当前位置： SCI文献检索 > JOURNAL OF LEUKOCYTE BIOLOGY期刊下所有文献 > Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes.

Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes.

Abstract：

:The oncogene EVI1 has been implicated in the etiology of AML and MDS. Although AML cells are characterized by accelerated proliferation and differentiation arrest, MDS cells hyperproliferate when immature but fail to differentiate later and die instead. In agreement with its roles in AML and in immature MDS cells, EVI1 was found to stimulate cell proliferation and inhibit differentiation in several experimental systems. In contrast, the variant protein MDS1/EVI1 caused the opposite effect in some of these assays. In the present study, we expressed EVI1 and MDS1/EVI1 in a tetracycline-regulable manner in the human myeloid cell line U937. Induction of either of these proteins caused cells to accumulate in the G(0)/G(1)-phase of the cell cycle and moderately increased the rate of spontaneous apoptosis. However, when EVI1- or MDS1/EVI1-expressing cells were induced to differentiate, they massively succumbed to apoptosis, as reflected by the accumulation of phosphatidylserine in the outer leaflet of the plasma membrane and increased rates of DNA fragmentation. In summary, these data show that inducible expression of EVI1 in U937 cells causes phenotypes that may be relevant for its role in MDS and provides a basis for further investigation of its contribution to this fatal disease.

journal_name

J Leukoc Biol

journal_title

Journal of leukocyte biology

authors

Konrad TA,Karger A,Hackl H,Schwarzinger I,Herbacek I,Wieser R

doi

10.1189/jlb.0109042

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

813-22

issue

4

eissn

0741-5400

issn

1938-3673

pii

jlb.0109042

journal_volume

86

pub_type

杂志文章

相关文献

JOURNAL OF LEUKOCYTE BIOLOGY文献大全
  • IL-17 superfamily cytokines modulate normal germinal center B cell migration.

    abstract：:The germinal center (GC) is a dynamic structure formed by proliferating B cells in the follicles of secondary lymphoid organs during T cell-dependent antibody responses to exogenous antigens. GC is composed by a dark zone, enriched in proliferating centroblasts (CBs), and a light zone where CBs migrate and transform i...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章,评审

    doi：10.1189/jlb.1VMR0216-096RR

    authors： Ferretti E,Ponzoni M,Doglioni C,Pistoia V

    更新日期：2016-11-01 00:00:00

  • Regulation by dietary essential fatty acid balance of tumor necrosis factor production in mouse macrophages.

    abstract：:Increasing the dietary alpha-linolenate (18:3n - 3)/linoleate (18:2n - 6) ratio results in an increase in lipopolysaccharide (LPS)-stimulated tumor necrosis factor (TNF) production in mouse resident and casein-induced peritoneal macrophages [3]. We found that prostaglandin E2 (PGE2) production is inversely related to ...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.53.2.151

    authors： Watanabe S,Onozaki K,Yamamoto S,Okuyama H

    更新日期：1993-02-01 00:00:00

  • Dynamics of rab5 activation in endocytosis and phagocytosis.

    abstract：:Fluid-phase endocytosis is stimulated by H-ras-linked growth factor receptors and this stimulation requires activation of rab5. We utilized a GFP-rab5a:wt fusion protein to monitor GFP-rab5a:wt activation in living fibroblasts and in J774 macrophages. Control CHO cells that expressed GFP-rab5a:wt were cultured in seru...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：

    authors： Roberts RL,Barbieri MA,Ullrich J,Stahl PD

    更新日期：2000-11-01 00:00:00

  • Metabolic energy sensors as targets for designing host-directed therapies for tuberculosis.

    abstract：:A wealth of scientific and clinical evidence during the past few years has lent credence to the idea that key components of the host immune effector mechanisms can be targeted to boost current tuberculosis (TB) treatment and control patient relapse. These host-directed strategies not only accelerate the clearance of p...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章,评审

    doi：10.1189/jlb.4MR0617-226R

    authors： Cheng CY,Böhme J,Singhal A

    更新日期：2018-02-01 00:00:00

  • Phenylhydrazine-induced leukocytosis in the rat.

    abstract：:Rats were injected with phenylhydrazine (PHZ) for periods of up to 6 months, during which time a marked leukocytosis was induced. The highest leukocyte counts occurred within 4-5 days following injection. An initial injection of 4 mg/100 gm body weight evoked a mean total leukocyte count of 129 X 10(3) cells/microlite...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.39.1.37

    authors： Dornfest BS,Lapin DM,Naughton BA,Adu S,Korn L,Gordon AS

    更新日期：1986-01-01 00:00:00

  • TNF-alpha-induced chemokine production and apoptosis in human neural precursor cells.

