The effects of 16,16-dimethyl PGE2 and phosphodiesterase inhibitors on Con A blastogenic responses and NK cytotoxic activity of mouse spleen cells.

abstract：:MRL/fas(lpr) mice, which undergo a systemic autoimmune disease with similarities to systemic lupus erythematosus (SLE), display reduced pathology and prolonged survival if rendered deficient in ICAM-1. However, it remains unclear whether this is a result of the ability of ICAM-1 to promote the immune response or media...

journal_title：Journal of leukocyte biology

authors： Norman MU,James WG,Hickey MJ

更新日期：2008-07-01 00:00:00

abstract：:The immune system of astronauts is disturbed during and after spaceflight. This situation may result from stressors encountered during the flight (microgravity, radiation, psychological stress, or confinement) or from physiological changes (demineralization or fluid shift). Therefore, ground-based investigations shoul...

journal_title：Journal of leukocyte biology

authors： Schmitt DA,Schaffar L

更新日期：1993-09-01 00:00:00

abstract：:The influence of ethanol (EtOH) on multiple dendritic cell (DC) subsets, in the steady state or following their mobilization in vivo, has not been characterized. Herein, generation of mouse bone marrow-derived DC (BMDC) in response to fms-like tyrosine kinase 3 ligand was inhibited by physiologically relevant concentr...

journal_title：Journal of leukocyte biology

authors： Lau AH,Abe M,Thomson AW

更新日期：2006-05-01 00:00:00

abstract：:Although endosomes, lysosomes, and phagosomes require a reductive environment for the optimal activity of disulfide reductases and other thiol-dependent enzymes, how these reductive environments are established and maintained remain unknown. Our goal in this study was to begin to elucidate the redox control systems re...

journal_title：Journal of leukocyte biology

authors： Balce DR,Greene CJ,Tailor P,Yates RM

更新日期：2016-07-01 00:00:00

abstract：:Extracellular cold-inducible RNA-binding protein (eCIRP) is a damage-associated molecular pattern. Neutrophils present in the mononuclear cell fraction of Ficoll gradient separation are called low-density neutrophils (LDNs). Here we report the novel role of eCIRP on LDNs' heterogeneity in sepsis. Sepsis was induced in...

journal_title：Journal of leukocyte biology

authors： Takizawa S,Murao A,Ochani M,Aziz M,Wang P

更新日期：2020-10-18 00:00:00

abstract：:Inflammation-limiting nonsteroidal pain relievers magnify myocardial infarction (MI) incidences and increase re-admission events in heart failure (HF) patients. However, the molecular and cellular mechanism of this provocative adverse effect is unclear. Our goal was to determine whether carprofen (CAP) impedes splenic...

journal_title：Journal of leukocyte biology

authors： Halade GV,Kain V,Wright GM,Jadapalli JK

更新日期：2018-12-01 00:00:00

abstract：:GM-CSF is well recognized as a proliferative agent for hematopoietic cells and exerts a priming function on neutrophils. The aim of this study was to determine if GM-CSF has a role as a neutrophil chemoattractant in vivo and if it can contribute to recruitment during intestinal inflammation. Initial studies in vitro, ...

journal_title：Journal of leukocyte biology

authors： Khajah M,Millen B,Cara DC,Waterhouse C,McCafferty DM

更新日期：2011-06-01 00:00:00

abstract：:Human CD4+CD25+ regulatory T (T(R)) cells express the transcription factor forkhead box p3 (FOXP3) and have potent immunosuppressive properties. While naturally occurring T(R) cells develop in the thymus, adaptive T(R) cells develop in the periphery from naive CD4+ T cells. Adaptive T(R) cells may express cyclooxygena...

journal_title：Journal of leukocyte biology

authors： Mahic M,Yaqub S,Bryn T,Henjum K,Eide DM,Torgersen KM,Aandahl EM,Taskén K

更新日期：2008-05-01 00:00:00

abstract：:We show that interleukin-18 is constitutively produced by dendritic cells; synthesis and secretion are poorly affected by maturative stimuli. Challenge of dendritic cells with autologous anti-tetanus toxoid T lymphocytes results in a secretory switch, with induction of secretion of biologically active interleukin-18 a...

journal_title：Journal of leukocyte biology

authors： Gardella S,Andrei C,Costigliolo S,Poggi A,Zocchi MR,Rubartelli A

更新日期：1999-08-01 00:00:00

abstract：:p67(phox) is the paramount cytosolic regulator of the superoxide-generating Nox of phagocytes, by controlling the conformation of the catalytic component, Nox2. The initiating event of this process is a protein-protein interaction between p67(phox) and the part of Nox2 protruding into the cytosol, known as the dehydro...

