Innate immune cell networking in hepatitis C virus infection.

abstract：:Annexin A1 is a glucocorticoid-regulated, anti-inflammatory protein, which plays an important role as an endogenous regulator of the inflammatory response. Many of these anti-inflammatory properties are retained in the N-terminal annexin A1 peptide Ac1-25, which is released from the full-length protein by a neutrophil...

journal_title：Journal of leukocyte biology

authors： Lange C,Starrett DJ,Goetsch J,Gerke V,Rescher U

更新日期：2007-12-01 00:00:00

abstract：:A cell resistant to concentrations of mitomycin-C associated with the inactivation of many in vitro immune responses is described. This cell is responsive to concanavalin A (Con A), poorly adherent to nylon wool, present in relatively greater numbers in lymph node than other lymphoid tissues, and is relatively radiose...

journal_title：Journal of leukocyte biology

authors： Anderson RE,Standefer JC,Troup GM,Pogue LE

更新日期：1987-01-01 00:00:00

abstract：:Activation of beta2 integrins is necessary for neutrophil adhesion and full activation of neutrophil effector functions. We demonstrated previously that inhibition of protein kinase A (PKA) activity in quiescent neutrophils is sufficient to increase beta2-integrin cell surface expression, affinity, and adhesion. Thus,...

journal_title：Journal of leukocyte biology

authors： Chilcoat CD,Sharief Y,Jones SL

更新日期：2008-04-01 00:00:00

abstract：:The triggering receptor expressed on myeloid cell locus encodes a family of receptors that is emerging as an important class of molecules involved in modulating the innate immune response and inflammation. Of the 4 conserved members, including triggering receptor expressed on myeloid cells 1 and 2 and triggering recep...

journal_title：Journal of leukocyte biology

authors： Thomas KA,King RG,Sestero CM,Justement LB

更新日期：2016-07-01 00:00:00

abstract：:Although HDPs were originally hypothesized to act as antimicrobial agents, they also have been shown to broadly modulate the immune response through the activation of different cell types. We recently developed a series of novel, synthetic peptides, termed IDRs, which are conceptually based on a natural HDP, bovine ba...

journal_title：Journal of leukocyte biology

authors： Niyonsaba F,Madera L,Afacan N,Okumura K,Ogawa H,Hancock RE

更新日期：2013-07-01 00:00:00

abstract：:Monocytes have been categorized in three main subpopulations based on CD14 and CD16 surface expression. Classical monocytes express the CD14(++)CD16(-)CCR2(+) phenotype and migrate to inflammatory sites by quickly responding to CCL2 signaling. Here, we identified and characterized the expansion of a novel monocyte sub...

journal_title：Journal of leukocyte biology

authors： Gama L,Shirk EN,Russell JN,Carvalho KI,Li M,Queen SE,Kalil J,Zink MC,Clements JE,Kallas EG

更新日期：2012-05-01 00:00:00

abstract：:The tissue-fixed macrophage is a key cellular element in the initiation and regulation of inflammation. Understanding the regulation of macrophage activation may provide valuable clues to the mechanisms involved in both beneficial and deleterious effects of inflammation. The lymphokine interferon-gamma (IFN-gamma) is ...

journal_title：Journal of leukocyte biology

authors： Williams JG,Jurkovich GJ,Hahnel GB,Maier RV

更新日期：1992-12-01 00:00:00

abstract：:The immune system in early life is regarded as immature. However, the IL-12 family member IL-23 is highly produced upon TLR stimulation by neonatal DCs. Human adult Vγ9Vδ2 T cells can be stimulated specifically via their TCR by phosphoantigens (as the pathogen-derived HMB-PP) or agents and infections that lead to thei...

journal_title：Journal of leukocyte biology

authors： Moens E,Brouwer M,Dimova T,Goldman M,Willems F,Vermijlen D

更新日期：2011-05-01 00:00:00

abstract：:Previous studies about basophils and mast cells identified the ability of IgE to up-regulate FcepsilonRI expression by a process that depends on stabilization of the surface receptor by IgE. However, the mechanism of loss from the cell surface, when unoccupied, is not known. The current studies have examined whether u...

journal_title：Journal of leukocyte biology

authors： MacGlashan DW Jr

更新日期：2007-10-01 00:00:00

abstract：:Antigen-dependent activation of IgE-bound mast cells is critical for immediate hypersensitivity and other allergic disorders. Recent studies have revealed the effects of monomeric IgEs on mast cell survival and activation. Furthermore, IgE molecules exhibit a wide range of heterogeneity in the ability to induce mast c...

journal_title：Journal of leukocyte biology

authors： Kashiwakura J,Xiao W,Kitaura J,Kawakami Y,Maeda-Yamamoto M,Pfeiffer JR,Wilson BS,Blank U,Kawakami T

