Immune regulation by peripheral suppressor T cells induced upon homotypic T cell/T cell interactions.

abstract：:Macrophages in brain, lung, and lymphatics constitute a major HIV reservoir during subclinical infection and disease. During HIV transmission macrophages are seemingly one of the first cells infected, being as efficient as T cells in supporting productive viral replication. Macrophages control a myriad of cell-mediate...

journal_title：Journal of leukocyte biology

authors： Stevenson M,Gendelman HE

更新日期：1994-09-01 00:00:00

abstract：:Absence of lymph nodes in nonmammalian species, expression of MHCII by APCs in the periphery, and the recent findings that T cells can change their polarization status after presentation in the lymph nodes imply a role for MHCII-mediated presentation outside the organized lymphoid tissue. This study shows that MHCII(+...

journal_title：Journal of leukocyte biology

authors： Inman CF,Singha S,Lewis M,Bradley B,Stokes C,Bailey M

更新日期：2010-09-01 00:00:00

abstract：:The adhesion and degranulation promoting adaptor protein (ADAP) is a multifunctional scaffold involved in many different signaling pathways that are important for the function of T cells, including the inside-out and outside-in signaling of integrins, the activation of NF-κB, and the subsequent production of proinflam...

journal_title：Journal of leukocyte biology

authors： Parzmair GP,Gereke M,Haberkorn O,Annemann M,Podlasly L,Kliche S,Reinhold A,Schraven B,Bruder D

更新日期：2017-02-01 00:00:00

abstract：:Polymorphonuclear leukocytes (PMN) play an important role in inflammation, immune responses, and tissue repair by secreting interleukin- 1 beta (IL-1 beta). We investigated the regulation of IL-1 beta gene expression in human PMN treated with granulocyte-macrophage colony-stimulating factor (GM-CSF). GM-CSF induced IL...

journal_title：Journal of leukocyte biology

authors： Fernandez MC,Walters J,Marucha P

更新日期：1996-04-01 00:00:00

abstract：:Resting microglia comprise up to 13% of the cells in human central nervous system (CNS) white matter. Their large number and dendritic morphology make them ideally suited to survey the CNS for noxious stimuli. Upon activation microglia gradually lose dendritic processes and transform into typical phagocytic macrophage...

journal_title：Journal of leukocyte biology

authors： Ulvestad E,Williams K,Bjerkvig R,Tiekotter K,Antel J,Matre R

更新日期：1994-12-01 00:00:00

abstract：:Activation of Kupffer cells is a prominent feature of necro-inflammatory liver injury. We have recently demonstrated that 5-lipoxygenase (5-LO) and its accessory protein, 5-LO-activating protein (FLAP), are essential for the survival of Kupffer cells in culture, as their inhibition drives these liver resident macropha...

journal_title：Journal of leukocyte biology

authors： Titos E,Clària J,Planagumà A,López-Parra M,González-Périz A,Gaya J,Miquel R,Arroyo V,Rodés J

更新日期：2005-10-01 00:00:00

abstract：:We evaluated the concept that the vascular entrance of both bacterial and nonbacterial particulate material could lead to hepatic parenchymal cell injury, either due to postphagocytic Kupffer cell activity or the margination of activated leukocytes in the liver. Injection of denatured, collagen-coated particles as wel...

journal_title：Journal of leukocyte biology

authors： Holman JM Jr,Saba TM

更新日期：1988-03-01 00:00:00

abstract：:The motheaten mouse was first described in 1975 as a model of systemic inflammation and autoimmunity, as a result of immune system dysregulation. The phenotype was later ascribed to mutations in the cytoplasmic tyrosine phosphatase Shp1. This phosphatase is expressed widely throughout the hematopoietic system and has ...

journal_title：Journal of leukocyte biology

authors： Abram CL,Lowell CA

更新日期：2017-09-01 00:00:00

abstract：:Deoxycytidyl-deoxyguanosine [(CpG)3] oligodeoxynucleotides (ODNs) signal through TLR9 to induce type-I IFN (IFN-alphabeta) and IFN-alphabeta-dependent MHC-I cross-presentation of exogenous antigens by dendritic cells (DCs). A puzzle was presented by our observation that three ODN classes, CpG-A, CpG-B, and CpG-C, had ...

journal_title：Journal of leukocyte biology

authors： Gray RC,Kuchtey J,Harding CV

更新日期：2007-04-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) encodes the MHC class I-like molecule UL18, which binds with high affinity to the leukocyte Ig-like receptor-1 (LIR-1), an inhibitory receptor commonly expressed on myeloid cells and subsets of NK and T cells. The exact role of UL18 is not known, in particular in relation to its proposed r...

