The significance of carbohydrates on G-CSF: differential sensitivity of G-CSFs to human neutrophil elastase degradation.

abstract：:Group B streptococcal (GBS) infections are associated with high morbidity and mortality. The molecular pathways mediating the pathophysiological events in GBS infection are not fully delineated. Cyclooxygenases (COX) are the enzymes that convert arachidonate to active eicosanoids. To identify the effects of GBS on eic...

journal_title：Journal of leukocyte biology

authors： Maloney CG,Thompson SD,Hill HR,Bohnsack JF,McIntyre TM,Zimmerman GA

更新日期：2000-05-01 00:00:00

abstract：:Neutrophils were classically described as powerful effectors of acute inflammation, and their main purpose was assumed to be restricted to pathogen killing through production of oxidants. As consequence, neutrophils also may lead to significant collateral damage to the healthy tissues, and after performing these tasks...

journal_title：Journal of leukocyte biology

authors： Mattos MS,Lopes ME,de Araujo AM,Alvarenga DM,Nakagaki BN,Mafra K,de Miranda CDM,Diniz AB,Antunes MM,Lopes MAF,Rezende RM,Menezes GB

更新日期：2020-10-01 00:00:00

abstract：:A murine anti-rat intercellular adhesion molecule 1 (ICAM-1) monoclonal antibody (mAb), 1A29, was used to investigate the importance of blood leukocyte-associated beta 2-integrin (CD11/CD18) vascular endothelium-associated ICAM-1 adhesive interactions in the reversed passive Arthus reaction (RPAR) in rats. An Arthus p...

journal_title：Journal of leukocyte biology

authors： Smith RJ,Chosay JG,Dunn CJ,Manning AM,Justen JM

更新日期：1996-03-01 00:00:00

abstract：:Protein synthetic patterns of murine peritoneal macrophages were analyzed by two-dimensional polyacrylamide gel electrophoresis (2D PAGE) of 35S methionine-labeled proteins. While the protein synthetic patterns exhibited by resident, inflammatory, and activated macrophages had numerous common features that distinguish...

journal_title：Journal of leukocyte biology

authors： Tannenbaum CS,Nurmi-McKernan L,Largen MT

更新日期：1987-06-01 00:00:00

abstract：:The transmembrane form of tumor necrosis factor (mTNF), expressed on activated monocytes (MO) and macrophages (MPhi), is able to induce apoptosis in human endothelial cells (EC). Apoptosis is mediated by two distinct mechanisms: direct cell contact and a yet-unidentified soluble protein, death factor X. In addition, m...

journal_title：Journal of leukocyte biology

authors： Kirchner S,Boldt S,Kolch W,Haffner S,Kazak S,Janosch P,Holler E,Andreesen R,Eissner G

更新日期：2004-02-01 00:00:00

abstract：:The field of innate immunity is witnessing a paradigm shift regarding "memory" and "programming" dynamics. Past studies of innate leukocytes characterized them as first responders to danger signals with no memory. However, recent findings suggest that innate leukocytes, such as monocytes and neutrophils, are capable o...

journal_title：Journal of leukocyte biology

authors： Lee C,Geng S,Zhang Y,Rahtes A,Li L

更新日期：2017-09-01 00:00:00

abstract：:Fluoroquinolones have immunomodulatory properties and interfere with cytokine production. The aim of this study was to characterize the extent of the superinduced mRNA levels in activated human lymphocytes incubated with ciprofloxacin (5 and 80 micro g/ml) using a cytokine gene expression microarray from R and D Syste...

journal_title：Journal of leukocyte biology

authors： Eriksson E,Forsgren A,Riesbeck K

更新日期：2003-09-01 00:00:00

abstract：:Insight into molecular and cellular mechanisms of innate immunity is critical to understand viral pathogenesis and immunopathology and might be exploited for therapy. Whereas the molecular mechanisms of the IFN defense are well established, cellular mechanisms of antiviral immunity are only emerging, and their pharmac...

journal_title：Journal of leukocyte biology

authors： Li S,Starckx S,Martens E,Dillen C,Lamerant-Fayel N,Berghmans N,Gouwy M,van Pel M,Heremans H,Kieda C,Fibbe WE,Billiau A,Van Damme J,Opdenakker G

更新日期：2010-11-01 00:00:00

abstract：:Glycoprotein 130 (gp130) is a shared receptor utilized by several related cytokines, including IL-6, IL-11, IL-27, Leukemia Inhibitory Factor (LIF), Oncostatin M (OSM), Ciliary Neurotrophic Factor (CNTF), Cardiotrophin 1 (CT-1) and Cardiotrophin-like Cytokine (CLC). Gp130 plays critical roles during development and gp...

journal_title：Journal of leukocyte biology

authors： Silver JS,Hunter CA

更新日期：2010-12-01 00:00:00

abstract：:Neutrophils are important mediators of the innate immune defense and of the host response to a physical trauma. Because aberrant infiltration of injured sites by neutrophils was shown to cause adverse effects after trauma, we investigated how neutrophil infiltration could be modulated at the cellular level. Our data i...

