Retinal transplantation: progress and problems in clinical application.

abstract：:Angiogenesis is essential in many physiological and pathological processes and can be stimulated by many different factors. To better understand and to manipulate this process more effectively, it would be beneficial to identify molecules common to the signaling pathways stimulated by different classes of angiogenic f...

journal_title：Journal of leukocyte biology

authors： Yao M,Zhou RH,Petreaca M,Zheng L,Shyy J,Martins-Green M

更新日期：2006-09-01 00:00:00

abstract：:The role of monocyte chemoattractant protein-1 (MCP-1) in the recruitment of blood-derived monocytes in a model of zymosan peritoneal inflammation was investigated. After zymosan injection (1 mg) a rapid influx of polymorphonuclear leukocytes (PMN) and monocytes into the peritoneal cavity associated with mouse MCP-1 (...

journal_title：Journal of leukocyte biology

authors： Ajuebor MN,Flower RJ,Hannon R,Christie M,Bowers K,Verity A,Perretti M

更新日期：1998-01-01 00:00:00

abstract：:Mer signaling participates in a novel inhibitory pathway in TLR activation. The purpose of the present study was to examine the role of Mer signaling in the down-regulation of TLR4 activation-driven immune responses in mice, i.t.-treated with LPS, using the specific Mer-blocking antibody. At 4 h and 24 h after LPS tre...

journal_title：Journal of leukocyte biology

authors： Lee YJ,Han JY,Byun J,Park HJ,Park EM,Chong YH,Cho MS,Kang JL

更新日期：2012-06-01 00:00:00

abstract：:Interaction of bacterial lipopolysaccharide (LPS) with monocytes stimulates production of a variety of mediators that are involved in the pathogenesis of septic shock and wound repair. We report here the mechanisms of LPS uptake and intracellular distribution of LPS in human monocytes. Ficoll-Hypaque-purified peripher...

journal_title：Journal of leukocyte biology

authors： Kang YH,Dwivedi RS,Lee CH

更新日期：1990-10-01 00:00:00

abstract：:The tissue-fixed macrophage is a key cellular element in the initiation and regulation of inflammation. Understanding the regulation of macrophage activation may provide valuable clues to the mechanisms involved in both beneficial and deleterious effects of inflammation. The lymphokine interferon-gamma (IFN-gamma) is ...

journal_title：Journal of leukocyte biology

authors： Williams JG,Jurkovich GJ,Hahnel GB,Maier RV

更新日期：1992-12-01 00:00:00

abstract：:Nucleotide receptors serve as sensors of extracellular ATP and are important for immune function. The nucleotide receptor P2RX7 is a cell-surface, ligand-gated cation channel that has been implicated in many diseases, including arthritis, granuloma formation, sepsis, and tuberculosis. These disorders are often exacerb...

journal_title：Journal of leukocyte biology

authors： Gavala ML,Pfeiffer ZA,Bertics PJ

更新日期：2008-10-01 00:00:00

abstract：:TLRs act as sentinels in professional immune cells to detect and initiate the innate immune response to pathogen challenge. TLR4 is a widely expressed TLR, responsible for initiating potent immune responses to LPS. TRAM acts to bridge TLR4 with TRIF, orchestrating the inflammatory response to pathogen challenge. We ha...

journal_title：Journal of leukocyte biology

authors： Verstak B,Stack J,Ve T,Mangan M,Hjerrild K,Jeon J,Stahl R,Latz E,Gay N,Kobe B,Bowie AG,Mansell A

更新日期：2014-09-01 00:00:00

abstract：:Fetal alcohol spectrum disorder (FASD), which results from ethanol exposure during pregnancy, and alcohol use disorder (AUD), which includes both binge and chronic alcohol abuse, are strikingly common and costly at personal and societal levels. These disorders are associated with significant pathology, including that ...

journal_title：Journal of leukocyte biology

authors： Kane CJ,Drew PD

更新日期：2016-11-01 00:00:00

abstract：:We reported that PARP-1 exhibits differential roles in expression of inflammatory factors. Here, we show that PARP-1 deletion was associated with a significant reduction in inflammatory cell recruitment to mouse airways upon intratracheal administration of LPS. However, PARP-1 deletion exerted little effect in respons...

journal_title：Journal of leukocyte biology

authors： Zerfaoui M,Naura AS,Errami Y,Hans CP,Rezk BM,Park J,Elsegeiny W,Kim H,Lord K,Kim JG,Boulares AH

更新日期：2009-12-01 00:00:00

abstract：:To understand the modulation and the behavior of glycocalyx elements during adhesion, we explored one of its components, the CD43 molecule, on human monocytic THP-1 cells exposed to cytokine stimulation and its redistribution during heterotypic adhesion to opsonized erythrocytes. First we demonstrated by immunofluores...

journal_title：Journal of leukocyte biology

authors： Soler M,Merant C,Servant C,Fraterno M,Allasia C,Lissitzky JC,Bongrand P,Foa C

