Abstract:
:Complement component C1q is a member of a family of soluble proteins called defense collagens, which are important in host defense and apoptotic cell clearance. Failure to efficiently clear apoptotic cells in the absence of C1q is associated with autoimmunity. Here, we review the literature describing a central role for C1q in the enhancement of phagocyte function and focus specifically on C1q in apoptotic cell clearance. In addition, we highlight our recent findings demonstrating that C1q elicits a macrophage phenotype that is tailored specifically for clearance of apoptotic cells.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Galvan MD,Greenlee-Wacker MC,Bohlson SSdoi
10.1189/jlb.0212099subject
Has Abstractpub_date
2012-09-01 00:00:00pages
489-97issue
3eissn
0741-5400issn
1938-3673pii
jlb.0212099journal_volume
92pub_type
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