Macrophage differentiation and expression of macrophage colony-stimulating factor in murine milky spots and omentum after macrophage elimination.

abstract：:Scaffolding molecules bind simultaneously and link together various components of signal-transduction pathways. Grb2-associated binder 2 (Gab2) is a scaffolding protein required for FcgammaR-initiated allergic responses in mast cells and FcgammaR-mediated phagocytosis in macrophages, where it links IgE and IgG recepto...

journal_title：Journal of leukocyte biology

authors： Zompi S,Gu H,Colucci F

更新日期：2004-10-01 00:00:00

abstract：:Macrophages and dendritic cells are in the front line of host defense. When they sense host invasion, they produce cytokines that alert other innate immune cells and also abet the development of an adaptive immune response. Although lipolysaccharide (LPS), peptidoglycan, unmethylated DNA, and other microbial products ...

journal_title：Journal of leukocyte biology

authors： Beutler B,Hoebe K,Du X,Ulevitch RJ

更新日期：2003-10-01 00:00:00

abstract：:The persistent infection caused by hepatitis C virus (HCV) is presumably explained by a deficient immune response to the infection, but the basis for the inefficiency of immune-mediated virus eradication is not known in detail. This study addresses mechanisms of relevance to dysfunction of cytotoxic lymphocytes in HCV...

journal_title：Journal of leukocyte biology

authors： Thorén F,Romero A,Lindh M,Dahlgren C,Hellstrand K

更新日期：2004-12-01 00:00:00

abstract：:PI(3)Kγ is thought to mediate leukocyte migration to injured tissues and may be important in the pathogenesis of various T-lymphocyte-dependent pathologies, including autoimmune and inflammatory diseases. The present study evaluated the relevance of PI(3)Kγ in donor cells for the pathogenesis of acute GVHD using a mod...

journal_title：Journal of leukocyte biology

authors： Castor MG,Rezende BM,Bernardes PT,Vieira AT,Vieira EL,Arantes RM,Souza DG,Silva TA,Teixeira MM,Pinho V

更新日期：2011-06-01 00:00:00

abstract：:Interaction of bacterial lipopolysaccharide (LPS) with monocytes stimulates production of a variety of mediators that are involved in the pathogenesis of septic shock and wound repair. We report here the mechanisms of LPS uptake and intracellular distribution of LPS in human monocytes. Ficoll-Hypaque-purified peripher...

journal_title：Journal of leukocyte biology

authors： Kang YH,Dwivedi RS,Lee CH

更新日期：1990-10-01 00:00:00

abstract：:The viral CC chemokines MC148, encoded by the poxvirus molluscum contagiosum, and viral macrophage inflammatory protein (vMIP)-I and vMIP-II, encoded by human herpesvirus 8, were probed on the murine CC receptor (CCR) 8 in parallel with human CCR8. In calcium mobilization assays, vMIP-I acted as a high-affinity agonis...

journal_title：Journal of leukocyte biology

authors： Lüttichau HR,Gerstoft J,Schwartz TW

更新日期：2001-08-01 00:00:00

abstract：:The identification of an anti-tumor effect displayed by cells of innate immunity has opened new scenarios, not only in the field of allo-HSCT but also for nontransplanted patients with hematological malignancies or solid tumors. Donor-derived NK cells have been shown to contribute to the eradication of malignant cells...

journal_title：Journal of leukocyte biology

authors： Locatelli F,Merli P,Rutella S

更新日期：2013-12-01 00:00:00

abstract：:Extravasation of leukocytes is a crucial process in the immunological defense. In response to a local concentration of chemokines, circulating leukocytes adhere to and migrate across the vascular endothelium toward the inflamed tissue. The small guanosinetriphosphatase Rap1 plays an important role in the regulation of...

journal_title：Journal of leukocyte biology

authors： Lorenowicz MJ,van Gils J,de Boer M,Hordijk PL,Fernandez-Borja M

更新日期：2006-12-01 00:00:00

abstract：:TNF is implicated in the suppression of neutrophil apoptosis during sepsis. Multiple signaling pathways are involved in TNF-mediated antiapoptotic signaling; a role for the MAP kinases (MAPK), ERK1/2, and p38 MAPK has been suggested. Antiapoptotic signaling is mediated principally through TNF receptor-1 (TNFR-1), and ...

journal_title：Journal of leukocyte biology

authors： Kilpatrick LE,Sun S,Mackie D,Baik F,Li H,Korchak HM

更新日期：2006-12-01 00:00:00

abstract：:The RAGE binds multiple ligand families linked to hyperglycemia, aging, inflammation, neurodegeneration, and cancer. Activation of RAGE by its ligands stimulates diverse signaling cascades. The recent observation that the cytoplasmic domain of RAGE interacts with diaphanous or mDia-1 links RAGE signal transduction to ...

