Abstract:
:Leukocytes are a large population of cells spread within most tissues in the body. These cells may be either sessile (called as resident cells) or circulating leukocytes, which travel long journeys inside the vessels during their lifespan. Although production and maturation of these leukocytes in adults primarily occur in the bone marrow, it is well known that this process-called hematopoiesis-started in the embryonic life in different sites, including the yolk sac, placenta, and the liver. In this review, we will discuss how the liver acts as a pivotal site for leukocyte maturation during the embryo phase, and also how the most frequent liver-resident immune cell populations-namely Kupffer cells, dendritic cells, and lymphocytes-play a vital role in both tolerance and inflammatory responses to antigens from food, microbiota, and pathogens.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Mafra K,Nakagaki BN,Castro Oliveira HM,Rezende RM,Antunes MM,Menezes GBdoi
10.1002/JLB.MR1118-455Rsubject
Has Abstractpub_date
2019-09-01 00:00:00pages
687-693issue
3eissn
0741-5400issn
1938-3673journal_volume
106pub_type
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