    abstract：:Recent studies have shown that proinflammatory cytokines damage rodent neural precursor cells (NPCs), a source of self-renewing, multipotent cells that play an important role in the developing as well as adult brain. In this study, the effects of tumor necrosis factor alpha (TNF-alpha) on cytokine and chemokine produc...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0405221

    authors： Sheng WS,Hu S,Ni HT,Rowen TN,Lokensgard JR,Peterson PK

    更新日期：2005-12-01 00:00:00

  • The RP105/MD-1 complex: molecular signaling mechanisms and pathophysiological implications.

    abstract：:Radioprotective 105 kDa (CD180) is an unusual TLR that lacks an intracellular Toll-IL-1R signaling domain and exhibits unconventional homodimerization behavior. Differential expression and functions of radioprotective 105 kDa have been associated with immune-mediated pathologies, including infection, chronic inflammat...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章,评审

    doi：10.1189/jlb.2VMR1215-582R

    authors： Schultz TE,Blumenthal A

    更新日期：2017-01-01 00:00:00

  • Calcium/calmodulin-dependent protein kinase (CaMK) Ialpha mediates the macrophage inflammatory response to sepsis.

    abstract：:Dysregulated Ca(2+) handling is prevalent during sepsis and postulated to perpetuate the aberrant inflammation underlying subsequent organ dysfunction and death. The signal transduction cascades mediating these processes are unknown. Here, we identify that CaMKIα mediates the Mϕ response to LPS in vitro and the inflam...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0510286

    authors： Zhang X,Guo L,Collage RD,Stripay JL,Tsung A,Lee JS,Rosengart MR

    更新日期：2011-08-01 00:00:00

  • IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals.

    abstract：:The IL-1-related molecules, IL-1 and IL-18, can promote Th2 cytokine production by IgE/antigen-FcepsilonRI-stimulated mouse mast cells. Another IL-1-related molecule, IL-33, was identified recently as a ligand for T1/ST2. Although mouse mast cells constitutively express ST2, the effects of IL-33 on mast cell function ...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0407200

    authors： Ho LH,Ohno T,Oboki K,Kajiwara N,Suto H,Iikura M,Okayama Y,Akira S,Saito H,Galli SJ,Nakae S

    更新日期：2007-12-01 00:00:00

  • Response of blood leukocytes to thrombin receptor peptides.

    abstract：:Thrombin has receptor-mediated effects on a variety of cell types. A recently cloned platelet thrombin receptor exerts its effects by a tethered-ligand mechanism. A similar receptor was shown in at least two nonplatelet cell types, fibroblasts and endothelial cells. Thrombin has biologically important effects on leuko...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.54.2.145

    authors： Hoffman M,Church FC

    更新日期：1993-08-01 00:00:00

  • Activation of the sympathetic nervous system modulates neutrophil function.

    abstract：:Emerging evidence has revealed that noradrenaline (NA), the main neurotransmitter of the sympathetic nervous system (SNS), regulates a variety of immune functions via binding to adrenergic receptors present on immune cells. In this study, we examined the role of NA in the regulation of neutrophil functions. Neutrophil...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/JLB.3MA0517-194RR

    authors： Nicholls AJ,Wen SW,Hall P,Hickey MJ,Wong CHY

    更新日期：2018-02-01 00:00:00

  • IL-20 receptor cytokines in autoimmune diseases.

    abstract：:IL-19, IL-20, and IL-24 are the members of IL-10 family. They are also known as IL-20 receptor (IL-20R) cytokines as they all signal through the IL-20RA/IL-20RB receptor complex; IL-20 and IL-24 (but not IL-19) also signal through the IL-20RB/IL22RA1 receptor complex. Despite their protein structure homology and share...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章,评审

    doi：10.1002/JLB.MR1117-471R

    authors： Chen J,Caspi RR,Chong WP

    更新日期：2018-11-01 00:00:00

  • Exudation of proliferative macrophages in local inflammation in the peritoneum.

    abstract：:Thioglycollate (TG)-elicited peritoneal macrophages (m phi s) were highly proliferative and formed m phi colonies in vitro in the presence of m phi colony-stimulating factor (M-CSF), while resident peritoneal m phi s did not. To determine whether such proliferative m phi s are immigrant or locally activated resident m...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.52.4.421

    authors： Oghiso Y,Yamada Y,Shibata Y

    更新日期：1992-10-01 00:00:00

  • The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system.

    abstract：:The human cathelicidin LL-37 is a cationic host defense peptide (antimicrobial peptide) expressed primarily by neutrophils and epithelial cells. This peptide, up-regulated under conditions of inflammation, has immunomodulatory and antimicrobial functions. We demonstrate that LL-37 is a potent inhibitor of human neutro...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.1005560

    authors： Barlow PG,Li Y,Wilkinson TS,Bowdish DM,Lau YE,Cosseau C,Haslett C,Simpson AJ,Hancock RE,Davidson DJ

