Cellular metabolism of myeloid cells in sepsis.

Abstract:

:In recent years, it has become appreciated that immune cells have different metabolic profiles depending on their activation status. During sepsis, circulating leukocytes go through a hyperinflammatory state, which can be accompanied or followed by defective antimicrobial defenses (also described as immune tolerance or paralysis). In this review, the modulation of different cellular metabolic pathways during sepsis in monocytes and macrophages will be discussed. Glycolysis is studied extensively in sepsis and is up-regulated in hyperinflammatory cells, whereas in immune tolerance, it is often down-regulated. Few data are available on other metabolic pathways in immune cells from patients with sepsis. The pentose phosphate pathway is up-regulated during acute hyperinflammatory responses, whereas fatty acid β-oxidation is increased later during sepsis and is associated with an anti-inflammatory (M2) phenotype of macrophages. Within the amino acid metabolism we will discuss the most studied metabolites. Collectively, these data argue that exploration of the immunometabolic pathways in sepsis is an important area of research, and the targeting of metabolic pathways may represent a promising novel strategy as a therapy of sepsis.

journal_name

J Leukoc Biol

authors

Arts RJ,Gresnigt MS,Joosten LA,Netea MG

doi

10.1189/jlb.4MR0216-066R

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

151-164

issue

1

eissn

0741-5400

issn

1938-3673

pii

jlb.4MR0216-066R

journal_volume

101

pub_type

杂志文章,评审
  • Inflammation programs self-reactive CD8+ T cells to acquire T-box-mediated effector function but does not prevent deletional tolerance.

    abstract::CD8(+) T cells must detect foreign antigens and differentiate into effector cells to eliminate infections. But, when self-antigen is recognized instead, mechanisms of peripheral tolerance prevent acquisition of effector function to avoid autoimmunity. These distinct responses are influenced by inflammatory and regulat...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.1A0913-500RR

    authors: Jackson SR,Yuan J,Berrien-Elliott MM,Chen CL,Meyer JM,Donlin MJ,Teague RM

    更新日期:2014-09-01 00:00:00

  • How we detect microbes and respond to them: the Toll-like receptors and their transducers.

    abstract::Macrophages and dendritic cells are in the front line of host defense. When they sense host invasion, they produce cytokines that alert other innate immune cells and also abet the development of an adaptive immune response. Although lipolysaccharide (LPS), peptidoglycan, unmethylated DNA, and other microbial products ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1189/jlb.0203082

    authors: Beutler B,Hoebe K,Du X,Ulevitch RJ

    更新日期:2003-10-01 00:00:00

  • Protein kinase C agonists enhance phagocytosis of P. aeruginosa by murine alveolar macrophages.

    abstract::Pulmonary alveolar macrophages (AMphis) are incompetent to phagocytose unopsonized Pseudomonas aeruginosa, but ingestion by other macrophage phenotypes (i.e., peritoneal macrophages) occurs efficiently. The purpose of this study was to explore factors that might control such phenotypic differences. Our laboratory has ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:

    authors: Heale JP,Speert DP

    更新日期:2001-01-01 00:00:00

  • Phospholipase D mediates Fc gamma receptor activation of neutrophils and provides specificity between high-valency immune complexes and fMLP signaling pathways.

    abstract::Neutrophils phagocytize high-valency immune complexes (HIC) by an Fc gamma receptor-mediated mechanism, activating an oxidative burst and initiating degranulation. In contrast, neutrophils exhibit chemotaxis to N-formylated peptides [e.g., N-formyl-methionyl-leucyl-phenylalanine (fMLP)] and secrete far fewer oxidants ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.61.4.522

    authors: Gewirtz AT,Simons ER

    更新日期:1997-04-01 00:00:00

  • Human monocytes respond to extracellular cAMP through A2A and A2B adenosine receptors.

    abstract::In this study, we test the hypothesis that cAMP, acting as an extracellular mediator, affects the physiology and function of human myeloid cells. The cAMP is a second messenger recognized as a universal regulator of several cellular functions in different organisms. Many studies have shown that extracellular cAMP exer...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.3A0513-302RR

    authors: Sciaraffia E,Riccomi A,Lindstedt R,Gesa V,Cirelli E,Patrizio M,De Magistris MT,Vendetti S

    更新日期:2014-07-01 00:00:00

  • Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain.

    abstract::Interleukin-15 (IL-15) is a cytokine that possesses interesting, potential therapeutic properties. However, based on several parameters including activation of neutrophils, it is also recognized as a proinflammatory cytokine. The mechanisms by which IL-15 activates human neutrophil functions are not fully understood. ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0605298

    authors: Ratthé C,Girard D

    更新日期:2004-07-01 00:00:00

  • IL-8 induces T cell chemotaxis, suppresses IL-4, and up-regulates IL-8 production by CD4+ T cells.

