Enhanced phospholipase A2 and C activities of peripheral blood polymorphonuclear leukocytes from patients with rheumatoid arthritis.

abstract：:IL-27, an IL-12 family member, was initially described as a proinflammatory cytokine. Nevertheless, it also poses anti-inflammatory activity, being involved in suppressing development of TH-17 cells as well as in the induction of inhibitory Tr1 cells. Recent data obtained in mice suggest that it can down-modulate the ...

journal_title：Journal of leukocyte biology

authors： Karakhanova S,Bedke T,Enk AH,Mahnke K

更新日期：2011-06-01 00:00:00

abstract：:C-reactive protein (CRP) is a prototypical acute-phase reactant, the humoral and plasma concentrations of which rise dramatically after tissue injury or inflammation. The effects of CRP on superoxide production and intracellular calcium mobilization by guinea pig alveolar macrophages challenged with platelet-activatin...

journal_title：Journal of leukocyte biology

authors： Földes-Filep E,Filep JG,Sirois P

更新日期：1992-01-01 00:00:00

abstract：:The Charcot-Leyden crystal (CLC) protein, a prominent cell constituent unique to eosinophils and basophils, possesses lysophospholipase activity. This activity and the extracellular deposition and formation of CLC in tissues and body fluids in association with eosinophils suggest an extracellular function for this pro...

journal_title：Journal of leukocyte biology

authors： Golightly LM,Thomas LL,Dvorak AM,Ackerman SJ

更新日期：1992-04-01 00:00:00

abstract：:Thrombin has receptor-mediated effects on a variety of cell types. A recently cloned platelet thrombin receptor exerts its effects by a tethered-ligand mechanism. A similar receptor was shown in at least two nonplatelet cell types, fibroblasts and endothelial cells. Thrombin has biologically important effects on leuko...

journal_title：Journal of leukocyte biology

authors： Hoffman M,Church FC

更新日期：1993-08-01 00:00:00

abstract：:There is currently no real treatment for blinding disorders that stem from the degeneration of cells in the retina and affect at least 50 million individuals worldwide. The excitement that accompanied the first studies showing the potential of retinal cell transplantation to alleviate the progress of blindness in such...

journal_title：Journal of leukocyte biology

authors： Lund RD,Ono SJ,Keegan DJ,Lawrence JM

更新日期：2003-08-01 00:00:00

abstract：:The germinal center (GC) is a dynamic structure formed by proliferating B cells in the follicles of secondary lymphoid organs during T cell-dependent antibody responses to exogenous antigens. GC is composed by a dark zone, enriched in proliferating centroblasts (CBs), and a light zone where CBs migrate and transform i...

journal_title：Journal of leukocyte biology

authors： Ferretti E,Ponzoni M,Doglioni C,Pistoia V

更新日期：2016-11-01 00:00:00

abstract：:GM-CSF is well recognized as a proliferative agent for hematopoietic cells and exerts a priming function on neutrophils. The aim of this study was to determine if GM-CSF has a role as a neutrophil chemoattractant in vivo and if it can contribute to recruitment during intestinal inflammation. Initial studies in vitro, ...

journal_title：Journal of leukocyte biology

authors： Khajah M,Millen B,Cara DC,Waterhouse C,McCafferty DM

更新日期：2011-06-01 00:00:00

abstract：:The ability of encapsulated and acapsular strains of Cryptococcus neoformans to activate dendritic cells (DC) derived from monocytes stimulated with granulocyte macrophage-colony stimulating factor and interleukin-4 was evaluated. Profound differences in DC response to encapsulated and acapsular C. neoformans strains ...

journal_title：Journal of leukocyte biology

authors： Vecchiarelli A,Pietrella D,Lupo P,Bistoni F,McFadden DC,Casadevall A

更新日期：2003-09-01 00:00:00

abstract：:In the pathogenesis of chronic inflammatory periodontal disease, neutrophils are recognized as a major cellular component from the histopathology of the periodontal lesion around teeth and from clinical cases where absence or dysfunction of neutrophils results in major periodontal destruction. Neutrophils are recruite...

journal_title：Journal of leukocyte biology

authors： Galicia JC,Benakanakere MR,Stathopoulou PG,Kinane DF

更新日期：2009-07-01 00:00:00

abstract：:Epinephrine inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF) production by increasing intracellular cAMP concentrations. Because agents that increase cAMP levels can enhance TNF receptor expression in vitro, granulocyte and monocyte TNF receptors were determined by FACS-analysis in 7 normal humans...

