Characterization of macrophage subsets regulating murine natural killer cell activity.

abstract：:The expression of the inducible isoform of nitric oxide synthase (NOS2, iNOS) is increased in patients undergoing sepsis as well as in animal models in which septic shock is induced by injection of bacterial lipopolysaccharide (LPS). Transforming growth factor-beta1 (TGF-beta1) potently suppresses NO production both i...

journal_title：Journal of leukocyte biology

authors： Vodovotz Y,Kopp JB,Takeguchi H,Shrivastav S,Coffin D,Lucia MS,Mitchell JB,Webber R,Letterio J,Wink D,Roberts AB

更新日期：1998-01-01 00:00:00

abstract：:The role of monocyte chemoattractant protein-1 (MCP-1) in the recruitment of blood-derived monocytes in a model of zymosan peritoneal inflammation was investigated. After zymosan injection (1 mg) a rapid influx of polymorphonuclear leukocytes (PMN) and monocytes into the peritoneal cavity associated with mouse MCP-1 (...

journal_title：Journal of leukocyte biology

authors： Ajuebor MN,Flower RJ,Hannon R,Christie M,Bowers K,Verity A,Perretti M

更新日期：1998-01-01 00:00:00

abstract：:Radioprotective 105 kDa (CD180) is an unusual TLR that lacks an intracellular Toll-IL-1R signaling domain and exhibits unconventional homodimerization behavior. Differential expression and functions of radioprotective 105 kDa have been associated with immune-mediated pathologies, including infection, chronic inflammat...

journal_title：Journal of leukocyte biology

authors： Schultz TE,Blumenthal A

更新日期：2017-01-01 00:00:00

abstract：:The membrane fusion events observed during neutrophil degranulation are important aspects of the immunoregulatory system. In an attempt to understand the regulation of granule-plasma membrane fusion, we have begun characterizing human neutrophil cytosol for fusion activity, finding that 50% of the fusogenic activity c...

journal_title：Journal of leukocyte biology

authors： Hessler RJ,Blackwood RA,Brock TG,Francis JW,Harsh DM,Smolen JE

更新日期：1998-03-01 00:00:00

abstract：:Neutrophils showed a rapid and transient adhesion to immunoglobulin G (IgG)-coated plates compared with their adhesion to bovine serum albumin (BSA)-coated plates: the adhesion reached a peak after 15 min of incubation and then gradually returned to almost the basal state in 60 min. The addition of monomeric IgG or an...

journal_title：Journal of leukocyte biology

authors： Kusunoki T,Tsuruta S,Higashi H,Hosoi S,Hata D,Sugie K,Mayumi M,Mikawa H

更新日期：1994-06-01 00:00:00

abstract：:Polymorphonuclear leukocytes (PMNs) are crucial for initial control of Streptococcus pneumoniae (pneumococcus) lung infection; however, as the infection progresses their persistence in the lungs becomes detrimental. Here we explored why the antimicrobial efficacy of PMNs declines over the course of infection. We found...

journal_title：Journal of leukocyte biology

authors： Siwapornchai N,Lee JN,Tchalla EYI,Bhalla M,Yeoh JH,Roggensack SE,Leong JM,Bou Ghanem EN

更新日期：2020-09-01 00:00:00

abstract：:Growth hormone controls somatic growth in mammals by regulating the production of IGF-1, which is predominantly made by the liver. The development of cells within the MPS is controlled by the lineage-specific growth factor M-CSF (CSF-1). In this review, we summarize the role of CSF-1-dependent macrophages in somatic g...

journal_title：Journal of leukocyte biology

authors： Gow DJ,Sester DP,Hume DA

更新日期：2010-09-01 00:00:00

abstract：:Persistent viral infection, such as HCV infection, is the result of the inability of the host immune system to mount a successful antiviral response, as well as the escape strategies devised by the virus. Although each individual component of the host immune system plays important roles in antiviral immunity, the inte...

journal_title：Journal of leukocyte biology

authors： Saha B,Szabo G

更新日期：2014-11-01 00:00:00

abstract：:The restriction of herpes simplex virus type 1 (HSV-1) gene expression in nonpermissive murine resident peritoneal macrophages (ResPMO) was analyzed at the level of transcription. Using nuclear run-on assays, we established that transcription of a representative gene from each HSV-1 kinetic class was initiated in both...

journal_title：Journal of leukocyte biology

authors： Wu L,Morahan PS,Leary K

更新日期：1993-01-01 00:00:00

abstract：:A wealth of scientific and clinical evidence during the past few years has lent credence to the idea that key components of the host immune effector mechanisms can be targeted to boost current tuberculosis (TB) treatment and control patient relapse. These host-directed strategies not only accelerate the clearance of p...

