IL-1 and TNF independent pathways mediate ICAM-1/VCAM-1 up-regulation in ischemia reperfusion injury.

abstract：:In this study, we have investigated the expression of phospholipase C-beta2 during the course of granulocytic differentiation of normal and malignant progenitors. As a model system, we used the NB4 cell line, a reliable in vitro model for the study of acute promyelocytic leukemia (APL), a variety of acute myeloid leuk...

journal_title：Journal of leukocyte biology

authors： Bertagnolo V,Marchisio M,Pierpaoli S,Colamussi ML,Brugnoli F,Visani G,Zauli G,Capitani S

更新日期：2002-06-01 00:00:00

abstract：:p67(phox) is the paramount cytosolic regulator of the superoxide-generating Nox of phagocytes, by controlling the conformation of the catalytic component, Nox2. The initiating event of this process is a protein-protein interaction between p67(phox) and the part of Nox2 protruding into the cytosol, known as the dehydro...

journal_title：Journal of leukocyte biology

authors： Dahan I,Smith SM,Pick E

更新日期：2015-11-01 00:00:00

abstract：:It has been reported recently that granulocyte-colony stimulating factor (G-CSF) is degraded upon exposure to human neutrophil elastase (HNE), and this has a negative effect on the ability of the cytokine to promote the in vitro proliferation and maturation of CD34+ cells. This has important implications on the possib...

journal_title：Journal of leukocyte biology

authors： Carter CR,Whitmore KM,Thorpe R

更新日期：2004-03-01 00:00:00

abstract：:Osteopontin is an RGD-containing bone matrix protein with cytokine-like functions that is associated with early stages of Th1-mediated diseases. Although the function of osteopontin in these responses is unknown, it is expressed by activated T cells and macrophages and can costimulate T cell proliferation. Studies hav...

journal_title：Journal of leukocyte biology

authors： O'Regan AW,Hayden JM,Berman JS

更新日期：2000-10-01 00:00:00

abstract：:Nucleotide receptors serve as sensors of extracellular ATP and are important for immune function. The nucleotide receptor P2RX7 is a cell-surface, ligand-gated cation channel that has been implicated in many diseases, including arthritis, granuloma formation, sepsis, and tuberculosis. These disorders are often exacerb...

journal_title：Journal of leukocyte biology

authors： Gavala ML,Pfeiffer ZA,Bertics PJ

更新日期：2008-10-01 00:00:00

abstract：:The adhesion and degranulation promoting adaptor protein (ADAP) is a multifunctional scaffold involved in many different signaling pathways that are important for the function of T cells, including the inside-out and outside-in signaling of integrins, the activation of NF-κB, and the subsequent production of proinflam...

journal_title：Journal of leukocyte biology

authors： Parzmair GP,Gereke M,Haberkorn O,Annemann M,Podlasly L,Kliche S,Reinhold A,Schraven B,Bruder D

更新日期：2017-02-01 00:00:00

abstract：:Recent advances have led to the identification and characterization of an array of transmembrane proteases that mediate the proteolysis of various substrates (including bioactive peptides, components of the extracellular matrix, and integral proteins) and cell-cell or cell-matrix adhesion. The membrane proteases known...

journal_title：Journal of leukocyte biology

authors： Bauvois B

更新日期：2001-07-01 00:00:00

abstract：:Vertebrate lectin purified from loach egg was tested for induction of tumor lysis mediated by macrophages. Loach egg lectin lysed tumor cells but not normal spleen cells in cooperation with BCG- or glucan (TAK)-elicited peritoneal macrophages of mice. Corynebacterium parvum-, OK432-, glycogen-, lipopolysaccharide-elic...

journal_title：Journal of leukocyte biology

authors： Yamazaki M,Okutomi T,Sakakibara F,Kawauchi H,Mizuno D

更新日期：1984-03-01 00:00:00

abstract：:Zinc is an essential element important for growth, the nervous system, and especially the immune system. Zinc deficiency as well as levels well above normal, due to high-dose treatment, showed an impaired immune function. This review summarizes the current status of zinc's significance for leukocyte biology and health...

journal_title：Journal of leukocyte biology

authors： Wellinghausen N,Rink L

更新日期：1998-11-01 00:00:00

abstract：:Mast cells are immune sentinels and a driving force in both normal and pathological contexts of inflammation, with a prominent role in allergic hypersensitivities. Crosslinking of FcεRI by allergen-bound IgE Abs leads to mast cell degranulation, resulting in an early-phase response and release of newly synthesized pro...

journal_title：Journal of leukocyte biology

authors： Yousef M,Crozier RWE,Hicks NJ,Watson CJF,Boyd T,Tsiani E,MacNeil AJ

更新日期：2020-05-01 00:00:00

abstract：:Exacerbations of asthma are most commonly triggered by viral infections, which amplify allergic inflammation. Cytokines released by virus-infected AECs may be important in driving this response. This review focuses on accumulating evidence in support of a role for epithelial cytokines, including IL-33, IL-25, and TSLP...