    abstract::Interleukin-8 (IL-8), a neutrophil-activating cytokine, also activates certain T cell functions such as chemotaxis. We additionally find (n = 6) that recombinant (rIL-8; 1-100 ng/ml), when added to 24 h culture of human CD4+ T cells, suppressed the spontaneous production of IL-4 (50-85%). Steady state production of Il...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.59.3.407

    authors: Gesser B,Lund M,Lohse N,Vestergaad C,Matsushima K,Sindet-Pedersen S,Jensen SL,Thestrup-Pedersen K,Larsen CG

    更新日期:1996-03-01 00:00:00

  • Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni- bacterium acnes.

    abstract::Recognition of Gram-positive bacteria by Toll-like receptor 2 (TLR2) induces activation of proinflammatory pathways. In mice, sensitization with the Gram-positive Propionibacterium acnes followed by a challenge with the TLR4 ligand, lipopolysaccharide (LPS), results in fulminant hepatic failure. Here, we investigated ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0804448

    authors: Romics L Jr,Dolganiuc A,Velayudham A,Kodys K,Mandrekar P,Golenbock D,Kurt-Jones E,Szabo G

    更新日期:2005-12-01 00:00:00

  • Novel interferon-beta-induced gene expression in peripheral blood cells.

    abstract::Type I IFNs are used for treating viral, neoplastic, and inflammatory disorders. The protein products encoded by IFN-stimulated genes (ISGs) likely mediate clinical effects of IFN in patients. Macroarray assays, used for studying ISG induction in IFN-treated patients, comprise genes identified predominantly through an...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0507273

    authors: Rani MR,Shrock J,Appachi S,Rudick RA,Williams BR,Ransohoff RM

    更新日期:2007-11-01 00:00:00

  • The inflammatory potential of IL-2: local induction of a specific chronic granulomatous lesion in mice.

    abstract::Subcutaneous injection of recombinant human interleukin-2 (rhuIL-2) at 10(2)-10(4) U/mouse induced delayed (48 h) accumulation of mononuclear leukocytes with diffuse granulocytes, including eosinophils. Subcutaneous local infusion of rhuIL-2 or recombinant murine IL-2 (10(2)-10(4) U/mouse) via implanted Alzet miniosmo...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.60.1.27

    authors: Dunn CJ,Hardee MM,Fidler SF,Shields SK,Chosay JG

    更新日期:1996-07-01 00:00:00

  • Chemokine decoy receptor D6 mimicking trap (D6MT) prevents allosensitization and immune rejection in murine corneal allograft model.

    abstract::Although corneal allotransplantation is performed in the immune-privileged cornea, many grafts are still rejected after transplantation. This study examined the role of chemokine receptor D6 expression in a corneal allograft rejection, investigated the modulation of D6 expression in cells, and determined the effect of...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.5A0414-233RR

    authors: Choi W,Byun YJ,Jung E,Noh H,Hajrasouliha AR,Sadrai Z,Chang E,Lee JH,Lee HK

    更新日期:2015-02-01 00:00:00

  • Dendritic cell differentiation pathways of CD34+ cells from the peripheral blood of head and neck cancer patients.

    abstract::Patients with head and neck squamous cell carcinoma (HNSCC) have increased levels of immune-suppressive peripheral blood CD34+ cells. This study showed that the peripheral blood CD34+ cells of HNSCC patients are capable of differentiating into dendritic cells. Because CD34+ cells can differentiate through several path...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.65.5.623

    authors: Lathers DM,Lubbers E,Wright MA,Young MR

    更新日期:1999-05-01 00:00:00

  • In vitro assessment of chemokine receptor-ligand interactions mediating mouse eosinophil migration.

    abstract::Eosinophil migration from circulation is controlled, in part, by chemokines through a family of G-protein-coupled chemokine receptors (CCR). Studies of human eosinophils have demonstrated that signaling through CCR3 receptors is a prominent pathway leading to chemotaxis, although several other receptor-ligand interact...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:

    authors: Borchers MT,Ansay T,DeSalle R,Daugherty BL,Shen H,Metzger M,Lee NA,Lee JJ

    更新日期:2002-06-01 00:00:00

  • Detection of the production of oxygen-centered free radicals by human neutrophils using spin trapping techniques: a critical perspective.

