IL-10 receptor dysfunction in macrophages during chronic inflammation.

Abstract:

:The immunosuppressive activity of interleukin-10 (IL-10) makes this cytokine a potentially important clinical tool to reduce inflammatory responses in various diseases. Its efficacy as a therapeutic modality is dependent on the responsiveness of immune cells. We report that macrophages from mice chronically infected with the LP-BM5 retrovirus had a reduced capacity to respond to IL-10 in vitro. The ability of IL-10 to inhibit lipopolysaccharide-induced production of tumor necrosis factor (TNF) alpha and IL-6 was significantly reduced in both alveolar and peritoneal macrophages from infected versus uninfected mice. IL-10 hyporesponsiveness was not related to direct infection by the retrovirus, because bone marrow-derived macrophages infected in vitro with LP-BM5 were as responsive to IL-10 as were uninfected bone marrow-derived macrophages. TNF-alpha appeared to contribute to development of IL-10 hyporesponsiveness, because exposure of normal macrophages to TNF-alpha but not interferon-gamma reduced macrophage responsiveness to IL-10. Reverse transcriptase-PCR and flow cytometry demonstrated normal expression of the alpha and beta chains of the IL-10 receptor in macrophages from infected mice, suggesting that IL-10 hyporesponsiveness is not related to a change in receptor expression. The potential role of reduced IL-10 responsiveness in the chronicity of inflammation in this and other diseases is discussed.

journal_name

J Leukoc Biol

authors

Avdiushko R,Hongo D,Lake-Bullock H,Kaplan A,Cohen D

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

624-32

issue

4

eissn

0741-5400

issn

1938-3673

journal_volume

70

pub_type

杂志文章
  • MIC-1 is a novel TGF-beta superfamily cytokine associated with macrophage activation.

    abstract::As part of a study to identify novel genes associated with macrophage activation, we have cloned a new member of the transforming growth factor beta (TGF-beta) superfamily designated macrophage inhibitory cytokine 1 (MIC-1). MIC-1 is synthesized as a 62-kDa intracellular protein, which, after cleavage by a furin like ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1002/jlb.65.1.2

    authors: Fairlie WD,Moore AG,Bauskin AR,Russell PK,Zhang HP,Breit SN

    更新日期:1999-01-01 00:00:00

  • CD8+ T cells produce a dialyzable antigen-specific activator of dendritic cells.

    abstract::Cellular lysates from PPD+ donors have been reported to transfer tuberculin reactivity to naïve recipients, but not diphtheria reactivity, and vice versa. A historically controversial topic, the terms "transfer factor" and "DLE" were used to characterize the reactivity-transferring properties of lysates. Intrigued by ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.3A0216-082R

    authors: Myles IA,Zhao M,Nardone G,Olano LR,Reckhow JD,Saleem D,Break TJ,Lionakis MS,Myers TG,Gardina PJ,Kirkpatrick CH,Holland SM,Datta SK

    更新日期:2017-01-01 00:00:00

  • Contrasting effects of alpha- and beta-androstenediol on oncogenic myeloid cell lines in vitro.

    abstract::The in vitro effects of 17 alpha AED, the isomer of 5-androstene-3 beta,17 beta diol (17 beta AED) on the basal growth of murine RAW 264.7, P388D1, and human HL-60 cells were investigated. 17 alpha AED treatment of RAW cells for 48 h reduced total cell number without increasing cell death as detected by trypan blue ex...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.62.2.258

    authors: Huynh PN,Loria RM

    更新日期:1997-08-01 00:00:00

  • Synthetic hexapeptides derived from the transmembrane envelope proteins of retroviruses suppress N-formylpeptide-induced monocyte polarization.

    abstract::Retroviral infections are frequently associated with immunosuppression. Retroviral transmembrane envelope proteins (TM proteins) play an important role in this phenomenon. CKS-17, a synthetic heptadecapeptide, represents the immunosuppressive site of these retroviral TM proteins. Here we support on the further delinea...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.51.3.282

    authors: Oostendorp RA,Schaaper WM,Post J,Meloen RH,Scheper RJ

    更新日期:1992-03-01 00:00:00

  • A single assay for measuring the rates of phagocytosis and bacterial killing by neutrophils.

    abstract::We have developed a method that enables the rates of phagocytosis and killing of bacteria by neutrophils to be measured in a single assay. Neutrophils were incubated with bacteria, and at specific intervals were separated from uningested bacteria by low speed centrifugation. Rates of phagocytosis and killing were calc...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.55.2.147

    authors: Hampton MB,Vissers MC,Winterbourn CC

    更新日期:1994-02-01 00:00:00

  • Matrix metalloproteinase-9 promotes neutrophil and T cell recruitment and migration in the postischemic liver.