journal_title：Journal of leukocyte biology

authors： Cheng CY,Böhme J,Singhal A

更新日期：2018-02-01 00:00:00

abstract：:The oxidative burst of polymorphonuclear neutrophils (PMN) and their ability to inhibit Paracoccidioides brasiliensis growth was studied in susceptible (B10.A) and resistant (A/J) mice. The cells were obtained after subcutaneous inoculation in air pouches, yielding highly pure PMN preparations; the number of cells was...

journal_title：Journal of leukocyte biology

authors： Meloni-Bruneri LH,Campa A,Abdalla DS,Calich VL,Lenzi HL,Burger E

更新日期：1996-04-01 00:00:00

abstract：:IL-10 is a key anti-inflammatory cytokine secreted by activated macrophages as a feedback control mechanism to prevent excessive inflammatory responses. Here, we define multiple intracellular trafficking pathways involved in the secretion of newly synthesized IL-10 from macrophages following TLR4 activation with LPS, ...

journal_title：Journal of leukocyte biology

authors： Stanley AC,Lieu ZZ,Wall AA,Venturato J,Khromykh T,Hamilton NA,Gleeson PA,Stow JL

更新日期：2012-12-01 00:00:00

abstract：:This is largely a history of attempts from approximately 1960 until about 1980-81 to understand the mechanisms by which neutrophils are activated by chemotactic factors to induce chemotaxis and granule secretion. As such, it deals with the growth of our knowledge of neutrophil chemotactic factors and their receptors; ...

journal_title：Journal of leukocyte biology

authors： Becker EL

更新日期：1990-04-01 00:00:00

abstract：:To become competent killer cells, CD8(+) T cells require stimulation through signal transduction pathways associated with the T-cell receptor, costimulatory molecules such as CD28, and cytokine receptors such as the interleukin (IL)-2 receptor. We used wortmannin and LY294002, two inhibitors of phosphatidylinositol 3-...

journal_title：Journal of leukocyte biology

authors： Phu T,Haeryfar SM,Musgrave BL,Hoskin DW

更新日期：2001-05-01 00:00:00

abstract：:Endotoxin tolerance is characterized by attenuated macrophage activation to subsequent LPS challenge and can be reversed through nonspecific protein kinase C (PKC) activation, and activation by LPS within naïve cells requires the activation of the cell surface receptors CD14 and TLR4 on lipid rafts. The effect of PKC ...

journal_title：Journal of leukocyte biology

authors： Cuschieri J,Billigren J,Maier RV

更新日期：2006-12-01 00:00:00

abstract：:Highly active antiretroviral therapy (HAART) against human immunodeficiency virus type 1 (HIV-1) infection dramatically suppresses viral load, leading to marked reductions in HIV-1 associated morbidity and mortality. However, infected cell reservoirs and low-level replication persist in the face of suppressive HAART, ...

journal_title：Journal of leukocyte biology

authors： Kennedy PE,Bera TK,Wang QC,Gallo M,Wagner W,Lewis MG,Berger EA,Pastan I

更新日期：2006-11-01 00:00:00

abstract：:Changes in leukocyte subpopulations and function after spaceflight have been observed but the mechanisms underlying these changes are not well defined. This study investigated the effects of short-term spaceflight (8-15 days) on circulating leukocyte subsets, stress hormones, immunoglobulin levels, and neutrophil func...

journal_title：Journal of leukocyte biology

authors： Stowe RP,Sams CF,Mehta SK,Kaur I,Jones ML,Feeback DL,Pierson DL

更新日期：1999-02-01 00:00:00

abstract：:In recent years, it has become appreciated that immune cells have different metabolic profiles depending on their activation status. During sepsis, circulating leukocytes go through a hyperinflammatory state, which can be accompanied or followed by defective antimicrobial defenses (also described as immune tolerance o...

journal_title：Journal of leukocyte biology

authors： Arts RJ,Gresnigt MS,Joosten LA,Netea MG

更新日期：2017-01-01 00:00:00

abstract：:Investigators from two different laboratories have compared several variables in the short-term macrophage-mediated cytotoxicity assays used by each group to study the role of MuIFN-gamma in macrophage activation. The findings suggest that the capacity of MuIFN-gamma to activate macrophages without the need for a seco...

journal_title：Journal of leukocyte biology

authors： Pace JL,Varesio L,Russell SW,Blasi E

更新日期：1985-04-01 00:00:00

abstract：:Macrophage-like tumor cells can be obtained in large quantities as rather homogeneous populations, making these cells useful for chemotaxis assays. Therefore, macrophage-like cells J774A, WEHI-3, P388D1, IC-21, and NCTC 1469, all of murine origin, and U937 of human origin, were tested for chemotactic activity to a num...

journal_title：Journal of leukocyte biology

authors： Terheggen P,Van Loveren H,Den Otter W

更新日期：1985-12-01 00:00:00

abstract：:A murine interleukin-2 (IL-2)-dependent T-cell line, CTLL-2, was infected with a retrovirus carrying the mouse c-myc cDNA and the Tn-5 neogene. Transduced cells were selected in the presence of Geneticin sulfate (G418); these cells were shown to express both the endogenous and the transduced c-myc genes. The IL-2 requ...