journal_title：Journal of leukocyte biology

authors： Ramasamy R,Yan SF,Schmidt AM

更新日期：2009-09-01 00:00:00

abstract：:Many intracellular signals, such as host danger-associated molecules and bacterial toxins during infection, elicit inflammasome activation. However, the mechanical environment in tissues may also influence the sensitivity of various inflammasomes to activation. The cellular mechanical environment is determined by the ...

journal_title：Journal of leukocyte biology

authors： Joshi H,Morley SC

更新日期：2019-07-01 00:00:00

abstract：:In this study we present data on a novel cell surface antigen recognized by monoclonal antibody (mAb) VPM30, originally thought to recognize only bovine and ovine sIg+ B cells from peripheral blood. Here we show that the antigen, molecular mass 28 kDa, is not only found in B cell follicles in frozen sections, but when...

journal_title：Journal of leukocyte biology

authors： Campbell JD,Hopkins J,Howie SE,Oliver RA,Nichani AK,Goel P,Spooner RL,Glass EJ

更新日期：1998-05-01 00:00:00

abstract：:We tested several of the functions of macrophages (M phi) in the early phase after allogeneic bone marrow transfer to get information about this important aspect of the nonspecific immune system in the T-cell-deficient recipient. On days 3-5 after transfer, the number of M phi was reduced in the spleen, liver, lungs, ...

journal_title：Journal of leukocyte biology

authors： Roesler J,Baccarini M,Vogt B,Lohmann-Matthes ML

更新日期：1989-08-01 00:00:00

abstract：:Neutrophils kill invading pathogens by AMPs, including cathelicidins, ROS, and NETs. The human pathogen Staphylococcus aureus exhibits enhanced resistance to neutrophil AMPs, including the murine cathelicidin CRAMP, in part, as a result of alanylation of teichoic acids by the dlt operon. In this study, we took advanta...

journal_title：Journal of leukocyte biology

authors： Jann NJ,Schmaler M,Kristian SA,Radek KA,Gallo RL,Nizet V,Peschel A,Landmann R

更新日期：2009-11-01 00:00:00

abstract：:To determine if the release of IL-1 alpha and IL-1 beta by cultured PBMC could be independently modulated by different exogenous stimuli, we examined the effect of LPS, IFN gamma, latex beads, and indomethacin on the release of IL-1 alpha and IL-1 beta. PBMC culture supernatants were fractionated by Sephacryl-S-200 co...

journal_title：Journal of leukocyte biology

authors： Sandborg CI,Berman MA,Imfeld KL,Zaldivar F Jr,Masada MP,Kenney JS

更新日期：1989-11-01 00:00:00

abstract：:Dynamic rearrangements of the actin cytoskeleton are crucial for the function of numerous cellular elements including T lymphocytes. They are required for migration of T lymphocytes through the body to scan for the presence of antigens, as well as for the formation and stabilization of the immunological synapse at the...

journal_title：Journal of leukocyte biology

authors： Samstag Y,Eibert SM,Klemke M,Wabnitz GH

更新日期：2003-01-01 00:00:00

abstract：:A simple and rapid method for the purification of morphologically and functionally intact eosinophils from human blood of both normal and eosinophilic subjects is described. The method is based on a single centrifugation of total blood leukocytes suspended in Percoll with specific gravity 1.0853 g/ml, after erythrocyt...

journal_title：Journal of leukocyte biology

authors： Cramer R,Dri P,Zabucchi G,Patriarca P

更新日期：1992-09-01 00:00:00

abstract：:T cell-mediated immunity against Chlamydia in mice is mediated at least in part by T cell-derived interferon-gamma (IFN-gamma) induction of the nitric oxide synthase (iNOS) system in infected epithelial cells. Although IFN-gamma alone could stimulate nitric oxide (NO) production from epithelial cells and inhibit the i...

journal_title：Journal of leukocyte biology

authors： Igietseme JU,Uriri IM,Hawkins R,Rank RG

更新日期：1996-05-01 00:00:00

abstract：:Maintenance of blood DC homeostasis is essential to preventing autoimmunity while controlling chronic infection. However, the ability of bacteremic pathogens to directly regulate blood DC homeostasis has not been defined. One such bacteremic pathogen, Porphyromonas gingivalis, is shown by our group to survive within m...

journal_title：Journal of leukocyte biology

authors： Miles B,Scisci E,Carrion J,Sabino GJ,Genco CA,Cutler CW

更新日期：2013-08-01 00:00:00

abstract：:In the presence of adenosine, formyl-Met-Leu-Phe-stimulated human neutrophils show a greatly diminished production of superoxide anion. Analysis of changes in levels of intracellular calcium revealed that the immediate increase (occurring within seconds) in intracellular calcium following addition of formyl-Met-Leu-Ph...