更新日期：1997-05-01 00:00:00

abstract：:Several alterations in the expression of immune-related transcripts were identified recently in the degenerating retina of the retinoschisin knockout (Rs1h(-/Y)) mouse, including the strong expression of the adaptor protein Dap12. As Dap12 is found in leukocytes, we hypothesized that its disease-related expression may...

journal_title：Journal of leukocyte biology

authors： Weigelt K,Ernst W,Walczak Y,Ebert S,Loenhardt T,Klug M,Rehli M,Weber BH,Langmann T

更新日期：2007-12-01 00:00:00

abstract：:The immune system in early life is regarded as immature. However, the IL-12 family member IL-23 is highly produced upon TLR stimulation by neonatal DCs. Human adult Vγ9Vδ2 T cells can be stimulated specifically via their TCR by phosphoantigens (as the pathogen-derived HMB-PP) or agents and infections that lead to thei...

journal_title：Journal of leukocyte biology

authors： Moens E,Brouwer M,Dimova T,Goldman M,Willems F,Vermijlen D

更新日期：2011-05-01 00:00:00

abstract：:The transcription factor nuclear factor (NF)-kappaB controls the expression of genes involved in inflammation, cell proliferation, apoptosis, and differentiation. Impaired regulation of NF-kappaB has been associated with many diseases; thus, there is significant interest in therapeutic approaches based on modulation o...

journal_title：Journal of leukocyte biology

authors： Diatchenko L,Romanov S,Malinina I,Clarke J,Tchivilev I,Li X,Makarov SS

更新日期：2005-12-01 00:00:00

abstract：:Mast cells and MDSCs are increased by parasitic infection and tumor growth. We previously demonstrated that enhanced MDSC development in ADAM10 transgenic mice yielded resistance to Nb infection and that coculturing MDSCs and mast cells enhanced cytokine production. In the current work, we show that MDSC-mast cell coc...

journal_title：Journal of leukocyte biology

authors： Morales JK,Saleem SJ,Martin RK,Saunders BL,Barnstein BO,Faber TW,Pullen NA,Kolawole EM,Brooks KB,Norton SK,Sturgill J,Graham L,Bear HD,Urban JF Jr,Lantz CS,Conrad DH,Ryan JJ

更新日期：2014-04-01 00:00:00

abstract：:The key role of TRAF6 in TLR signaling pathways is well known. More recent evidence has implicated TRAF3 as another TRAF family member important to certain TLR responses of myeloid cells. Previous studies demonstrate that TRAF3 functions are highly context-dependent, displaying receptor and cell-type specificity. We t...

journal_title：Journal of leukocyte biology

authors： Xie P,Poovassery J,Stunz LL,Smith SM,Schultz ML,Carlin LE,Bishop GA

更新日期：2011-12-01 00:00:00

abstract：:Eosinophils were isolated from peritoneal lavages of repeated horse serum-injected guinea pigs or rhesus monkeys and from peripheral blood of normal human donors. Eicosanoid metabolism and chemotaxis by these cells were studied by in vitro techniques. Upon calcium ionophore stimulation guinea pig eosinophils released ...

journal_title：Journal of leukocyte biology

authors： Sun FF,Crittenden NJ,Czuk CI,Taylor BM,Stout BK,Johnson HG

更新日期：1991-08-01 00:00:00

abstract：:The triggering receptor expressed on myeloid cell locus encodes a family of receptors that is emerging as an important class of molecules involved in modulating the innate immune response and inflammation. Of the 4 conserved members, including triggering receptor expressed on myeloid cells 1 and 2 and triggering recep...

journal_title：Journal of leukocyte biology

authors： Thomas KA,King RG,Sestero CM,Justement LB

更新日期：2016-07-01 00:00:00

abstract：:The expression of the inducible isoform of nitric oxide synthase (NOS2, iNOS) is increased in patients undergoing sepsis as well as in animal models in which septic shock is induced by injection of bacterial lipopolysaccharide (LPS). Transforming growth factor-beta1 (TGF-beta1) potently suppresses NO production both i...

journal_title：Journal of leukocyte biology

authors： Vodovotz Y,Kopp JB,Takeguchi H,Shrivastav S,Coffin D,Lucia MS,Mitchell JB,Webber R,Letterio J,Wink D,Roberts AB

更新日期：1998-01-01 00:00:00

abstract：:The adhesion molecule CD44 consists of many isoforms of which particularly CD44v7 is of major importance in hematopoietic progenitor cell homing. An increase of progenitor cells in the periphery was observed after treating mice with a CD44v7-specific antibody, concomitant with a substantially augmented marrow-repopula...

journal_title：Journal of leukocyte biology

authors： Christ O,Günthert U,Haas R,Zöller M

更新日期：2001-03-01 00:00:00

abstract：:Mono-Mac-6 (MM6) human monocytes ingest IgG-opsonized particles better than other human cell lines. We compared the phagocytic signaling pathway in MM6 with human monocytes. MM6 expressed FcgammaRI at levels similar to monocytes, whereas FcRgammaII expression was approximately double. MM6 ingested IgG-opsonized erythr...

