Granulocyte-macrophage colony-stimulating factor (GM-CSF): a chemoattractive agent for murine leukocytes in vivo.

abstract：:Leukocytes are a large population of cells spread within most tissues in the body. These cells may be either sessile (called as resident cells) or circulating leukocytes, which travel long journeys inside the vessels during their lifespan. Although production and maturation of these leukocytes in adults primarily occu...

journal_title：Journal of leukocyte biology

authors： Mafra K,Nakagaki BN,Castro Oliveira HM,Rezende RM,Antunes MM,Menezes GB

更新日期：2019-09-01 00:00:00

abstract：:The in vitro studies have proposed that human Th1 cells favor expression of CXCR3 or CCR5, whereas Th2 cells favor CCR3 and CCR4. In this study, the in vivo relevance of expression of these chemokine receptors on Th cells was investigated in patients with atopic dermatitis (AD) as the Th2-dominated disorder and nonato...

journal_title：Journal of leukocyte biology

authors： Yamamoto J,Adachi Y,Onoue Y,Adachi YS,Okabe Y,Itazawa T,Toyoda M,Seki T,Morohashi M,Matsushima K,Miyawaki T

更新日期：2000-10-01 00:00:00

abstract：:The adjuvant effect of gamma-inulin, a strong activator of the alternative complement pathway, is well-known, but its exact mechanism is not revealed yet. Here, we show that macrophages, isolated from the peritoneal cavity of gamma-inulin-injected mice and used as antigen-presenting cells, enhance the proliferation of...

journal_title：Journal of leukocyte biology

authors： Kerekes K,Cooper PD,Prechl J,Józsi M,Bajtay Z,Erdei A

更新日期：2001-01-01 00:00:00

abstract：:Neutrophil's responses to G protein-coupled chemoattractants are highly dependent on store-operated calcium (Ca(2+)) entry (SOCE). Platelet-activating factor (PAF), a primary chemoattractant, simultaneously increases cytosolic-free Ca(2+), intracellular pH (pH(i)), ERK1/2, and Akt/protein kinase B (PKB) phosphorylatio...

journal_title：Journal of leukocyte biology

authors： Sandoval AJ,Riquelme JP,Carretta MD,Hancke JL,Hidalgo MA,Burgos RA

更新日期：2007-11-01 00:00:00

abstract：:LPS induces dendritic cell (DC) activation, but the precise in vivo mechanism is unclear since DCs express low levels of TLR4. Here, it is shown that DCs can be activated in response to LPS through a bystander mechanism. This result was obtained using chimeric mice reconstituted with LPS-responsive and nonresponsive b...

journal_title：Journal of leukocyte biology

authors： Yadav R,Zammit DJ,Lefrancois L,Vella AT

更新日期：2006-12-01 00:00:00

abstract：:IL-33 is a more recently identified member of the IL-1 cytokine family, expressed in the nucleus of epithelial cells and released into the extracellular space following tissue damage. The impact of IL-33 as a regulator of the adaptive immune response has been studied extensively, with an understood role for IL-33 in t...

journal_title：Journal of leukocyte biology

authors： Lott JM,Sumpter TL,Turnquist HR

更新日期：2015-06-01 00:00:00

abstract：:The membrane fusion events observed during neutrophil degranulation are important aspects of the immunoregulatory system. In an attempt to understand the regulation of granule-plasma membrane fusion, we have begun characterizing human neutrophil cytosol for fusion activity, finding that 50% of the fusogenic activity c...

journal_title：Journal of leukocyte biology

authors： Hessler RJ,Blackwood RA,Brock TG,Francis JW,Harsh DM,Smolen JE

更新日期：1998-03-01 00:00:00

abstract：:This report focuses on the modulatory role of endogenous H(2)O(2) on lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma)-induced inducible nitric oxide synthase (NOS2) gene expression in rat peritoneal macrophages. Exogenously added H(2)O(2) was initially found to inhibit the synthesis of NOS2, which prompted us to ...

journal_title：Journal of leukocyte biology

authors： Vega A,Chacón P,Monteseirín J,El Bekay R,Alvarez M,Alba G,Conde J,Martín-Nieto J,Bedoya FJ,Pintado E,Sobrino F

更新日期：2004-06-01 00:00:00

abstract：:HIV infection results in depletion and dysfunction of naïve CD4(+) T cells. The mechanisms underlying these deficiencies are not understood. We investigated the frequencies of CD4(+) naïve subsets in HIV disease as defined by expression of CD25 and/or FoxP3 and the relationship of these frequencies to naïve T cell pro...

journal_title：Journal of leukocyte biology

authors： Rodriguez B,Bazdar DA,Funderburg N,Asaad R,Luciano AA,Yadavalli G,Kalayjian RC,Lederman MM,Sieg SF

更新日期：2011-09-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) is one of the recently defined damage-associated molecular pattern molecules, passively released from necrotic cells and secreted by activated macrophage/monocytes. Whether cytolytic cells induce HMGB1 release from tumor cells is not known. We developed a highly sensitive method for d...

