Abstract:
:The activation of dendritic cells (DC) via Toll-like receptors (TLRs) plays a decisive role in shaping the outcome of primary immune responses. Following TLR engagement by microbial products, DC migrate from peripheral tissues to lymphoid organs and up-regulate major histocompatibility complex and costimulatory molecules, acquiring the unique capacity to prime pathogen-specific, naïve T cells. In addition, DC determine the character of the ensuing immune response by secreting cytokines that drive the development of T cells into T helper cell type 1 (Th1), Th2, or T regulatory effector cells. Three major factors influence the pattern of cytokines released by DC and accordingly, the Th balance: the lineage to which DC belong; the maturation stimulus; and inflammatory mediators present at the site of infection. A major focus of this review is the capacity of DC to integrate these factors and elicit distinct classes of immune responses.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Mazzoni A,Segal DMdoi
10.1189/jlb.1003482subject
Has Abstractpub_date
2004-05-01 00:00:00pages
721-30issue
5eissn
0741-5400issn
1938-3673pii
jlb.1003482journal_volume
75pub_type
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