journal_title：Journal of leukocyte biology

authors： Karimi K,Gemmill TR,Lennartz MR

更新日期：1999-06-01 00:00:00

abstract：:In inflammatory diseases, circulating neutrophils are recruited to sites of injury. Attractant signals are provided by many different chemotactic molecules, such that blockade of one may not prevent neutrophil recruitment effectively. The Slit family of secreted proteins and their transmembrane receptor, Robo, repel a...

journal_title：Journal of leukocyte biology

authors： Tole S,Mukovozov IM,Huang YW,Magalhaes MA,Yan M,Crow MR,Liu GY,Sun CX,Durocher Y,Glogauer M,Robinson LA

更新日期：2009-12-01 00:00:00

abstract：:The adhesion and degranulation promoting adaptor protein (ADAP) is a multifunctional scaffold involved in many different signaling pathways that are important for the function of T cells, including the inside-out and outside-in signaling of integrins, the activation of NF-κB, and the subsequent production of proinflam...

journal_title：Journal of leukocyte biology

authors： Parzmair GP,Gereke M,Haberkorn O,Annemann M,Podlasly L,Kliche S,Reinhold A,Schraven B,Bruder D

更新日期：2017-02-01 00:00:00

abstract：:This study investigated the expression of MUC5B by AMs in the lungs of cigarette smokers and nonsmokers. We analyzed MUC5B expression by measuring the levels of apomucin and mRNA in human BALF cells from 50 subjects (20 nonsmokers, 17 patients with CB, and 13 patients with COPD). apoMUC5B was observed in BALF mononucl...

journal_title：Journal of leukocyte biology

authors： Sepper R,Prikk K,Metsis M,Sergejeva S,Pugatsjova N,Bragina O,Marran S,Fehniger TE

更新日期：2012-08-01 00:00:00

abstract：:The macrophage mannose receptor (MR) appears to play an important role in the binding and phagocytosis of several human pathogens, but its phagocytic property and signaling pathways have been poorly defined. The general strategy to explore such topics is to express the protein of interest in nonphagocytic cells, but i...

journal_title：Journal of leukocyte biology

authors： Le Cabec V,Emorine LJ,Toesca I,Cougoule C,Maridonneau-Parini I

更新日期：2005-06-01 00:00:00

abstract：:Mast cells are immune sentinels and a driving force in both normal and pathological contexts of inflammation, with a prominent role in allergic hypersensitivities. Crosslinking of FcεRI by allergen-bound IgE Abs leads to mast cell degranulation, resulting in an early-phase response and release of newly synthesized pro...

journal_title：Journal of leukocyte biology

authors： Yousef M,Crozier RWE,Hicks NJ,Watson CJF,Boyd T,Tsiani E,MacNeil AJ

更新日期：2020-05-01 00:00:00

abstract：:ADAM23 is a member of the brain macrophage-derived chemokine family. Structural homology of ADAM proteins suggests their function as integrin receptors. Previous studies have linked ADAM23 as a dominant contributor to brain development and cancer metastasis. The present studies now show that ADAM23 expression on DCs p...

journal_title：Journal of leukocyte biology

authors： Elizondo DM,Andargie TE,Marshall KM,Zariwala AM,Lipscomb MW

更新日期：2016-11-01 00:00:00

abstract：:We examined the relationship of I-A expression by normal murine macrophages to their immunoregulatory role on natural killer cell activity. Macrophages were isolated on the basis of plastic adherence; characterized on the basis of conventional markers such as phagocytic ability, cytoplasmic non-specific esterase activ...

journal_title：Journal of leukocyte biology

authors： Nelson JA,Parhar RS,Scodras JM,Lala PK

更新日期：1990-11-01 00:00:00

abstract：:We have developed a method that enables the rates of phagocytosis and killing of bacteria by neutrophils to be measured in a single assay. Neutrophils were incubated with bacteria, and at specific intervals were separated from uningested bacteria by low speed centrifugation. Rates of phagocytosis and killing were calc...

journal_title：Journal of leukocyte biology

authors： Hampton MB,Vissers MC,Winterbourn CC

更新日期：1994-02-01 00:00:00

abstract：:Apoptotic loss of CD4+ T cells has been proposed as a mechanism of T cell depletion in human immunodeficiency virus (HIV) infections resulting in immunodeficiency. The Env glycoprotein has been implicated in apoptosis of uninfected bystander cells via gp120 binding to CD4/CXC chemokine receptor 4 as well as the fusion...

journal_title：Journal of leukocyte biology

authors： Garg H,Blumenthal R

更新日期：2006-02-01 00:00:00

abstract：:We show that interleukin-18 is constitutively produced by dendritic cells; synthesis and secretion are poorly affected by maturative stimuli. Challenge of dendritic cells with autologous anti-tetanus toxoid T lymphocytes results in a secretory switch, with induction of secretion of biologically active interleukin-18 a...

journal_title：Journal of leukocyte biology

authors： Gardella S,Andrei C,Costigliolo S,Poggi A,Zocchi MR,Rubartelli A

更新日期：1999-08-01 00:00:00