    abstract::Human neutrophils generate oxygen reduction products as a consequence of membrane interactions with a number of stimuli. One oxygen-centered free radical (superoxide) has been unequivocally shown to result from this "respiratory burst," and some experimental evidence for another (hydroxyl radical) has been published, ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1002/jlb.41.4.349

    authors: Britigan BE,Cohen MS,Rosen GM

    更新日期:1987-04-01 00:00:00

  • Viral dsRNA-activated human dendritic cells produce IL-27, which selectively promotes cytotoxicity in naive CD8+ T cells.

    abstract::Viral recognition programs DCs to express Signal 3 molecules that promote the differentiation of effector CD8(+) T cells. Besides IL-12, another DC-derived IL-12 family member, IL-27, has been reported to contribute herein, but its specific role is not well understood. Here, we show that whereas IL-12 potently induces...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0112045

    authors: de Groot R,van Beelen AJ,Bakdash G,Taanman-Kueter EW,de Jong EC,Kapsenberg ML

    更新日期:2012-09-01 00:00:00

  • Cyclosporin A inhibition of macrophage colony-stimulating factor (M-CSF) production by activated human T lymphocytes.

    abstract::M-CSF is a pleiotropic cytokine involved in the survival, proliferation, and differentiation of cells of the monocyte/macrophage lineage. M-CSF is produced by numerous cells including CD3-activated T cells. M-CSF serum levels are increased during acute graft rejection. We tested the in vitro production of M-CSF, GM-CS...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:

    authors: Frétier S,Besse A,Delwail A,Garcia M,Morel F,Leprivey-Lorgeot V,Wijdenes J,Praloran V,Lecron JC

    更新日期:2002-02-01 00:00:00

  • Characterization of cytosolic proliferating cell nuclear antigen (PCNA) in neutrophils: antiapoptotic role of the monomer.

    abstract::We have shown previously that PCNA, a nuclear factor involved in DNA replication and repair in proliferating cells, is localized exclusively in the cytoplasm of neutrophils, where it regulates their survival. Nuclear PCNA functions are tightly linked to its ring-shaped structure, which allows PCNA to bind to numerous ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.1212637

    authors: De Chiara A,Pederzoli-Ribeil M,Mocek J,Candalh C,Mayeux P,Millet A,Witko-Sarsat V

    更新日期:2013-10-01 00:00:00

  • The human monocyte-like cell line THP-1 expresses Fc gamma RI and Fc gamma RII.

    abstract::THP-1 cells are a monocyte-like cell line derived from a patient with acute monocytic leukemia and unlike other leukemic cell lines has a normal diploid karyotype. We have characterized Fc gamma R expression on this cell line by flow cytometry, radiolabeled IgG1 and monoclonal antibody (mAb) binding assays, and bioche...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.49.6.556

    authors: Fleit HB,Kobasiuk CD

    更新日期:1991-06-01 00:00:00

  • Protein phenotypes of mouse macrophages activated in vivo for tumor cell killing.

    abstract::We have shown previously that the cellular proteins 47b and 71/73 could be used to construct phenotypes that distinguish among bone marrow culture-derived (BMCD) macrophages that were either unstimulated or primed by gamma interferon or fully activated for tumor cell killing by gamma interferon in combination with lip...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.42.3.213

    authors: MacKay RJ,Russell SW

    更新日期:1987-09-01 00:00:00

  • Reduced CD4+ subset and Th1 bias of the human iNKT cells in Type 1 diabetes mellitus.

    abstract::Invariant NKT (iNKT) cells are considered to be important in some autoimmune diseases including Type 1 diabetes mellitus (T1DM). So far, the published data are contradictory in regard to the role of iNKT cells in T1DM. We aimed to study iNKT cell frequency and the function of different iNKT cell subgroups in T1DM. We ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.1106654

    authors: Kis J,Engelmann P,Farkas K,Richman G,Eck S,Lolley J,Jalahej H,Borowiec M,Kent SC,Treszl A,Orban T

    更新日期:2007-03-01 00:00:00

  • Endogenous and exogenous pathways maintain the reductive capacity of the phagosome.

    abstract::Although endosomes, lysosomes, and phagosomes require a reductive environment for the optimal activity of disulfide reductases and other thiol-dependent enzymes, how these reductive environments are established and maintained remain unknown. Our goal in this study was to begin to elucidate the redox control systems re...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.2HI0315-083R

    authors: Balce DR,Greene CJ,Tailor P,Yates RM

    更新日期:2016-07-01 00:00:00

  • Infection of a murine T-cell line with a retrovirus carrying c-myc decreases the interleukin-2 cell dependence by a nonautocrine mechanism.

