Abstract:
:The mannose receptor is a macrophage surface receptor that mediates both endocytosis and phagocytosis. Previous work has demonstrated that the prototypical Th 2 cytokine, interleukin-4 (IL-4), increases both cell-surface receptor expression and mannose receptor-mediated endocytosis, whereas the prototypical Th 1 cytokine, interferon-γ (IFN-γ), decreases both surface expression and endocytosis. In many aspects of the immune response, Th 1 and Th 2 cytokines oppose each others' actions. We demonstrate that IL-4 and IFN-γ alone and together enhance mannose receptor-mediated phagocytosis, despite opposing effects on cell-surface mannose receptor expression and endocytosis. Thus these usually antagonistic cytokines cooperate in increasing mannose receptor phagocytic function. The cooperative effect of these cytokines is not observed for Fc receptor-mediated phagocytosis. The Th 2 cytokine IL-13 exerts similar effects to IL-4. Our results suggest that Th 1 and Th 2 cytokines may act in concert at sites of inflammation to enhance mannose receptor-mediated phagocytosis of microorganisms. J. Leukoc. Biol. 64: 108-113; 1998.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Raveh D,Kruskal BA,Farland J,Ezekowitz RABdoi
10.1002/jlb.64.1.108subject
Has Abstractpub_date
1998-07-01 00:00:00pages
108-113issue
1eissn
0741-5400issn
1938-3673journal_volume
64pub_type
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