee J,Krzyzaniak M,Winfield R,Potenza B,Eliceiri BP

更新日期：2012-05-01 00:00:00

abstract：:Protein synthetic patterns of murine peritoneal macrophages were analyzed by two-dimensional polyacrylamide gel electrophoresis (2D PAGE) of 35S methionine-labeled proteins. While the protein synthetic patterns exhibited by resident, inflammatory, and activated macrophages had numerous common features that distinguish...

journal_title：Journal of leukocyte biology

authors： Tannenbaum CS,Nurmi-McKernan L,Largen MT

更新日期：1987-06-01 00:00:00

abstract：:Cytokines and chemokines play an essential role in recruiting leukocytes from the circulation to the peripheral sites of inflammation by modulating cellular interactions with endothelial cell ligands and extracellular matrix (ECM). Herein, we examined regulation of T cell adhesion to ECM ligands by two major proinflam...

journal_title：Journal of leukocyte biology

authors： Ariel A,Novick D,Rubinstein M,Dinarello CA,Lider O,Hershkoviz R

更新日期：2002-07-01 00:00:00

abstract：:We have investigated the role of the purinergic P2X7 receptor in the formation of multinucleated giant cells in human monocyte/macrophage cultures stimulated with either concanavalin A or phytohemagglutinin. Macrophage fusion can be blocked by a P2X7-selective pharmacological antagonist or by a mAb directed against th...

journal_title：Journal of leukocyte biology

authors： Di Virgilio F,Falzoni S,Chiozzi P,Sanz JM,Ferrari D,Buell GN

更新日期：1999-11-01 00:00:00

abstract：:Prostaglandin J2 metabolite 15-deoxy-delta(12,14)-prostaglandin J2 (15-PGJ2) appears to possess anti-inflammatory properties. Unlike other prostaglandins, it has no known plasma membrane receptor. Its effects have been thought to occur through activation of the nuclear peroxisome proliferator-activated receptor gamma ...

journal_title：Journal of leukocyte biology

authors： Guyton K,Bond R,Reilly C,Gilkeson G,Halushka P,Cook J

更新日期：2001-04-01 00:00:00

abstract：:GenBank entries for mouse Il33 reveal the existence of two transcripts, Il33a and Il33b, with different 5'UTRs but coding for the same protein. We investigated expression of these transcripts in different mouse organs and cell types in basal and inflammatory conditions. Il33a and Il33b mRNAs start with different nonco...

journal_title：Journal of leukocyte biology

authors： Talabot-Ayer D,Calo N,Vigne S,Lamacchia C,Gabay C,Palmer G

更新日期：2012-01-01 00:00:00

abstract：:The switch from fetal to adult hematopoietic stem/progenitor cells (HSPCs) is associated with profound changes in several genetic programs. Although HSPC ageing corresponds to alterations in Wnt signaling, relatively little is known about the relative roles of different Wnt signaling pathways in HSPC ontogeny. We hypo...

journal_title：Journal of leukocyte biology

authors： Kwarteng EO,Hétu-Arbour R,Heinonen KM

更新日期：2018-03-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is a potent natural adjuvant, commonly used to amplify Th1 responses. Here, we report that systemic immunization using LPS generates large numbers of specific Th17 cells in murine small intestinal lamina propria. The priming of these Th17 cells required IL-23p19 production by bone marrow-deriv...

journal_title：Journal of leukocyte biology

authors： McAleer JP,Liu B,Li Z,Ngoi SM,Dai J,Oft M,Vella AT

更新日期：2010-07-01 00:00:00

abstract：:The heterotrimeric guanine nucleotide-binding protein Galphai2 is involved in regulation of immune responses against microbial and nonmicrobial stimuli. Galphai2-/- mice have a selectively impaired IgM response consistent with a disorder in B cell development yet have augmented T cell effector function associated with...

