Dendritic cell expression of ADAM23 governs T cell proliferation and cytokine production through the α(v)β(3) integrin receptor.

abstract：:Human alveolar macrophages (AMO) have been investigated for their ability to produce three monokines, tumor necrosis factor-alpha (TNF), macrophage colony stimulating factor (CSF-1), and interleukin 1-beta (IL-1). No TNF activity was found in supernatants of unstimulated AMO cultured for 20 h, although TNF mRNA was de...

journal_title：Journal of leukocyte biology

authors： Becker S,Devlin RB,Haskill JS

更新日期：1989-04-01 00:00:00

abstract：:Epinephrine inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF) production by increasing intracellular cAMP concentrations. Because agents that increase cAMP levels can enhance TNF receptor expression in vitro, granulocyte and monocyte TNF receptors were determined by FACS-analysis in 7 normal humans...

journal_title：Journal of leukocyte biology

authors： van der Poll T,Calvano SE,Kumar A,Coyle SM,Lowry SF

更新日期：1997-02-01 00:00:00

abstract：:In this study, we have investigated the expression of phospholipase C-beta2 during the course of granulocytic differentiation of normal and malignant progenitors. As a model system, we used the NB4 cell line, a reliable in vitro model for the study of acute promyelocytic leukemia (APL), a variety of acute myeloid leuk...

journal_title：Journal of leukocyte biology

authors： Bertagnolo V,Marchisio M,Pierpaoli S,Colamussi ML,Brugnoli F,Visani G,Zauli G,Capitani S

更新日期：2002-06-01 00:00:00

abstract：:Alpha-defensins are antimicrobial peptides that contribute to innate-immune functions of neutrophils and intestinal Paneth cells. Transcription of alpha-defensin genes occurs early in neutrophilic myelopoeisis. To examine the mechanisms that regulate alpha-defensin gene expression, we analyzed transcription of rat neu...

journal_title：Journal of leukocyte biology

authors： Yamamoto CM,Banaiee N,Yount NY,Patel B,Selsted ME

更新日期：2004-02-01 00:00:00

abstract：:Evidence that gamma/delta T cells play a broad, immunoregulatory role has been accumulating steadily. We show here that myeloid cells are disregulated after peritoneal infection with Listeria monocytogenes in mice lacking gamma/delta T cells. Inflammatory populations of neutrophils and monocytes recruited to the site ...

journal_title：Journal of leukocyte biology

authors： Skeen MJ,Freeman MM,Ziegler HK

更新日期：2004-07-01 00:00:00

abstract：:The agent(s) and mechanism(s) responsible for suppression of neutrophil chemotaxis in association with major thermal injury have not been identified. We have proposed that the reduced random motility characterizing patients' cells may contribute to their generalized chemotactic dysfunction. Here we report that actin p...

journal_title：Journal of leukocyte biology

authors： Hasslen SR,Ahrenholz DH,Solem LD,Nelson RD

更新日期：1992-11-01 00:00:00

abstract：:The magnitude and efficacy of CD8(+) T cell memory may notably regress, especially if immune induction occurs in the absence of adequate CD4(+) help. This report demonstrates that this CD8(+) memory malfunction could be remedied if a source of cognate antigen-recognizing helper cells were provided during recall. The i...

journal_title：Journal of leukocyte biology

authors： Kumaraguru U,Banerjee K,Rouse BT

更新日期：2005-10-01 00:00:00

abstract：:TLRs mediate host defense against microbial pathogens by eliciting production of inflammatory mediators and activating expression of MHC, adhesion, and costimulatory molecules. Endotoxin tolerance limits excessive TLR-driven inflammation during sepsis and reprograms macrophage responses to LPS, decreasing expression o...

journal_title：Journal of leukocyte biology

authors： Xiong Y,Medvedev AE

更新日期：2011-12-01 00:00:00

abstract：:Apoptosis of polymorphonuclear leukocytes (PMNs) is a critical step in the resolution of tissue inflammation. PMN apoptosis has been studied extensively in vitro, and diverse inflammatory mediators have been shown to modulate the process. The reported effects of interleukin-6 (IL-6) on PMN apoptosis are inconsistent; ...

journal_title：Journal of leukocyte biology

authors： Biffl WL,Moore EE,Moore FA,Barnett CC Jr

更新日期：1995-11-01 00:00:00

abstract：:Group B streptococcal (GBS) infections are associated with high morbidity and mortality. The molecular pathways mediating the pathophysiological events in GBS infection are not fully delineated. Cyclooxygenases (COX) are the enzymes that convert arachidonate to active eicosanoids. To identify the effects of GBS on eic...

