Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals.

abstract：:Mucosa represents the main site of pathogen/cell interactions. The two main types of cells forming the epithelial structure [epithelial cells and Langerhans cells (LC)] coordinate the first defense responses to avoid infection. To evaluate the involvement of epithelial cells in the early steps leading to a specific ad...

journal_title：Journal of leukocyte biology

authors： Cremel M,Berlier W,Hamzeh H,Cognasse F,Lawrence P,Genin C,Bernengo JC,Lambert C,Dieu-Nosjean MC,Delézay O

更新日期：2005-07-01 00:00:00

abstract：:Mycobacterium avium complex (MAC) is a significant cause of opportunistic infection in patients with acquired immunodeficiency syndrome. Although the major route of entry of MAC is via the gastrointestinal tract, MAC can infect humans through the respiratory tract and eventually encounter alveolar macrophages within t...

journal_title：Journal of leukocyte biology

authors： Lopez JP,Clark E,Shepherd VL

更新日期：2003-10-01 00:00:00

abstract：:Recruitment of leukocytes from bloodstream to extrahematic sites is tightly regulated by a variety of adhesion molecules that are expressed on the leukocytes and the vessel walls. In this manuscript, we describe the interactions between natural killer (NK) cells and activated, autologous platelets under physiologic fl...

journal_title：Journal of leukocyte biology

authors： Sheikh S,Parhar RS,Bakheet R,Saleh S,Collison K,Al-Mohanna F

更新日期：2004-09-01 00:00:00

abstract：:The basal presence of immunologically potent cells within the intestinal muscularis externa and their functional significance is unclear. Our aim was to investigate the basal distribution of various leukocyte populations within the rat jejunal muscularis. In addition, we sought to immunohistochemically phenotype the m...

journal_title：Journal of leukocyte biology

authors： Kalff JC,Schwarz NT,Walgenbach KJ,Schraut WH,Bauer AJ

更新日期：1998-06-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is a potent natural adjuvant, commonly used to amplify Th1 responses. Here, we report that systemic immunization using LPS generates large numbers of specific Th17 cells in murine small intestinal lamina propria. The priming of these Th17 cells required IL-23p19 production by bone marrow-deriv...

journal_title：Journal of leukocyte biology

authors： McAleer JP,Liu B,Li Z,Ngoi SM,Dai J,Oft M,Vella AT

更新日期：2010-07-01 00:00:00

abstract：:Macrophage activation by IFN-gamma results in a cascade of gene expression. To identify genes activated in mouse peritoneal macrophages by IFN-gamma, we created a cDNA subtraction library of IFN-gamma-induced genes. We have isolated from this subtraction library a novel cDNA clone, called Mg21, whose mRNA is absent in...

journal_title：Journal of leukocyte biology

authors： Lafuse WP,Brown D,Castle L,Zwilling BS

更新日期：1995-03-01 00:00:00

abstract：:Although endosomes, lysosomes, and phagosomes require a reductive environment for the optimal activity of disulfide reductases and other thiol-dependent enzymes, how these reductive environments are established and maintained remain unknown. Our goal in this study was to begin to elucidate the redox control systems re...

journal_title：Journal of leukocyte biology

authors： Balce DR,Greene CJ,Tailor P,Yates RM

更新日期：2016-07-01 00:00:00

abstract：:In this report, the construction of a functional, immunocompetent, full-thickness skin equivalent (SE) is described, consisting of an epidermal compartment containing keratinocytes, melanocytes, and human LCs derived from the MUTZ-3 cell line (MUTZ-LC) and a fibroblast-populated dermal compartment. The CD1a(+)Langerin...

journal_title：Journal of leukocyte biology

authors： Ouwehand K,Spiekstra SW,Waaijman T,Scheper RJ,de Gruijl TD,Gibbs S

更新日期：2011-11-01 00:00:00

abstract：:Neutrophils are the first cells arriving at sites of tissue injury or infection to combat invading pathogens. Successful neutrophil recruitment to sites of inflammation highly depends on specific molecular mechanisms, fine-tuning the received information into signaling pathways and converting them into well-described ...

journal_title：Journal of leukocyte biology

authors： Begandt D,Thome S,Sperandio M,Walzog B

更新日期：2017-09-01 00:00:00

abstract：:It has been shown that lead (Pb) potentiates lipopolysaccharide (LPS) lethality in animals by increasing the secretion and uptake or reactivity of tumor necrosis factor-alpha (TNF-alpha). Herein we report that PbCl2 increased TNF-alpha secretion from LPS-treated human peripheral blood mononuclear cells (PBMC) in a con...

journal_title：Journal of leukocyte biology

authors： Guo TL,Mudzinski SP,Lawrence DA

更新日期：1996-06-01 00:00:00

abstract：:In resident mouse peritoneal macrophages, group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) mediates arachidonic acid (AA) release and eicosanoid production in response to diverse agonists such as A23187, phorbol myristate acetate, zymosan, and the enterotoxin, okadaic acid (OA). cPLA(2)alpha is regulated by phosp...

