MIC-1 is a novel TGF-beta superfamily cytokine associated with macrophage activation.

abstract：:Autism spectrum disorders (ASD) are part of a broad spectrum of neurodevelopmental disorders known as pervasive developmental disorders, which occur in childhood. They are characterized by impairments in social interaction, verbal and nonverbal communication and the presence of restricted and repetitive stereotyped be...

journal_title：Journal of leukocyte biology

authors： Ashwood P,Wills S,Van de Water J

更新日期：2006-07-01 00:00:00

abstract：:CXC chemokines, which induce angiogenesis, have glutamine-leucine-arginine amino acid residues (ELR motif) in the amino terminus and bind CXCR2 and the Duffy antigen chemokine-binding protein. Duffy, a seven transmembrane protein that binds CXC and CC chemokines, has not been shown to couple to trimeric G proteins or ...

journal_title：Journal of leukocyte biology

authors： Du J,Luan J,Liu H,Daniel TO,Peiper S,Chen TS,Yu Y,Horton LW,Nanney LB,Strieter RM,Richmond A

更新日期：2002-01-01 00:00:00

abstract：:Neutrophils are the most abundant leukocytes in blood. From the circulation, they are quickly mobilized to sites of inflammation and/or infection. At the affected tissues, neutrophils display an impressive array of antimicrobial functions, including degranulation, production of reactive oxygen species (ROS), phagocyto...

journal_title：Journal of leukocyte biology

authors： Rosales C

更新日期：2020-07-01 00:00:00

abstract：:HIV infection causes rapid and lasting defects in the population of Vgamma2Vdelta2 T cells. To fully describe the impact of HIV, we examined PBMC samples from HIV+ patients receiving highly active antiretroviral therapy, who had displayed prolonged viral control and CD4 counts above 300 cells/mm3. We observed lower fr...

journal_title：Journal of leukocyte biology

authors： Cummings JS,Cairo C,Armstrong C,Davis CE,Pauza CD

更新日期：2008-08-01 00:00:00

abstract：:The mannose receptor, present on the plasma membrane of macrophages, promotes the internalization of glycoproteins and glycoconjugates via both endocytic and phagocytic pathways. The expression of this receptor is tightly modulated during monocyte/Mphi differentiation and cellular activation. We isolated clonal popula...

journal_title：Journal of leukocyte biology

authors： Fiani ML,Beitz J,Turvy D,Blum JS,Stahl PD

更新日期：1998-07-01 00:00:00

abstract：:IL-27, an IL-12 family member, was initially described as a proinflammatory cytokine. Nevertheless, it also poses anti-inflammatory activity, being involved in suppressing development of TH-17 cells as well as in the induction of inhibitory Tr1 cells. Recent data obtained in mice suggest that it can down-modulate the ...

journal_title：Journal of leukocyte biology

authors： Karakhanova S,Bedke T,Enk AH,Mahnke K

更新日期：2011-06-01 00:00:00

abstract：:The Hedgehog (Hh) family of signaling molecules functions in the development of numerous tissues during embryogenesis and has also been involved in adult self-renewing tissues. Recent results have demonstrated that the different components of the Hh signaling pathway are expressed in the human thymus. In this study, w...

journal_title：Journal of leukocyte biology

authors： Varas A,Hernández-López C,Valencia J,Mattavelli S,Martínez VG,Hidalgo L,Gutiérrez-Frías C,Zapata AG,Sacedón R,Vicente A

更新日期：2008-06-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a multifunctional cytokine that plays a pivotal role in mediating neovascularization as well as other endothelial cell alterations during inflammation. In this study, we demonstrate that human neutrophils are a source of VEGF. We observed that isolated blood neutrophils rel...

journal_title：Journal of leukocyte biology

authors： Taichman NS,Young S,Cruchley AT,Taylor P,Paleolog E

更新日期：1997-09-01 00:00:00

abstract：:Maturation of cells of the mononuclear phagocyte lineage from bone marrow precursors to tissue macrophages (MAC) via circulating blood monocytes (MO) is a multistep process only partially understood. Similarly, MAC differentiation can be observed if MO are cultured in vitro. In an attempt to further characterize molec...

journal_title：Journal of leukocyte biology

authors： Krause SW,Rehli M,Kreutz M,Schwarzfischer L,Paulauskis JD,Andreesen R

更新日期：1996-10-01 00:00:00

abstract：:There is currently no real treatment for blinding disorders that stem from the degeneration of cells in the retina and affect at least 50 million individuals worldwide. The excitement that accompanied the first studies showing the potential of retinal cell transplantation to alleviate the progress of blindness in such...

journal_title：Journal of leukocyte biology

authors： Lund RD,Ono SJ,Keegan DJ,Lawrence JM

更新日期：2003-08-01 00:00:00

abstract：:Structurally, the monocyte chemotactic proteins MCP-1, -2, and -3 form a subfamily of the C-C or beta-chemokines. Like other chemokines, MCPs are produced by a variety of cells on stimulation with cytokines (interleukin-1, tumor necrosis factor-alpha, interferon-gamma), bacterial and viral products or mitogens. MCP-1 ...