journal_title：Journal of leukocyte biology

authors： Maloney CG,Thompson SD,Hill HR,Bohnsack JF,McIntyre TM,Zimmerman GA

更新日期：2000-05-01 00:00:00

abstract：:Dendritic cells (DCs) are specialized APCs present in all tissues, including tumors. They play a major role in orchestrating immune responses and were shown to occur in various functional states in tumors. In this respect, immunogenic tumor-associated DCs (TADCs) are required to initiate and sustain T cell-dependent a...

journal_title：Journal of leukocyte biology

authors： Keirsse J,Van Damme H,Van Ginderachter JA,Laoui D

更新日期：2017-08-01 00:00:00

abstract：:Macrophage-like tumor cells can be obtained in large quantities as rather homogeneous populations, making these cells useful for chemotaxis assays. Therefore, macrophage-like cells J774A, WEHI-3, P388D1, IC-21, and NCTC 1469, all of murine origin, and U937 of human origin, were tested for chemotactic activity to a num...

journal_title：Journal of leukocyte biology

authors： Terheggen P,Van Loveren H,Den Otter W

更新日期：1985-12-01 00:00:00

abstract：:The receptor for urokinase plasminogen activator (uPAR; CD87) is a 50- to 65-kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed by leukocytes and tumor cells where it facilitates uPA-dependent, plasmin-mediated pericellular proteolysis during cellular invasion. Because uPAR is inducibly shed into c...

journal_title：Journal of leukocyte biology

authors： Mizukami IF,Todd RF 3rd

更新日期：1998-08-01 00:00:00

abstract：:A cell resistant to concentrations of mitomycin-C associated with the inactivation of many in vitro immune responses is described. This cell is responsive to concanavalin A (Con A), poorly adherent to nylon wool, present in relatively greater numbers in lymph node than other lymphoid tissues, and is relatively radiose...

journal_title：Journal of leukocyte biology

authors： Anderson RE,Standefer JC,Troup GM,Pogue LE

更新日期：1987-01-01 00:00:00

abstract：:The effect of coupling C3bi to immunoglobulin G (IgG) immune complexes (IC) on their ability to produce protein tyrosine phosphorylation and activation of the mitogen-activated protein kinase (MAPK) and the Akt/protein kinase B (PKB) routes was assessed in human monocytes. Cross-linking Fc receptors for IgG activated ...

journal_title：Journal of leukocyte biology

authors： Trinidad AG,de la Puerta ML,Fernández N,Bayón Y,Crespo MS,Alonso A

更新日期：2006-05-01 00:00:00

abstract：:ANCA to either PR3 or MPO are found in patients with necrotizing vasculitis and glomerulonephritis. ANCA binding to their target antigens on neutrophils and subsequent neutrophil activation are pivotal disease mechanisms that lead to vascular inflammation and necrosis. ANCA interaction with PR3 is more complex than wi...

journal_title：Journal of leukocyte biology

authors： Schreiber A,Eulenberg-Gustavus C,Bergmann A,Jerke U,Kettritz R

更新日期：2016-12-01 00:00:00

abstract：:Neutrophils are the most abundant leukocytes in blood. From the circulation, they are quickly mobilized to sites of inflammation and/or infection. At the affected tissues, neutrophils display an impressive array of antimicrobial functions, including degranulation, production of reactive oxygen species (ROS), phagocyto...

journal_title：Journal of leukocyte biology

authors： Rosales C

更新日期：2020-07-01 00:00:00

abstract：:Neutrophils phagocytize high-valency immune complexes (HIC) by an Fc gamma receptor-mediated mechanism, activating an oxidative burst and initiating degranulation. In contrast, neutrophils exhibit chemotaxis to N-formylated peptides [e.g., N-formyl-methionyl-leucyl-phenylalanine (fMLP)] and secrete far fewer oxidants ...

journal_title：Journal of leukocyte biology

authors： Gewirtz AT,Simons ER

更新日期：1997-04-01 00:00:00

abstract：:The production of IL-12 by macrophages/dendritic cells (Mphi/DC) is mediated either by a T cell-dependent pathway that is induced primarily by the interaction of CD40 ligand (CD40L) on activated T cells with CD40 on IL-12-producing cells or by a T cell-independent pathway that is induced by bacteria or bacterial produ...

journal_title：Journal of leukocyte biology

authors： Takenaka H,Maruo S,Yamamoto N,Wysocka M,Ono S,Kobayashi M,Yagita H,Okumura K,Hamaoka T,Trinchieri G,Fujiwara H

更新日期：1997-01-01 00:00:00

abstract：:Highly active antiretroviral therapy (HAART) against human immunodeficiency virus type 1 (HIV-1) infection dramatically suppresses viral load, leading to marked reductions in HIV-1 associated morbidity and mortality. However, infected cell reservoirs and low-level replication persist in the face of suppressive HAART, ...

