Epac1-Rap1 signaling regulates monocyte adhesion and chemotaxis.

abstract：:Neutrophil accumulation and plasma leakage induced in rabbit skin by neutrophil-activating peptide-1 (NAP-1, a 72 amino acid peptide produced by monocytes and a variety of tissue cells), E. coli endotoxin, and interleukin-1 (IL-1) were compared. Neutrophil accumulation at sites injected with NAP-1 was intense, rapid, ...

journal_title：Journal of leukocyte biology

authors： Colditz IG,Zwahlen RD,Baggiolini M

更新日期：1990-08-01 00:00:00

abstract：:Autoreactive CD4+ and CD8+ T cells directed against CNS autoantigens may play a role in the development of multiple sclerosis (MS). Identical twins share the same genetic background but not the TCR repertoire that is shaped by the encounter with self or foreign antigens. To gain insights into the interplay between MS ...

journal_title：Journal of leukocyte biology

authors： Somma P,Ristori G,Battistini L,Cannoni S,Borsellino G,Diamantini A,Salvetti M,Sorrentino R,Fiorillo MT

更新日期：2007-03-01 00:00:00

abstract：:To determine if the release of IL-1 alpha and IL-1 beta by cultured PBMC could be independently modulated by different exogenous stimuli, we examined the effect of LPS, IFN gamma, latex beads, and indomethacin on the release of IL-1 alpha and IL-1 beta. PBMC culture supernatants were fractionated by Sephacryl-S-200 co...

journal_title：Journal of leukocyte biology

authors： Sandborg CI,Berman MA,Imfeld KL,Zaldivar F Jr,Masada MP,Kenney JS

更新日期：1989-11-01 00:00:00

abstract：:SIRS is associated with lymphopenia, and prolonged lymphopenia of septic patients has been associated with increased mortality risk. We hypothesize that elevated adenosine during SIRS down-regulates Gi-coupled A1R, which signals an effect that sensitizes a cAMP-dependent lymphotoxic response. In this study, we evaluat...

journal_title：Journal of leukocyte biology

authors： Riff R,Cohen Y,Eini-Rider H,Naamani O,Mazar J,Haviv YS,Chaimovitz C,Douvdevani A

更新日期：2017-07-01 00:00:00

abstract：:Protein kinase B (Akt) is known to be involved in proinflammatory and chemotactic events in response to injury. Akt activation also leads to the induction of heme oxygenase (HO)-1. Up-regulation of HO-1 mediates potent, anti-inflammatory effects and attenuates organ injury. Although studies have shown that 17beta-estr...

journal_title：Journal of leukocyte biology

authors： Hsu JT,Kan WH,Hsieh CH,Choudhry MA,Schwacha MG,Bland KI,Chaudry IH

更新日期：2007-10-01 00:00:00

abstract：:The IV meeting of the European Mucosal Immunology Group, held October 8-10, 2004, in Lyon, gathered fundamental and clinical research scientists to discuss the most recent updates on basic and clinical aspects of mucosal immunology. The meeting was focused on innate and acquired immune mechanisms underlying handling a...

journal_title：Journal of leukocyte biology

authors： Kaiserlian D,Cerf-Bensussan N,Hosmalin A

更新日期：2005-08-01 00:00:00

abstract：:We compared the effects of live or inactivated bovine respiratory syncytial virus (BRSV) on cytokine production by bovine monocyte-derived dendritic cells (MoDC). We also investigated the response of resting memory CD4(+) T cells to MoDC exposed to both viral preparations. Although BRSV did not appear to replicate in ...

journal_title：Journal of leukocyte biology

authors： Werling D,Collins RA,Taylor G,Howard CJ

更新日期：2002-08-01 00:00:00

abstract：:Sexual transmission is the primary route of HIV-1 infection, and DC subsets are thought to be involved in viral dissemination to T cells. In the genital mucosa, two main subsets of DCs are present: epithelial LCs capture and degrade HIV-1 through C-type lectin Langerin, whereas subepithelial DCs express DC-SIGN, which...

journal_title：Journal of leukocyte biology

authors： de Jong MA,de Witte L,Santegoets SJ,Fluitsma D,Taylor ME,de Gruijl TD,Geijtenbeek TB

更新日期：2010-04-01 00:00:00

abstract：:Murine peritoneal exudate cells (PEC) pre-exposed to bacterial lipopolysaccharide (LPS) show augmented nitric oxide (NO) production by LPS restimulation, in contrast to LPS tolerance with reduced production of tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6). Significant amounts of interferon-gamma (IF...

journal_title：Journal of leukocyte biology

authors： Tominaga K,Saito S,Matsuura M,Funatogawa K,Matsumura H,Nakano M

更新日期：1999-12-01 00:00:00

abstract：:Type I IFNs play an important role in innate and adaptive immunity against viral infections. A novel type I IFN, namely IFN-ε, which can protect against vaginal transmission of HSV2 and Chlamydia muridarum bacterial infection, has been described in mice and humans. Nevertheless, the principle cell type and the express...