journal_title：Journal of leukocyte biology

authors： Walker BA,Hagenlocker BE,Douglas VK,Ward PA

更新日期：1990-09-01 00:00:00

abstract：:MMPs are generally considered to regulate degradation and remodeling of the ECM. Convincing data also implicate a role for MMPs in inflammatory conditions, such as AP, although the mechanisms are not known. The aim of this study was to define the role of MMPs in regulating activation of trypsinogen and tissue damage i...

journal_title：Journal of leukocyte biology

authors： Awla D,Abdulla A,Syk I,Jeppsson B,Regnér S,Thorlacius H

更新日期：2012-05-01 00:00:00

abstract：:We have shown previously that homotypic interaction of resting memory CD4 T cells with activated T cells induces the production of cytokines with immunoregulatory potential (IL-10, IL-4) from the former. Here, we analyzed the effector functions of these T cells stimulated by homotypic T cell interaction. T cells induc...

journal_title：Journal of leukocyte biology

authors： Thümmler K,Leipe J,Ramming A,Schulze-Koops H,Skapenko A

更新日期：2010-11-01 00:00:00

abstract：:In the present work, we demonstrate that interleukin (IL)-4 is able to rescue B cells from Trypanosoma cruzi-infected mice, counteracting the strong apoptotic signals that these cells received in vivo. We have observed that IL-4 restrains the apoptosis of immunoglobulin (Ig)M(+) and IgG(+) B cells from infected and no...

journal_title：Journal of leukocyte biology

authors： Acosta Rodriguez EV,Zuñiga E,Montes CL,Gruppi A

更新日期：2003-01-01 00:00:00

abstract：:CD137, a member of the TNF receptor family, and its ligand are expressed on T lymphocytes and antigen-presenting cells (APC), respectively. During interaction with APC, T lymphocytes receive a potent, costimulatory signal through CD137. Reverse signaling has been demonstrated for the CD137 ligand, which causes activat...

journal_title：Journal of leukocyte biology

authors： Pauly S,Broll K,Wittmann M,Giegerich G,Schwarz H

更新日期：2002-07-01 00:00:00

abstract：:Regulation of macrophage PCD plays an important role in pathogenesis of leishmaniasis. However, the precise involvement of any parasite molecule in this process remains uncertain. In the current study, in silico wide analysis demonstrated that genes in the Leishmania donovani genome are highly enriched for CpG motifs,...

journal_title：Journal of leukocyte biology

authors： Das S,Ghosh AK,Singh S,Saha B,Ganguly A,Das P

更新日期：2015-02-01 00:00:00

abstract：:Introduction of alloantigens into the AC induces a form of immune tolerance known as ACAID, which induces antigen-specific CD8+ Tregs, contributing to ocular immune privilege by down-regulating immune responses. Recent evidence suggests IFN-γ is needed for the suppressive function of CD8+ ACAID Tregs. This study teste...

journal_title：Journal of leukocyte biology

authors： Paunicka K,Chen PW,Niederkorn JY

更新日期：2012-03-01 00:00:00

abstract：:In vitro studies have suggested that targeting interleukin (IL)-1 and tumor necrosis factor (TNF) can be used to regulate intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) and potentially treat kidney inflammation. We therefore evaluated ICAM-1 and VCAM-1 regulation in knockout ...

journal_title：Journal of leukocyte biology

authors： Burne MJ,Elghandour A,Haq M,Saba SR,Norman J,Condon T,Bennett F,Rabb H

更新日期：2001-08-01 00:00:00

abstract：:The present study was initiated to identify the antigen recognized by the monoclonal antibody (MAb) MAC387 which is widely used for phenotypical characterization of myelomonocytic cells in situ. MAC387 has been described to show a similar reaction pattern as antisera to a complex formed by the calcium-binding proteins...

journal_title：Journal of leukocyte biology

authors： Goebeler M,Roth J,Teigelkamp S,Sorg C

更新日期：1994-02-01 00:00:00

abstract：:Recombinant fusion proteins consisting of the extracellular domain of immunoregulatory proteins and the constant domain of immunoglobulin G (IgG) are a novel class of human therapeutics. IgG isoforms exert different levels of immune effector functions, such as complement lysis and antibody-dependent cell cytotoxicity ...

journal_title：Journal of leukocyte biology

authors： Taylor L,Bachler M,Duncan I,Keen S,Fallon R,Mair C,McDonald TT,Schwarz H

更新日期：2002-09-01 00:00:00

abstract：:The human endometrium is exposed to cyclical fluctuations of ovarian-derived sex steroids resulting in proliferation, differentiation (decidualization), and menstruation. An influx of leukocytes (up to 15% macrophages) occurs during the latter stages of the menstrual cycle, including menses. We believe the endometrial...

journal_title：Journal of leukocyte biology

authors： Thiruchelvam U,Dransfield I,Saunders PT,Critchley HO

更新日期：2013-02-01 00:00:00