    abstract::Matrix metalloproteinases-2 and -9 (MMP-2/9) are critically involved in degradation of extracellular matrix, and their inhibition is discussed as a promising strategy against hepatic ischemia-reperfusion (I/R) injury. Here, we analyzed the role of MMP-2 and -9 for leukocyte migration and tissue injury in sham-operated...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0805468

    authors: Khandoga A,Kessler JS,Hanschen M,Khandoga AG,Burggraf D,Reichel C,Hamann GF,Enders G,Krombach F

    更新日期:2006-06-01 00:00:00

  • The axonal repellent, Slit2, inhibits directional migration of circulating neutrophils.

    abstract::In inflammatory diseases, circulating neutrophils are recruited to sites of injury. Attractant signals are provided by many different chemotactic molecules, such that blockade of one may not prevent neutrophil recruitment effectively. The Slit family of secreted proteins and their transmembrane receptor, Robo, repel a...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0609391

    authors: Tole S,Mukovozov IM,Huang YW,Magalhaes MA,Yan M,Crow MR,Liu GY,Sun CX,Durocher Y,Glogauer M,Robinson LA

    更新日期:2009-12-01 00:00:00

  • Regulatory T cell-mediated suppression: potential role of ICER.

    abstract::How regulatory T (TR) cells dampen T cell responses remains unclear. Multiple modes of action have been proposed, including cell contact-dependent and/or cytokine-dependent mechanisms. Suppression may involve direct contact between TR cells and responder T cells. Alternatively, TR cells may act on dendritic cells to r...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1189/jlb.0706474

    authors: Bodor J,Fehervari Z,Diamond B,Sakaguchi S

    更新日期:2007-01-01 00:00:00

  • Potential role for Duffy antigen chemokine-binding protein in angiogenesis and maintenance of homeostasis in response to stress.

    abstract::CXC chemokines, which induce angiogenesis, have glutamine-leucine-arginine amino acid residues (ELR motif) in the amino terminus and bind CXCR2 and the Duffy antigen chemokine-binding protein. Duffy, a seven transmembrane protein that binds CXC and CC chemokines, has not been shown to couple to trimeric G proteins or ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:

    authors: Du J,Luan J,Liu H,Daniel TO,Peiper S,Chen TS,Yu Y,Horton LW,Nanney LB,Strieter RM,Richmond A

    更新日期:2002-01-01 00:00:00

  • Dendritic cells in genetic immunization.

    abstract::Both humoral and cellular immune responses are inducible by inoculation of naked plasmid DNA encoding a polypeptide antigen. This new vaccination protocol, known as genetic immunization, has been used to initiate protective immunity against a variety of infectious pathogens and tumors in experimental animals. Dendriti...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1002/jlb.66.2.350

    authors: Takashima A,Morita A

    更新日期:1999-08-01 00:00:00

  • Endotoxin stimulates the expression of glucose-6-phosphate dehydrogenase in Kupffer and hepatic endothelial cells.

    abstract::The aim of the study was to elucidate the effect of lipopolysaccharide (LPS) administration in vivo (Escherichia coli endotoxin, 1 mg/kg body weight) on the expression and cellular activity of glucose-6-phosphate dehydrogenase (G6PDH, EC 1.1.1.49), the rate-limiting enzyme of the hexose monophosphate shunt in hepatic ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.56.4.453

    authors: Spolarics Z,Navarro L

    更新日期:1994-10-01 00:00:00

  • LPS resistance in monocytic cells caused by reverse signaling through transmembrane TNF (mTNF) is mediated by the MAPK/ERK pathway.

    abstract::The transmembrane form of tumor necrosis factor (mTNF), expressed on activated monocytes (MO) and macrophages (MPhi), is able to induce apoptosis in human endothelial cells (EC). Apoptosis is mediated by two distinct mechanisms: direct cell contact and a yet-unidentified soluble protein, death factor X. In addition, m...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0703343

    authors: Kirchner S,Boldt S,Kolch W,Haffner S,Kazak S,Janosch P,Holler E,Andreesen R,Eissner G

    更新日期:2004-02-01 00:00:00

  • Synthesis of 5-oxo-6,8,11,14-eicosatetraenoic acid by human monocytes and lymphocytes.

    abstract::We recently demonstrated that the arachidonate metabolite 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) is converted by a highly specific dehydrogenase in human neutrophils to 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE), which is a potent stimulator of these cells. The objective of this study was to dete...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.59.6.847

    authors: Zhang Y,Styhler A,Powell WS

    更新日期:1996-06-01 00:00:00

  • IL-20 receptor cytokines in autoimmune diseases.

