ICAM-1 expression and low-molecular-weight G-protein activation of human bronchial epithelial cells (A549) infected with RSV.

abstract：:To determine if the release of IL-1 alpha and IL-1 beta by cultured PBMC could be independently modulated by different exogenous stimuli, we examined the effect of LPS, IFN gamma, latex beads, and indomethacin on the release of IL-1 alpha and IL-1 beta. PBMC culture supernatants were fractionated by Sephacryl-S-200 co...

journal_title：Journal of leukocyte biology

authors： Sandborg CI,Berman MA,Imfeld KL,Zaldivar F Jr,Masada MP,Kenney JS

更新日期：1989-11-01 00:00:00

abstract：:An increase in intracellular calcium concentration is one of the major initial steps in B cell activation following antigen receptor (BCR) ligation. We show herein that in C57BL/6 murine B lymphocytes and in model cell lines, BCR-mediated calcium ion (Ca(2+)) influx occurs via highly selective Ca(2+) release-activated...

journal_title：Journal of leukocyte biology

authors： Lyubchenko T,Nielsen JP,Miller SM,Liubchenko GA,Holers VM

更新日期：2009-02-01 00:00:00

abstract：:The basal presence of immunologically potent cells within the intestinal muscularis externa and their functional significance is unclear. Our aim was to investigate the basal distribution of various leukocyte populations within the rat jejunal muscularis. In addition, we sought to immunohistochemically phenotype the m...

journal_title：Journal of leukocyte biology

authors： Kalff JC,Schwarz NT,Walgenbach KJ,Schraut WH,Bauer AJ

更新日期：1998-06-01 00:00:00

abstract：:MΦs are important sensory cells of the innate immune system and regulate immune responses through releasing different combinations of cytokines. In this study, we examined whether cytokines released by MΦs in response to the probiotic bacterial strain GR-1 modulate the responses of DCs. The cytokine profile released b...

journal_title：Journal of leukocyte biology

authors： Martins AJ,Spanton S,Sheikh HI,Kim SO

更新日期：2011-06-01 00:00:00

abstract：:Type I IFNs play an important role in innate and adaptive immunity against viral infections. A novel type I IFN, namely IFN-ε, which can protect against vaginal transmission of HSV2 and Chlamydia muridarum bacterial infection, has been described in mice and humans. Nevertheless, the principle cell type and the express...

journal_title：Journal of leukocyte biology

authors： Demers A,Kang G,Ma F,Lu W,Yuan Z,Li Y,Lewis M,Kraiselburd EN,Montaner L,Li Q

更新日期：2014-12-01 00:00:00

abstract：:PGE(2) and other cAMP-elevating agents are known to down-regulate most functions stimulated by fMLP in human polymorphonuclear neutrophils. We reported previously that the inhibitory potential of PGE(2) resides in its capacity to suppress fMLP-stimulated PI-3Kgamma activation via the PGE(2) receptor EP(2) and hence, t...

journal_title：Journal of leukocyte biology

authors： Burelout C,Naccache PH,Bourgoin SG

更新日期：2007-06-01 00:00:00

abstract：:Sexual transmission is the primary route of HIV-1 infection, and DC subsets are thought to be involved in viral dissemination to T cells. In the genital mucosa, two main subsets of DCs are present: epithelial LCs capture and degrade HIV-1 through C-type lectin Langerin, whereas subepithelial DCs express DC-SIGN, which...

journal_title：Journal of leukocyte biology

authors： de Jong MA,de Witte L,Santegoets SJ,Fluitsma D,Taylor ME,de Gruijl TD,Geijtenbeek TB

更新日期：2010-04-01 00:00:00

abstract：:Neutrophils are the first cells arriving at sites of tissue injury or infection to combat invading pathogens. Successful neutrophil recruitment to sites of inflammation highly depends on specific molecular mechanisms, fine-tuning the received information into signaling pathways and converting them into well-described ...

journal_title：Journal of leukocyte biology

authors： Begandt D,Thome S,Sperandio M,Walzog B

更新日期：2017-09-01 00:00:00

abstract：:The activation of dendritic cells (DC) via Toll-like receptors (TLRs) plays a decisive role in shaping the outcome of primary immune responses. Following TLR engagement by microbial products, DC migrate from peripheral tissues to lymphoid organs and up-regulate major histocompatibility complex and costimulatory molecu...

journal_title：Journal of leukocyte biology

authors： Mazzoni A,Segal DM

更新日期：2004-05-01 00:00:00

abstract：:We have previously reported that human neutrophils can be permeabilized with the cholesterol-complexing agent digitonin. These permeabilized cells can be induced to secrete lysosomal constituents when exposed to micromolar levels of free Ca2+, a process that is enhanced by certain guanine nucleotides. We examined the ...