journal_title：Journal of leukocyte biology

authors： Tucker DE,Gijón MA,Spencer DM,Qiu ZH,Gelb MH,Leslie CC

更新日期：2008-09-01 00:00:00

abstract：:We have shown previously that ulcerogenic (type I) strains of Helicobacter pylori (Hp) retard their entry into macrophages. However, the signaling pathways that regulate Hp phagocytosis are largely undefined. We show here that Hp strongly activated class IA phosphoinositide3-kinases (PI3Ks) in macrophages, coincident ...

journal_title：Journal of leukocyte biology

authors： Allen LA,Allgood JA,Han X,Wittine LM

更新日期：2005-07-01 00:00:00

abstract：:Type I IFNs display multiple biological effects. They have a strong antiviral action, not only directly but also indirectly through activation of the immune system. They may also have actions that are deleterious for the host. The cells that produce type I IFN are mostly plasmacytoid dendritic cells (pDC), but this de...

journal_title：Journal of leukocyte biology

authors： Hosmalin A,Lebon P

更新日期：2006-11-01 00:00:00

abstract：:TLRs are a class of pattern recognition receptors (PRRs) that detect invading microbes by recognizing pathogen-associated molecular patterns (PAMPs). Upon PAMP engagement, TLRs activate a signaling cascade that leads to the production of inflammatory mediators. The localization of TLRs, either on the plasma membrane o...

journal_title：Journal of leukocyte biology

authors： Marongiu L,Gornati L,Artuso I,Zanoni I,Granucci F

更新日期：2019-07-01 00:00:00

abstract：:The effect of recombinant human interleukin-2 (IL-2) on tumor cell cycle kinetics was evaluated in rats bearing the Walker-256 carcinosarcoma. Seven days after implantation, tumor-bearing rats were infused intravenously with IL-2 at a dose of 500 mg/kg body weight or 5% dextrose for 6 h. Tumor cell mean DNA synthesis ...

journal_title：Journal of leukocyte biology

authors： Wan JM,Bistrian BR,Figoni MA,Istfan NW

更新日期：1994-02-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) encodes the MHC class I-like molecule UL18, which binds with high affinity to the leukocyte Ig-like receptor-1 (LIR-1), an inhibitory receptor commonly expressed on myeloid cells and subsets of NK and T cells. The exact role of UL18 is not known, in particular in relation to its proposed r...

journal_title：Journal of leukocyte biology

authors： Wagner CS,Walther-Jallow L,Buentke E,Ljunggren HG,Achour A,Chambers BJ

更新日期：2008-01-01 00:00:00

abstract：:During the development of immune responses to pathogens, self-antigens, or environmental allergens, naive CD4(+) T cells differentiate into subsets of effector cells including Th1, Th2, and Th17 cells. The differentiation into these subsets is controlled by specific transcription factors. The activity of these effecto...

journal_title：Journal of leukocyte biology

authors： Chapoval S,Dasgupta P,Dorsey NJ,Keegan AD

更新日期：2010-06-01 00:00:00

abstract：:Mer signaling participates in a novel inhibitory pathway in TLR activation. The purpose of the present study was to examine the role of Mer signaling in the down-regulation of TLR4 activation-driven immune responses in mice, i.t.-treated with LPS, using the specific Mer-blocking antibody. At 4 h and 24 h after LPS tre...

journal_title：Journal of leukocyte biology

authors： Lee YJ,Han JY,Byun J,Park HJ,Park EM,Chong YH,Cho MS,Kang JL

更新日期：2012-06-01 00:00:00

abstract：:Human immunodeficiency virus type-1 (HIV-1)-associated dementia (HAD) is a neurodegenerative disease characterized by HIV infection and replication in brain tissue. HIV-1-infected monocytes overexpress inflammatory molecules that facilitate their entry into the brain. Prostanoids are lipid mediators of inflammation th...

journal_title：Journal of leukocyte biology

authors： Pereira CF,Boven LA,Middel J,Verhoef J,Nottet HS

更新日期：2000-09-01 00:00:00

abstract：:Feline peritoneal cells were collected by lavage with isotonic saline without the use of irritants or need for euthanasia of the cats. Macrophages were purified by centrifugation on Percoll followed by selective adherence. Although few macrophages could be obtained from an initial lavage, a second lavage performed on ...

journal_title：Journal of leukocyte biology

authors： Stoddart CA,Scott FW

更新日期：1988-11-01 00:00:00

abstract：:CXC chemokines, which induce angiogenesis, have glutamine-leucine-arginine amino acid residues (ELR motif) in the amino terminus and bind CXCR2 and the Duffy antigen chemokine-binding protein. Duffy, a seven transmembrane protein that binds CXC and CC chemokines, has not been shown to couple to trimeric G proteins or ...

