Regulatory B cells and advances in transplantation.


:The effects of B cell subsets with regulatory activity on the immune response to an allograft have evoked increasing interest. Here, we summarize the function and signaling of regulatory B cells (Bregs) and their potential effects on transplantation. These cells are able to suppress the immune system directly via ligand-receptor interactions and indirectly by secretion of immunosuppressive cytokines, particularly IL-10. In experimental animal models, the extensively studied IL-10-producing B cells have shown unique therapeutic advantages in the transplant field. In addition, adoptive transfer of B cell subsets with regulatory activity may reveal a new approach to prolonging allograft survival. Recent clinical observations on currently available therapies targeting B cells have revealed that Bregs play an important role in immune tolerance and that these cells are expected to become a new target of immunotherapy for transplant-related diseases.


J Leukoc Biol


Li J,Luo Y,Wang X,Feng G




Has Abstract


2019-04-01 00:00:00












  • MERTK as negative regulator of human T cell activation.

    abstract::The aim of this study was to test the hypothesis whether MERTK, which is up-regulated in human DCs treated with immunosuppressive agents, is directly involved in modulating T cell activation. MERTK is a member of the TAM family and contributes to regulating innate immune response to ACs by inhibiting DC activation in ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Cabezón R,Carrera-Silva EA,Flórez-Grau G,Errasti AE,Calderón-Gómez E,Lozano JJ,España C,Ricart E,Panés J,Rothlin CV,Benítez-Ribas D

    更新日期:2015-04-01 00:00:00

  • Microorganisms and their interaction with the immune system.

    abstract::Microorganisms interact with the immune system in multiple ways. In an interaction between a microorganism and its host, the defense of the host does not go unchallenged. Microorganisms have for decades been suspected of possessing the capabilities of hiding from and escaping the consequences of immune surveillance. E...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审


    authors: Kotwal GJ

    更新日期:1997-10-01 00:00:00

  • New revelations from an old receptor: Immunoregulatory functions of the inhibitory Fc gamma receptor, FcγRIIB (CD32B).

    abstract::The Fc gamma receptor IIB (FcγRIIB/CD32B) was generated million years ago during evolution. It is the sole inhibitory receptor for IgG, and has long been associated with the regulation of humoral immunity and innate immune homeostasis. However, new and surprising functions of FcγRIIB are emerging. In particular, FcγRI...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审


    authors: Roghanian A,Stopforth RJ,Dahal LN,Cragg MS

    更新日期:2018-02-06 00:00:00

  • Frontline Science: Tim-3-mediated dysfunctional engulfment of apoptotic cells in SLE.

    abstract::T cell Ig and mucin domain-containing molecule 3 (Tim-3) has been found to play important roles in autoimmune diseases, but whether Tim-3-mediated engulfment of apoptotic cells is involved in systemic lupus erythematosus (SLE) remains to be elucidated. In this study, we verified the role of human Tim-3 (hTim-3) as the...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Zhao D,Guo M,Liu B,Lin Q,Xie T,Zhang Q,Jia X,Shu Q,Liang X,Gao L,Ma C

    更新日期:2017-12-01 00:00:00

  • Regulation of adaptive immune responses by innate cells expressing NK markers and antigen-transporting macrophages.

    abstract::A continuing theme of work done in our laboratory involves regulation of adaptive immune response by innate cells, in general, and immuneregulation by natural killer (NK) and NKT cells, in particular. Studies include work with the lung and the eye. In addition to immune surveillance of tumor cells, the NK cell is ofte...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审


    authors: Stein-Streilein J,Sonoda KH,Faunce D,Zhang-Hoover J

    更新日期:2000-04-01 00:00:00

  • Phosphoinositide3-kinase regulates actin polymerization during delayed phagocytosis of Helicobacter pylori.

    abstract::We have shown previously that ulcerogenic (type I) strains of Helicobacter pylori (Hp) retard their entry into macrophages. However, the signaling pathways that regulate Hp phagocytosis are largely undefined. We show here that Hp strongly activated class IA phosphoinositide3-kinases (PI3Ks) in macrophages, coincident ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Allen LA,Allgood JA,Han X,Wittine LM

    更新日期:2005-07-01 00:00:00

  • Stimulus-specific regulation of chemokine expression involves differential activation of the redox-responsive transcription factors AP-1 and NF-kappaB.

