Regulation of mannose receptor synthesis and turnover in mouse J774 macrophages.


:The mannose receptor, present on the plasma membrane of macrophages, promotes the internalization of glycoproteins and glycoconjugates via both endocytic and phagocytic pathways. The expression of this receptor is tightly modulated during monocyte/Mphi differentiation and cellular activation. We isolated clonal populations from murine J774 macrophage tumor cells, which differ in their surface expression of functional mannose receptors. To examine the potential mechanisms regulating receptor function in these cell lines, the interaction of receptor with ligand as well as receptor synthesis and degradation was analyzed. J774 clones with both high and low levels of mannose receptor activity were found to synthesize significant amounts of receptor protein, suggesting that the protein may be regulated at the level of synthesis and degradation. In J774 clones expressing very low receptor activity and protein, the half-life of mannose receptor molecules was substantially decreased. The evolution of multiple mechanisms modulating mannose receptor function may be critical in fine-tuning the role of this receptor in antigen processing and in scavenger and host defense functions.


J Leukoc Biol


Fiani ML,Beitz J,Turvy D,Blum JS,Stahl PD




Has Abstract


1998-07-01 00:00:00












  • Identification of a region in p47phox/NCF1 crucial for phagocytic NADPH oxidase (NOX2) activation.

    abstract::A point mutation in the mouse Ncf1(m1J) gene decreases production of ROS by the phagocytic NOX2 complex. Three mRNA splice variants are expressed, but only one is expressed as a protein, although at lower levels than the WT NCF1 (also known as p47phox). Our aim was to investigate whether the mutant p47phox, lacking 8 ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Sareila O,Jaakkola N,Olofsson P,Kelkka T,Holmdahl R

    更新日期:2013-03-01 00:00:00

  • Neonatal neutrophil interaction with P-selectin: contribution of P-selectin glycoprotein ligand-1 and sialic acid.

    abstract::Previously we had determined that neonatal neutrophils had decreased interaction with monolayers expressing P-selectin compared to adult cells. In this study we examined the function of neonatal P-selectin glycoprotein ligand-1 (PSGL-1). A rabbit polyclonal antibody directed against the amino terminus of human PSGL-1 ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Tcharmtchi MH,Smith CW,Mariscalco MM

    更新日期:2000-01-01 00:00:00

  • Insulin-like growth factor-I stimulates IL-10 production in human T cells.

    abstract::There is vast body of evidence that the insulin-like growth factor (IGF)-I exerts immunomodulatory effects in vitro and in vivo. In vitro studies indicate that stimulatory effects of IGF-I may be exerted through augmentation of inflammatory cytokine production. To further explore the immunomodulatory effects of IGF-I ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Kooijman R,Coppens A

    更新日期:2004-10-01 00:00:00

  • Isolation and confinement as a model for spaceflight immune changes.

    abstract::The immune system of astronauts is disturbed during and after spaceflight. This situation may result from stressors encountered during the flight (microgravity, radiation, psychological stress, or confinement) or from physiological changes (demineralization or fluid shift). Therefore, ground-based investigations shoul...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审


    authors: Schmitt DA,Schaffar L

    更新日期:1993-09-01 00:00:00

  • The effect of adenovirus-specific antibodies on adenoviral vector-induced, transgene product-specific T cell responses.

    abstract::In this study, we tested the effect of neutralizing Abs to different serotypes of E1-deleted Ad vectors on the immunogenicity of the homologous Ad vector or a vector derived from a heterologous serotype. Our results showed that, as expected, even low titers of passively transferred neutralizing Abs significantly reduc...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Small JC,Haut LH,Bian A,Ertl HC

    更新日期:2014-11-01 00:00:00

  • Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators.

    abstract::Neutrophil apoptosis leads to macrophage ingestion of intact senescent neutrophils. This may represent a neutrophil removal mechanism that is important both in the control of inflammatory tissue injury and for the normal resolution processes of inflammation. Because apoptosis is likely to be a key control process in c...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Lee A,Whyte MK,Haslett C

    更新日期:1993-10-01 00:00:00

  • Induction of various immune modulatory molecules in CD34(+) hematopoietic cells.

    abstract::Lipopolysaccharide (LPS) has been shown to induce proliferation of human T-lymphocytes only in the presence of monocytes and CD34(+) hematopoietic cells (HCs) from peripheral blood. This finding provided evidence of an active role of CD34(+) HCs during inflammation and immunological events. To investigate mechanisms b...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Umland O,Heine H,Miehe M,Marienfeld K,Staubach KH,Ulmer AJ