journal_title：Journal of leukocyte biology

authors： Wagner CS,Walther-Jallow L,Buentke E,Ljunggren HG,Achour A,Chambers BJ

更新日期：2008-01-01 00:00:00

abstract：:Rac2 is a hematopoietic-specific Rho-GTPase that plays a stimulus-specific role in regulating reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation and other functional responses in neutrophils. In this study, rac2-/- neutrophils were shown to have significantly decreased NADPH oxidase activit...

journal_title：Journal of leukocyte biology

authors： Kim C,Dinauer MC

更新日期：2006-01-01 00:00:00

abstract：:Blocking monoclonal antibodies (mAbs) specific to mouse interleukin-1 receptor antagonist (IL-1ra) were prepared by immunizing Armenian hamsters with recombinant mouse IL-1ra. A sensitive and specific ELISA against mouse IL-1ra was also established. In Propionibacterium acnes-induced liver injury, P. acnes induced tra...

journal_title：Journal of leukocyte biology

authors： Fujioka N,Mukaida N,Harada A,Akiyama M,Kasahara T,Kuno K,Ooi A,Mai M,Matsushima K

更新日期：1995-07-01 00:00:00

abstract：:Mature macrophages, derived in vitro from bone marrow progenitors under the influence of either macrophage colony stimulating factor (CSF-1) or granulocyte-macrophage (GM)-CSF, have been shown to differ morphologically and functionally. The data presented in this report demonstrate that macrophages derived from bone m...

journal_title：Journal of leukocyte biology

authors： Falk LA,Vogel SN

更新日期：1990-07-01 00:00:00

abstract：:CD137, a member of the TNF receptor family, and its ligand are expressed on T lymphocytes and antigen-presenting cells (APC), respectively. During interaction with APC, T lymphocytes receive a potent, costimulatory signal through CD137. Reverse signaling has been demonstrated for the CD137 ligand, which causes activat...

journal_title：Journal of leukocyte biology

authors： Pauly S,Broll K,Wittmann M,Giegerich G,Schwarz H

更新日期：2002-07-01 00:00:00

abstract：:In RAW 264.7 cells, PKC-ε regulates FcγR-mediated phagocytosis. BMDM behave similarly; PKC-ε concentrates at phagosomes and internalization are reduced in PKC-ε⁻/⁻ cells. Two questions were asked: what is the role of PKC-ε? and what domains are necessary for PKC-ε concentration? Function was studied using BMDM and fru...

journal_title：Journal of leukocyte biology

authors： Wood TR,Chow RY,Hanes CM,Zhang X,Kashiwagi K,Shirai Y,Trebak M,Loegering DJ,Saito N,Lennartz MR

更新日期：2013-07-01 00:00:00

abstract：:A cell resistant to concentrations of mitomycin-C associated with the inactivation of many in vitro immune responses is described. This cell is responsive to concanavalin A (Con A), poorly adherent to nylon wool, present in relatively greater numbers in lymph node than other lymphoid tissues, and is relatively radiose...

journal_title：Journal of leukocyte biology

authors： Anderson RE,Standefer JC,Troup GM,Pogue LE

更新日期：1987-01-01 00:00:00

abstract：:Dendritic cell (DC) and DC-derived exosomes (EXO) have been used extensively for tumor vaccination. However, its therapeutic efficiency is limited to only production of prophylactic immunity against tumors. T cells can uptake DC-released EXO. However, the functional effect of transferred exosomal molecules on T cells ...

journal_title：Journal of leukocyte biology

authors： Hao S,Yuan J,Xiang J

更新日期：2007-10-01 00:00:00

abstract：:Neutrophils, an essential component of the innate immune system, are produced at a rate 10(11) cells/day and are consequently the most abundant leukocyte in the blood. These granulocytes have a relatively short half-life (6-8 h) in the blood, and as a result of the cytotoxic nature of their contents, it is critical th...

journal_title：Journal of leukocyte biology

authors： Rankin SM

更新日期：2010-08-01 00:00:00

abstract：:An epithelial cell line, IT-45R1, has been established from a thymus of normal Wistar rat and was found to produce growth factor which stimulated the proliferation of bone marrow cells. This growth factor induced the formation of colonies composed of macrophages, granulocytes, or both, in semi-solid medium and stimula...

journal_title：Journal of leukocyte biology

authors： Nanno M,Takahashi T,Sakata T,Horikawa T,Sako T,Suzuki R,Itoh T,Kumagai K

更新日期：1991-12-01 00:00:00

abstract：:The oncogene EVI1 has been implicated in the etiology of AML and MDS. Although AML cells are characterized by accelerated proliferation and differentiation arrest, MDS cells hyperproliferate when immature but fail to differentiate later and die instead. In agreement with its roles in AML and in immature MDS cells, EVI...

