A role for a 70-kDa amino-terminal fibronectin fragment in supporting soluble gelatin interactions with rat peritoneal macrophages.

abstract：:Endotoxin tolerance is characterized by diminished expression of inflammatory cytokines after sequential exposure to Toll-like receptor stimuli. Many mechanisms contribute to tolerance; however, chromatin remodeling appears to be the most significant regulator. The type II interferon, IFN-γ, has been recognized as bei...

journal_title：Journal of leukocyte biology

authors： Shi L,Song L,Maurer K,Sharp J,Zhang Z,Sullivan KE

更新日期：2015-10-01 00:00:00

abstract：:We have shown previously that the cellular proteins 47b and 71/73 could be used to construct phenotypes that distinguish among bone marrow culture-derived (BMCD) macrophages that were either unstimulated or primed by gamma interferon or fully activated for tumor cell killing by gamma interferon in combination with lip...

journal_title：Journal of leukocyte biology

authors： MacKay RJ,Russell SW

更新日期：1987-09-01 00:00:00

abstract：:Although HDPs were originally hypothesized to act as antimicrobial agents, they also have been shown to broadly modulate the immune response through the activation of different cell types. We recently developed a series of novel, synthetic peptides, termed IDRs, which are conceptually based on a natural HDP, bovine ba...

journal_title：Journal of leukocyte biology

authors： Niyonsaba F,Madera L,Afacan N,Okumura K,Ogawa H,Hancock RE

更新日期：2013-07-01 00:00:00

abstract：:Effector T cell development is directly driven by APCs, in particular, by antigen-primed dendritic cells (DCs). Depending on the pathogenic stimulus and the microenvironment, DCs induce proliferation and polarization of naive CD4+ T cells into different effector subsets, such as Th1, Th2, Th17, or regulatory T cells (...

journal_title：Journal of leukocyte biology

authors： Breedveld A,Groot Kormelink T,van Egmond M,de Jong EC

更新日期：2017-10-01 00:00:00

abstract：:CXCL8 is the principal human neutrophil-attracting chemokine and a major mediator of inflammation. The chemokine exerts its neutrophil-chemotactic and neutrophil-activating activities via interaction with glycosaminoglycans (GAGs) and activation of the G protein-coupled receptors (GPCRs) CXCR1 and CXCR2. Natural CXCL8...

journal_title：Journal of leukocyte biology

authors： Metzemaekers M,Vandendriessche S,Berghmans N,Gouwy M,Proost P

更新日期：2020-06-01 00:00:00

abstract：:To understand the modulation and the behavior of glycocalyx elements during adhesion, we explored one of its components, the CD43 molecule, on human monocytic THP-1 cells exposed to cytokine stimulation and its redistribution during heterotypic adhesion to opsonized erythrocytes. First we demonstrated by immunofluores...

journal_title：Journal of leukocyte biology

authors： Soler M,Merant C,Servant C,Fraterno M,Allasia C,Lissitzky JC,Bongrand P,Foa C

更新日期：1997-05-01 00:00:00

abstract：:The ability of neutrophils to sense and migrate toward damaged tissue is a vital component of the innate immune response. Paradoxically, this same migration serves as the hallmark of a number of inflammatory conditions, including ischemic reperfusion injury, atherosclerosis, arthritis, and Crohn's disease. More recent...

journal_title：Journal of leukocyte biology

authors： Maher BM,Dhonnchu TN,Burke JP,Soo A,Wood AE,Watson RW

更新日期：2009-01-01 00:00:00

abstract：:In this study we describe the isolation and characterization of a new chicken (Gallus gallus) chemokine. This molecule belongs to the C or gamma-chemokine family and is related to the mouse and human lymphotactin (Lptn). Mouse and human Lptn are distinguished from alpha and beta chemokines by the absence of two cystei...

journal_title：Journal of leukocyte biology

authors： Rossi D,Sanchez-García J,McCormack WT,Bazan JF,Zlotnik A

更新日期：1999-01-01 00:00:00

abstract：:Antigen-dependent activation of IgE-bound mast cells is critical for immediate hypersensitivity and other allergic disorders. Recent studies have revealed the effects of monomeric IgEs on mast cell survival and activation. Furthermore, IgE molecules exhibit a wide range of heterogeneity in the ability to induce mast c...

journal_title：Journal of leukocyte biology

authors： Kashiwakura J,Xiao W,Kitaura J,Kawakami Y,Maeda-Yamamoto M,Pfeiffer JR,Wilson BS,Blank U,Kawakami T

更新日期：2008-08-01 00:00:00

abstract：:TLR agonists such as LPS and poly(I:C) induce expression of type I IFNs, such as IFN-α and -β, by macrophages. To examine the role of IFN-β in the induction of ISGs by LPS, we compared the ability of LPS to induce ISGF3 activity and ISG expression in bone marrow-derived macrophages from WT and Ifnb1(-/-) mice. We foun...