journal_title：Journal of leukocyte biology

authors： Dahan I,Smith SM,Pick E

更新日期：2015-11-01 00:00:00

abstract：:Leukotriene B4 (LTB4 ) plays a prominent role in innate immunity as it induces phagocyte recruitment, the release of antimicrobial effectors, and as it potentiates the ingestion and killing of pathogens. In humans, LTB4 has a short half-life and is rapidly metabolized by leukocytes, notably into 20-OH- and 20-COOH-LTB...

journal_title：Journal of leukocyte biology

authors： Archambault AS,Poirier S,Lefebvre JS,Robichaud PP,Larose MC,Turcotte C,Martin C,Provost V,Boudreau LH,McDonald PP,Laviolette M,Surette ME,Flamand N

更新日期：2019-06-01 00:00:00

abstract：:NLRs are cytoplasmic proteins that sense cellular stress and intracellular damage resulting from pathogen uptake. To date, the role of NLRs has been studied using combinations of NLR and TLR agonists, but the interplay between two different NLRs remains uncharacterized. In this study, we employed microarrays to invest...

journal_title：Journal of leukocyte biology

authors： Conforti-Andreoni C,Beretta O,Licandro G,Qian HL,Urbano M,Vitulli F,Ricciardi-Castagnoli P,Mortellaro A

更新日期：2010-12-01 00:00:00

abstract：:Concanavalin A (Con A)-induced hepatitis is a model for human T cell-mediated hepatitis. We evaluated the role of L-selectin and intercellular adhesion molecule-1 (ICAM-1) in this model by injecting Con A intravenously in mice lacking L-selectin (L-selectin-/-), ICAM-1 (ICAM-1-/-), or both (L-selectin/ICAM-1-/-). Bloo...

journal_title：Journal of leukocyte biology

authors： Kawasuji A,Hasegawa M,Horikawa M,Fujita T,Matsushita Y,Matsushita T,Fujimoto M,Steeber DA,Tedder TF,Takehara K,Sato S

更新日期：2006-04-01 00:00:00

abstract：:In resident mouse peritoneal macrophages, group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) mediates arachidonic acid (AA) release and eicosanoid production in response to diverse agonists such as A23187, phorbol myristate acetate, zymosan, and the enterotoxin, okadaic acid (OA). cPLA(2)alpha is regulated by phosp...

journal_title：Journal of leukocyte biology

authors： Tucker DE,Gijón MA,Spencer DM,Qiu ZH,Gelb MH,Leslie CC

更新日期：2008-09-01 00:00:00

abstract：:Because myotonic dystrophy (MD) is an autosomal dominant multisystemic disorder affecting plasma membrane, we have studied the oxidative burst of PMNs. The PMA and fMet-Leu-Phe-stimulated superoxide generation is defective in the patient group as compared to controls: the response is both delayed and low. The kinetic ...

journal_title：Journal of leukocyte biology

authors： Mege JL,Pouget J,Capo C,Andre P,Benoliel AM,Serratrice G,Bongrand P

更新日期：1988-09-01 00:00:00

abstract：:We have developed a method that enables the rates of phagocytosis and killing of bacteria by neutrophils to be measured in a single assay. Neutrophils were incubated with bacteria, and at specific intervals were separated from uningested bacteria by low speed centrifugation. Rates of phagocytosis and killing were calc...

journal_title：Journal of leukocyte biology

authors： Hampton MB,Vissers MC,Winterbourn CC

更新日期：1994-02-01 00:00:00

abstract：:Interleukin-1beta is a secreted protein that accumulates in the cytosol as an inactive precursor (pIL-1beta) before processing and release of biologically active protein. To understand the impact of this property on IL-1beta production, we examined the intracellular stability of pIL-1beta in lipopolysaccharide (LPS)-s...

journal_title：Journal of leukocyte biology

authors： Moors MA,Mizel SB

更新日期：2000-07-01 00:00:00

abstract：:Macrophages play an important role in effector mechanisms of various chronic inflammatory diseases. We studied the effect of gluten, the agent inducing celiac disease, and other food antigens on the activation of macrophages. Nitric oxide (NO) and cytokine production were followed as markers of activation, using cultu...

journal_title：Journal of leukocyte biology

authors： Tucková L,Flegelová Z,Tlaskalová-Hogenová H,Zídek Z

更新日期：2000-03-01 00:00:00

abstract：:Leukocyte adhesion is a key factor in the pathogenesis of organ injury following a variety of stimuli. In this study we have addressed the role of leukocyte adhesion in hypertensives as a risk factor for organ injury. In the spontaneously hypertensive rat (SHR), the number of circulating leukocytes and their level of ...

journal_title：Journal of leukocyte biology

authors： Suzuki H,Zweifach BW,Forrest MJ,Schmid-Schönbein GW

更新日期：1995-01-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is a potent natural adjuvant, commonly used to amplify Th1 responses. Here, we report that systemic immunization using LPS generates large numbers of specific Th17 cells in murine small intestinal lamina propria. The priming of these Th17 cells required IL-23p19 production by bone marrow-deriv...