    abstract::The promoters of the IL-8, MCP-1, and RANTES genes contain binding sites for the redox-responsive transcription factors AP-1 and NF-kappaB, which have been shown to be important for their expression. In this overview, we present evidence from our laboratories that the stimulus-specific regulation of these chemokines b...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审


    authors: Roebuck KA,Carpenter LR,Lakshminarayanan V,Page SM,Moy JN,Thomas LL

    更新日期:1999-03-01 00:00:00

  • C1q and phagocytosis: the perfect complement to a good meal.

    abstract::Complement component C1q is a member of a family of soluble proteins called defense collagens, which are important in host defense and apoptotic cell clearance. Failure to efficiently clear apoptotic cells in the absence of C1q is associated with autoimmunity. Here, we review the literature describing a central role f...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审


    authors: Galvan MD,Greenlee-Wacker MC,Bohlson SS

    更新日期:2012-09-01 00:00:00

  • Charcot-Leyden crystal protein in the degranulation and recovery of activated basophils.

    abstract::The Charcot-Leyden crystal (CLC) protein, a prominent cell constituent unique to eosinophils and basophils, possesses lysophospholipase activity. This activity and the extracellular deposition and formation of CLC in tissues and body fluids in association with eosinophils suggest an extracellular function for this pro...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Golightly LM,Thomas LL,Dvorak AM,Ackerman SJ

    更新日期:1992-04-01 00:00:00

  • An eosinophil immune response characterizes the inflammatory skin disease observed in Tie-2 transgenic mice.

    abstract::Although mouse models of inflammatory skin diseases such as psoriasis and atopic dermatitis fail to completely phenocopy disease in humans, they provide invaluable tools to examine the molecular and cellular mechanisms responsible for the epidermal hyperplasia, inflammation, and excess angiogenesis observed in human d...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Voskas D,Babichev Y,Ling LS,Alami J,Shaked Y,Kerbel RS,Ciruna B,Dumont DJ

    更新日期:2008-07-01 00:00:00

  • Alpha-defensin expression during myelopoiesis: identification of cis and trans elements that regulate expression of NP-3 in rat promyelocytes.

    abstract::Alpha-defensins are antimicrobial peptides that contribute to innate-immune functions of neutrophils and intestinal Paneth cells. Transcription of alpha-defensin genes occurs early in neutrophilic myelopoeisis. To examine the mechanisms that regulate alpha-defensin gene expression, we analyzed transcription of rat neu...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Yamamoto CM,Banaiee N,Yount NY,Patel B,Selsted ME

    更新日期:2004-02-01 00:00:00

  • Interleukin-4 biases differentiation of B cells from Trypanosoma cruzi-infected mice and restrains their fratricide: role of Fas ligand down-regulation and MHC class II-transactivator up-regulation.

    abstract::In the present work, we demonstrate that interleukin (IL)-4 is able to rescue B cells from Trypanosoma cruzi-infected mice, counteracting the strong apoptotic signals that these cells received in vivo. We have observed that IL-4 restrains the apoptosis of immunoglobulin (Ig)M(+) and IgG(+) B cells from infected and no...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Acosta Rodriguez EV,Zuñiga E,Montes CL,Gruppi A

    更新日期:2003-01-01 00:00:00

  • Human B lymphoblastoid cells contain distinct patterns of cathepsin activity in endocytic compartments and regulate MHC class II transport in a cathepsin S-independent manner.

    abstract::Endocytic proteolysis represents a major functional component of the major histocompatibility complex class II antigen-presentation machinery. Although transport and assembly of class II molecules in the endocytic compartment are well characterized, we lack information about the pattern of endocytic protease activity ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Lautwein A,Kraus M,Reich M,Burster T,Brandenburg J,Overkleeft HS,Schwarz G,Kammer W,Weber E,Kalbacher H,Nordheim A,Driessen C

    更新日期:2004-05-01 00:00:00

  • Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice.

    abstract::Hepatic Macs, consisting of resident KCs and infiltrating monocytes/IMs, are thought to play an important role in the pathogenesis of ALD. Previous work has focused on KCs or studied hepatic Macs as one cell population. The aim of the current study is to distinguish IMs from KCs and to compare their phenotypes and fun...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Wang M,You Q,Lor K,Chen F,Gao B,Ju C

