Shp1 function in myeloid cells.

abstract：:The signaling adapters MyD88 and TRIF are engaged by TLRs and/or receptors of the IL-1 family and are considered important for innate immune responses that combat bacterial infections. Here, the consequences of a combined MyD88 and TRIF deficiency for the innate immune response against severe septic peritonitis was ex...

journal_title：Journal of leukocyte biology

authors： Reim D,Rossmann-Bloeck T,Jusek G,Prazeres da Costa O,Holzmann B

更新日期：2011-09-01 00:00:00

abstract：:It has been reported recently that granulocyte-colony stimulating factor (G-CSF) is degraded upon exposure to human neutrophil elastase (HNE), and this has a negative effect on the ability of the cytokine to promote the in vitro proliferation and maturation of CD34+ cells. This has important implications on the possib...

journal_title：Journal of leukocyte biology

authors： Carter CR,Whitmore KM,Thorpe R

更新日期：2004-03-01 00:00:00

abstract：:Effector T cell development is directly driven by APCs, in particular, by antigen-primed dendritic cells (DCs). Depending on the pathogenic stimulus and the microenvironment, DCs induce proliferation and polarization of naive CD4+ T cells into different effector subsets, such as Th1, Th2, Th17, or regulatory T cells (...

journal_title：Journal of leukocyte biology

authors： Breedveld A,Groot Kormelink T,van Egmond M,de Jong EC

更新日期：2017-10-01 00:00:00

abstract：:Secreted IgM (sIgM) is a multifunctional evolutionary conserved antibody that is critical for the maintenance of tissue homeostasis as well as the development of fully protective humoral responses to pathogens. Constitutive secretion of self- and polyreactive natural IgM, produced mainly by B-1 cells, provides a circu...

journal_title：Journal of leukocyte biology

authors： Blandino R,Baumgarth N

更新日期：2019-11-01 00:00:00

abstract：:Extracellular cold-inducible RNA-binding protein (eCIRP) is a damage-associated molecular pattern. Neutrophils present in the mononuclear cell fraction of Ficoll gradient separation are called low-density neutrophils (LDNs). Here we report the novel role of eCIRP on LDNs' heterogeneity in sepsis. Sepsis was induced in...

journal_title：Journal of leukocyte biology

authors： Takizawa S,Murao A,Ochani M,Aziz M,Wang P

更新日期：2020-10-18 00:00:00

abstract：:Leukocytes are a central cellular element of innate-immune defense in mammals. In addition to the generation of toxic oxygen radicals and nitric oxide, leukocytes express and secrete a broad array of antimicrobial proteins and peptides. In the study, an antimicrobial polypeptide was isolated and purified from human pe...

journal_title：Journal of leukocyte biology

authors： Feng Y,Huang N,Wu Q,Wang B

更新日期：2005-11-01 00:00:00

abstract：:Pulmonary macrophages (Mphi) increase in tissue and bronchoalveolar lavage (BAL) fluid during inflammation caused by bleomycin (BLM). This study demonstrates that increasing numbers of exudate Mphi in BLM lung injury exhibit dendritic cell (DC) features. After the intratracheal administration of BLM (0.075 U), adheren...

journal_title：Journal of leukocyte biology

authors： Tager AM,Luster AD,Leary CP,Sakamoto H,Zhao LH,Preffer F,Kradin RL

更新日期：1999-12-01 00:00:00

abstract：:The switch from fetal to adult hematopoietic stem/progenitor cells (HSPCs) is associated with profound changes in several genetic programs. Although HSPC ageing corresponds to alterations in Wnt signaling, relatively little is known about the relative roles of different Wnt signaling pathways in HSPC ontogeny. We hypo...

journal_title：Journal of leukocyte biology

authors： Kwarteng EO,Hétu-Arbour R,Heinonen KM

更新日期：2018-03-01 00:00:00

abstract：:Although IFN-alpha forms the foundation of therapy for chronic hepatitis C, only a minority of patients has a sustained response to IFN-alpha alone. The antiviral activities of IFN-alpha formed the rationale for its use in viral hepatitis. However, IFN-alpha and the other Type I IFNs are also pleiotropic immune regula...

journal_title：Journal of leukocyte biology

authors： Byrnes AA,Li DY,Park K,Thompson D,Mocilnikar C,Mohan P,Molleston JP,Narkewicz M,Zhou H,Wolf SF,Schwarz KB,Karp CL

更新日期：2007-03-01 00:00:00

abstract：:Macrophages are known to be present in the murine uterus and are known to be among those cells comprising the uterine decidual response to pregnancy. The extent of macrophage involvement in the decidual response has not been documented, and there are unresolved questions regarding expression of markers normally associ...

journal_title：Journal of leukocyte biology

authors： Hunt JS,Manning LS,Mitchell D,Selanders JR,Wood GW

更新日期：1985-08-01 00:00:00

abstract：:An acute inflammatory response requires that circulating monocytes bind to and migrate across the endothelium of the vessel wall to gain access to inflamed sites. Various mediators of inflammation--cytokines and chemoattractants--have been shown to initiate and regulate the margination and extravasation of monocytes. ...