journal_title：Journal of leukocyte biology

authors： Smolen JE,Stoehr SJ,Traynor AE,Sklar LA

更新日期：1987-01-01 00:00:00

abstract：:Recombinant tissue plasminogen activator (t-PA), the only approved stroke treatment, is used for clot lysis within the occluded brain artery. Unfortunately, matrix metalloproteinase-9 (MMP-9) concentration increases after t-PA treatment and has been related to hemorrhagic transformation after ischemic stroke. Although...

journal_title：Journal of leukocyte biology

authors： Cuadrado E,Ortega L,Hernández-Guillamon M,Penalba A,Fernández-Cadenas I,Rosell A,Montaner J

更新日期：2008-07-01 00:00:00

abstract：:Neutrophils are indispensable in the innate immune defense against invading microorganisms. Neutrophils contain SVs and several subsets of granules that are essential for their function. Proteins present in neutrophil SVs and granules are synthesized during terminal granulopoiesis in the bone marrow. The heterogeneity...

journal_title：Journal of leukocyte biology

authors： Rørvig S,Østergaard O,Heegaard NH,Borregaard N

更新日期：2013-10-01 00:00:00

abstract：:CD4+CD25+ regulatory T cells play an important role in peripheral tolerance. Upon T cell receptor (TCR)-mediated activation, the cells fail to proliferate but are induced to have a suppressor function. The intracellular signaling events that lead to their responses have not been elucidated. In this study, we have exam...

journal_title：Journal of leukocyte biology

authors： Tsang JY,Camara NO,Eren E,Schneider H,Rudd C,Lombardi G,Lechler R

更新日期：2006-07-01 00:00:00

abstract：:Eosinophil activation during allergic diseases has a detrimental role in the generation of pathophysiologic responses. Stem cell factor (SCF) has recently shown an inflammatory, gene-activating role on eosinophils and contributes to the generation of pathophysiologic changes in the airways during allergic responses. T...

journal_title：Journal of leukocyte biology

authors： Dolgachev V,Thomas M,Berlin A,Lukacs NW

更新日期：2007-04-01 00:00:00

abstract：:ICAM-1 is a cell surface glycoprotein and an adhesion receptor that is best known for regulating leukocyte recruitment from circulation to sites of inflammation. However, in addition to vascular endothelial cells, ICAM-1 expression is also robustly induced on epithelial and immune cells in response to inflammatory sti...

journal_title：Journal of leukocyte biology

authors： Bui TM,Wiesolek HL,Sumagin R

更新日期：2020-09-01 00:00:00

abstract：:Using a panel of vaccines that provided different degrees of protection, we previously identified the IL-12 receptor subunit β2 as a mediator, whose relative expression correlated with strength of protection against secondary lethal challenge of vaccinated mice with an intracellular bacterium, the LVS of Francisella t...

journal_title：Journal of leukocyte biology

authors： Melillo AA,Foreman O,Elkins KL

更新日期：2013-05-01 00:00:00

abstract：:In this study, we analyzed the specific effects of transforming growth factor beta (TGF-beta1) and/or IL-4 on monocyte-derived cells. Monocytes were cultured with GM-CSF, GM-CSF/TGF-beta1, GM-CSF/IL-4, or GM-CSF/IL-4/TGF-beta1 before cell morphology, phenotype, and function were assessed. As expected, interleukin-4 is...

journal_title：Journal of leukocyte biology

authors： Guironnet G,Dezutter-Dambuyant C,Vincent C,Bechetoille N,Schmitt D,Péguet-Navarro J

更新日期：2002-05-01 00:00:00

abstract：:Proteoglycans (PGs) play a dominant role within the bone marrow (BM), but their role in homing of transplanted hematopoietic progenitor cells (HPC) is unknown. In this study, the role of heparan sulfate (HS) PGs on BM endothelium as adhesive structures was investigated. HPC (primary CD34+ cells and cell line KG-1a) we...

journal_title：Journal of leukocyte biology

authors： Netelenbos T,van den Born J,Kessler FL,Zweegman S,Huijgens PC,Drager AM

更新日期：2003-12-01 00:00:00

abstract：:The signaling adapters MyD88 and TRIF are engaged by TLRs and/or receptors of the IL-1 family and are considered important for innate immune responses that combat bacterial infections. Here, the consequences of a combined MyD88 and TRIF deficiency for the innate immune response against severe septic peritonitis was ex...

journal_title：Journal of leukocyte biology

authors： Reim D,Rossmann-Bloeck T,Jusek G,Prazeres da Costa O,Holzmann B

更新日期：2011-09-01 00:00:00

abstract：:Although HDPs were originally hypothesized to act as antimicrobial agents, they also have been shown to broadly modulate the immune response through the activation of different cell types. We recently developed a series of novel, synthetic peptides, termed IDRs, which are conceptually based on a natural HDP, bovine ba...