    更新日期：2006-09-01 00:00:00

  • CD40 ligation and phagocytosis differently affect the differentiation of monocytes into dendritic cells.

    abstract：:That monocytes can differentiate into macrophages or dendritic cells (DCs) makes them an essential link between innate and adaptive immunity. However, little is known about how interactions with pathogens or T cells influence monocyte engagement toward DCs. We approached this point in cultures where granulocyte macrop...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：

    authors： Rosenzwajg M,Jourquin F,Tailleux L,Gluckman JC

    更新日期：2002-12-01 00:00:00

  • EBI2 in splenic and local immune responses and in autoimmunity.

    abstract：:The seven transmembrane G protein-coupled receptor EBV-induced gene 2 (EBI2), also known as GPR183, is expressed in particular in immune cells. Activated by its endogenous ligands, which are a group of oxysterols, it functions as a chemo-attractant receptor, mediating cell migration. In coordination with other recepto...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章,评审

    doi：10.1002/JLB.2VMR1217-510R

    authors： Barington L,Wanke F,Niss Arfelt K,Holst PJ,Kurschus FC,Rosenkilde MM

    更新日期：2018-08-01 00:00:00

  • Transcriptional regulation of LDL receptor-related protein by IFN-gamma and the antagonistic activity of TGF-beta(1) in the RAW 264.7 macrophage-like cell line.

    abstract：:Low density lipoprotein receptor-related protein (LRP) is a major receptor for multiple ligands, including chylomicron and VLDL remnants, bacterial toxins, viruses, proteinases, lipoprotein lipase, and activated alpha2-macroglobulin (alpha2M). In this study, we used Northern blot analyses and nuclear run-on experiment...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.59.5.733

    authors： Hussaini IM,LaMarre J,Lysiak JJ,Karns LR,VandenBerg SR,Gonias SL

    更新日期：1996-05-01 00:00:00

  • Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites.

    abstract：:2-Arachidonoyl-glycerol (2-AG) and arachidonyl-ethanolamide (AEA) are endocannabinoids that have been implicated in many physiologic disorders, including obesity, metabolic syndromes, hepatic diseases, pain, neurologic disorders, and inflammation. Their immunomodulatory effects are numerous and are not always mediated...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章,评审

    doi：10.1189/jlb.3RU0115-021R

    authors： Turcotte C,Chouinard F,Lefebvre JS,Flamand N

    更新日期：2015-06-01 00:00:00

  • Transmembrane proteases in focus: diversity and redundancy?

    abstract：:Recent advances have led to the identification and characterization of an array of transmembrane proteases that mediate the proteolysis of various substrates (including bioactive peptides, components of the extracellular matrix, and integral proteins) and cell-cell or cell-matrix adhesion. The membrane proteases known...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章,评审

    doi：

    authors： Bauvois B

    更新日期：2001-07-01 00:00:00

  • Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals.

    abstract：:Antagonism of ROS signaling can inhibit cell apoptosis and autophagy, thus favoring the maintenance and expansion of hematopoietic stem cells. Alpha lipoic acid (ALA), a small antioxidant molecule, affects cell apoptosis by lowering the ROS level. In this study, we show that ALA promoted production of human pluripoten...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/JLB.1A0520-179R

    authors： Dong Y,Bai J,Zhang Y,Zhou Y,Pan X,Li X,Zhou Q,Chen Y,Lai M,Mao B,Bian G,Feng J,Xie F,Chen B,Nakahata T,Zhang Y,Ma F

    更新日期：2020-12-01 00:00:00

  • Secreted poxvirus chemokine binding proteins.

    abstract：:Poxviruses encode a variety of immunomodulatory proteins that subvert the cytokine networks of infected hosts. Myxoma virus, a poxvirus pathogen of rabbits, expresses two distinct 35- to 40-kDa secreted glycoproteins that bind a broad spectrum of chemokines. The first of these, designated M-T7, is encoded by the T7 ge...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章,评审

    doi：10.1002/jlb.62.5.570

    authors： Lalani AS,McFadden G

    更新日期：1997-11-01 00:00:00

  • Signaling networks regulating beta1 integrin-mediated adhesion of T lymphocytes to extracellular matrix.

    abstract：:T-cell recognition of foreign antigen and migration to specific anatomic sites in vivo involves transient adhesive contacts between beta1 integrins expressed on T cells and cell surface proteins or extracellular-matrix components. Engagement of the CD3-T-cell receptor (CD3-TCR) complex initiates a complex signaling ca...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章,评审

    doi：

    authors： Woods ML,Shimizu Y

    更新日期：2001-06-01 00:00:00

  • Modulation of neutrophil migration by exogenous gaseous nitric oxide.