    更新日期:2004-04-01 00:00:00

  • Differential responsiveness to constitutive vs. inducible chemokines of immature and mature mouse dendritic cells.

    abstract::Upon exposure to immune or inflammatory stimuli, dendritic cells (DC) migrate from peripheral tissues to lymphoid organs, where they present antigen. The molecular basis for the peculiar trafficking properties of DC is largely unknown. In this study, mouse DC were generated from CD34+ bone marrow precursors and cultur...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Vecchi A,Massimiliano L,Ramponi S,Luini W,Bernasconi S,Bonecchi R,Allavena P,Parmentier M,Mantovani A,Sozzani S

    更新日期:1999-09-01 00:00:00

  • IL-23R and TCR signaling drives the generation of neonatal Vgamma9Vdelta2 T cells expressing high levels of cytotoxic mediators and producing IFN-gamma and IL-17.

    abstract::The immune system in early life is regarded as immature. However, the IL-12 family member IL-23 is highly produced upon TLR stimulation by neonatal DCs. Human adult Vγ9Vδ2 T cells can be stimulated specifically via their TCR by phosphoantigens (as the pathogen-derived HMB-PP) or agents and infections that lead to thei...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Moens E,Brouwer M,Dimova T,Goldman M,Willems F,Vermijlen D

    更新日期:2011-05-01 00:00:00

  • Transcriptional and post-transcriptional regulation of GM-CSF-induced IL-1 beta gene expression in PMN.

    abstract::Polymorphonuclear leukocytes (PMN) play an important role in inflammation, immune responses, and tissue repair by secreting interleukin- 1 beta (IL-1 beta). We investigated the regulation of IL-1 beta gene expression in human PMN treated with granulocyte-macrophage colony-stimulating factor (GM-CSF). GM-CSF induced IL...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Fernandez MC,Walters J,Marucha P

    更新日期:1996-04-01 00:00:00

  • Partial characterization of a mitomycin-C resistant T cell.

    abstract::A cell resistant to concentrations of mitomycin-C associated with the inactivation of many in vitro immune responses is described. This cell is responsive to concanavalin A (Con A), poorly adherent to nylon wool, present in relatively greater numbers in lymph node than other lymphoid tissues, and is relatively radiose...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Anderson RE,Standefer JC,Troup GM,Pogue LE

    更新日期:1987-01-01 00:00:00

  • 20-Hydroxy- and 20-carboxy-leukotriene (LT) B4 downregulate LTB4 -mediated responses of human neutrophils and eosinophils.

    abstract::Leukotriene B4 (LTB4 ) plays a prominent role in innate immunity as it induces phagocyte recruitment, the release of antimicrobial effectors, and as it potentiates the ingestion and killing of pathogens. In humans, LTB4 has a short half-life and is rapidly metabolized by leukocytes, notably into 20-OH- and 20-COOH-LTB...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Archambault AS,Poirier S,Lefebvre JS,Robichaud PP,Larose MC,Turcotte C,Martin C,Provost V,Boudreau LH,McDonald PP,Laviolette M,Surette ME,Flamand N

    更新日期:2019-06-01 00:00:00

  • Pivotal advance: peritoneal cavity B-1 B cells have phagocytic and microbicidal capacities and present phagocytosed antigen to CD4+ T cells.

    abstract::Breaking the long-held paradigm that primary B cells are not phagocytic, several studies have demonstrated recently that B cells from fish, amphibians, and reptilians have a significant phagocytic capacity. Whether such capacity has remained conserved in certain mammalian B cell subsets is presently an enigma. Here, w...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Parra D,Rieger AM,Li J,Zhang YA,Randall LM,Hunter CA,Barreda DR,Sunyer JO

    更新日期:2012-04-01 00:00:00

  • Glucan: mechanisms involved in its "radioprotective" effect.

    abstract::It has generally been accepted that most biologically derived agents that are radioprotective in the hemopoietic-syndrome dose range (eg, endotoxin, Bacillus Calmette Guerin, Corynebacterium parvum, etc) exert their beneficial properties by enhancing hemopoietic recovery and hence, by regenerating the host's ability t...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Patchen ML,D'Alesandro MM,Brook I,Blakely WF,MacVittie TJ