journal_title：Journal of leukocyte biology

authors： Ito N,DeMarco RA,Mailliard RB,Han J,Rabinowich H,Kalinski P,Stolz DB,Zeh HJ 3rd,Lotze MT

更新日期：2007-01-01 00:00:00

abstract：:Osteopontin is an RGD-containing bone matrix protein with cytokine-like functions that is associated with early stages of Th1-mediated diseases. Although the function of osteopontin in these responses is unknown, it is expressed by activated T cells and macrophages and can costimulate T cell proliferation. Studies hav...

journal_title：Journal of leukocyte biology

authors： O'Regan AW,Hayden JM,Berman JS

更新日期：2000-10-01 00:00:00

abstract：:Recent studies have revealed that aloe emodin (AE), a natural compound from the root and rhizome of Rheum palmatum L., exhibits significant pharmacologic activities. However, the pharmacologic relevance of the compound, particularly for cardiovascular disease, remains largely unknown. Here, we hypothesized that AE cou...

journal_title：Journal of leukocyte biology

authors： Zhang Y,Song Z,Huang S,Zhu L,Liu T,Shu H,Wang L,Huang Y,Chen Y

更新日期：2020-12-01 00:00:00

abstract：:Mer signaling participates in a novel inhibitory pathway in TLR activation. The purpose of the present study was to examine the role of Mer signaling in the down-regulation of TLR4 activation-driven immune responses in mice, i.t.-treated with LPS, using the specific Mer-blocking antibody. At 4 h and 24 h after LPS tre...

journal_title：Journal of leukocyte biology

authors： Lee YJ,Han JY,Byun J,Park HJ,Park EM,Chong YH,Cho MS,Kang JL

更新日期：2012-06-01 00:00:00

abstract：:HL-60 cells are promyelocytic leukemia cells that respond to culture conditions with differentiation into granulocytelike or macrophagelike phagocytes. O2 metabolism is critical to the microbicidal function of phagocytic cells. O2 metabolism was studied in HL-60 cells differentiated with dimethylsulfoxide (Me2SO) and ...

journal_title：Journal of leukocyte biology

authors： Thompson BY,Sivam G,Britigan BE,Rosen GM,Cohen MS

更新日期：1988-02-01 00:00:00

abstract：:Blocking monoclonal antibodies (mAbs) specific to mouse interleukin-1 receptor antagonist (IL-1ra) were prepared by immunizing Armenian hamsters with recombinant mouse IL-1ra. A sensitive and specific ELISA against mouse IL-1ra was also established. In Propionibacterium acnes-induced liver injury, P. acnes induced tra...

journal_title：Journal of leukocyte biology

authors： Fujioka N,Mukaida N,Harada A,Akiyama M,Kasahara T,Kuno K,Ooi A,Mai M,Matsushima K

更新日期：1995-07-01 00:00:00

abstract：:A continuing theme of work done in our laboratory involves regulation of adaptive immune response by innate cells, in general, and immuneregulation by natural killer (NK) and NKT cells, in particular. Studies include work with the lung and the eye. In addition to immune surveillance of tumor cells, the NK cell is ofte...

journal_title：Journal of leukocyte biology

authors： Stein-Streilein J,Sonoda KH,Faunce D,Zhang-Hoover J

更新日期：2000-04-01 00:00:00

abstract：:The transcription factor nuclear factor (NF)-kappaB controls the expression of genes involved in inflammation, cell proliferation, apoptosis, and differentiation. Impaired regulation of NF-kappaB has been associated with many diseases; thus, there is significant interest in therapeutic approaches based on modulation o...

journal_title：Journal of leukocyte biology

authors： Diatchenko L,Romanov S,Malinina I,Clarke J,Tchivilev I,Li X,Makarov SS

更新日期：2005-12-01 00:00:00

abstract：:PGE(2) and other cAMP-elevating agents are known to down-regulate most functions stimulated by fMLP in human polymorphonuclear neutrophils. We reported previously that the inhibitory potential of PGE(2) resides in its capacity to suppress fMLP-stimulated PI-3Kgamma activation via the PGE(2) receptor EP(2) and hence, t...

journal_title：Journal of leukocyte biology

authors： Burelout C,Naccache PH,Bourgoin SG

更新日期：2007-06-01 00:00:00

abstract：:To elucidate the differentiation mechanisms of macrophages in the murine omentum, we studied the repopulation of these cells and the expression of macrophage colony-stimulating factor (M-CSF) in the milky spots and omental tissues in mice depleted of macrophages following administration of liposome-encapsulated dichlo...

journal_title：Journal of leukocyte biology

authors： Zhu H,Naito M,Umezu H,Moriyama H,Takatsuka H,Takahashi K,Shultz LD

更新日期：1997-04-01 00:00:00

abstract：:We have characterized the beta-adrenergic receptor binding site and the beta-adrenergic cAMP response of the HL-60 cell. The hydrophilic ligand [3H]-(-)-CGP-12177 was specifically and reversibly bound to one single class of binding sites (Kd 220 pM and Bmax 1,970 sites/cell). The adrenergic agonists inhibited the spec...

