The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4.

abstract：:Mast cells and MDSCs are increased by parasitic infection and tumor growth. We previously demonstrated that enhanced MDSC development in ADAM10 transgenic mice yielded resistance to Nb infection and that coculturing MDSCs and mast cells enhanced cytokine production. In the current work, we show that MDSC-mast cell coc...

journal_title：Journal of leukocyte biology

authors： Morales JK,Saleem SJ,Martin RK,Saunders BL,Barnstein BO,Faber TW,Pullen NA,Kolawole EM,Brooks KB,Norton SK,Sturgill J,Graham L,Bear HD,Urban JF Jr,Lantz CS,Conrad DH,Ryan JJ

更新日期：2014-04-01 00:00:00

abstract：:Signaling through chemokine receptor, C-X-C chemokine receptor type 4 (CXCR4) regulates essential processes in normal physiology, including embryogenesis, tissue repair, angiogenesis, and trafficking of immune cells. Tumors co-opt many of these fundamental processes to directly stimulate proliferation, invasion, and m...

journal_title：Journal of leukocyte biology

authors： Luker GD,Yang J,Richmond A,Scala S,Festuccia C,Schottelius M,Wester HJ,Zimmermann J

更新日期：2020-10-26 00:00:00

abstract：:CEACAM6 (CD66c) and CEACAM8 (CD66b) are cell-adhesion proteins on neutrophils that belong to the human carcinoembryonic antigen (CEA) family. CEACAM6 reveals homophilic adhesion and heterophilic adhesion to other CEACAM family antigens including CEACAM8, CEACAM1, and CEA, whereas CEACAM8 exhibits only heterophilic adh...

journal_title：Journal of leukocyte biology

authors： Kuroki M,Abe H,Imakiirei T,Liao S,Uchida H,Yamauchi Y,Oikawa S,Kuroki M

更新日期：2001-10-01 00:00:00

abstract：:The activation of dendritic cells (DC) via Toll-like receptors (TLRs) plays a decisive role in shaping the outcome of primary immune responses. Following TLR engagement by microbial products, DC migrate from peripheral tissues to lymphoid organs and up-regulate major histocompatibility complex and costimulatory molecu...

journal_title：Journal of leukocyte biology

authors： Mazzoni A,Segal DM

更新日期：2004-05-01 00:00:00

abstract：:This report focuses on the modulatory role of endogenous H(2)O(2) on lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma)-induced inducible nitric oxide synthase (NOS2) gene expression in rat peritoneal macrophages. Exogenously added H(2)O(2) was initially found to inhibit the synthesis of NOS2, which prompted us to ...

journal_title：Journal of leukocyte biology

authors： Vega A,Chacón P,Monteseirín J,El Bekay R,Alvarez M,Alba G,Conde J,Martín-Nieto J,Bedoya FJ,Pintado E,Sobrino F

更新日期：2004-06-01 00:00:00

abstract：:A murine model of allergic bronchopulmonary aspergillosis (ABPA), developed by exposure to Aspergillus fumigatus antigens, demonstrated eosinophilia of peripheral blood (PB), bone marrow (BM), and lung. The eosinophilia was abrogated by monoclonal anti-interleukin-5 (IL-5) antibody (TRFK-5) and not by an isotype contr...

journal_title：Journal of leukocyte biology

authors： Murali PS,Kumar A,Choi H,Banasal NK,Fink JN,Kurup VP

更新日期：1993-03-01 00:00:00

abstract：:MΦs are important sensory cells of the innate immune system and regulate immune responses through releasing different combinations of cytokines. In this study, we examined whether cytokines released by MΦs in response to the probiotic bacterial strain GR-1 modulate the responses of DCs. The cytokine profile released b...

journal_title：Journal of leukocyte biology

authors： Martins AJ,Spanton S,Sheikh HI,Kim SO

更新日期：2011-06-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that accumulate during pathologic conditions, such as cancer. Patients diagnosed with advanced metastatic cancers have an average survival of 12-24 mo, a survival time that hasn't changed significantly in the past 30 yr. ...

journal_title：Journal of leukocyte biology

authors： Chesney JA,Mitchell RA,Yaddanapudi K

更新日期：2017-09-01 00:00:00

abstract：:Absence of lymph nodes in nonmammalian species, expression of MHCII by APCs in the periphery, and the recent findings that T cells can change their polarization status after presentation in the lymph nodes imply a role for MHCII-mediated presentation outside the organized lymphoid tissue. This study shows that MHCII(+...

journal_title：Journal of leukocyte biology

authors： Inman CF,Singha S,Lewis M,Bradley B,Stokes C,Bailey M

更新日期：2010-09-01 00:00:00

abstract：:HIV infection of mononuclear phagocytes (MP), mostly as tissue macrophages, is a dominant feature in the pathogenesis of HIV disease and its progression to AIDS. Although the general mechanism of infection is not dissimilar to that of CD4+ T lymphocytes occurring via interaction of the viral envelope with CD4 and a ch...