journal_title：Journal of leukocyte biology

authors： Beekhuizen H,van Furth R

更新日期：1993-10-01 00:00:00

abstract：:Dietary olive oil supplementation and more recently, olive oil phenols have been recommended as important therapeutic interventions in preventive medicine. Ole has several pharmacological properties, including antioxidant, anti-inflammatory, antiatherogenic, anticancer, antimicrobial, and antiviral and for these reaso...

journal_title：Journal of leukocyte biology

authors： Campolo M,Di Paola R,Impellizzeri D,Crupi R,Morittu VM,Procopio A,Perri E,Britti D,Peli A,Esposito E,Cuzzocrea S

更新日期：2013-02-01 00:00:00

abstract：:We studied the tissue distribution of CD6(+) lymphocytes and cells expressing the CD6 ligand (also known as activated leukocyte cell adhesion molecule CD166) in calves by immunohistochemistry using an anti-bovine CD6 monoclonal antibody (mAb), a human CD6 (huCD6)-immunoglobulin G1 fusion protein (huCD6-Ig), and an ant...

journal_title：Journal of leukocyte biology

authors： Konno A,Ahn JS,Kitamura H,Hamilton MJ,Gebe JA,Aruffo A,Davis WC

更新日期：2001-06-01 00:00:00

abstract：:The peritoneal cavity of the mouse is a major source of connective tissue-type mast cells (CTMCs). Flow cytometric analysis using biotinylated recombinant murine mast cell growth factor (rMuMGF) showed that 1 to 3% of the cells in the peritoneal cavity exhibited MGF receptor (MGFR) (or c-kit). CTMCs were the only cell...

journal_title：Journal of leukocyte biology

authors： Chen B,Scheding S,Nakeff A,Ruan Q

更新日期：1994-05-01 00:00:00

abstract：:This study addresses the role of (pro)MMP-9 overexpression in CLL cell migration. We have used primary CLL cells and CLL-derived MEC-1 cells transfected with empty (mock cells) or proMMP-9-encoding (MMP-9 cells) lentiviral vectors. The constitutive (pro)MMP-9 expression in mock cells and primary CLL cells was similar,...

journal_title：Journal of leukocyte biology

authors： Bailón E,Ugarte-Berzal E,Amigo-Jiménez I,Van den Steen P,Opdenakker G,García-Marco JA,García-Pardo A

更新日期：2014-03-11 00:00:00

abstract：:TLRs are a class of pattern recognition receptors (PRRs) that detect invading microbes by recognizing pathogen-associated molecular patterns (PAMPs). Upon PAMP engagement, TLRs activate a signaling cascade that leads to the production of inflammatory mediators. The localization of TLRs, either on the plasma membrane o...

journal_title：Journal of leukocyte biology

authors： Marongiu L,Gornati L,Artuso I,Zanoni I,Granucci F

更新日期：2019-07-01 00:00:00

abstract：:IL-10 is a key anti-inflammatory cytokine secreted by activated macrophages as a feedback control mechanism to prevent excessive inflammatory responses. Here, we define multiple intracellular trafficking pathways involved in the secretion of newly synthesized IL-10 from macrophages following TLR4 activation with LPS, ...

journal_title：Journal of leukocyte biology

authors： Stanley AC,Lieu ZZ,Wall AA,Venturato J,Khromykh T,Hamilton NA,Gleeson PA,Stow JL

更新日期：2012-12-01 00:00:00

abstract：:Dendritic cells (DC) are professional antigen-presenting cells that are used in vaccine approaches to cancer. Classically, mature monocyte-derived DC are generated in vitro in the presence of interleukin (IL)-4, granulocyte macrophage-colony stimulating factor, and inflammatory cytokines (G4-DC). Recently, it has been...

journal_title：Journal of leukocyte biology

authors： Breckpot K,Corthals J,Bonehill A,Michiels A,Tuyaerts S,Aerts C,Heirman C,Thielemans K

更新日期：2005-10-01 00:00:00

abstract：:During inflammatory and immunological responses, leukocytes respond to external stimuli by altering the stability of cytokine and cytokine receptor messages. Change in message stability is an effective mechanism for rapidly regulating steady state levels of mRNA. Cytokine messages containing A-U-rich elements located ...

journal_title：Journal of leukocyte biology

authors： Xu L,Rahimpour R,Ran L,Kong C,Biragyn A,Andrews J,Devries M,Wang JM,Kelvin DJ

更新日期：1997-11-01 00:00:00

abstract：:Mycobacterium avium complex (MAC) is a significant cause of opportunistic infection in patients with acquired immunodeficiency syndrome. Although the major route of entry of MAC is via the gastrointestinal tract, MAC can infect humans through the respiratory tract and eventually encounter alveolar macrophages within t...

journal_title：Journal of leukocyte biology

authors： Lopez JP,Clark E,Shepherd VL

更新日期：2003-10-01 00:00:00

abstract：:The neutrophil inflammatory response can be altered profoundly by contact with extracellular matrix proteins (ECMs). We characterized functional responses (intracellular calcium, actin polymerization, degranulation, adhesion, and oxidative burst) of bovine neutrophils adhered to selected ECM proteins [collagen IV, lam...