journal_title：Journal of leukocyte biology

authors： Demers A,Kang G,Ma F,Lu W,Yuan Z,Li Y,Lewis M,Kraiselburd EN,Montaner L,Li Q

更新日期：2014-12-01 00:00:00

abstract：:Leukocyte adhesion is a key factor in the pathogenesis of organ injury following a variety of stimuli. In this study we have addressed the role of leukocyte adhesion in hypertensives as a risk factor for organ injury. In the spontaneously hypertensive rat (SHR), the number of circulating leukocytes and their level of ...

journal_title：Journal of leukocyte biology

authors： Suzuki H,Zweifach BW,Forrest MJ,Schmid-Schönbein GW

更新日期：1995-01-01 00:00:00

abstract：:Mature macrophages, derived in vitro from bone marrow progenitors under the influence of either macrophage colony stimulating factor (CSF-1) or granulocyte-macrophage (GM)-CSF, have been shown to differ morphologically and functionally. The data presented in this report demonstrate that macrophages derived from bone m...

journal_title：Journal of leukocyte biology

authors： Falk LA,Vogel SN

更新日期：1990-07-01 00:00:00

abstract：:The macrophage mannose receptor (MR) appears to play an important role in the binding and phagocytosis of several human pathogens, but its phagocytic property and signaling pathways have been poorly defined. The general strategy to explore such topics is to express the protein of interest in nonphagocytic cells, but i...

journal_title：Journal of leukocyte biology

authors： Le Cabec V,Emorine LJ,Toesca I,Cougoule C,Maridonneau-Parini I

更新日期：2005-06-01 00:00:00

abstract：:Bovine plasma contains factors that can stimulate bovine neutrophils. Bovine plasma at 1:1,000,000-1:1,000 dilution induced a dose-dependent superoxide production in bovine neutrophils. When bovine plasma was fractionated with a protein G column, only the IgG fraction contained induction activity. At similar concentra...

journal_title：Journal of leukocyte biology

authors： Tao W,Corbett MJ,Pickett W

更新日期：1995-08-01 00:00:00

abstract：:Human skin mast cells (HSMC) in situ were examined by electron microscopy of surgical biopsy specimens obtained from a wide variety of circumstances. From these studies, it is apparent that the general ultrastructural morphology of normal HSMC is similar to that of human mast cells from other sites, except that the mo...

journal_title：Journal of leukocyte biology

authors： Dvorak AM,Kissell S

更新日期：1991-02-01 00:00:00

abstract：:Thimerosal is an organic mercury compound that is used as a preservative in vaccines and pharmaceutical products. Recent studies have shown a TH2-skewing effect of mercury, although the underlying mechanisms have not been identified. In this study, we investigated whether thimerosal can exercise a TH2-promoting effect...

journal_title：Journal of leukocyte biology

authors： Agrawal A,Kaushal P,Agrawal S,Gollapudi S,Gupta S

更新日期：2007-02-01 00:00:00

abstract：:The switch from fetal to adult hematopoietic stem/progenitor cells (HSPCs) is associated with profound changes in several genetic programs. Although HSPC ageing corresponds to alterations in Wnt signaling, relatively little is known about the relative roles of different Wnt signaling pathways in HSPC ontogeny. We hypo...

journal_title：Journal of leukocyte biology

authors： Kwarteng EO,Hétu-Arbour R,Heinonen KM

更新日期：2018-03-01 00:00:00

abstract：:The recognition that apoptosis is regulated by an evolutionarily conserved set of polypeptides from the nematode Caenorhabditis elegans to humans suggests that a conserved set of biochemical mechanisms may also he involved in the response. Work from a number of independent laboratories suggests that alterations in cyt...

journal_title：Journal of leukocyte biology

authors： McConkey DJ,Orrenius S

更新日期：1996-06-01 00:00:00

abstract：:HIV infection of mononuclear phagocytes (MP), mostly as tissue macrophages, is a dominant feature in the pathogenesis of HIV disease and its progression to AIDS. Although the general mechanism of infection is not dissimilar to that of CD4+ T lymphocytes occurring via interaction of the viral envelope with CD4 and a ch...

journal_title：Journal of leukocyte biology

authors： Cassol E,Alfano M,Biswas P,Poli G

更新日期：2006-11-01 00:00:00

abstract：:A simple and rapid method for the purification of morphologically and functionally intact eosinophils from human blood of both normal and eosinophilic subjects is described. The method is based on a single centrifugation of total blood leukocytes suspended in Percoll with specific gravity 1.0853 g/ml, after erythrocyt...

journal_title：Journal of leukocyte biology

authors： Cramer R,Dri P,Zabucchi G,Patriarca P

更新日期：1992-09-01 00:00:00

abstract：:Anti-proteinase-3 (anti-PR3) or anti-myeloperoxidase (anti-MPO) antibodies are capable of activating human neutrophils primed by TNF-alpha in vitro. We described previously the involvement of FcgammaRIIa and beta(2) integrins in this neutrophil activation. In the literature, the requirement of TNF priming has been att...