journal_title：Journal of leukocyte biology

authors： van der Poll T,Calvano SE,Kumar A,Coyle SM,Lowry SF

更新日期：1997-02-01 00:00:00

abstract：:An understanding of the binding specificity of leukocyte integrins is important to determine the range of ligands that interact with these receptors during inflammatory processes. In this study we show that the alpha4beta1 integrin can interact with casein and denatured albumin and promote leukocyte adhesion through t...

journal_title：Journal of leukocyte biology

authors： Davis GE,Thomas JS,Madden S

更新日期：1997-09-01 00:00:00

abstract：:We investigated the pathogenesis of lung injury in sepsis (septic adult respiratory distress syndrome) by focusing on the functional changes of alveolar macrophages (AMs). Sepsis was induced in male WK rats by cecal ligation and puncture. Histological examination of the lungs from this experimental model revealed edem...

journal_title：Journal of leukocyte biology

authors： Goya T,Abe M,Shimura H,Torisu M

更新日期：1992-08-01 00:00:00

abstract：:Autism spectrum disorders (ASD) are part of a broad spectrum of neurodevelopmental disorders known as pervasive developmental disorders, which occur in childhood. They are characterized by impairments in social interaction, verbal and nonverbal communication and the presence of restricted and repetitive stereotyped be...

journal_title：Journal of leukocyte biology

authors： Ashwood P,Wills S,Van de Water J

更新日期：2006-07-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a multifunctional cytokine that plays a pivotal role in mediating neovascularization as well as other endothelial cell alterations during inflammation. In this study, we demonstrate that human neutrophils are a source of VEGF. We observed that isolated blood neutrophils rel...

journal_title：Journal of leukocyte biology

authors： Taichman NS,Young S,Cruchley AT,Taylor P,Paleolog E

更新日期：1997-09-01 00:00:00

abstract：:The magnitude and efficacy of CD8(+) T cell memory may notably regress, especially if immune induction occurs in the absence of adequate CD4(+) help. This report demonstrates that this CD8(+) memory malfunction could be remedied if a source of cognate antigen-recognizing helper cells were provided during recall. The i...

journal_title：Journal of leukocyte biology

authors： Kumaraguru U,Banerjee K,Rouse BT

更新日期：2005-10-01 00:00:00

abstract：:The airway epithelial cell of the lower respiratory tract is the primary host target cell for respiratory syncytial virus (RSV) infection. To estimate whether infected epithelial cells contribute to the inflammatory host response observed during the acute infection phase we analyzed the cell surface expression of inte...

journal_title：Journal of leukocyte biology

authors： Arnold R,Konig W

更新日期：1996-12-01 00:00:00

abstract：:Complex syndromes such as atherosclerosis and type 2 diabetes are disorders that are associated with inflammatory processes involving innate and adaptive immunity. Emerging knowledge about the pathological consequences of immune imbalances in a wide range of disease settings is expected to help to identify novel thera...

journal_title：Journal of leukocyte biology

authors： Rose B,Herder C,Löffler H,Kolb H,Martin S

更新日期：2004-04-01 00:00:00

abstract：:HIV is known to subvert cellular machinery to enhance its replication. Recently, HIV has been reported to enhance TC renin expression. We hypothesized that HIV induces and maintains high renin expression to promote its own replication in TCs. Renin enhanced HIV replication in TCs in a dose-dependent manner. (P)RR-defi...

journal_title：Journal of leukocyte biology

authors： Chandel N,Ayasolla K,Lan X,Rai P,Mikulak J,Husain M,Malhotra A,McGowan J,Singhal PC

更新日期：2014-10-01 00:00:00

abstract：:The effects of B cell subsets with regulatory activity on the immune response to an allograft have evoked increasing interest. Here, we summarize the function and signaling of regulatory B cells (Bregs) and their potential effects on transplantation. These cells are able to suppress the immune system directly via liga...

journal_title：Journal of leukocyte biology

authors： Li J,Luo Y,Wang X,Feng G

更新日期：2019-04-01 00:00:00

abstract：:We recently demonstrated that the arachidonate metabolite 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) is converted by a highly specific dehydrogenase in human neutrophils to 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE), which is a potent stimulator of these cells. The objective of this study was to dete...

journal_title：Journal of leukocyte biology

authors： Zhang Y,Styhler A,Powell WS

更新日期：1996-06-01 00:00:00

abstract：:The in vitro effects of 17 alpha AED, the isomer of 5-androstene-3 beta,17 beta diol (17 beta AED) on the basal growth of murine RAW 264.7, P388D1, and human HL-60 cells were investigated. 17 alpha AED treatment of RAW cells for 48 h reduced total cell number without increasing cell death as detected by trypan blue ex...