journal_title：Journal of leukocyte biology

authors： Wille C,Eiseler T,Langenberger ST,Richter J,Mizuno K,Radermacher P,Knippschild U,Huber-Lang M,Seufferlein T,Paschke S

更新日期：2018-09-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) more than doubles tritiated thymidine ([3H]TdR) uptake in mouse macrophages stimulated by macrophage colony-stimulating factor (CSF-1). However, nothing is known of how TNF-alpha affects this increase or even whether it is manifested by increased cellular proliferation. Here we ...

journal_title：Journal of leukocyte biology

authors： Guilbert LJ,Winkler-Lowen B,Smith A,Branch DR,Garcia-Lloret M

更新日期：1993-07-01 00:00:00

abstract：:T helper cell type 1 (Th1)-polarizing cytokines are induced by Legionella pneumophila infection and are suppressed by pretreatment with marijuana cannabinoids (CB). Glucocorticoids and prostaglandin E2(PGE2) are also reported to suppress Th1 polarization and are induced by Delta9-tetrahydrocannabinol (THC), so their r...

journal_title：Journal of leukocyte biology

authors： Newton CA,Lu T,Nazian SJ,Perkins I,Friedman H,Klein TW

更新日期：2004-10-01 00:00:00

abstract：:Ketorolac tromethamine, a new nonsteroidal anti-inflammatory agent of the pyrrolo-pyrrole group, was assayed for inhibitory effects on polymorphonuclear leukocytes (PMN) in a variety of systems. Ketorolac inhibited PMN superoxide anion generation, lysozyme release, myeloperoxidase release, adherence to plastic surface...

journal_title：Journal of leukocyte biology

authors： Hyers TM,Tricomi SM,Liao JJ

更新日期：1992-05-01 00:00:00

abstract：:An anti-macrophage monoclonal antibody designated TRPM-3 was produced using thioglycollate-elicited rat peritoneal macrophages as immunogen. By the immunoperoxidase method, TRPM-3 was found to be specific for certain macrophage populations, such as marginal zone macrophages and marginal metallophils of the spleen, sin...

journal_title：Journal of leukocyte biology

authors： Takeya M,Hsiao L,Takahashi K

更新日期：1987-03-01 00:00:00

abstract：:The Hedgehog (Hh) family of signaling molecules functions in the development of numerous tissues during embryogenesis and has also been involved in adult self-renewing tissues. Recent results have demonstrated that the different components of the Hh signaling pathway are expressed in the human thymus. In this study, w...

journal_title：Journal of leukocyte biology

authors： Varas A,Hernández-López C,Valencia J,Mattavelli S,Martínez VG,Hidalgo L,Gutiérrez-Frías C,Zapata AG,Sacedón R,Vicente A

更新日期：2008-06-01 00:00:00

abstract：:Neutrophil apoptosis leads to macrophage ingestion of intact senescent neutrophils. This may represent a neutrophil removal mechanism that is important both in the control of inflammatory tissue injury and for the normal resolution processes of inflammation. Because apoptosis is likely to be a key control process in c...

journal_title：Journal of leukocyte biology

authors： Lee A,Whyte MK,Haslett C

更新日期：1993-10-01 00:00:00

abstract：:The phenotype of wound macrophages has not been studied by direct examination of these cells, yet macrophages recruited to sites of injury are described as alternatively activated macrophages, requiring IL-4 or IL-13 for phenotypic expression. This study characterized wound macrophage phenotype in the PVA sponge wound...

journal_title：Journal of leukocyte biology

authors： Daley JM,Brancato SK,Thomay AA,Reichner JS,Albina JE

更新日期：2010-01-01 00:00:00

abstract：:Mast cells are immune sentinels and a driving force in both normal and pathological contexts of inflammation, with a prominent role in allergic hypersensitivities. Crosslinking of FcεRI by allergen-bound IgE Abs leads to mast cell degranulation, resulting in an early-phase response and release of newly synthesized pro...

journal_title：Journal of leukocyte biology

authors： Yousef M,Crozier RWE,Hicks NJ,Watson CJF,Boyd T,Tsiani E,MacNeil AJ

更新日期：2020-05-01 00:00:00

abstract：:Traumatic brain injury (TBI) is often accompanied by an acute inflammatory reaction mediated initially by neutrophils. Adhesion molecules expressed on vascular endothelium are requisite elements during recruitment of leukocytes at sites of inflammation. In a rat model of TBI the induction and persistent expression of ...

journal_title：Journal of leukocyte biology

authors： Carlos TM,Clark RS,Franicola-Higgins D,Schiding JK,Kochanek PM

更新日期：1997-03-01 00:00:00

abstract：:HL-60 cells are promyelocytic leukemia cells that respond to culture conditions with differentiation into granulocytelike or macrophagelike phagocytes. O2 metabolism is critical to the microbicidal function of phagocytic cells. O2 metabolism was studied in HL-60 cells differentiated with dimethylsulfoxide (Me2SO) and ...