    abstract::A murine interleukin-2 (IL-2)-dependent T-cell line, CTLL-2, was infected with a retrovirus carrying the mouse c-myc cDNA and the Tn-5 neogene. Transduced cells were selected in the presence of Geneticin sulfate (G418); these cells were shown to express both the endogenous and the transduced c-myc genes. The IL-2 requ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.44.6.559

    authors: Shapiro IM,Winberg G,Stefanescu I,Wigzell H,Menezes J

    更新日期:1988-12-01 00:00:00

  • Alcohol enhances symptoms and propensity for infection in inflammatory bowel disease patients and a murine model of DSS-induced colitis.

    abstract::Over 1.4 million Americans have been diagnosed with inflammatory bowel disease (IBD), and ulcerative colitis (UC) makes up approximately half of those diagnoses. As a disease, UC cycles between periods of remission and flare, which is characterized by intense abdominal pain, increased weight loss, intestinal inflammat...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/JLB.4MA1217-506R

    authors: Cannon AR,Kuprys PV,Cobb AN,Ding X,Kothari AN,Kuo PC,Eberhardt JM,Hammer AM,Morris NL,Li X,Choudhry MA

    更新日期:2018-09-01 00:00:00

  • Pivotal advance: IgE accelerates in vitro development of mast cells and modifies their phenotype.

    abstract::Antigen-dependent activation of IgE-bound mast cells is critical for immediate hypersensitivity and other allergic disorders. Recent studies have revealed the effects of monomeric IgEs on mast cell survival and activation. Furthermore, IgE molecules exhibit a wide range of heterogeneity in the ability to induce mast c...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.1207841

    authors: Kashiwakura J,Xiao W,Kitaura J,Kawakami Y,Maeda-Yamamoto M,Pfeiffer JR,Wilson BS,Blank U,Kawakami T

    更新日期:2008-08-01 00:00:00

  • Regulatory B cells and advances in transplantation.

    abstract::The effects of B cell subsets with regulatory activity on the immune response to an allograft have evoked increasing interest. Here, we summarize the function and signaling of regulatory B cells (Bregs) and their potential effects on transplantation. These cells are able to suppress the immune system directly via liga...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1002/JLB.5RU0518-199R

    authors: Li J,Luo Y,Wang X,Feng G

    更新日期:2019-04-01 00:00:00

  • Effects of 8-aminoguanosine on the toxicity of guanosine and deoxyguanosine for malignant and normal lymphoid cells.

    abstract::The toxicity of guanosine and deoxyguanosine in the presence or absence of the purine nucleoside phosphorylase inhibitor, 8-aminoguanosine, for malignant lymphoid cell lines and mitogen-stimulated peripheral blood lymphocytes has been studied. Deoxyguanosine inhibited the proliferation of lymphoid cells more strongly ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.44.1.46

    authors: van der Kraan PM,van Zandvoort PM,De Abreu RA,Bakkeren JA

    更新日期:1988-07-01 00:00:00

  • Human neutrophil elastase abolishes interleukin-8 chemotactic activity.

    abstract::A large body of literature supports the role of interleukin-8 (IL-8) in inflammatory lung disease. Numerous factors induce the local synthesis and secretion of this potent chemokine leading to the recruitment and activation of polymorphonuclear leukocytes. However, little is currently known about the fate of IL-8 secr...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.61.3.361

    authors: Leavell KJ,Peterson MW,Gross TJ

    更新日期:1997-03-01 00:00:00

  • Spatiotemporal photolabeling of neutrophil trafficking during inflammation in live zebrafish.

    abstract::How neutrophils traffic during inflammation in vivo remains elusive. To visualize the origin and fate of neutrophils during induction and resolution of inflammation, we established a genetically encoded photolabeling system by generating transgenic zebrafish that express a photoconvertible fluorescent reporter Dendra2...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.1010567

    authors: Yoo SK,Huttenlocher A

    更新日期:2011-05-01 00:00:00

  • Localization and characterization of macrophages in murine uterus.

    abstract::Macrophages are known to be present in the murine uterus and are known to be among those cells comprising the uterine decidual response to pregnancy. The extent of macrophage involvement in the decidual response has not been documented, and there are unresolved questions regarding expression of markers normally associ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.38.2.255

    authors: Hunt JS,Manning LS,Mitchell D,Selanders JR,Wood GW

    更新日期:1985-08-01 00:00:00

  • Synthesis of 5-oxo-6,8,11,14-eicosatetraenoic acid by human monocytes and lymphocytes.

    abstract::We recently demonstrated that the arachidonate metabolite 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) is converted by a highly specific dehydrogenase in human neutrophils to 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE), which is a potent stimulator of these cells. The objective of this study was to dete...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.59.6.847

    authors: Zhang Y,Styhler A,Powell WS

    更新日期:1996-06-01 00:00:00