Regulatory B cells and advances in transplantation.

Abstract:

:The effects of B cell subsets with regulatory activity on the immune response to an allograft have evoked increasing interest. Here, we summarize the function and signaling of regulatory B cells (Bregs) and their potential effects on transplantation. These cells are able to suppress the immune system directly via ligand-receptor interactions and indirectly by secretion of immunosuppressive cytokines, particularly IL-10. In experimental animal models, the extensively studied IL-10-producing B cells have shown unique therapeutic advantages in the transplant field. In addition, adoptive transfer of B cell subsets with regulatory activity may reveal a new approach to prolonging allograft survival. Recent clinical observations on currently available therapies targeting B cells have revealed that Bregs play an important role in immune tolerance and that these cells are expected to become a new target of immunotherapy for transplant-related diseases.

journal_name

J Leukoc Biol

authors

Li J,Luo Y,Wang X,Feng G

doi

10.1002/JLB.5RU0518-199R

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

657-668

issue

4

eissn

0741-5400

issn

1938-3673

journal_volume

105

pub_type

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