journal_title：Journal of leukocyte biology

authors： Shapiro IM,Winberg G,Stefanescu I,Wigzell H,Menezes J

更新日期：1988-12-01 00:00:00

abstract：:Successful remodeling of the uterine spiral arteries is essential for a complication-free pregnancy and is best described in terms of its morphologic features. The molecular mediators and cellular sources of spiral artery remodeling are not known, although a role for uterine leukocytes has been proposed. Immunohistoch...

journal_title：Journal of leukocyte biology

authors： Lash GE,Pitman H,Morgan HL,Innes BA,Agwu CN,Bulmer JN

更新日期：2016-08-01 00:00:00

abstract：:Galectin-1 (Gal-1) is a beta-galactoside-binding protein endowed with anti-inflammatory properties. The purpose of this study was to investigate the effects of endogenous and exogenous Gal-1 on neutrophil recruitment onto TNF-treated endothelium. The effect of human recombinant (hr)Gal-1 on markers of neutrophil activ...

journal_title：Journal of leukocyte biology

authors： Cooper D,Norling LV,Perretti M

更新日期：2008-06-01 00:00:00

abstract：:ICAM-1 is a cell surface glycoprotein and an adhesion receptor that is best known for regulating leukocyte recruitment from circulation to sites of inflammation. However, in addition to vascular endothelial cells, ICAM-1 expression is also robustly induced on epithelial and immune cells in response to inflammatory sti...

journal_title：Journal of leukocyte biology

authors： Bui TM,Wiesolek HL,Sumagin R

更新日期：2020-09-01 00:00:00

abstract：:To assess the effect of hypoxemia on the responses of polymorphonuclear neutrophils (PMN) during an inflammatory response, rats were maintained in a low F1O2 atmosphere (9% O2) or room air for 12 h before intrathoracic injection of carrageenin or intradermal injections of agonists. After 4 h, hypoxemic rats had 50% mo...

journal_title：Journal of leukocyte biology

authors： Tremblay PB,Macari DM,Martel D,du Souich P,Barja-Fidalgo C,Marleau S

更新日期：2000-06-01 00:00:00

abstract：:Live, but not dead Bacillus Calmette-Guérin (BCG) is partially protective against infection by Mycobacterium tuberculosis, which causes a disease with high mortality in immune compromised individuals. We have shown that uptake of BCG induces maturation of immature dendritic cells (DCs) regardless of the viability of t...

journal_title：Journal of leukocyte biology

authors： Tsunetsugu-Yokota Y,Tamura H,Tachibana M,Ogata K,Honda M,Takemori T

更新日期：2002-07-01 00:00:00

abstract：:Blood leukocyte count alterations induced by PAF-acether in anesthetized and nonanesthetized rats were investigated. Intravenous injection of increasing amounts of PAF-acether (1.5-8 micrograms/kg) in nonanesthetized animals induced dose-dependent hemoconcentration and leukocytosis. The former was apparent within 10 m...

journal_title：Journal of leukocyte biology

authors： Bozza PT,Silva PM,Castro-Faria-Neto HC,Martins MA,Cordeiro RS

更新日期：1992-02-01 00:00:00

abstract：:p67(phox) is the paramount cytosolic regulator of the superoxide-generating Nox of phagocytes, by controlling the conformation of the catalytic component, Nox2. The initiating event of this process is a protein-protein interaction between p67(phox) and the part of Nox2 protruding into the cytosol, known as the dehydro...

journal_title：Journal of leukocyte biology

authors： Dahan I,Smith SM,Pick E

更新日期：2015-11-01 00:00:00

abstract：:Brucella abortus is a Gram-negative intracellular bacterial pathogen that causes a zoonosis of worldwide occurrence, leading to undulant fever in humans and abortion in domestic animals. B. abortus is recognized by several pattern-recognition receptors triggering pathways during the host innate immune response. Theref...

journal_title：Journal of leukocyte biology

authors： Gomes MT,Campos PC,Pereira Gde S,Bartholomeu DC,Splitter G,Oliveira SC

更新日期：2016-05-01 00:00:00

abstract：:Concanavalin A (Con A)-induced hepatitis is a model for human T cell-mediated hepatitis. We evaluated the role of L-selectin and intercellular adhesion molecule-1 (ICAM-1) in this model by injecting Con A intravenously in mice lacking L-selectin (L-selectin-/-), ICAM-1 (ICAM-1-/-), or both (L-selectin/ICAM-1-/-). Bloo...

journal_title：Journal of leukocyte biology

authors： Kawasuji A,Hasegawa M,Horikawa M,Fujita T,Matsushita Y,Matsushita T,Fujimoto M,Steeber DA,Tedder TF,Takehara K,Sato S

更新日期：2006-04-01 00:00:00