Abstract:
:Leukocyte migration across the endothelial barrier plays an essential role in CNS inflammation. The migration process requires complex endothelial adhesion molecules concentrated at the junctions of endothelial cells. Recent findings suggest that cerebral endothelial cells play an active role in the pathogenesis of CNS inflammatory diseases. This review describes our current understanding of the effects of various inflammatory mediators of leukocyte migration on cerebral endothelial cells, the mechanisms underlying the leukocyte-endothelial cell interactions, and the crosstalk between endothelial cells and glial cells or platelets. These emerging mechanisms may provide new therapeutic strategies for a variety of CNS inflammatory diseases.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Wu F,Liu L,Zhou Hdoi
10.1189/jlb.3RU0816-352RRsubject
Has Abstractpub_date
2017-05-01 00:00:00pages
1119-1132issue
5eissn
0741-5400issn
1938-3673pii
jlb.3RU0816-352RRjournal_volume
101pub_type
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journal_title:Journal of leukocyte biology
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journal_title:Journal of leukocyte biology
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
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journal_title:Journal of leukocyte biology
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doi:10.1189/jlb.3HI0814-371RR
更新日期:2015-05-01 00:00:00
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journal_title:Journal of leukocyte biology
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journal_title:Journal of leukocyte biology
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journal_title:Journal of leukocyte biology
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
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journal_title:Journal of leukocyte biology
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journal_title:Journal of leukocyte biology
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journal_title:Journal of leukocyte biology
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journal_title:Journal of leukocyte biology
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更新日期:2001-08-01 00:00:00
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