journal_title：Journal of leukocyte biology

authors： Sheikh F,Dickensheets H,Gamero AM,Vogel SN,Donnelly RP

更新日期：2014-10-01 00:00:00

abstract：:GenBank entries for mouse Il33 reveal the existence of two transcripts, Il33a and Il33b, with different 5'UTRs but coding for the same protein. We investigated expression of these transcripts in different mouse organs and cell types in basal and inflammatory conditions. Il33a and Il33b mRNAs start with different nonco...

journal_title：Journal of leukocyte biology

authors： Talabot-Ayer D,Calo N,Vigne S,Lamacchia C,Gabay C,Palmer G

更新日期：2012-01-01 00:00:00

abstract：:Rats were injected with phenylhydrazine (PHZ) for periods of up to 6 months, during which time a marked leukocytosis was induced. The highest leukocyte counts occurred within 4-5 days following injection. An initial injection of 4 mg/100 gm body weight evoked a mean total leukocyte count of 129 X 10(3) cells/microlite...

journal_title：Journal of leukocyte biology

authors： Dornfest BS,Lapin DM,Naughton BA,Adu S,Korn L,Gordon AS

更新日期：1986-01-01 00:00:00

abstract：:Pulmonary sequestration and activation of polymorphonuclear leukocytes (PMNLs) are characteristic of many forms of acute lung injury. The present experiments were designed to study the effects of mepacrine on human neutrophils challenged with N-formylmethionyl-leucyl-phenylalanine (fMLP). Mepacrine inhibited fMLP-indu...

journal_title：Journal of leukocyte biology

authors： Földes-Filep E,Filep JG

更新日期：1992-11-01 00:00:00

abstract：:During the development of immune responses to pathogens, self-antigens, or environmental allergens, naive CD4(+) T cells differentiate into subsets of effector cells including Th1, Th2, and Th17 cells. The differentiation into these subsets is controlled by specific transcription factors. The activity of these effecto...

journal_title：Journal of leukocyte biology

authors： Chapoval S,Dasgupta P,Dorsey NJ,Keegan AD

更新日期：2010-06-01 00:00:00

abstract：:Dichloromethylene diphosphonate (MDPCl2) encapsulated in multilamellar liposomes was selectively incorporated by macrophages, immediately transferred to lysosomes, then released from liposomes into lysosomes by enzymatic digestion of the liposomal lipid layers. From 4 h after ingesting liposome-encapsulated MDPCL2 mur...

journal_title：Journal of leukocyte biology

authors： Naito M,Nagai H,Kawano S,Umezu H,Zhu H,Moriyama H,Yamamoto T,Takatsuka H,Takei Y

更新日期：1996-09-01 00:00:00

abstract：:Stromal cell-derived factor 1alpha (SDF-1alpha) is the exclusive ligand for the chemokine receptor CXCR4. This receptor plays a pivotal role in immune responses, the pathogenesis of infection such as HIV, and cellular trafficking. However, the signaling mechanisms regulating SDF-driven T cell migration are not well de...

journal_title：Journal of leukocyte biology

authors： Shahabi NA,McAllen K,Sharp BM

更新日期：2008-03-01 00:00:00

abstract：:Activation of the microvasculature is a major component of the inflammatory response. During inflammation the vascular endothelium not only becomes more permeable to plasma proteins but also develops adhesion molecules that initiate the local immigration of leukocytes. We describe herein the in vivo changes in the thr...

journal_title：Journal of leukocyte biology

authors： Abe Y,Sugisaki K,Dannenberg AM Jr

更新日期：1996-12-01 00:00:00

abstract：:Fluoroquinolones have immunomodulatory properties and interfere with cytokine production. The aim of this study was to characterize the extent of the superinduced mRNA levels in activated human lymphocytes incubated with ciprofloxacin (5 and 80 micro g/ml) using a cytokine gene expression microarray from R and D Syste...

journal_title：Journal of leukocyte biology

authors： Eriksson E,Forsgren A,Riesbeck K

更新日期：2003-09-01 00:00:00

abstract：:To assess the effect of hypoxemia on the responses of polymorphonuclear neutrophils (PMN) during an inflammatory response, rats were maintained in a low F1O2 atmosphere (9% O2) or room air for 12 h before intrathoracic injection of carrageenin or intradermal injections of agonists. After 4 h, hypoxemic rats had 50% mo...

journal_title：Journal of leukocyte biology

authors： Tremblay PB,Macari DM,Martel D,du Souich P,Barja-Fidalgo C,Marleau S

更新日期：2000-06-01 00:00:00

abstract：:PI3Ks have been identified as key signaling proteins involved in many basic biologic processes in health and disease. Transgenic animals have been essential tools to study the underlying molecular mechanisms in this context and therefore, have been widely used to elucidate the role of these factors in many different s...

journal_title：Journal of leukocyte biology

authors： Schneider C,Nobs SP,Heer AK,Hirsch E,Penninger J,Siggs OM,Kopf M

更新日期：2017-02-01 00:00:00

abstract：:Type I IFNs play an important role in innate and adaptive immunity against viral infections. A novel type I IFN, namely IFN-ε, which can protect against vaginal transmission of HSV2 and Chlamydia muridarum bacterial infection, has been described in mice and humans. Nevertheless, the principle cell type and the express...