    abstract::IL-19, IL-20, and IL-24 are the members of IL-10 family. They are also known as IL-20 receptor (IL-20R) cytokines as they all signal through the IL-20RA/IL-20RB receptor complex; IL-20 and IL-24 (but not IL-19) also signal through the IL-20RB/IL22RA1 receptor complex. Despite their protein structure homology and share...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1002/JLB.MR1117-471R

    authors: Chen J,Caspi RR,Chong WP

    更新日期:2018-11-01 00:00:00

  • Protein kinase C agonists enhance phagocytosis of P. aeruginosa by murine alveolar macrophages.

    abstract::Pulmonary alveolar macrophages (AMphis) are incompetent to phagocytose unopsonized Pseudomonas aeruginosa, but ingestion by other macrophage phenotypes (i.e., peritoneal macrophages) occurs efficiently. The purpose of this study was to explore factors that might control such phenotypic differences. Our laboratory has ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:

    authors: Heale JP,Speert DP

    更新日期:2001-01-01 00:00:00

  • Differential expression of beta 2-integrins and cytokine production between gammadelta and alphabeta T cells in experimental autoimmune encephalomyelitis.

    abstract::The expression of beta 2-integrins on gammadelta T cells in naïve mice or those with experimental autoimmune encephalomyelitis (EAE) remains poorly characterized. We compared beta 2-integrin expression and cytokine production between gammadelta and alphabeta T cells over the acute course of EAE. We observed that unlik...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0407263

    authors: Smith SS,Barnum SR

    更新日期:2008-01-01 00:00:00

  • Scavenger receptor cysteine-rich domains 9 and 11 of WC1 are receptors for the WC1 counter receptor.

    abstract::Workshop cluster 1 (WC1) is a member of the scavenger receptor cysteine-rich (SRCR) superfamily that includes CD5, CD6, CD163, and M160. Bovine WC1 consists of 11 SRCR domains, a unique domain 1, and two homologous 5 SRCR domain cassettes, WC1 domains 2-6 and 7-11. The porcine orthologue of WC1 contains five SRCR doma...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:

    authors: Ahn JS,Konno A,Gebe JA,Aruffo A,Hamilton MJ,Park YH,Davis WC

    更新日期:2002-08-01 00:00:00

  • CSF-1, IGF-1, and the control of postnatal growth and development.

    abstract::Growth hormone controls somatic growth in mammals by regulating the production of IGF-1, which is predominantly made by the liver. The development of cells within the MPS is controlled by the lineage-specific growth factor M-CSF (CSF-1). In this review, we summarize the role of CSF-1-dependent macrophages in somatic g...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1189/jlb.0310158

    authors: Gow DJ,Sester DP,Hume DA

    更新日期:2010-09-01 00:00:00

  • Frequencies of FoxP3+ naive T cells are related to both viral load and naive T cell proliferation responses in HIV disease.

    abstract::HIV infection results in depletion and dysfunction of naïve CD4(+) T cells. The mechanisms underlying these deficiencies are not understood. We investigated the frequencies of CD4(+) naïve subsets in HIV disease as defined by expression of CD25 and/or FoxP3 and the relationship of these frequencies to naïve T cell pro...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.1210661

    authors: Rodriguez B,Bazdar DA,Funderburg N,Asaad R,Luciano AA,Yadavalli G,Kalayjian RC,Lederman MM,Sieg SF

    更新日期:2011-09-01 00:00:00

  • Frontline Science: Corticotropin-releasing factor receptor subtype 1 is a critical modulator of mast cell degranulation and stress-induced pathophysiology.

    abstract::Life stress is a major risk factor in the onset and exacerbation of mast cell-associated diseases, including allergy/anaphylaxis, asthma, and irritable bowel syndrome. Although it is known that mast cells are highly activated upon stressful events, the mechanisms by which stress modulates mast cell function and diseas...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.2HI0317-088RR

    authors: Ayyadurai S,Gibson AJ,D'Costa S,Overman EL,Sommerville LJ,Poopal AC,Mackey E,Li Y,Moeser AJ

    更新日期:2017-12-01 00:00:00

  • Cognate MHC-TCR interaction leads to apoptosis of antigen-presenting cells.

    abstract::Antigen presentation to T lymphocytes has been characterized extensively in terms of T lymphocyte activation and eventual cell death. In contrast, little is known about the consequences of antigen presentation for the antigen-presenting cell (APC). We have determined the outcome of major histocompatibility complex cla...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0703356

    authors: Setterblad N,Blancheteau V,Delaguillaumie A,Michel F,Bécart S,Lombardi G,Acuto O,Charron D,Mooney N

    更新日期:2004-06-01 00:00:00

  • Transferrin receptor in T cell activation and transplantation.

    abstract::Transferrin receptor (TfR) expression is up-regulated during T cell activation after the interaction of the T cell receptor with the antigen-major histocompatibility complex and the expression of interleukin-2 (IL-2) receptor. We hypothesize that anti-TfR monoclonal antibody (mAb) will prolong allograft survival by al...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.64.1.19

    authors: Bayer AL,Baliga P,Woodward JE

    更新日期:1998-07-01 00:00:00

  • Glucan: mechanisms involved in its "radioprotective" effect.