journal_title：Journal of leukocyte biology

authors： McAleer JP,Liu B,Li Z,Ngoi SM,Dai J,Oft M,Vella AT

更新日期：2010-07-01 00:00:00

abstract：:In this study, we demonstrate that freshly adherent bovine monocytes release tumor necrosis factor-alpha (TNF-alpha) in response to stimulation with bacterial lipopolysaccharide (LPS). TNF-alpha was detected using actinomycin D-treated WEHI-164 murine fibrosarcoma cells as targets in an 18 hr cytotoxicity assay. Doses...

journal_title：Journal of leukocyte biology

authors： Adams JL,Czuprynski CJ

更新日期：1990-12-01 00:00:00

abstract：:CXCL8 is the principal human neutrophil-attracting chemokine and a major mediator of inflammation. The chemokine exerts its neutrophil-chemotactic and neutrophil-activating activities via interaction with glycosaminoglycans (GAGs) and activation of the G protein-coupled receptors (GPCRs) CXCR1 and CXCR2. Natural CXCL8...

journal_title：Journal of leukocyte biology

authors： Metzemaekers M,Vandendriessche S,Berghmans N,Gouwy M,Proost P

更新日期：2020-06-01 00:00:00

abstract：:Murine CD11c(+)CD8alpha(-) and CD11c(+)CD8alpha(+) dendritic cells (DCs) differentially regulate T cell responses. Although specific chemokines that recruit immature (i) or mature (m) CD8alpha(-) DCs have been identified, little is known about the influence of chemokines on CD8alpha(+) DCs. iDCs and mDCs isolated from...

journal_title：Journal of leukocyte biology

authors： Colvin BL,Morelli AE,Logar AJ,Lau AH,Thomson AW

更新日期：2004-02-01 00:00:00

abstract：:Neutrophil apoptosis leads to macrophage ingestion of intact senescent neutrophils. This may represent a neutrophil removal mechanism that is important both in the control of inflammatory tissue injury and for the normal resolution processes of inflammation. Because apoptosis is likely to be a key control process in c...

journal_title：Journal of leukocyte biology

authors： Lee A,Whyte MK,Haslett C

更新日期：1993-10-01 00:00:00

abstract：:Secreted IgM (sIgM) is a multifunctional evolutionary conserved antibody that is critical for the maintenance of tissue homeostasis as well as the development of fully protective humoral responses to pathogens. Constitutive secretion of self- and polyreactive natural IgM, produced mainly by B-1 cells, provides a circu...

journal_title：Journal of leukocyte biology

authors： Blandino R,Baumgarth N

更新日期：2019-11-01 00:00:00

abstract：:Previous studies about basophils and mast cells identified the ability of IgE to up-regulate FcepsilonRI expression by a process that depends on stabilization of the surface receptor by IgE. However, the mechanism of loss from the cell surface, when unoccupied, is not known. The current studies have examined whether u...

journal_title：Journal of leukocyte biology

authors： MacGlashan DW Jr

更新日期：2007-10-01 00:00:00

abstract：:The adjuvant effect of gamma-inulin, a strong activator of the alternative complement pathway, is well-known, but its exact mechanism is not revealed yet. Here, we show that macrophages, isolated from the peritoneal cavity of gamma-inulin-injected mice and used as antigen-presenting cells, enhance the proliferation of...

journal_title：Journal of leukocyte biology

authors： Kerekes K,Cooper PD,Prechl J,Józsi M,Bajtay Z,Erdei A

更新日期：2001-01-01 00:00:00

abstract：:The adhesion molecule CD44 consists of many isoforms of which particularly CD44v7 is of major importance in hematopoietic progenitor cell homing. An increase of progenitor cells in the periphery was observed after treating mice with a CD44v7-specific antibody, concomitant with a substantially augmented marrow-repopula...

journal_title：Journal of leukocyte biology

authors： Christ O,Günthert U,Haas R,Zöller M

更新日期：2001-03-01 00:00:00

abstract：:Annexin A1 is a glucocorticoid-regulated, anti-inflammatory protein, which plays an important role as an endogenous regulator of the inflammatory response. Many of these anti-inflammatory properties are retained in the N-terminal annexin A1 peptide Ac1-25, which is released from the full-length protein by a neutrophil...

journal_title：Journal of leukocyte biology

authors： Lange C,Starrett DJ,Goetsch J,Gerke V,Rescher U

更新日期：2007-12-01 00:00:00

abstract：:Neutrophils are quickly recruited to tissues in response to proinflammatory cues; however, little is known about tissue neutrophil phenotypes in health. We employ a multicolor flow cytometric approach to assess surface markers of activation on neutrophils from the bone marrow, blood, peritoneum, spleen, liver, fat, co...

journal_title：Journal of leukocyte biology

authors： Chadwick JW,Fine N,Khoury W,Tasevski N,Sun CX,Boroumand P,Klip A,Glogauer M

更新日期：2020-11-04 00:00:00