journal_title：Journal of leukocyte biology

authors： Demers A,Kang G,Ma F,Lu W,Yuan Z,Li Y,Lewis M,Kraiselburd EN,Montaner L,Li Q

更新日期：2014-12-01 00:00:00

abstract：:Naïve T cells, when activated by specific antigen and cytokines, up-regulate adhesion molecules as well as chemokine receptors on their surface, which allows them to migrate to inflamed tissues. Human studies have shown that CXCR3 is one of the chemokine receptors that is induced during T cell activation. Moreover, CX...

journal_title：Journal of leukocyte biology

authors： Xie JH,Nomura N,Lu M,Chen SL,Koch GE,Weng Y,Rosa R,Di Salvo J,Mudgett J,Peterson LB,Wicker LS,DeMartino JA

更新日期：2003-06-01 00:00:00

abstract：:Brucella abortus is a Gram-negative intracellular bacterial pathogen that causes a zoonosis of worldwide occurrence, leading to undulant fever in humans and abortion in domestic animals. B. abortus is recognized by several pattern-recognition receptors triggering pathways during the host innate immune response. Theref...

journal_title：Journal of leukocyte biology

authors： Gomes MT,Campos PC,Pereira Gde S,Bartholomeu DC,Splitter G,Oliveira SC

更新日期：2016-05-01 00:00:00

abstract：:TLRs are a class of pattern recognition receptors (PRRs) that detect invading microbes by recognizing pathogen-associated molecular patterns (PAMPs). Upon PAMP engagement, TLRs activate a signaling cascade that leads to the production of inflammatory mediators. The localization of TLRs, either on the plasma membrane o...

journal_title：Journal of leukocyte biology

authors： Marongiu L,Gornati L,Artuso I,Zanoni I,Granucci F

更新日期：2019-07-01 00:00:00

abstract：:Soluble mediators and inducible cell-surface and matrix-bound molecules coordinate the cascade of events giving rise to leukocyte emigration. Knowledge of the specific mechanisms underlying the attraction of cells into a local site, however, remains sketchy. In particular, it is unclear how chemoattractants cause rapi...

journal_title：Journal of leukocyte biology

authors： Wiedermann CJ,Reinisch N,Bellmann R,Schratzberger P,Kowald E,Kähler CM

更新日期：1995-10-01 00:00:00

abstract：:The agent(s) and mechanism(s) responsible for suppression of neutrophil chemotaxis in association with major thermal injury have not been identified. We have proposed that the reduced random motility characterizing patients' cells may contribute to their generalized chemotactic dysfunction. Here we report that actin p...

journal_title：Journal of leukocyte biology

authors： Hasslen SR,Ahrenholz DH,Solem LD,Nelson RD

更新日期：1992-11-01 00:00:00

abstract：:We have studied two key stages of CD4 development that serve as important checkpoints in determining whether a response will occur, how big it will be, and how long it will last. The response of naive CD4 cells is strictly regulated by the requirement for interaction of the potential precursor with an antigen-presenti...

journal_title：Journal of leukocyte biology

authors： Swain SL

更新日期：1995-05-01 00:00:00

abstract：:The nucleosome, the basic structure of chromatin and normal product of cell apoptosis, plays a pivotal role both in the induction and the pathogenesis of systemic lupus erythematosus (SLE). Nucleosomes have been found to circulate at high levels in patients with SLE and apoptosis of lymphoid cells is increased during ...

journal_title：Journal of leukocyte biology

authors： Laderach D,Bach JF,Koutouzov S

更新日期：1998-12-01 00:00:00

abstract：:To determine whether monocytes can be generated from CD34+ hematopoietic progenitors in large numbers, cord blood CD34+ cells were first expanded for 3-10 days in X-VIVO 10 medium supplemented with FCS, stem cell factor (SCF), thrombopoietin (TPO), and Flt-3 Ligand (Flt-3L), and then differentiated in IMDM medium supp...

journal_title：Journal of leukocyte biology

authors： Stec M,Weglarczyk K,Baran J,Zuba E,Mytar B,Pryjma J,Zembala M

更新日期：2007-09-01 00:00:00

abstract：:Antagonism of ROS signaling can inhibit cell apoptosis and autophagy, thus favoring the maintenance and expansion of hematopoietic stem cells. Alpha lipoic acid (ALA), a small antioxidant molecule, affects cell apoptosis by lowering the ROS level. In this study, we show that ALA promoted production of human pluripoten...

journal_title：Journal of leukocyte biology

authors： Dong Y,Bai J,Zhang Y,Zhou Y,Pan X,Li X,Zhou Q,Chen Y,Lai M,Mao B,Bian G,Feng J,Xie F,Chen B,Nakahata T,Zhang Y,Ma F

更新日期：2020-12-01 00:00:00