journal_title：Journal of leukocyte biology

authors： Kennedy PE,Bera TK,Wang QC,Gallo M,Wagner W,Lewis MG,Berger EA,Pastan I

更新日期：2006-11-01 00:00:00

abstract：:Mycobacterium tuberculosis antigens that are recognized by human CD8+ T cells are potentially important vaccine target molecules. We used a motif-based strategy to screen selected proteins of M. tuberculosis for peptides predicted to bind to human leukocyte antigen (HLA)-A*0201. We identified two 10 amino acid peptide...

journal_title：Journal of leukocyte biology

authors： Shams H,Barnes PF,Weis SE,Klucar P,Wizel B

更新日期：2003-12-01 00:00:00

abstract：:In this study we present data on a novel cell surface antigen recognized by monoclonal antibody (mAb) VPM30, originally thought to recognize only bovine and ovine sIg+ B cells from peripheral blood. Here we show that the antigen, molecular mass 28 kDa, is not only found in B cell follicles in frozen sections, but when...

journal_title：Journal of leukocyte biology

authors： Campbell JD,Hopkins J,Howie SE,Oliver RA,Nichani AK,Goel P,Spooner RL,Glass EJ

更新日期：1998-05-01 00:00:00

abstract：:Vascular occlusion is the main cause of the morbidity and mortality observed in patients with sickle cell disease (SCD). Increasing evidence indicates that (activated) neutrophils could play an important role in the initiation and propagation of vaso-occlusive processes in SCD. In this study, the activation state of n...

journal_title：Journal of leukocyte biology

authors： Lard LR,Mul FP,de Haas M,Roos D,Duits AJ

更新日期：1999-09-01 00:00:00

abstract：:The role of JNK in neutrophil chemotaxis and killing of microbial pathogens remains unclear. Using a recently described cell-permeable peptide inhibitor of the JNK pathway, based on the JBD of JIP-1, coupled to the protein transduction domain of HIV-TAT (TAT-JIP), in association with control peptides, we demonstrate t...

journal_title：Journal of leukocyte biology

authors： Yeh MC,Mukaro V,Hii CS,Ferrante A

更新日期：2010-05-01 00:00:00

abstract：:We identified fresh human leukocytes as an abundant source of the candidate epithelial tumor suppressor gene, Ecrg4, an epigenetically regulated gene, which unlike other tumor suppressor genes, encodes an orphan-secreted, ligand-like protein. In human cell lines, Ecrg4 gene expression was low, Ecrg4 protein undetectab...

journal_title：Journal of leukocyte biology

authors： Baird A,Coimbra R,Dang X,Lopez N,Lee J,Krzyzaniak M,Winfield R,Potenza B,Eliceiri BP

更新日期：2012-05-01 00:00:00

abstract：:Lymphocyte development is initiated from hematopoietic stem cells and can be divided into multiple phenotypically distinct stages. Transcription factors play important roles in programming the developmental process of lymphocytes. Recent studies have identified key roles of several orphan nuclear receptors in T lympho...

journal_title：Journal of leukocyte biology

authors： He YW

更新日期：2002-09-01 00:00:00

abstract：:We compared the effects of live or inactivated bovine respiratory syncytial virus (BRSV) on cytokine production by bovine monocyte-derived dendritic cells (MoDC). We also investigated the response of resting memory CD4(+) T cells to MoDC exposed to both viral preparations. Although BRSV did not appear to replicate in ...

journal_title：Journal of leukocyte biology

authors： Werling D,Collins RA,Taylor G,Howard CJ

更新日期：2002-08-01 00:00:00

abstract：:Macrophages and dendritic cells are in the front line of host defense. When they sense host invasion, they produce cytokines that alert other innate immune cells and also abet the development of an adaptive immune response. Although lipolysaccharide (LPS), peptidoglycan, unmethylated DNA, and other microbial products ...

journal_title：Journal of leukocyte biology

authors： Beutler B,Hoebe K,Du X,Ulevitch RJ

更新日期：2003-10-01 00:00:00

abstract：:Macrophages (m phi s), important cells in host resistance, undergo a series of biochemical changes during their progression from the resident to the fully activated stage. Both resident and inflammatory m phi s are characterized by some unique properties. In the present study, female BALB/c mice were prenatally treate...

journal_title：Journal of leukocyte biology

authors： Theus SA,Lau KA,Tabor DR,Soderberg LS,Barnett JB

更新日期：1992-04-01 00:00:00

abstract：:Inbred strains of mice, notably the susceptible C57BL/6 and the resistant A/J strains of mice, were infected with a strain of Mycobacterium evium. The infection in the visceral organs of mice was then studied, and the effect of colony-stimulating factors, i.e., interleukin-3 (IL-3), granulocyte-macrophage colony-stimu...

journal_title：Journal of leukocyte biology

authors： Denis M

更新日期：1991-09-01 00:00:00