journal_title：Journal of leukocyte biology

authors： Sager G,Bang BE,Pedersen M,Aarbakke J

更新日期：1988-07-01 00:00:00

abstract：:Specific prion peptides have been shown to mimic the pathologic isoform of the prion protein (PrP) and to induce a neurotoxic effect in vitro and in vivo. As monocytic cells are thought to play a role in the transmission and pathogenesis of prion disease, the use of these peptides in regulating monocytic cell function...

journal_title：Journal of leukocyte biology

authors： Bacot SM,Lenz P,Frazier-Jessen MR,Feldman GM

更新日期：2003-07-01 00:00:00

abstract：:Mycoplasmas and mycoplasma membranes have been shown to induce the production of inflammatory cytokines, including tumor necrosis factor alpha and interleukin-6, as well as nitric oxide, by mouse macrophages and rat brain astrocytes. Luminol-enhanced chemiluminescence was used as a sensitive method to show that Mycopl...

journal_title：Journal of leukocyte biology

authors： Avron A,Gallily R

更新日期：1995-02-01 00:00:00

abstract：:Clostridioides difficile (C. difficile) is the major cause of hospital-acquired gastrointestinal infections in individuals following antibiotics treatment. The pathogenesis of C. difficile infection (CDI) is mediated mainly by the production of toxins that induce tissue damage and host inflammatory responses. While in...

journal_title：Journal of leukocyte biology

authors： Hernández Del Pino RE,Barbero AM,Español LÁ,Morro LS,Pasquinelli V

更新日期：2020-08-23 00:00:00

abstract：:Dietary olive oil supplementation and more recently, olive oil phenols have been recommended as important therapeutic interventions in preventive medicine. Ole has several pharmacological properties, including antioxidant, anti-inflammatory, antiatherogenic, anticancer, antimicrobial, and antiviral and for these reaso...

journal_title：Journal of leukocyte biology

authors： Campolo M,Di Paola R,Impellizzeri D,Crupi R,Morittu VM,Procopio A,Perri E,Britti D,Peli A,Esposito E,Cuzzocrea S

更新日期：2013-02-01 00:00:00

abstract：:To become competent killer cells, CD8(+) T cells require stimulation through signal transduction pathways associated with the T-cell receptor, costimulatory molecules such as CD28, and cytokine receptors such as the interleukin (IL)-2 receptor. We used wortmannin and LY294002, two inhibitors of phosphatidylinositol 3-...

journal_title：Journal of leukocyte biology

authors： Phu T,Haeryfar SM,Musgrave BL,Hoskin DW

更新日期：2001-05-01 00:00:00

abstract：:HIV is known to subvert cellular machinery to enhance its replication. Recently, HIV has been reported to enhance TC renin expression. We hypothesized that HIV induces and maintains high renin expression to promote its own replication in TCs. Renin enhanced HIV replication in TCs in a dose-dependent manner. (P)RR-defi...

journal_title：Journal of leukocyte biology

authors： Chandel N,Ayasolla K,Lan X,Rai P,Mikulak J,Husain M,Malhotra A,McGowan J,Singhal PC

更新日期：2014-10-01 00:00:00

abstract：:Endotoxin tolerance is characterized by attenuated macrophage activation to subsequent LPS challenge and can be reversed through nonspecific protein kinase C (PKC) activation, and activation by LPS within naïve cells requires the activation of the cell surface receptors CD14 and TLR4 on lipid rafts. The effect of PKC ...

journal_title：Journal of leukocyte biology

authors： Cuschieri J,Billigren J,Maier RV

更新日期：2006-12-01 00:00:00

abstract：:Endocytic proteolysis represents a major functional component of the major histocompatibility complex class II antigen-presentation machinery. Although transport and assembly of class II molecules in the endocytic compartment are well characterized, we lack information about the pattern of endocytic protease activity ...

journal_title：Journal of leukocyte biology

authors： Lautwein A,Kraus M,Reich M,Burster T,Brandenburg J,Overkleeft HS,Schwarz G,Kammer W,Weber E,Kalbacher H,Nordheim A,Driessen C

更新日期：2004-05-01 00:00:00

abstract：:Human immunodeficiency virus type-1 (HIV-1)-associated dementia (HAD) is a neurodegenerative disease characterized by HIV infection and replication in brain tissue. HIV-1-infected monocytes overexpress inflammatory molecules that facilitate their entry into the brain. Prostanoids are lipid mediators of inflammation th...

journal_title：Journal of leukocyte biology

authors： Pereira CF,Boven LA,Middel J,Verhoef J,Nottet HS

更新日期：2000-09-01 00:00:00

abstract：:In this report, the construction of a functional, immunocompetent, full-thickness skin equivalent (SE) is described, consisting of an epidermal compartment containing keratinocytes, melanocytes, and human LCs derived from the MUTZ-3 cell line (MUTZ-LC) and a fibroblast-populated dermal compartment. The CD1a(+)Langerin...

journal_title：Journal of leukocyte biology

authors： Ouwehand K,Spiekstra SW,Waaijman T,Scheper RJ,de Gruijl TD,Gibbs S

更新日期：2011-11-01 00:00:00