journal_title：Journal of leukocyte biology

authors： Proost P,Wuyts A,Van Damme J

更新日期：1996-01-01 00:00:00

abstract：:Extracellular vesicles (EVs) are nanosized particles that have emerged as mediators for intercellular communication in physiologic and pathologic conditions. EVs carry signaling information on their bilipid membrane as well as cargo within, allowing them to perform a wide range of biologic processes and contribute to ...

journal_title：Journal of leukocyte biology

authors： Lam KCK,Lam MKN,Chim CS,Chan GCF,Li JCB

更新日期：2020-11-01 00:00:00

abstract：:Hybridoma cell lines were produced by fusion of SP2/0 murine myeloma cell line with the spleen cells of Wister rats which were immunized with IgG2a-binding protein isolated from the detergent lysate of a murine macrophagelike cell line, P388D1, by affinity chromatography on IgG-Sepharose 4B. A monoclonal clone (design...

journal_title：Journal of leukocyte biology

authors： Kagami M,Funatsu Y,Suzuki T

更新日期：1989-04-01 00:00:00

abstract：:Besides their growth-inhibiting and differentiation-inducing properties, retinoids have been shown to exert immunomodulatory and anti-inflammatory functions by mechanisms that are not well understood. Tumor necrosis factor-alpha (TNF), a cytokine produced by mononuclear phagocytes, has been shown to be an important me...

journal_title：Journal of leukocyte biology

authors： Mehta K,McQueen T,Tucker S,Pandita R,Aggarwal BB

更新日期：1994-03-01 00:00:00

abstract：:Murine peritoneal exudate cells (PEC) pre-exposed to bacterial lipopolysaccharide (LPS) show augmented nitric oxide (NO) production by LPS restimulation, in contrast to LPS tolerance with reduced production of tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6). Significant amounts of interferon-gamma (IF...

journal_title：Journal of leukocyte biology

authors： Tominaga K,Saito S,Matsuura M,Funatogawa K,Matsumura H,Nakano M

更新日期：1999-12-01 00:00:00

abstract：:We have previously reported that human neutrophils can be permeabilized with the cholesterol-complexing agent digitonin. These permeabilized cells can be induced to secrete lysosomal constituents when exposed to micromolar levels of free Ca2+, a process that is enhanced by certain guanine nucleotides. We examined the ...

journal_title：Journal of leukocyte biology

authors： Smolen JE,Stoehr SJ,Traynor AE,Sklar LA

更新日期：1987-01-01 00:00:00

abstract：:Natural killer (NK) cells arise from immature progenitors present in fetal tissues and adult bone marrow, but the factors responsible for driving the proliferation and differentiation of these progenitors are poorly understood. Mouse NK cells had previously been thought not to express interleukin (IL)-2Ralpha chains, ...

journal_title：Journal of leukocyte biology

authors： Toomey JA,Gays F,Foster D,Brooks CG

更新日期：2003-08-01 00:00:00

abstract：:HIV infection of mononuclear phagocytes (MP), mostly as tissue macrophages, is a dominant feature in the pathogenesis of HIV disease and its progression to AIDS. Although the general mechanism of infection is not dissimilar to that of CD4+ T lymphocytes occurring via interaction of the viral envelope with CD4 and a ch...

journal_title：Journal of leukocyte biology

authors： Cassol E,Alfano M,Biswas P,Poli G

更新日期：2006-11-01 00:00:00

abstract：:This study addresses the role of (pro)MMP-9 overexpression in CLL cell migration. We have used primary CLL cells and CLL-derived MEC-1 cells transfected with empty (mock cells) or proMMP-9-encoding (MMP-9 cells) lentiviral vectors. The constitutive (pro)MMP-9 expression in mock cells and primary CLL cells was similar,...

journal_title：Journal of leukocyte biology

authors： Bailón E,Ugarte-Berzal E,Amigo-Jiménez I,Van den Steen P,Opdenakker G,García-Marco JA,García-Pardo A

更新日期：2014-03-11 00:00:00

abstract：:The cytosolic adaptor molecule SKAP-HOM, similar to the T cell-specific homologue SKAP55, interacts directly with ADAP, and both molecules are involved in inside-out signaling. Previous studies have shown that in the absence of SKAP-HOM, antigen receptor-triggered integrin-mediated adhesion is impaired severely in B c...

journal_title：Journal of leukocyte biology

authors： Reinhold A,Reimann S,Reinhold D,Schraven B,Togni M

更新日期：2009-07-01 00:00:00

abstract：:IRG are a family of IFN-regulated proteins that are critical for resistance to infection. Mouse IRG proteins are divided into GMS and GKS subfamilies, based on a sequence within the G1 GTP-binding motif. The GMS proteins have a particularly profound impact on immunity, as typified by Irgm1, of which absence leads to a...