journal_title：Journal of leukocyte biology

authors： Huynh PN,Loria RM

更新日期：1997-08-01 00:00:00

abstract：:Role of IL-18 on proliferation and survival of CD8+ T cells, activated by immobilized anti-CD3 antibody (anti-CD3), was examined. Proliferation and survival of activated T cells, especially that of CD8+ T cells, were impaired by IL-18 deficiency [IL-18 knockout (KO)]. After 3 days of culture with anti-CD3, the number ...

journal_title：Journal of leukocyte biology

authors： Li W,Kashiwamura S,Ueda H,Sekiyama A,Okamura H

更新日期：2007-07-01 00:00:00

abstract：:Prostaglandins function as down regulators of immune responses probably by increasing the concentration of intracellular cAMP. Phosphodiesterase inhibitors, which prevent the breakdown of cAMP, also increase the intracellular levels of cAMP. Prostaglandins and phosphodiesterase inhibitors have both been shown to suppr...

journal_title：Journal of leukocyte biology

authors： Ellis NK,Duffie GP,Young MR,Wepsic HT

更新日期：1990-04-01 00:00:00

abstract：:Osteoarticular complications are common in human brucellosis, but the pathogenic mechanisms involved are largely unknown. In this manuscript, we described an immune mechanism for inflammatory bone loss in response to infection by Brucella abortus. We established a requirement for MyD88 and TLR2 in TNF-α-elicited osteo...

journal_title：Journal of leukocyte biology

authors： Delpino MV,Barrionuevo P,Macedo GC,Oliveira SC,Genaro SD,Scian R,Miraglia MC,Fossati CA,Baldi PC,Giambartolomei GH

更新日期：2012-02-01 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains the leading global cause of death from an infectious agent. Mycobacteria thrive within their host Mϕs and presently, there is no animal model that permits combined in vitro and in vivo study of mycobacteria-host Mϕ interactions. Mycoba...

journal_title：Journal of leukocyte biology

authors： Popovic M,Yaparla A,Paquin-Proulx D,Koubourli DV,Webb R,Firmani M,Grayfer L

更新日期：2019-12-01 00:00:00

abstract：:In this study, we test the hypothesis that cAMP, acting as an extracellular mediator, affects the physiology and function of human myeloid cells. The cAMP is a second messenger recognized as a universal regulator of several cellular functions in different organisms. Many studies have shown that extracellular cAMP exer...

journal_title：Journal of leukocyte biology

authors： Sciaraffia E,Riccomi A,Lindstedt R,Gesa V,Cirelli E,Patrizio M,De Magistris MT,Vendetti S

更新日期：2014-07-01 00:00:00

abstract：:An epithelial cell line, IT-45R1, has been established from a thymus of normal Wistar rat and was found to produce growth factor which stimulated the proliferation of bone marrow cells. This growth factor induced the formation of colonies composed of macrophages, granulocytes, or both, in semi-solid medium and stimula...

journal_title：Journal of leukocyte biology

authors： Nanno M,Takahashi T,Sakata T,Horikawa T,Sako T,Suzuki R,Itoh T,Kumagai K

更新日期：1991-12-01 00:00:00

abstract：:Neutrophils can attach to E-selectin under flow. Proposed ligands for E-selectin carry SLe(x)-type glycans. The leukocyte beta2 integrins are glycosylated with SLe(x). Thus, we speculated that beta2 integrins could support attachment to E-selectin. To test this hypothesis, we coated 10-microm-diameter microspheres wit...

journal_title：Journal of leukocyte biology

authors： Crutchfield KL,Shinde Patil VR,Campbell CJ,Parkos CA,Allport JR,Goetz DJ

更新日期：2000-02-01 00:00:00

abstract：:Lymphocyte function-associated antigen (LFA-1) is a member of the beta2 family of integrins that is selectively expressed on leukocytes. Herein, we show that Ca(2)(+) mobilizing agents A23187, thapsigargin, and ionomycin induce an increase in adhesion to the LFA-1 ligand intercellular adhesion molecule-1 (ICAM-1) and ...

journal_title：Journal of leukocyte biology

authors： Rodríguez-Fernández JL,Sánchez-Martín L,de Frutos CA,Sancho D,Robinson M,Sánchez-Madrid F,Cabañas C

更新日期：2002-03-01 00:00:00

abstract：:Lipopolysaccharide (LPS) has been shown to induce proliferation of human T-lymphocytes only in the presence of monocytes and CD34(+) hematopoietic cells (HCs) from peripheral blood. This finding provided evidence of an active role of CD34(+) HCs during inflammation and immunological events. To investigate mechanisms b...

journal_title：Journal of leukocyte biology

authors： Umland O,Heine H,Miehe M,Marienfeld K,Staubach KH,Ulmer AJ

更新日期：2004-04-01 00:00:00