journal_title：Journal of leukocyte biology

authors： Konrad TA,Karger A,Hackl H,Schwarzinger I,Herbacek I,Wieser R

更新日期：2009-10-01 00:00:00

abstract：:Polyamines naturally occur in all living beings and play an important role in the regulation of cell proliferation, differentiation, and functional stimulation of terminally differentiated cells. Our studies, using specific inhibitors of polyamine biosynthesis such as alpha-difluoromethylornithine and methylglyoxal-bi...

journal_title：Journal of leukocyte biology

authors： Messina L,Spampinato G,Arcidiacono A,Malaguarnera L,Pagano M,Kaminska B,Kaczmarek L,Messina A

更新日期：1992-12-01 00:00:00

abstract：:The human endometrium is exposed to cyclical fluctuations of ovarian-derived sex steroids resulting in proliferation, differentiation (decidualization), and menstruation. An influx of leukocytes (up to 15% macrophages) occurs during the latter stages of the menstrual cycle, including menses. We believe the endometrial...

journal_title：Journal of leukocyte biology

authors： Thiruchelvam U,Dransfield I,Saunders PT,Critchley HO

更新日期：2013-02-01 00:00:00

abstract：:The lymphotoxin signaling pathway plays an important role in the homeostasis and function of peripheral and mucosal dendritic cells, and dendritic cell-intrinsic lymphotoxin β receptor expression is required for optimal responses to opportunistic intestinal bacteria. However, it is unknown whether dendritic cell-intri...

journal_title：Journal of leukocyte biology

authors： Sun T,Rojas OL,Li C,Philpott DJ,Gommerman JL

更新日期：2016-07-01 00:00:00

abstract：:Colorectal cancer is the second most common cause of cancer-related death. Novel prognostic factors should be identified and validated to refine the present tumor-node-metastasis system. The presence of immune cells infiltrating colorectal cancers is a common phenomenon. However, the current belief is that clinically ...

journal_title：Journal of leukocyte biology

authors： Pagès F,Galon J,Fridman WH

更新日期：2008-10-01 00:00:00

abstract：:IL-1 receptor-associated kinase (IRAK) 4 is a central enzyme of the TLR pathways. This study tested the hypothesis that IRAK4 kinase activity is prerequisite for regulating innate immunity during infections with intracellular bacteria. To this end, we analyzed responses of macrophages obtained from mice expressing wil...

journal_title：Journal of leukocyte biology

authors： Pattabiraman G,Murphy M,Agliano F,Karlinsey K,Medvedev AE

更新日期：2018-10-01 00:00:00

abstract：:We have studied two key stages of CD4 development that serve as important checkpoints in determining whether a response will occur, how big it will be, and how long it will last. The response of naive CD4 cells is strictly regulated by the requirement for interaction of the potential precursor with an antigen-presenti...

journal_title：Journal of leukocyte biology

authors： Swain SL

更新日期：1995-05-01 00:00:00

abstract：:G-CSF and GM-CSF play important roles in regulating neutrophil production, survival, differentiation, and function. However, we have shown previously that G-CSF/GM-CSF double-deficient [knockout (KO)] mice still develop a profound neutrophilia in bone marrow and blood after infection with Candida albicans. This findin...

journal_title：Journal of leukocyte biology

authors： Zhang HH,Basu S,Wu F,Begley CG,Saris CJ,Dunn AR,Burgess AW,Walker F

更新日期：2007-10-01 00:00:00

abstract：:Leukocytes are a large population of cells spread within most tissues in the body. These cells may be either sessile (called as resident cells) or circulating leukocytes, which travel long journeys inside the vessels during their lifespan. Although production and maturation of these leukocytes in adults primarily occu...

journal_title：Journal of leukocyte biology

authors： Mafra K,Nakagaki BN,Castro Oliveira HM,Rezende RM,Antunes MM,Menezes GB

更新日期：2019-09-01 00:00:00

abstract：:Persistent viral infection, such as HCV infection, is the result of the inability of the host immune system to mount a successful antiviral response, as well as the escape strategies devised by the virus. Although each individual component of the host immune system plays important roles in antiviral immunity, the inte...

journal_title：Journal of leukocyte biology

authors： Saha B,Szabo G

更新日期：2014-11-01 00:00:00

abstract：:Mast cell activation requires Cl(-) flux, which maintains the driving force for entry of extracellular calcium and initiates release of mediators such as histamine. However, chloride channel expression in mast cells has been poorly understood. For the first time, reverse transcriptase-polymerase chain reaction shows t...

journal_title：Journal of leukocyte biology

authors： Kulka M,Gilchrist M,Duszyk M,Befus AD

更新日期：2002-01-01 00:00:00