journal_title：Journal of leukocyte biology

authors： Thompson BY,Sivam G,Britigan BE,Rosen GM,Cohen MS

更新日期：1988-02-01 00:00:00

abstract：:We provide new information on how apoptosis regulates the expansion and survival of dendritic cell (DC) elements during in vitro hematopoiesis. Functionally distinct apoptotic schedules were associated with different phases of DC development when multipotent CD34+ progenitor cells were treated with GM-CSF + TNF +/- SC...

journal_title：Journal of leukocyte biology

authors： Santiago-Schwarz F,Borrero M,Tucci J,Palaia T,Carsons SE

更新日期：1997-10-01 00:00:00

abstract：:In the presence of adenosine, formyl-Met-Leu-Phe-stimulated human neutrophils show a greatly diminished production of superoxide anion. Analysis of changes in levels of intracellular calcium revealed that the immediate increase (occurring within seconds) in intracellular calcium following addition of formyl-Met-Leu-Ph...

journal_title：Journal of leukocyte biology

authors： Walker BA,Hagenlocker BE,Douglas VK,Ward PA

更新日期：1990-09-01 00:00:00

abstract：:Carcinoembryonic antigen (CEA), a member of the immunoglobulin supergene family, is recognized by a specific 80-kd receptor on Kupffer cells and alveolar macrophages. Peritoneal macrophages were harvested from male Sprague-Dawley rats 72 h after intraperitoneal injection with thioglycolate broth and from unstimulated ...

journal_title：Journal of leukocyte biology

authors： Toth CA

更新日期：1992-05-01 00:00:00

abstract：:Hematopoietic cells extend multiple podia of yet unknown function. Our morphological studies using scanning electron microscopy and functional studies using time-lapse video microscopy suggest that podia formed by CD34+ hematopoietic stem cells (HSC) on the bone marrow stroma component fibronectin are characteristic o...

journal_title：Journal of leukocyte biology

authors： Fruehauf S,Srbic K,Seggewiss R,Topaly J,Ho AD

更新日期：2002-03-01 00:00:00

abstract：:The effect of endothelial cells (EC) on lymphocyte mitogen responses was examined. Irradiated or mitomycin C treated EC were co-cultured with allogeneic peripheral blood mononuclear cells (PBM), and proliferative responses to pokeweed mitogen (PWM) and phytohemagglutinin (PHA) were assessed by 3H-thymidine incorporati...

journal_title：Journal of leukocyte biology

authors： Shanahan WR Jr,Weston DM,Korn JH

更新日期：1985-03-01 00:00:00

abstract：:STAT1 is a key effector of cytokines involved in the resistance to pathogens; its identified transcriptional targets mediate the innate immune response involved in the defense against viruses and bacteria. Little is known about the role of STAT1 in adaptive immunity, including its impact on BCR or surface Ig expressio...

journal_title：Journal of leukocyte biology

authors： Najjar I,Deglesne PA,Schischmanoff PO,Fabre EE,Boisson-Dupuis S,Nimmerjahn F,Bornkamm GW,Dusanter-Fourt I,Fagard R

更新日期：2010-06-01 00:00:00

abstract：:We have shown previously that the cellular proteins 47b and 71/73 could be used to construct phenotypes that distinguish among bone marrow culture-derived (BMCD) macrophages that were either unstimulated or primed by gamma interferon or fully activated for tumor cell killing by gamma interferon in combination with lip...

journal_title：Journal of leukocyte biology

authors： MacKay RJ,Russell SW

更新日期：1987-09-01 00:00:00

abstract：:SHP-1 is a cytoplasm protein tyrosine phosphatase expressed primarily in hematopoietic cells. In the immune system, SHP-1 plays critical roles in regulation of many receptor-mediated signaling cascades, and SHP-1 deficiency in mice causes spontaneous inflammation and autoimmunity. Here, we report a unique requirement ...

journal_title：Journal of leukocyte biology

authors： Zhou D,Collins CA,Wu P,Brown EJ

更新日期：2010-05-01 00:00:00

abstract：:The mechanisms by which concanavalin A (Con A), a lectin, activates T cells are poorly studied. A low dose of Con A is stimulatory for T cells, whereas a high dose of Con A results in suppression of proliferation and enhanced T cell death. The expression and functional roles of costimulatory receptors, CD28 and cytoto...

journal_title：Journal of leukocyte biology

authors： Mukherjee S,Ahmed A,Nandi D

更新日期：2005-07-01 00:00:00

abstract：:p67(phox) is the paramount cytosolic regulator of the superoxide-generating Nox of phagocytes, by controlling the conformation of the catalytic component, Nox2. The initiating event of this process is a protein-protein interaction between p67(phox) and the part of Nox2 protruding into the cytosol, known as the dehydro...

journal_title：Journal of leukocyte biology

authors： Dahan I,Smith SM,Pick E

更新日期：2015-11-01 00:00:00