    abstract：:We studied the effect of exogenous nitric oxide (NO) on migration of rabbit peritoneal neutrophils. Exogenous NO enhanced random migration of neutrophils in a concentration-dependent way. An optimally stimulatory effect was observed with 0.5 microM NO, whereas at higher NO concentrations the enhancing effect decreased...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.60.1.94

    authors： VanUffelen BE,de Koster BM,Van den Broek PJ,VanSteveninck J,Elferink JG

    更新日期：1996-07-01 00:00:00

  • Flow cytometric analysis of I-J expression on murine bone marrow-derived macrophages.

    abstract：:Attempts to analyze bone marrow-derived macrophages (BMDM) by flow cytometry have been prohibited because of their high autofluorescence. Using an autofluorescence reduction method of Steinkamp and Stewart to reduce the autofluorescence of BMDM, we were able to examine several macrophage populations for their expressi...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.43.6.557

    authors： Malley A,Stewart CC,Stewart SJ,Waldbeser L,Bradley LM,Shiigi SM

    更新日期：1988-06-01 00:00:00

  • The effect of adenovirus-specific antibodies on adenoviral vector-induced, transgene product-specific T cell responses.

    abstract：:In this study, we tested the effect of neutralizing Abs to different serotypes of E1-deleted Ad vectors on the immunogenicity of the homologous Ad vector or a vector derived from a heterologous serotype. Our results showed that, as expected, even low titers of passively transferred neutralizing Abs significantly reduc...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.1A0813-451RR

    authors： Small JC,Haut LH,Bian A,Ertl HC

    更新日期：2014-11-01 00:00:00

  • Hypoxemia modifies circulating and exudate neutrophil number and functional responses in carrageenin-induced pleurisy in the rat.

    abstract：:To assess the effect of hypoxemia on the responses of polymorphonuclear neutrophils (PMN) during an inflammatory response, rats were maintained in a low F1O2 atmosphere (9% O2) or room air for 12 h before intrathoracic injection of carrageenin or intradermal injections of agonists. After 4 h, hypoxemic rats had 50% mo...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.67.6.785

    authors： Tremblay PB,Macari DM,Martel D,du Souich P,Barja-Fidalgo C,Marleau S

    更新日期：2000-06-01 00:00:00

  • H2 complex controls CD4/CD8 ratio, recurrent responsiveness to repeated stimulations, and resistance to activation-induced apoptosis during T cell response to mycobacterial antigens.

    abstract：:Genetic variation in the major histocompatibility complex (MHC) influences susceptibility and immune responses to Mycobacterium tuberculosis in mice and humans, but connections among the severity of tuberculosis (TB), dynamic changes in T cell responses to mycobacteria, and MHC genetic polymorphisms are poorly charact...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0705392

    authors： Pichugin AV,Petrovskaya SN,Apt AS

    更新日期：2006-04-01 00:00:00

  • Exposure of cultured murine peritoneal macrophages to low concentrations of beryllium induces increases in intracellular calcium concentrations and stimulates DNA synthesis.

    abstract：:Exposure of humans to beryllium dusts can induce a specific form of chronic pneumonitis that consists mainly of noncaseating granulomas in the lungs. Multiple studies have documented both genetic and immune components of chronic berylliosis. Much work has focused on T cells and their reactivity in berylliosis, but les...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.65.6.786

    authors： Misra UK,Gawdi G,Pizzo SV,Lewis JG

    更新日期：1999-06-01 00:00:00

  • Phospholipase D mediates Fc gamma receptor activation of neutrophils and provides specificity between high-valency immune complexes and fMLP signaling pathways.

    abstract：:Neutrophils phagocytize high-valency immune complexes (HIC) by an Fc gamma receptor-mediated mechanism, activating an oxidative burst and initiating degranulation. In contrast, neutrophils exhibit chemotaxis to N-formylated peptides [e.g., N-formyl-methionyl-leucyl-phenylalanine (fMLP)] and secrete far fewer oxidants ...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.61.4.522

    authors： Gewirtz AT,Simons ER

    更新日期：1997-04-01 00:00:00

  • Interactions between HIV-infected monocytes and the extracellular matrix: HIV-infected monocytes secrete neutral metalloproteases that degrade basement membrane protein matrices.

    abstract：:The frequency of human immunodeficiency virus (HIV)-infected monocytes that spread on a model basement membrane was about twofold greater than that of an equal number of uninfected control cells through the initial 12 to 18 h of culture. By 24 h, virtually all HIV-infected and uninfected control cells spread on the ba...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.52.2.244

    authors： Dhawan S,Toro LA,Jones BE,Meltzer MS

    更新日期：1992-08-01 00:00:00