    abstract::It has generally been accepted that most biologically derived agents that are radioprotective in the hemopoietic-syndrome dose range (eg, endotoxin, Bacillus Calmette Guerin, Corynebacterium parvum, etc) exert their beneficial properties by enhancing hemopoietic recovery and hence, by regenerating the host's ability t...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.42.2.95

    authors: Patchen ML,D'Alesandro MM,Brook I,Blakely WF,MacVittie TJ

    更新日期:1987-08-01 00:00:00

  • Regulation of CD 163 on human macrophages: cross-linking of CD163 induces signaling and activation.

    abstract::CD163 is a member of the group B scavenger receptor cysteine-rich (SRCR) superfamily. This study describes aspects of the tissue distribution, the regulation of expression, and signal transduction after cross-linking of this receptor at the cell surface of macrophages. CD163 showed an exclusive expression on resident ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.66.5.858

    authors: Van den Heuvel MM,Tensen CP,van As JH,Van den Berg TK,Fluitsma DM,Dijkstra CD,Döpp EA,Droste A,Van Gaalen FA,Sorg C,Högger P,Beelen RH

    更新日期:1999-11-01 00:00:00

  • poly(I:C) and LPS induce distinct IRF3 and NF-kappaB signaling during type-I IFN and TNF responses in human macrophages.

    abstract::Macrophages play major roles in the onset of immune responses and inflammation by inducing a variety of cytokines such as TNF and IFN-beta. The pathogen-associated molecular pattern, polyinosinic-polycytidylic acid [poly(I:C)], and LPS were used to study type-I IFN and TNF responses in human macrophages. Additionally,...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0607412

    authors: Reimer T,Brcic M,Schweizer M,Jungi TW

    更新日期:2008-05-01 00:00:00

  • CD4 T cell development and cytokine polarization: an overview.

    abstract::We have studied two key stages of CD4 development that serve as important checkpoints in determining whether a response will occur, how big it will be, and how long it will last. The response of naive CD4 cells is strictly regulated by the requirement for interaction of the potential precursor with an antigen-presenti...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1002/jlb.57.5.795

    authors: Swain SL

    更新日期:1995-05-01 00:00:00

  • Frontline Science: Characterization and regulation of osteoclast precursors following chronic Porphyromonas gingivalis infection.

    abstract::Bone destruction in inflammatory osteolytic diseases including periodontitis is related to excessive activity of osteoclasts (OC), which originate from precursor cells of the myeloid lineage, termed osteoclast precursors (OCP). In contrast to ample knowledge that we currently have on mature OC, little is known about O...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/JLB.1HI0620-230R

    authors: Zhao Y,Li Z,Su L,Ballesteros-Tato A,Katz J,Michalek SM,Feng X,Zhang P

    更新日期:2020-10-01 00:00:00

  • Macrophage function in murine allogeneic bone marrow radiation chimeras in the early phase after transplantation.

    abstract::We tested several of the functions of macrophages (M phi) in the early phase after allogeneic bone marrow transfer to get information about this important aspect of the nonspecific immune system in the T-cell-deficient recipient. On days 3-5 after transfer, the number of M phi was reduced in the spleen, liver, lungs, ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.46.2.134

    authors: Roesler J,Baccarini M,Vogt B,Lohmann-Matthes ML

    更新日期:1989-08-01 00:00:00

  • Overexpression of progelatinase B/proMMP-9 affects migration regulatory pathways and impairs chronic lymphocytic leukemia cell homing to bone marrow and spleen.

    abstract::This study addresses the role of (pro)MMP-9 overexpression in CLL cell migration. We have used primary CLL cells and CLL-derived MEC-1 cells transfected with empty (mock cells) or proMMP-9-encoding (MMP-9 cells) lentiviral vectors. The constitutive (pro)MMP-9 expression in mock cells and primary CLL cells was similar,...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0913521

    authors: Bailón E,Ugarte-Berzal E,Amigo-Jiménez I,Van den Steen P,Opdenakker G,García-Marco JA,García-Pardo A

    更新日期:2014-03-11 00:00:00

  • In vitro model for hematopoietic progenitor cell homing reveals endothelial heparan sulfate proteoglycans as direct adhesive ligands.

    abstract::Proteoglycans (PGs) play a dominant role within the bone marrow (BM), but their role in homing of transplanted hematopoietic progenitor cells (HPC) is unknown. In this study, the role of heparan sulfate (HS) PGs on BM endothelium as adhesive structures was investigated. HPC (primary CD34+ cells and cell line KG-1a) we...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.1202593

    authors: Netelenbos T,van den Born J,Kessler FL,Zweegman S,Huijgens PC,Drager AM

    更新日期:2003-12-01 00:00:00