journal_title：Journal of leukocyte biology

authors： Padigel UM,Stein L,Redding K,Lee JJ,Nolan TJ,Schad GA,Birnbaumer L,Abraham D

更新日期：2007-04-01 00:00:00

abstract：:C-reactive protein (CRP) is a prototypical acute-phase reactant, the humoral and plasma concentrations of which rise dramatically after tissue injury or inflammation. The effects of CRP on superoxide production and intracellular calcium mobilization by guinea pig alveolar macrophages challenged with platelet-activatin...

journal_title：Journal of leukocyte biology

authors： Földes-Filep E,Filep JG,Sirois P

更新日期：1992-01-01 00:00:00

abstract：:We tested several of the functions of macrophages (M phi) in the early phase after allogeneic bone marrow transfer to get information about this important aspect of the nonspecific immune system in the T-cell-deficient recipient. On days 3-5 after transfer, the number of M phi was reduced in the spleen, liver, lungs, ...

journal_title：Journal of leukocyte biology

authors： Roesler J,Baccarini M,Vogt B,Lohmann-Matthes ML

更新日期：1989-08-01 00:00:00

abstract：:Natural killer (NK) cells arise from immature progenitors present in fetal tissues and adult bone marrow, but the factors responsible for driving the proliferation and differentiation of these progenitors are poorly understood. Mouse NK cells had previously been thought not to express interleukin (IL)-2Ralpha chains, ...

journal_title：Journal of leukocyte biology

authors： Toomey JA,Gays F,Foster D,Brooks CG

更新日期：2003-08-01 00:00:00

abstract：:The immunosuppressive activity of interleukin-10 (IL-10) makes this cytokine a potentially important clinical tool to reduce inflammatory responses in various diseases. Its efficacy as a therapeutic modality is dependent on the responsiveness of immune cells. We report that macrophages from mice chronically infected w...

journal_title：Journal of leukocyte biology

authors： Avdiushko R,Hongo D,Lake-Bullock H,Kaplan A,Cohen D

更新日期：2001-10-01 00:00:00

abstract：:TNF is a pleiotropic cytokine involved in a variety of inflammatory processes and immune responses. TNF effects are mediated via two distinct membrane receptors: TNFR1 and TNFR2. Investigations concerning regulation and function of TNFR2 revealed a novel TNFR2 isoform in human and mouse cells, termed icp75TNFR, with m...

journal_title：Journal of leukocyte biology

authors： Bäumel M,Lechner A,Hehlgans T,Männel DN

更新日期：2008-07-01 00:00:00

abstract：:IL-33 is a more recently identified member of the IL-1 cytokine family, expressed in the nucleus of epithelial cells and released into the extracellular space following tissue damage. The impact of IL-33 as a regulator of the adaptive immune response has been studied extensively, with an understood role for IL-33 in t...

journal_title：Journal of leukocyte biology

authors： Lott JM,Sumpter TL,Turnquist HR

更新日期：2015-06-01 00:00:00

abstract：:Rats were injected with phenylhydrazine (PHZ) for periods of up to 6 months, during which time a marked leukocytosis was induced. The highest leukocyte counts occurred within 4-5 days following injection. An initial injection of 4 mg/100 gm body weight evoked a mean total leukocyte count of 129 X 10(3) cells/microlite...

journal_title：Journal of leukocyte biology

authors： Dornfest BS,Lapin DM,Naughton BA,Adu S,Korn L,Gordon AS

更新日期：1986-01-01 00:00:00

abstract：:Mycobacterium tuberculosis antigens that are recognized by human CD8+ T cells are potentially important vaccine target molecules. We used a motif-based strategy to screen selected proteins of M. tuberculosis for peptides predicted to bind to human leukocyte antigen (HLA)-A*0201. We identified two 10 amino acid peptide...

journal_title：Journal of leukocyte biology

authors： Shams H,Barnes PF,Weis SE,Klucar P,Wizel B

更新日期：2003-12-01 00:00:00