Abstract:
:IL-33 is a more recently identified member of the IL-1 cytokine family, expressed in the nucleus of epithelial cells and released into the extracellular space following tissue damage. The impact of IL-33 as a regulator of the adaptive immune response has been studied extensively, with an understood role for IL-33 in the effector functions of CD4(+) Th2 cells. IL-33, however, is now being shown to initiate the Th2-polarizing function of DCs, and stimulate the secretion of the type 2-associated cytokines, IL-4, IL-5, and IL-13, from tissue-resident innate-immune cells, especially ILCs and MCs. IL-33 also initiates and perpetuates local inflammatory responses through the recruitment and activation of type 2- and inflammatory-associated effectors, such as eosinophils, basophils, and neutrophils. As such, IL-33 drives and amplifies type 2-dependent immunity, as well as type 2-dependent tissue destruction and inflammation. It is also becoming apparent that IL-33 supports the reparative capacity of macrophage and ILCs, but these functions may also contribute to chronic fibrotic diseases. Herein, we review new developments in the understanding of IL-33 as it functions in Th2 cells and type 2 immunity. This includes a discussion of our evolving understanding of how IL-33 directly and indirectly promotes type 2 immune responses through action on innate cells in immunity and the pathogenesis of atopic and fibrotic diseases.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Lott JM,Sumpter TL,Turnquist HRdoi
10.1189/jlb.3RI1214-595Rsubject
Has Abstractpub_date
2015-06-01 00:00:00pages
1037-48issue
6eissn
0741-5400issn
1938-3673pii
jlb.3RI1214-595Rjournal_volume
97pub_type
杂志文章,评审abstract::Autism spectrum disorders (ASD) are part of a broad spectrum of neurodevelopmental disorders known as pervasive developmental disorders, which occur in childhood. They are characterized by impairments in social interaction, verbal and nonverbal communication and the presence of restricted and repetitive stereotyped be...
journal_title:Journal of leukocyte biology
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更新日期:2013-07-01 00:00:00
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doi:10.1189/jlb.0212099
更新日期:2012-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-12-01 00:00:00
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