journal_title：Journal of leukocyte biology

authors： Du J,Luan J,Liu H,Daniel TO,Peiper S,Chen TS,Yu Y,Horton LW,Nanney LB,Strieter RM,Richmond A

更新日期：2002-01-01 00:00:00

abstract：:Interleukin-10 (IL-10) is a potent anti-inflammatory cytokine with numerous immunomodulatory effects, including the inhibition of proinflammatory cytokine production. The mechanisms by which IL-10 exerts these effects still remain largely unknown. As there is evidence that suggests IL-10-mediated cytokine suppression ...

journal_title：Journal of leukocyte biology

authors： Williams L,Jarai G,Smith A,Finan P

更新日期：2002-10-01 00:00:00

abstract：:The Fc gamma receptor IIB (FcγRIIB/CD32B) was generated million years ago during evolution. It is the sole inhibitory receptor for IgG, and has long been associated with the regulation of humoral immunity and innate immune homeostasis. However, new and surprising functions of FcγRIIB are emerging. In particular, FcγRI...

journal_title：Journal of leukocyte biology

authors： Roghanian A,Stopforth RJ,Dahal LN,Cragg MS

更新日期：2018-02-06 00:00:00

abstract：:Previously, we demonstrated the stimulus-specific ability of platelet lysate or release products to inhibit neutrophil functions in response to f-met-leu-phe (fMLP) or phorbol myristate acetate (PMA). The present study further characterizes these activities and identifies one of the platelet inhibitors of neutrophil s...

journal_title：Journal of leukocyte biology

authors： McGarrity ST,Stephenson AH,Hyers TM,Webster RO

更新日期：1988-11-01 00:00:00

abstract：:Many intracellular signals, such as host danger-associated molecules and bacterial toxins during infection, elicit inflammasome activation. However, the mechanical environment in tissues may also influence the sensitivity of various inflammasomes to activation. The cellular mechanical environment is determined by the ...

journal_title：Journal of leukocyte biology

authors： Joshi H,Morley SC

更新日期：2019-07-01 00:00:00

abstract：:Phagocytosis is the process whereby cells engulf large particles, usually over 0.5 micro m in diameter. Phagocytosis is triggered by the interaction of opsonins that cover the particle to be internalized with specific receptors on the surface of the phagocyte. The best-studied phagocytic receptors include the Fc recep...

journal_title：Journal of leukocyte biology

authors： García-García E,Rosales C

更新日期：2002-12-01 00:00:00

abstract：:The majority of acute myeloid leukemia (AML) patients will respond to standard chemotherapy, however, resistance is a prevalent problem contributing to incomplete responses, refractory disease, and ultimately patient death. Therefore, choosing more sensitive and effective chemotherapy regimens is of key clinical impor...

journal_title：Journal of leukocyte biology

authors： Lin L,Tong Y,Straube J,Zhao J,Gao Y,Bai P,Li J,Wang J,Wang H,Wang X,Huang S,Xu W,Song X,Li L

更新日期：2020-05-01 00:00:00

abstract：:This report focuses on the modulatory role of endogenous H(2)O(2) on lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma)-induced inducible nitric oxide synthase (NOS2) gene expression in rat peritoneal macrophages. Exogenously added H(2)O(2) was initially found to inhibit the synthesis of NOS2, which prompted us to ...

journal_title：Journal of leukocyte biology

authors： Vega A,Chacón P,Monteseirín J,El Bekay R,Alvarez M,Alba G,Conde J,Martín-Nieto J,Bedoya FJ,Pintado E,Sobrino F

更新日期：2004-06-01 00:00:00

abstract：:Fluid-phase endocytosis is stimulated by H-ras-linked growth factor receptors and this stimulation requires activation of rab5. We utilized a GFP-rab5a:wt fusion protein to monitor GFP-rab5a:wt activation in living fibroblasts and in J774 macrophages. Control CHO cells that expressed GFP-rab5a:wt were cultured in seru...

journal_title：Journal of leukocyte biology

authors： Roberts RL,Barbieri MA,Ullrich J,Stahl PD

更新日期：2000-11-01 00:00:00

abstract：:A lethal human septic shock model, mouse generalized Shwartzman reaction (GSR), was elicited by two consecutive lippolysaccharide (LPS) injections (24 h apart) in which interferon-gamma (IFN-gamma) induced by interleukin (IL)-12 played a critical role in the priming phase, and tumor necrosis factor (TNF) was an import...

journal_title：Journal of leukocyte biology

authors： Motegi A,Kinoshita M,Sato K,Shinomiya N,Ono S,Nonoyama S,Hiraide H,Seki S

更新日期：2006-03-01 00:00:00