journal_title：Journal of leukocyte biology

authors： Cassol E,Alfano M,Biswas P,Poli G

更新日期：2006-11-01 00:00:00

abstract：:Retroviral infections are frequently associated with immunosuppression. Retroviral transmembrane envelope proteins (TM proteins) play an important role in this phenomenon. CKS-17, a synthetic heptadecapeptide, represents the immunosuppressive site of these retroviral TM proteins. Here we support on the further delinea...

journal_title：Journal of leukocyte biology

authors： Oostendorp RA,Schaaper WM,Post J,Meloen RH,Scheper RJ

更新日期：1992-03-01 00:00:00

abstract：:Osteoarticular complications are common in human brucellosis, but the pathogenic mechanisms involved are largely unknown. In this manuscript, we described an immune mechanism for inflammatory bone loss in response to infection by Brucella abortus. We established a requirement for MyD88 and TLR2 in TNF-α-elicited osteo...

journal_title：Journal of leukocyte biology

authors： Delpino MV,Barrionuevo P,Macedo GC,Oliveira SC,Genaro SD,Scian R,Miraglia MC,Fossati CA,Baldi PC,Giambartolomei GH

更新日期：2012-02-01 00:00:00

abstract：:Thrombin has receptor-mediated effects on a variety of cell types. A recently cloned platelet thrombin receptor exerts its effects by a tethered-ligand mechanism. A similar receptor was shown in at least two nonplatelet cell types, fibroblasts and endothelial cells. Thrombin has biologically important effects on leuko...

journal_title：Journal of leukocyte biology

authors： Hoffman M,Church FC

更新日期：1993-08-01 00:00:00

abstract：:Exacerbations of asthma are most commonly triggered by viral infections, which amplify allergic inflammation. Cytokines released by virus-infected AECs may be important in driving this response. This review focuses on accumulating evidence in support of a role for epithelial cytokines, including IL-33, IL-25, and TSLP...

journal_title：Journal of leukocyte biology

authors： Kumar RK,Foster PS,Rosenberg HF

更新日期：2014-09-01 00:00:00

abstract：:Using a panel of vaccines that provided different degrees of protection, we previously identified the IL-12 receptor subunit β2 as a mediator, whose relative expression correlated with strength of protection against secondary lethal challenge of vaccinated mice with an intracellular bacterium, the LVS of Francisella t...

journal_title：Journal of leukocyte biology

authors： Melillo AA,Foreman O,Elkins KL

更新日期：2013-05-01 00:00:00

abstract：:The macrophage mannose receptor (MR) appears to play an important role in the binding and phagocytosis of several human pathogens, but its phagocytic property and signaling pathways have been poorly defined. The general strategy to explore such topics is to express the protein of interest in nonphagocytic cells, but i...

journal_title：Journal of leukocyte biology

authors： Le Cabec V,Emorine LJ,Toesca I,Cougoule C,Maridonneau-Parini I

更新日期：2005-06-01 00:00:00

abstract：:The expression of the inducible isoform of nitric oxide synthase (NOS2, iNOS) is increased in patients undergoing sepsis as well as in animal models in which septic shock is induced by injection of bacterial lipopolysaccharide (LPS). Transforming growth factor-beta1 (TGF-beta1) potently suppresses NO production both i...

journal_title：Journal of leukocyte biology

authors： Vodovotz Y,Kopp JB,Takeguchi H,Shrivastav S,Coffin D,Lucia MS,Mitchell JB,Webber R,Letterio J,Wink D,Roberts AB

更新日期：1998-01-01 00:00:00

abstract：:Type I IFNs display multiple biological effects. They have a strong antiviral action, not only directly but also indirectly through activation of the immune system. They may also have actions that are deleterious for the host. The cells that produce type I IFN are mostly plasmacytoid dendritic cells (pDC), but this de...

journal_title：Journal of leukocyte biology

authors： Hosmalin A,Lebon P

更新日期：2006-11-01 00:00:00

abstract：:We reported previously that N-myc downstream-regulated gene 2 (NDRG2), a member of a new family of differentiation-related genes, is expressed specifically in dendritic cells (DC) differentiated from monocytes, CD34(+) progenitor cells, and the myelomonocytic leukemic cell line. In this study, we demonstrate that NDRG...

journal_title：Journal of leukocyte biology

authors： Choi SC,Kim KD,Kim JT,Kim JW,Lee HG,Kim JM,Jang YS,Yoon DY,Kim KI,Yang Y,Cho DH,Lim JS

更新日期：2008-01-01 00:00:00

abstract：:The key role of TRAF6 in TLR signaling pathways is well known. More recent evidence has implicated TRAF3 as another TRAF family member important to certain TLR responses of myeloid cells. Previous studies demonstrate that TRAF3 functions are highly context-dependent, displaying receptor and cell-type specificity. We t...