journal_title：Journal of leukocyte biology

authors： Niyonsaba F,Madera L,Afacan N,Okumura K,Ogawa H,Hancock RE

更新日期：2013-07-01 00:00:00

abstract：:Dynamic rearrangements of the actin cytoskeleton are crucial for the function of numerous cellular elements including T lymphocytes. They are required for migration of T lymphocytes through the body to scan for the presence of antigens, as well as for the formation and stabilization of the immunological synapse at the...

journal_title：Journal of leukocyte biology

authors： Samstag Y,Eibert SM,Klemke M,Wabnitz GH

更新日期：2003-01-01 00:00:00

abstract：:IL-27, an IL-12 family member, was initially described as a proinflammatory cytokine. Nevertheless, it also poses anti-inflammatory activity, being involved in suppressing development of TH-17 cells as well as in the induction of inhibitory Tr1 cells. Recent data obtained in mice suggest that it can down-modulate the ...

journal_title：Journal of leukocyte biology

authors： Karakhanova S,Bedke T,Enk AH,Mahnke K

更新日期：2011-06-01 00:00:00

abstract：:CXC chemokines, which induce angiogenesis, have glutamine-leucine-arginine amino acid residues (ELR motif) in the amino terminus and bind CXCR2 and the Duffy antigen chemokine-binding protein. Duffy, a seven transmembrane protein that binds CXC and CC chemokines, has not been shown to couple to trimeric G proteins or ...

journal_title：Journal of leukocyte biology

authors： Du J,Luan J,Liu H,Daniel TO,Peiper S,Chen TS,Yu Y,Horton LW,Nanney LB,Strieter RM,Richmond A

更新日期：2002-01-01 00:00:00

abstract：:Activation of the microvasculature is a major component of the inflammatory response. During inflammation the vascular endothelium not only becomes more permeable to plasma proteins but also develops adhesion molecules that initiate the local immigration of leukocytes. We describe herein the in vivo changes in the thr...

journal_title：Journal of leukocyte biology

authors： Abe Y,Sugisaki K,Dannenberg AM Jr

更新日期：1996-12-01 00:00:00

abstract：:Alum, aluminum-hydroxide-containing compounds, long used as adjuvants in human vaccinations, functions by ill-defined, immunostimulatory mechanisms. Antigen-free alum has been shown to act via a previously unidentified, splenic Gr1(+), IL-4-expressing myeloid cell population to stimulate early B cell priming. We demon...

journal_title：Journal of leukocyte biology

authors： Wang HB,Weller PF

更新日期：2008-04-01 00:00:00

abstract：:Intracellular zinc homeostasis is strictly regulated by zinc binding proteins and zinc transporters. In the present study, we quantified in a first global view the expression of all characterized human zinc exporters (hZnT-1-9) in different leukocyte subsets in response to zinc supplementation and depletion and analyz...

journal_title：Journal of leukocyte biology

authors： Overbeck S,Uciechowski P,Ackland ML,Ford D,Rink L

更新日期：2008-02-01 00:00:00

abstract：:A cell resistant to concentrations of mitomycin-C associated with the inactivation of many in vitro immune responses is described. This cell is responsive to concanavalin A (Con A), poorly adherent to nylon wool, present in relatively greater numbers in lymph node than other lymphoid tissues, and is relatively radiose...

journal_title：Journal of leukocyte biology

authors： Anderson RE,Standefer JC,Troup GM,Pogue LE

更新日期：1987-01-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that accumulate during pathologic conditions, such as cancer. Patients diagnosed with advanced metastatic cancers have an average survival of 12-24 mo, a survival time that hasn't changed significantly in the past 30 yr. ...

journal_title：Journal of leukocyte biology

authors： Chesney JA,Mitchell RA,Yaddanapudi K

更新日期：2017-09-01 00:00:00

abstract：:The last 18 months have witnessed the characterization of several new members of the tumor necrosis factor (TNF) receptor family. Among these are five receptors for the cytotoxic ligand TRAIL (TNF-related apoptosis-inducing ligand). Two of these receptors, TRAIL-R1 and TRAIL-R2, contain classical cytoplasmic death dom...

journal_title：Journal of leukocyte biology

authors： Degli-Esposti M

更新日期：1999-05-01 00:00:00

abstract：:Progressive loss of dopaminergic neurons in the substantia nigra pars compacta and their terminal connections in the striatum are central features in Parkinson's disease (PD). Emerging evidence supports the notion that microglia neuroinflammatory responses speed neurodegenerative events. We demonstrated previously tha...

journal_title：Journal of leukocyte biology

authors： Reynolds AD,Banerjee R,Liu J,Gendelman HE,Mosley RL

更新日期：2007-11-01 00:00:00