更新日期：2008-08-01 00:00:00

abstract：:We have investigated the role of the purinergic P2X7 receptor in the formation of multinucleated giant cells in human monocyte/macrophage cultures stimulated with either concanavalin A or phytohemagglutinin. Macrophage fusion can be blocked by a P2X7-selective pharmacological antagonist or by a mAb directed against th...

journal_title：Journal of leukocyte biology

authors： Di Virgilio F,Falzoni S,Chiozzi P,Sanz JM,Ferrari D,Buell GN

更新日期：1999-11-01 00:00:00

abstract：:The nucleosome, the basic structure of chromatin and normal product of cell apoptosis, plays a pivotal role both in the induction and the pathogenesis of systemic lupus erythematosus (SLE). Nucleosomes have been found to circulate at high levels in patients with SLE and apoptosis of lymphoid cells is increased during ...

journal_title：Journal of leukocyte biology

authors： Laderach D,Bach JF,Koutouzov S

更新日期：1998-12-01 00:00:00

abstract：:Dendritic cells (DCs) loaded extracorporeally with antigen can be used as an adjuvant in vivo. In this work, we analyzed the migration of transferred DC and monitored the phenotype of new migrants in the draining lymph nodes. It is surprising that we found that a majority of resident DCs expressed donor MHC molecules ...

journal_title：Journal of leukocyte biology

authors： de Heusch M,Blocklet D,Egrise D,Hauquier B,Vermeersch M,Goldman S,Moser M

更新日期：2007-10-01 00:00:00

abstract：:There is vast body of evidence that the insulin-like growth factor (IGF)-I exerts immunomodulatory effects in vitro and in vivo. In vitro studies indicate that stimulatory effects of IGF-I may be exerted through augmentation of inflammatory cytokine production. To further explore the immunomodulatory effects of IGF-I ...

journal_title：Journal of leukocyte biology

authors： Kooijman R,Coppens A

更新日期：2004-10-01 00:00:00

abstract：:C1qR(P) is a type I cell surface glycoprotein that has been shown to enhance ingestion of suboptimally opsonized targets by phagocytes in vitro. In this study, we developed and characterized polyclonal antibodies to study the tissue distribution of this receptor targeted to either the N- or C-terminal portion of the m...

journal_title：Journal of leukocyte biology

authors： Fonseca MI,Carpenter PM,Park M,Palmarini G,Nelson EL,Tenner AJ

更新日期：2001-11-01 00:00:00

abstract：:In the absence of IL-10, colonic inflammation ensues, which is characterized by high levels of IL-17. Here, we demonstrate a direct correlation between ICOS expression and IL-17 production in cIELs. IL-10(-/-) mice had increased numbers of cIELs and greater colon weight. Although the CD69 early activation antigen was ...

journal_title：Journal of leukocyte biology

authors： Schaefer JS,Montufar-Solis D,Vigneswaran N,Klein JR

更新日期：2010-02-01 00:00:00

abstract：:IL-10 is a key anti-inflammatory cytokine secreted by activated macrophages as a feedback control mechanism to prevent excessive inflammatory responses. Here, we define multiple intracellular trafficking pathways involved in the secretion of newly synthesized IL-10 from macrophages following TLR4 activation with LPS, ...

journal_title：Journal of leukocyte biology

authors： Stanley AC,Lieu ZZ,Wall AA,Venturato J,Khromykh T,Hamilton NA,Gleeson PA,Stow JL

更新日期：2012-12-01 00:00:00

abstract：:A murine interleukin-2 (IL-2)-dependent T-cell line, CTLL-2, was infected with a retrovirus carrying the mouse c-myc cDNA and the Tn-5 neogene. Transduced cells were selected in the presence of Geneticin sulfate (G418); these cells were shown to express both the endogenous and the transduced c-myc genes. The IL-2 requ...

journal_title：Journal of leukocyte biology

authors： Shapiro IM,Winberg G,Stefanescu I,Wigzell H,Menezes J

更新日期：1988-12-01 00:00:00

abstract：:Effector T cell development is directly driven by APCs, in particular, by antigen-primed dendritic cells (DCs). Depending on the pathogenic stimulus and the microenvironment, DCs induce proliferation and polarization of naive CD4+ T cells into different effector subsets, such as Th1, Th2, Th17, or regulatory T cells (...

journal_title：Journal of leukocyte biology

authors： Breedveld A,Groot Kormelink T,van Egmond M,de Jong EC

更新日期：2017-10-01 00:00:00

abstract：:Bone destruction in inflammatory osteolytic diseases including periodontitis is related to excessive activity of osteoclasts (OC), which originate from precursor cells of the myeloid lineage, termed osteoclast precursors (OCP). In contrast to ample knowledge that we currently have on mature OC, little is known about O...