journal_title：Journal of leukocyte biology

authors： Henry SC,Traver M,Daniell X,Indaram M,Oliver T,Taylor GA

更新日期：2010-02-01 00:00:00

abstract：:The effects of the carbocyclic nucleoside MDL 201,112 and the purine nucleoside adenosine on the interferon-gamma (IFN-gamma)-induced priming of macrophages (m phi s) for the respiratory burst and major histocompatibility class II (MHC class II) Ia+ antigen expression were compared. Priming of purified, peritoneal m p...

journal_title：Journal of leukocyte biology

authors： Edwards CK 3rd,Watts LM,Parmely MJ,Linnik MD,Long RE,Borcherding DR

更新日期：1994-08-01 00:00:00

abstract：:The effects on macrophage growth of seven phospholipids that are normally present in cell membranes were examined. Phosphatidylcholine and sphingomyelin which are the main phospholipid constituents of mammalian cell membranes, had no effect on growth of macrophages. Phosphatidylinositol also had little effect. On the ...

journal_title：Journal of leukocyte biology

authors： Yui S,Yamazaki M

更新日期：1986-06-01 00:00:00

abstract：:The Fanconi anemia proteins participate in a canonical pathway that repairs cross-linking agent-induced DNA damage. Cells with inactivated Fanconi anemia genes are universally hypersensitive to such agents. Fanconi anemia-deficient hematopoietic stem cells are also hypersensitive to inflammatory cytokines, and, as imp...

journal_title：Journal of leukocyte biology

authors： Garbati MR,Hays LE,Rathbun RK,Jillette N,Chin K,Al-Dhalimy M,Agarwal A,Newell AE,Olson SB,Bagby GC Jr

更新日期：2016-03-01 00:00:00

abstract：:Colostrum plays an important role in protecting newborn infants against acute gastrointestinal and respiratory infections. IgA antibodies have been considered the major effector component; however, the role of their receptors on colostral phagocytes, especially neutrophils, has not been studied. Here, we demonstrate t...

journal_title：Journal of leukocyte biology

authors： Honorio-França AC,Launay P,Carneiro-Sampaio MM,Monteiro RC

更新日期：2001-02-01 00:00:00

abstract：:Stimulation of the respiratory burst in phagocytes induces the formation of mixed disulfides between sulfhydryl groups of proteins and low-molecular-weight thiols. We hypothesized that this process (S-thiolation) might be involved in turning off the respiratory burst. However, induction of S-thiolation by pretreatment...

journal_title：Journal of leukocyte biology

authors： Moriguchi T,Seres T,Ravichandran V,Sasada M,Johnston RB Jr

更新日期：1996-08-01 00:00:00

abstract：:The transcription factor GATA-2 is expressed in hematopoietic stem and progenitor cells and is functionally implicated in their survival and proliferation. In the present study, we show that GATA-2 exists as an acetylated protein in immature precursor cells, KG1. GATA-2 was acetylated in vitro by p300 and GCN5. We hav...

journal_title：Journal of leukocyte biology

authors： Hayakawa F,Towatari M,Ozawa Y,Tomita A,Privalsky ML,Saito H

更新日期：2004-03-01 00:00:00

abstract：:Neutrophils showed a rapid and transient adhesion to immunoglobulin G (IgG)-coated plates compared with their adhesion to bovine serum albumin (BSA)-coated plates: the adhesion reached a peak after 15 min of incubation and then gradually returned to almost the basal state in 60 min. The addition of monomeric IgG or an...

journal_title：Journal of leukocyte biology

authors： Kusunoki T,Tsuruta S,Higashi H,Hosoi S,Hata D,Sugie K,Mayumi M,Mikawa H

更新日期：1994-06-01 00:00:00

abstract：:The switch from fetal to adult hematopoietic stem/progenitor cells (HSPCs) is associated with profound changes in several genetic programs. Although HSPC ageing corresponds to alterations in Wnt signaling, relatively little is known about the relative roles of different Wnt signaling pathways in HSPC ontogeny. We hypo...

journal_title：Journal of leukocyte biology

authors： Kwarteng EO,Hétu-Arbour R,Heinonen KM

更新日期：2018-03-01 00:00:00

abstract：:The ability of encapsulated and acapsular strains of Cryptococcus neoformans to activate dendritic cells (DC) derived from monocytes stimulated with granulocyte macrophage-colony stimulating factor and interleukin-4 was evaluated. Profound differences in DC response to encapsulated and acapsular C. neoformans strains ...

journal_title：Journal of leukocyte biology

authors： Vecchiarelli A,Pietrella D,Lupo P,Bistoni F,McFadden DC,Casadevall A

更新日期：2003-09-01 00:00:00