    更新日期:2014-10-01 00:00:00

  • RAGE: therapeutic target and biomarker of the inflammatory response--the evidence mounts.

    abstract::The RAGE binds multiple ligand families linked to hyperglycemia, aging, inflammation, neurodegeneration, and cancer. Activation of RAGE by its ligands stimulates diverse signaling cascades. The recent observation that the cytoplasmic domain of RAGE interacts with diaphanous or mDia-1 links RAGE signal transduction to ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审


    authors: Ramasamy R,Yan SF,Schmidt AM

    更新日期:2009-09-01 00:00:00

  • Cytokine responses of bovine dendritic cells and T cells following exposure to live or inactivated bovine respiratory syncytial virus.

    abstract::We compared the effects of live or inactivated bovine respiratory syncytial virus (BRSV) on cytokine production by bovine monocyte-derived dendritic cells (MoDC). We also investigated the response of resting memory CD4(+) T cells to MoDC exposed to both viral preparations. Although BRSV did not appear to replicate in ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Werling D,Collins RA,Taylor G,Howard CJ

    更新日期:2002-08-01 00:00:00

  • In vitro assessment of chemokine receptor-ligand interactions mediating mouse eosinophil migration.

    abstract::Eosinophil migration from circulation is controlled, in part, by chemokines through a family of G-protein-coupled chemokine receptors (CCR). Studies of human eosinophils have demonstrated that signaling through CCR3 receptors is a prominent pathway leading to chemotaxis, although several other receptor-ligand interact...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Borchers MT,Ansay T,DeSalle R,Daugherty BL,Shen H,Metzger M,Lee NA,Lee JJ

    更新日期:2002-06-01 00:00:00

  • The effect of adenovirus-specific antibodies on adenoviral vector-induced, transgene product-specific T cell responses.

    abstract::In this study, we tested the effect of neutralizing Abs to different serotypes of E1-deleted Ad vectors on the immunogenicity of the homologous Ad vector or a vector derived from a heterologous serotype. Our results showed that, as expected, even low titers of passively transferred neutralizing Abs significantly reduc...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Small JC,Haut LH,Bian A,Ertl HC

    更新日期:2014-11-01 00:00:00

  • Biochemical and functional differences between eosinophils from animal species and man.

    abstract::Eosinophils were isolated from peritoneal lavages of repeated horse serum-injected guinea pigs or rhesus monkeys and from peripheral blood of normal human donors. Eicosanoid metabolism and chemotaxis by these cells were studied by in vitro techniques. Upon calcium ionophore stimulation guinea pig eosinophils released ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Sun FF,Crittenden NJ,Czuk CI,Taylor BM,Stout BK,Johnson HG

    更新日期:1991-08-01 00:00:00

  • Differential presentation of tolerogenic immunoglobulin in vivo by macrophages and by a lymphoid dendritic cell-like tumor line.

    abstract::Previous work indicated that macrophages and a lymphoid dendritic cell-like tumor line, P388AD.2, possessed a differential ability to present a haptenated immunoglobulin (tolerogen) in vitro. Macrophages presented fluorescein-conjugated sheep gamma globulin (FL-SGG) and elicited B-cell unresponsiveness. In contrast, P...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Phipps RP,Illig K,Schad V,Bhimani K

    更新日期:1988-03-01 00:00:00

  • Profiling cellular heterogeneity in asthma with single cell multiparameter CyTOF.

    abstract::Asthma is a chronic inflammatory disease of the airways that afflicts over 30 million individuals in the United States and over 300 million individuals worldwide. The inflammatory response in the airways is often characterized by the analysis of sputum, which contains multiple types of cells including neutrophils, mac...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Stewart E,Wang X,Chupp GL,Montgomery RR

    更新日期:2020-11-01 00:00:00

  • Inhibitors of DNA methylation and histone deacetylation independently relieve AML1/ETO-mediated lysozyme repression.

    abstract::The human lysozyme (LZM) gene is highly methylated in LZM-nonexpressor immature myeloid and in nonmyeloid cells and unmethylated only in LZM-expressing cells. Extended methylation analyses of the CpG-poor 5' flanking region and of the exon 4 CpG island (both containing Alu elements) of the LZM gene were now performed....