journal_title：Journal of leukocyte biology

authors： Kumar RK,Foster PS,Rosenberg HF

更新日期：2014-09-01 00:00:00

abstract：:Dietary olive oil supplementation and more recently, olive oil phenols have been recommended as important therapeutic interventions in preventive medicine. Ole has several pharmacological properties, including antioxidant, anti-inflammatory, antiatherogenic, anticancer, antimicrobial, and antiviral and for these reaso...

journal_title：Journal of leukocyte biology

authors： Campolo M,Di Paola R,Impellizzeri D,Crupi R,Morittu VM,Procopio A,Perri E,Britti D,Peli A,Esposito E,Cuzzocrea S

更新日期：2013-02-01 00:00:00

abstract：:Effector T cell development is directly driven by APCs, in particular, by antigen-primed dendritic cells (DCs). Depending on the pathogenic stimulus and the microenvironment, DCs induce proliferation and polarization of naive CD4+ T cells into different effector subsets, such as Th1, Th2, Th17, or regulatory T cells (...

journal_title：Journal of leukocyte biology

authors： Breedveld A,Groot Kormelink T,van Egmond M,de Jong EC

更新日期：2017-10-01 00:00:00

abstract：:Asthma is a chronic inflammatory disease of the airways that afflicts over 30 million individuals in the United States and over 300 million individuals worldwide. The inflammatory response in the airways is often characterized by the analysis of sputum, which contains multiple types of cells including neutrophils, mac...

journal_title：Journal of leukocyte biology

authors： Stewart E,Wang X,Chupp GL,Montgomery RR

更新日期：2020-11-01 00:00:00

abstract：:Leukocyte migration across the endothelial barrier plays an essential role in CNS inflammation. The migration process requires complex endothelial adhesion molecules concentrated at the junctions of endothelial cells. Recent findings suggest that cerebral endothelial cells play an active role in the pathogenesis of CN...

journal_title：Journal of leukocyte biology

authors： Wu F,Liu L,Zhou H

更新日期：2017-05-01 00:00:00

abstract：:Freeze-fracture analysis has shown that treatment of cells with phorbol myristate acetate (PMA) results in a loss of intramembranous particles (IMP) associated with the external leaflet of their plasma membranes. It has also been demonstrated that phorbol esters markedly enhance the sensitivity of tumor targets to nat...

journal_title：Journal of leukocyte biology

authors： Nabi ZF,Zucker-Franklin D,Baten A

更新日期：1989-03-01 00:00:00

abstract：:The effects of the carbocyclic nucleoside MDL 201,112 and the purine nucleoside adenosine on the interferon-gamma (IFN-gamma)-induced priming of macrophages (m phi s) for the respiratory burst and major histocompatibility class II (MHC class II) Ia+ antigen expression were compared. Priming of purified, peritoneal m p...

journal_title：Journal of leukocyte biology

authors： Edwards CK 3rd,Watts LM,Parmely MJ,Linnik MD,Long RE,Borcherding DR

更新日期：1994-08-01 00:00:00

abstract：:The motheaten mouse was first described in 1975 as a model of systemic inflammation and autoimmunity, as a result of immune system dysregulation. The phenotype was later ascribed to mutations in the cytoplasmic tyrosine phosphatase Shp1. This phosphatase is expressed widely throughout the hematopoietic system and has ...

journal_title：Journal of leukocyte biology

authors： Abram CL,Lowell CA

更新日期：2017-09-01 00:00:00

abstract：:In inflammatory diseases, circulating neutrophils are recruited to sites of injury. Attractant signals are provided by many different chemotactic molecules, such that blockade of one may not prevent neutrophil recruitment effectively. The Slit family of secreted proteins and their transmembrane receptor, Robo, repel a...

journal_title：Journal of leukocyte biology

authors： Tole S,Mukovozov IM,Huang YW,Magalhaes MA,Yan M,Crow MR,Liu GY,Sun CX,Durocher Y,Glogauer M,Robinson LA

更新日期：2009-12-01 00:00:00

abstract：:Natural killer (NK) cells arise from immature progenitors present in fetal tissues and adult bone marrow, but the factors responsible for driving the proliferation and differentiation of these progenitors are poorly understood. Mouse NK cells had previously been thought not to express interleukin (IL)-2Ralpha chains, ...

journal_title：Journal of leukocyte biology

authors： Toomey JA,Gays F,Foster D,Brooks CG

更新日期：2003-08-01 00:00:00

abstract：:Elderly humans are more susceptible to bacterial infections because of declining immune status. We have investigated the effect of aging on neutrophil bactericidal responses, comparing neutrophil function in healthy, young (23-35 years) and elderly (>65 years) volunteers. Superoxide generation in response to fMLP was ...

