Abstract:
:Radioprotective 105 kDa (CD180) is an unusual TLR that lacks an intracellular Toll-IL-1R signaling domain and exhibits unconventional homodimerization behavior. Differential expression and functions of radioprotective 105 kDa have been associated with immune-mediated pathologies, including infection, chronic inflammation, and autoimmune disorders. Radioprotective 105 kDa activates macrophages and B cells independently of canonical TLR signaling. Current understanding of the functional consequences of radioprotective 105 kDa signaling in B cells, macrophages, and dendritic cells indicates overlapping, but also some apparent opposing, cell-specific roles for radioprotective 105 kDa in shaping cellular functions. This review compares interactions of radioprotective 105 kDa with its coreceptors, CD19, TLR4, and TLR2; integrates recent, novel findings on radioprotective 105 kDa-mediated molecular signaling mechanisms; and summarizes current understanding of its contributions to infectious, inflammatory, and autoimmune disease.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Schultz TE,Blumenthal Adoi
10.1189/jlb.2VMR1215-582Rsubject
Has Abstractpub_date
2017-01-01 00:00:00pages
183-192issue
1eissn
0741-5400issn
1938-3673pii
jlb.2VMR1215-582Rjournal_volume
101pub_type
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