journal_title：Journal of leukocyte biology

authors： Xie P,Poovassery J,Stunz LL,Smith SM,Schultz ML,Carlin LE,Bishop GA

更新日期：2011-12-01 00:00:00

abstract：:TTP is an anti-inflammatory protein that acts by binding to AREs in its target mRNAs, such as Tnf mRNA, and promoting their deadenylation and decay. TNF released from inflammatory cells can then stimulate gene expression in tissue cells, such as fibroblasts. To determine whether TTP could affect the decay of TNF-induc...

journal_title：Journal of leukocyte biology

authors： Qiu LQ,Lai WS,Bradbury A,Zeldin DC,Blackshear PJ

更新日期：2015-04-01 00:00:00

abstract：:Neuronal damage in HIV infection results mainly from chronic activation of brain tissue and involves inflammation, oxidative stress, and glutamate-related neurotoxicity. Glutamate toxicity acts via two distinct pathways: an excitotoxic one, in which glutamate receptors are hyperactivated, and an oxidative one, in whic...

journal_title：Journal of leukocyte biology

authors： Gras G,Porcheray F,Samah B,Leone C

更新日期：2006-11-01 00:00:00

abstract：:The IV meeting of the European Mucosal Immunology Group, held October 8-10, 2004, in Lyon, gathered fundamental and clinical research scientists to discuss the most recent updates on basic and clinical aspects of mucosal immunology. The meeting was focused on innate and acquired immune mechanisms underlying handling a...

journal_title：Journal of leukocyte biology

authors： Kaiserlian D,Cerf-Bensussan N,Hosmalin A

更新日期：2005-08-01 00:00:00

abstract：:Matrix metalloproteinases-2 and -9 (MMP-2/9) are critically involved in degradation of extracellular matrix, and their inhibition is discussed as a promising strategy against hepatic ischemia-reperfusion (I/R) injury. Here, we analyzed the role of MMP-2 and -9 for leukocyte migration and tissue injury in sham-operated...

journal_title：Journal of leukocyte biology

authors： Khandoga A,Kessler JS,Hanschen M,Khandoga AG,Burggraf D,Reichel C,Hamann GF,Enders G,Krombach F

更新日期：2006-06-01 00:00:00

abstract：:We have previously reported that human neutrophils can be permeabilized with the cholesterol-complexing agent digitonin. These permeabilized cells can be induced to secrete lysosomal constituents when exposed to micromolar levels of free Ca2+, a process that is enhanced by certain guanine nucleotides. We examined the ...

journal_title：Journal of leukocyte biology

authors： Smolen JE,Stoehr SJ,Traynor AE,Sklar LA

更新日期：1987-01-01 00:00:00

abstract：:Concanavalin A (Con A)-induced hepatitis is a model for human T cell-mediated hepatitis. We evaluated the role of L-selectin and intercellular adhesion molecule-1 (ICAM-1) in this model by injecting Con A intravenously in mice lacking L-selectin (L-selectin-/-), ICAM-1 (ICAM-1-/-), or both (L-selectin/ICAM-1-/-). Bloo...

journal_title：Journal of leukocyte biology

authors： Kawasuji A,Hasegawa M,Horikawa M,Fujita T,Matsushita Y,Matsushita T,Fujimoto M,Steeber DA,Tedder TF,Takehara K,Sato S

更新日期：2006-04-01 00:00:00

abstract：:IL-10 is a key anti-inflammatory cytokine secreted by activated macrophages as a feedback control mechanism to prevent excessive inflammatory responses. Here, we define multiple intracellular trafficking pathways involved in the secretion of newly synthesized IL-10 from macrophages following TLR4 activation with LPS, ...

journal_title：Journal of leukocyte biology

authors： Stanley AC,Lieu ZZ,Wall AA,Venturato J,Khromykh T,Hamilton NA,Gleeson PA,Stow JL

更新日期：2012-12-01 00:00:00

abstract：:2-Arachidonoyl-glycerol (2-AG) and arachidonyl-ethanolamide (AEA) are endocannabinoids that have been implicated in many physiologic disorders, including obesity, metabolic syndromes, hepatic diseases, pain, neurologic disorders, and inflammation. Their immunomodulatory effects are numerous and are not always mediated...

journal_title：Journal of leukocyte biology

authors： Turcotte C,Chouinard F,Lefebvre JS,Flamand N

更新日期：2015-06-01 00:00:00

abstract：:Membrane rafts are microdomains of the plasma membrane that have multiple biological functions. The involvement of these structures in the biology of T cells, namely in signal transduction by the TCR, has been widely studied. However, the role of membrane rafts in immunoreceptor signaling in NK cells is less well know...

journal_title：Journal of leukocyte biology

authors： Serrano-Pertierra E,Cernuda-Morollón E,Brdička T,Hoøejši V,López-Larrea C

更新日期：2014-09-01 00:00:00

abstract：:Neutrophils are the first cells arriving at sites of tissue injury or infection to combat invading pathogens. Successful neutrophil recruitment to sites of inflammation highly depends on specific molecular mechanisms, fine-tuning the received information into signaling pathways and converting them into well-described ...

journal_title：Journal of leukocyte biology

authors： Begandt D,Thome S,Sperandio M,Walzog B

更新日期：2017-09-01 00:00:00