journal_title：Journal of leukocyte biology

authors： Zhao Y,Li Z,Su L,Ballesteros-Tato A,Katz J,Michalek SM,Feng X,Zhang P

更新日期：2020-10-01 00:00:00

abstract：:To become competent killer cells, CD8(+) T cells require stimulation through signal transduction pathways associated with the T-cell receptor, costimulatory molecules such as CD28, and cytokine receptors such as the interleukin (IL)-2 receptor. We used wortmannin and LY294002, two inhibitors of phosphatidylinositol 3-...

journal_title：Journal of leukocyte biology

authors： Phu T,Haeryfar SM,Musgrave BL,Hoskin DW

更新日期：2001-05-01 00:00:00

abstract：:Nucleotide receptors serve as sensors of extracellular ATP and are important for immune function. The nucleotide receptor P2RX7 is a cell-surface, ligand-gated cation channel that has been implicated in many diseases, including arthritis, granuloma formation, sepsis, and tuberculosis. These disorders are often exacerb...

journal_title：Journal of leukocyte biology

authors： Gavala ML,Pfeiffer ZA,Bertics PJ

更新日期：2008-10-01 00:00:00

abstract：:Mature macrophages, derived in vitro from bone marrow progenitors under the influence of either macrophage colony stimulating factor (CSF-1) or granulocyte-macrophage (GM)-CSF, have been shown to differ morphologically and functionally. The data presented in this report demonstrate that macrophages derived from bone m...

journal_title：Journal of leukocyte biology

authors： Falk LA,Vogel SN

更新日期：1990-07-01 00:00:00

abstract：:To understand the modulation and the behavior of glycocalyx elements during adhesion, we explored one of its components, the CD43 molecule, on human monocytic THP-1 cells exposed to cytokine stimulation and its redistribution during heterotypic adhesion to opsonized erythrocytes. First we demonstrated by immunofluores...

journal_title：Journal of leukocyte biology

authors： Soler M,Merant C,Servant C,Fraterno M,Allasia C,Lissitzky JC,Bongrand P,Foa C

更新日期：1997-05-01 00:00:00

abstract：:Colorectal cancer is the second most common cause of cancer-related death. Novel prognostic factors should be identified and validated to refine the present tumor-node-metastasis system. The presence of immune cells infiltrating colorectal cancers is a common phenomenon. However, the current belief is that clinically ...

journal_title：Journal of leukocyte biology

authors： Pagès F,Galon J,Fridman WH

更新日期：2008-10-01 00:00:00

abstract：:Alum, aluminum-hydroxide-containing compounds, long used as adjuvants in human vaccinations, functions by ill-defined, immunostimulatory mechanisms. Antigen-free alum has been shown to act via a previously unidentified, splenic Gr1(+), IL-4-expressing myeloid cell population to stimulate early B cell priming. We demon...

journal_title：Journal of leukocyte biology

authors： Wang HB,Weller PF

更新日期：2008-04-01 00:00:00

abstract：:Pulmonary sequestration and activation of polymorphonuclear leukocytes (PMNLs) are characteristic of many forms of acute lung injury. The present experiments were designed to study the effects of mepacrine on human neutrophils challenged with N-formylmethionyl-leucyl-phenylalanine (fMLP). Mepacrine inhibited fMLP-indu...

journal_title：Journal of leukocyte biology

authors： Földes-Filep E,Filep JG

更新日期：1992-11-01 00:00:00

abstract：:Extracellular cold-inducible RNA-binding protein (eCIRP) is a damage-associated molecular pattern. Neutrophils present in the mononuclear cell fraction of Ficoll gradient separation are called low-density neutrophils (LDNs). Here we report the novel role of eCIRP on LDNs' heterogeneity in sepsis. Sepsis was induced in...

journal_title：Journal of leukocyte biology

authors： Takizawa S,Murao A,Ochani M,Aziz M,Wang P

更新日期：2020-10-18 00:00:00

abstract：:Adherence of monocytes to extracellular matrix components is critical for their accumulation at sites of infection. To gain insight into the factors that regulate monocyte recruitment, we have studied monocyte adherence with regard to the regulatory effects of bacterial lipopolysaccharide (LPS) and the mechanisms invo...

journal_title：Journal of leukocyte biology

authors： Owen CA,Campbell EJ,Stockley RA

更新日期：1992-04-01 00:00:00

abstract：:Previously, we showed that NO induces thymocyte apoptosis via a caspase-1-dependent mechanism [(1) ]. In the present study, we investigated the role of heme oxygenase, catalase, bax, and p53 in this process. The NO donor, S-nitroso-N-acetyl penicillamine (SNAP), induced DNA fragmentation in thymocytes in a time- and c...

journal_title：Journal of leukocyte biology

authors： Gordon SA,Abou-Jaoude W,Hoffman RA,McCarthy SA,Kim YM,Zhou X,Zhang XR,Simmons RL,Chen Y,Schall L,Ford HR

更新日期：2001-07-01 00:00:00