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Claus R,Fliegauf M,Stock M,Duque JA,Kolanczyk M,Lübbert M

    更新日期:2006-12-01 00:00:00

  • The immune response in autism: a new frontier for autism research.

    abstract::Autism spectrum disorders (ASD) are part of a broad spectrum of neurodevelopmental disorders known as pervasive developmental disorders, which occur in childhood. They are characterized by impairments in social interaction, verbal and nonverbal communication and the presence of restricted and repetitive stereotyped be...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审


    authors: Ashwood P,Wills S,Van de Water J

    更新日期:2006-07-01 00:00:00

  • Type I interferon production in HIV-infected patients.

    abstract::Type I IFNs display multiple biological effects. They have a strong antiviral action, not only directly but also indirectly through activation of the immune system. They may also have actions that are deleterious for the host. The cells that produce type I IFN are mostly plasmacytoid dendritic cells (pDC), but this de...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审


    authors: Hosmalin A,Lebon P

    更新日期:2006-11-01 00:00:00

  • Function and regulation of the murine lymphocyte CD2 receptor.

    abstract::The CD2 receptor on T-lymphocytes plays a major part in mediating adhesive interactions via the LFA-3 ligand and in transducing signals for lymphocyte activation. In this study the expression, function, and internalization of the CD2 receptor was investigated in resting and activated murine T-cells. Surface iodination...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Abraham DJ,Bou-Gharios G,Beauchamp JR,Plater-Zyberk C,Maini RN,Olsen I

    更新日期:1991-04-01 00:00:00

  • Nitric oxide post-transcriptionally up-regulates LPS-induced IL-8 expression through p38 MAPK activation.

    abstract::Nitric oxide (NO(.-)) contributes to vascular collapse in septic shock and regulates inflammation. Here, we demonstrate in lipopolysaccharide (LPS)-stimulated human THP-1 cells and monocytes that NO(.-) regulates interleukin (IL)-8 and tumor necrosis factor alpha (TNF-alpha) by distinct mechanisms. Dibutyryl-cyclic gu...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Ma P,Cui X,Wang S,Zhang J,Nishanian EV,Wang W,Wesley RA,Danner RL

    更新日期:2004-07-01 00:00:00

  • Chemiluminescence and lymphocyte proliferation: parallelism in collaboration between subpopulations of thymus cells for both types of responses.

    abstract::Rat thymocytes respond to exposure to phytomitogens by oxidant generation as detected by chemiluminescence in presence of luminol. Maximal chemiluminescent response to a wide variety of plant lectins was obtained only after the cells had been incubated for 18 hours at 37 degrees C but not at 4 degrees C. This temperat...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Mookerjee BK,Wakerle H,Sharon N,Fischer H

    更新日期:1984-04-01 00:00:00

  • Colony-stimulating factor-1- and interleukin-34-derived macrophages differ in their susceptibility to Mycobacterium marinum.

    abstract::Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains the leading global cause of death from an infectious agent. Mycobacteria thrive within their host Mϕs and presently, there is no animal model that permits combined in vitro and in vivo study of mycobacteria-host Mϕ interactions. Mycoba...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Popovic M,Yaparla A,Paquin-Proulx D,Koubourli DV,Webb R,Firmani M,Grayfer L

    更新日期:2019-12-01 00:00:00

  • HVEM/LIGHT/BTLA/CD160 cosignaling pathways as targets for immune regulation.

    abstract::Immunosuppression is currently the treatment of choice to attenuate the chronic deterioration of tissue function as a result of the effector mechanisms of the immunological response in transplant rejection and autoimmune diseases. However, global immunosuppression greatly increases the risk of acquiring life-threateni...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审


    authors: del Rio ML,Lucas CL,Buhler L,Rayat G,Rodriguez-Barbosa JI

    更新日期:2010-02-01 00:00:00

  • Proteasome-mediated regulation of interleukin-1beta turnover and export in human monocytes.

    abstract::Interleukin-1beta is a secreted protein that accumulates in the cytosol as an inactive precursor (pIL-1beta) before processing and release of biologically active protein. To understand the impact of this property on IL-1beta production, we examined the intracellular stability of pIL-1beta in lipopolysaccharide (LPS)-s...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Moors MA,Mizel SB

    更新日期:2000-07-01 00:00:00