journal_title：Journal of leukocyte biology

authors： Butcher SK,Chahal H,Nayak L,Sinclair A,Henriquez NV,Sapey E,O'Mahony D,Lord JM

更新日期：2001-12-01 00:00:00

abstract：:Alveolar macrophages from chronic obstructive pulmonary disease patients and cigarette smokers are deficient in their ability to phagocytose apoptotic bronchial epithelial cells (efferocytosis). We hypothesized that the defect is mediated via inhibition of sphingosine kinases and/or their subcellular mislocalization i...

journal_title：Journal of leukocyte biology

authors： Tran HB,Barnawi J,Ween M,Hamon R,Roscioli E,Hodge G,Reynolds PN,Pitson SM,Davies LT,Haberberger R,Hodge S

更新日期：2016-07-01 00:00:00

abstract：:Previous work indicated that macrophages and a lymphoid dendritic cell-like tumor line, P388AD.2, possessed a differential ability to present a haptenated immunoglobulin (tolerogen) in vitro. Macrophages presented fluorescein-conjugated sheep gamma globulin (FL-SGG) and elicited B-cell unresponsiveness. In contrast, P...

journal_title：Journal of leukocyte biology

authors： Phipps RP,Illig K,Schad V,Bhimani K

更新日期：1988-03-01 00:00:00

abstract：:Recombinant fusion proteins consisting of the extracellular domain of immunoregulatory proteins and the constant domain of immunoglobulin G (IgG) are a novel class of human therapeutics. IgG isoforms exert different levels of immune effector functions, such as complement lysis and antibody-dependent cell cytotoxicity ...

journal_title：Journal of leukocyte biology

authors： Taylor L,Bachler M,Duncan I,Keen S,Fallon R,Mair C,McDonald TT,Schwarz H

更新日期：2002-09-01 00:00:00

abstract：:Mycobacterium avium complex (MAC) is a significant cause of opportunistic infection in patients with acquired immunodeficiency syndrome. Although the major route of entry of MAC is via the gastrointestinal tract, MAC can infect humans through the respiratory tract and eventually encounter alveolar macrophages within t...

journal_title：Journal of leukocyte biology

authors： Lopez JP,Clark E,Shepherd VL

更新日期：2003-10-01 00:00:00

abstract：:The effect of recombinant human interleukin-2 (IL-2) on tumor cell cycle kinetics was evaluated in rats bearing the Walker-256 carcinosarcoma. Seven days after implantation, tumor-bearing rats were infused intravenously with IL-2 at a dose of 500 mg/kg body weight or 5% dextrose for 6 h. Tumor cell mean DNA synthesis ...

journal_title：Journal of leukocyte biology

authors： Wan JM,Bistrian BR,Figoni MA,Istfan NW

更新日期：1994-02-01 00:00:00

abstract：:Group B streptococcal (GBS) infections are associated with high morbidity and mortality. The molecular pathways mediating the pathophysiological events in GBS infection are not fully delineated. Cyclooxygenases (COX) are the enzymes that convert arachidonate to active eicosanoids. To identify the effects of GBS on eic...

journal_title：Journal of leukocyte biology

authors： Maloney CG,Thompson SD,Hill HR,Bohnsack JF,McIntyre TM,Zimmerman GA

更新日期：2000-05-01 00:00:00

abstract：:Antigen presentation to T lymphocytes has been characterized extensively in terms of T lymphocyte activation and eventual cell death. In contrast, little is known about the consequences of antigen presentation for the antigen-presenting cell (APC). We have determined the outcome of major histocompatibility complex cla...

journal_title：Journal of leukocyte biology

authors： Setterblad N,Blancheteau V,Delaguillaumie A,Michel F,Bécart S,Lombardi G,Acuto O,Charron D,Mooney N

更新日期：2004-06-01 00:00:00

abstract：:LPS has been widely used to induce inflammatory pain, attributing to production of inflammatory cytokines and sensitization of nociceptors. Paeoniflorin (PF) possesses anti-nociceptive property, but its effect on LPS-induced inflammatory pain has not been investigated. In this study, we aimed to investigate the analge...

journal_title：Journal of leukocyte biology

authors： Yin N,Gao Q,Tao W,Chen J,Bi J,Ding F,Wang Z

更新日期：2020-07-01 00:00:00

abstract：:During B-cell differentiation, the gene expression of B-cell differentiation-related transcription factors must be strictly controlled by epigenetic mechanisms including histone acetylation and deacetylation, to complete the differentiation pathway. GCN5, one of the most important histone acetyltransferases, is involv...

journal_title：Journal of leukocyte biology

authors： Kikuchi H,Nakayama M,Kuribayashi F,Imajoh-Ohmi S,Nishitoh H,Takami Y,Nakayama T

更新日期：2014-03-01 00:00:00