journal_title：Journal of leukocyte biology

authors： Borgquist JD,Quinn MT,Swain SD

更新日期：2002-05-01 00:00:00

abstract：:In this study we present data on a novel cell surface antigen recognized by monoclonal antibody (mAb) VPM30, originally thought to recognize only bovine and ovine sIg+ B cells from peripheral blood. Here we show that the antigen, molecular mass 28 kDa, is not only found in B cell follicles in frozen sections, but when...

journal_title：Journal of leukocyte biology

authors： Campbell JD,Hopkins J,Howie SE,Oliver RA,Nichani AK,Goel P,Spooner RL,Glass EJ

更新日期：1998-05-01 00:00:00

abstract：:Flagellin, as a TLR5 agonist, is an established mucosal adjuvant for enhancing mucosal IgA responses by i.n. immunization. Nasal epithelial cells (NECs) are the first sentinel cells to be exposed to antigen and adjuvant in i.n. immunization, and it is suggested that they play an important role in the mucosal adjuvant ...

journal_title：Journal of leukocyte biology

authors： Cao Y,Zhang E,Yang J,Yang Y,Yu J,Xiao Y,Li W,Zhou D,Li Y,Zhao B,Yan H,Lu M,Zhong M,Yan H

更新日期：2017-09-01 00:00:00

abstract：:Elderly humans are more susceptible to bacterial infections because of declining immune status. We have investigated the effect of aging on neutrophil bactericidal responses, comparing neutrophil function in healthy, young (23-35 years) and elderly (>65 years) volunteers. Superoxide generation in response to fMLP was ...

journal_title：Journal of leukocyte biology

authors： Butcher SK,Chahal H,Nayak L,Sinclair A,Henriquez NV,Sapey E,O'Mahony D,Lord JM

更新日期：2001-12-01 00:00:00

abstract：:Osteoarticular complications are common in human brucellosis, but the pathogenic mechanisms involved are largely unknown. In this manuscript, we described an immune mechanism for inflammatory bone loss in response to infection by Brucella abortus. We established a requirement for MyD88 and TLR2 in TNF-α-elicited osteo...

journal_title：Journal of leukocyte biology

authors： Delpino MV,Barrionuevo P,Macedo GC,Oliveira SC,Genaro SD,Scian R,Miraglia MC,Fossati CA,Baldi PC,Giambartolomei GH

更新日期：2012-02-01 00:00:00

abstract：:Antagonism of ROS signaling can inhibit cell apoptosis and autophagy, thus favoring the maintenance and expansion of hematopoietic stem cells. Alpha lipoic acid (ALA), a small antioxidant molecule, affects cell apoptosis by lowering the ROS level. In this study, we show that ALA promoted production of human pluripoten...

journal_title：Journal of leukocyte biology

authors： Dong Y,Bai J,Zhang Y,Zhou Y,Pan X,Li X,Zhou Q,Chen Y,Lai M,Mao B,Bian G,Feng J,Xie F,Chen B,Nakahata T,Zhang Y,Ma F

更新日期：2020-12-01 00:00:00

abstract：:Interleukin-15 (IL-15) is a cytokine that possesses interesting, potential therapeutic properties. However, based on several parameters including activation of neutrophils, it is also recognized as a proinflammatory cytokine. The mechanisms by which IL-15 activates human neutrophil functions are not fully understood. ...

journal_title：Journal of leukocyte biology

authors： Ratthé C,Girard D

更新日期：2004-07-01 00:00:00

abstract：:Recombinant tissue plasminogen activator (t-PA), the only approved stroke treatment, is used for clot lysis within the occluded brain artery. Unfortunately, matrix metalloproteinase-9 (MMP-9) concentration increases after t-PA treatment and has been related to hemorrhagic transformation after ischemic stroke. Although...

journal_title：Journal of leukocyte biology

authors： Cuadrado E,Ortega L,Hernández-Guillamon M,Penalba A,Fernández-Cadenas I,Rosell A,Montaner J

更新日期：2008-07-01 00:00:00

abstract：:Recognition of Gram-positive bacteria by Toll-like receptor 2 (TLR2) induces activation of proinflammatory pathways. In mice, sensitization with the Gram-positive Propionibacterium acnes followed by a challenge with the TLR4 ligand, lipopolysaccharide (LPS), results in fulminant hepatic failure. Here, we investigated ...

journal_title：Journal of leukocyte biology

authors： Romics L Jr,Dolganiuc A,Velayudham A,Kodys K,Mandrekar P,Golenbock D,Kurt-Jones E,Szabo G

更新日期：2005-12-01 00:00:00

abstract：:SHP-1 is a cytoplasm protein tyrosine phosphatase expressed primarily in hematopoietic cells. In the immune system, SHP-1 plays critical roles in regulation of many receptor-mediated signaling cascades, and SHP-1 deficiency in mice causes spontaneous inflammation and autoimmunity. Here, we report a unique requirement ...

journal_title：Journal of leukocyte biology

authors： Zhou D,Collins CA,Wu P,Brown EJ

更新日期：2010-05-01 00:00:00