journal_title：Journal of leukocyte biology

authors： Reumaux D,Hordijk PL,Duthilleul P,Roos D

更新日期：2006-12-01 00:00:00

abstract：:Previously, we showed that NO induces thymocyte apoptosis via a caspase-1-dependent mechanism [(1) ]. In the present study, we investigated the role of heme oxygenase, catalase, bax, and p53 in this process. The NO donor, S-nitroso-N-acetyl penicillamine (SNAP), induced DNA fragmentation in thymocytes in a time- and c...

journal_title：Journal of leukocyte biology

authors： Gordon SA,Abou-Jaoude W,Hoffman RA,McCarthy SA,Kim YM,Zhou X,Zhang XR,Simmons RL,Chen Y,Schall L,Ford HR

更新日期：2001-07-01 00:00:00

abstract：:Six IgG monoclonal antibodies representing the four murine IgG isotypes were active individually in ADCC to T-lymphoma targets mediated by murine macrophages and human blood K cells. The monoclonals were directed against four antigens (Thy-1.2, H-2k, Ly 2.1, Ly 9.2). None was as effective in ADCC as allo-anti-Thy-1.2 ...

journal_title：Journal of leukocyte biology

authors： Ralph P,Nakoinz I

更新日期：1984-01-01 00:00:00

abstract：:Chemokines play a crucial role in combating microbial infection by recruiting blood neutrophils to infected tissue. In mice, the chemokines Cxcl1/KC and Cxcl2/MIP2 fulfill this role. Cxcl1 and Cxcl2 exist as monomers and dimers, and exert their function by activating the Cxcr2 receptor and binding glycosaminoglycans (...

journal_title：Journal of leukocyte biology

authors： Sawant KV,Sepuru KM,Lowry E,Penaranda B,Frevert CW,Garofalo RP,Rajarathnam K

更新日期：2020-09-02 00:00:00

abstract：:Chemotactic factors and phorbol esters may act synergistically to evoke neutrophil responses, but the mechanism of such interaction is not entirely clear. We investigated the combined effects of the chemotactic peptide n-formyl-methionyl-leucyl-phenylalanine (FMLP) and phorbol myristate acetate (PMA) on protein kinase...

journal_title：Journal of leukocyte biology

authors： Gay JC,Stitt ES

更新日期：1990-01-01 00:00:00

abstract：:The activation of collagenase released by polymorphonuclear leukocytes (PMNs) has been extensively studied in vitro, but the activation of the enzyme in vivo is not fully understood. For further evaluation of the relative role of oxidative and proteolytic mechanisms in the activation of collagenase, PMNs were stimulat...

journal_title：Journal of leukocyte biology

authors： Claesson R,Karlsson M,Zhang Y,Carlsson J

更新日期：1996-11-01 00:00:00

abstract：:The influence of ethanol (EtOH) on multiple dendritic cell (DC) subsets, in the steady state or following their mobilization in vivo, has not been characterized. Herein, generation of mouse bone marrow-derived DC (BMDC) in response to fms-like tyrosine kinase 3 ligand was inhibited by physiologically relevant concentr...

journal_title：Journal of leukocyte biology

authors： Lau AH,Abe M,Thomson AW

更新日期：2006-05-01 00:00:00

abstract：:Compared with CD4+25+ regulatory T cells (Tregs), the mechanisms for natural, polyclonal CD8+25+ Treg immune suppression have been significantly less studied. We previously showed that polyclonal T cells can acquire antigen-specific targeting activity through arming with exosomal peptide-MHC (pMHC). In this study, we ...

journal_title：Journal of leukocyte biology

authors： Mu C,Zhang X,Wang L,Xu A,Ahmed KA,Pang X,Chibbar R,Freywald A,Huang J,Zhu Y,Xiang J

更新日期：2017-05-01 00:00:00

abstract：:As part of a study to identify novel genes associated with macrophage activation, we have cloned a new member of the transforming growth factor beta (TGF-beta) superfamily designated macrophage inhibitory cytokine 1 (MIC-1). MIC-1 is synthesized as a 62-kDa intracellular protein, which, after cleavage by a furin like ...

journal_title：Journal of leukocyte biology

authors： Fairlie WD,Moore AG,Bauskin AR,Russell PK,Zhang HP,Breit SN

更新日期：1999-01-01 00:00:00

abstract：:Nitric oxide (NO(.-)) contributes to vascular collapse in septic shock and regulates inflammation. Here, we demonstrate in lipopolysaccharide (LPS)-stimulated human THP-1 cells and monocytes that NO(.-) regulates interleukin (IL)-8 and tumor necrosis factor alpha (TNF-alpha) by distinct mechanisms. Dibutyryl-cyclic gu...

journal_title：Journal of leukocyte biology

authors： Ma P,Cui X,Wang S,Zhang J,Nishanian EV,Wang W,Wesley RA,Danner RL

更新日期：2004-07-01 00:00:00