    更新日期:1987-08-01 00:00:00

  • Decidual macrophages: key regulators of vascular remodeling in human pregnancy.

    abstract::Successful remodeling of the uterine spiral arteries is essential for a complication-free pregnancy and is best described in terms of its morphologic features. The molecular mediators and cellular sources of spiral artery remodeling are not known, although a role for uterine leukocytes has been proposed. Immunohistoch...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Lash GE,Pitman H,Morgan HL,Innes BA,Agwu CN,Bulmer JN

    更新日期:2016-08-01 00:00:00

  • Inhibitors of DNA methylation and histone deacetylation independently relieve AML1/ETO-mediated lysozyme repression.

    abstract::The human lysozyme (LZM) gene is highly methylated in LZM-nonexpressor immature myeloid and in nonmyeloid cells and unmethylated only in LZM-expressing cells. Extended methylation analyses of the CpG-poor 5' flanking region and of the exon 4 CpG island (both containing Alu elements) of the LZM gene were now performed....

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Claus R,Fliegauf M,Stock M,Duque JA,Kolanczyk M,Lübbert M

    更新日期:2006-12-01 00:00:00

  • C1q and phagocytosis: the perfect complement to a good meal.

    abstract::Complement component C1q is a member of a family of soluble proteins called defense collagens, which are important in host defense and apoptotic cell clearance. Failure to efficiently clear apoptotic cells in the absence of C1q is associated with autoimmunity. Here, we review the literature describing a central role f...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审


    authors: Galvan MD,Greenlee-Wacker MC,Bohlson SS

    更新日期:2012-09-01 00:00:00

  • Inhibition of neutrophil functions by platelets and platelet-derived products: description of multiple inhibitory properties.

    abstract::The effect of platelets and their products on in vitro responses of human neutrophils to f-met-leu-phe (fMLP) and phorbol myristate acetate (PMA) was studied. Platelets produced a concentration-dependent inhibition of neutrophil superoxide anion (O2-) generation with maximum inhibition of the response to fMLP approach...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: McGarrity ST,Hyers TM,Webster RO

    更新日期:1988-08-01 00:00:00

  • Biochemical and functional differences between eosinophils from animal species and man.

    abstract::Eosinophils were isolated from peritoneal lavages of repeated horse serum-injected guinea pigs or rhesus monkeys and from peripheral blood of normal human donors. Eicosanoid metabolism and chemotaxis by these cells were studied by in vitro techniques. Upon calcium ionophore stimulation guinea pig eosinophils released ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Sun FF,Crittenden NJ,Czuk CI,Taylor BM,Stout BK,Johnson HG

    更新日期:1991-08-01 00:00:00

  • ARNO but not cytohesin-1 translocation is phosphatidylinositol 3-kinase-dependent in HL-60 cells.

    abstract::Cytohesin-1 and ARNO are guanine nucleotide-exchange factors (GEFs) for ADP-ribosylation factor (Arf). Here, we show that ARNO is expressed in HL-60 cells and established that granulocytic differentiation induced with Me2SO stimulated cytohesin-1 but not ARNO expression. Cytohesin-1 levels in HL-60 granulocytes were s...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Bourgoin SG,Houle MG,Singh IN,Harbour D,Gagnon S,Morris AJ,Brindley DN

    更新日期:2002-04-01 00:00:00

  • Phosphatidylserine expression and phagocytosis of apoptotic thymocytes during differentiation of monocytic cells.

    abstract::Expression of phosphatidylserine (PS) on the surface of both macrophages and their apoptotic targets is required for efficient phagocytosis. Monocytes, the precursors of macrophages, do not express PS on their surface and do not efficiently phagocytose apoptotic cells. We report here that PS appears on the surface of ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Callahan MK,Halleck MS,Krahling S,Henderson AJ,Williamson P,Schlegel RA

    更新日期:2003-11-01 00:00:00

  • Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes.

    abstract::The oncogene EVI1 has been implicated in the etiology of AML and MDS. Although AML cells are characterized by accelerated proliferation and differentiation arrest, MDS cells hyperproliferate when immature but fail to differentiate later and die instead. In agreement with its roles in AML and in immature MDS cells, EVI...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Konrad TA,Karger A,Hackl H,Schwarzinger I,Herbacek I,Wieser R

    更新日期:2009-10-01 00:00:00

  • PI3Kγ controls leukocyte recruitment, tissue injury, and lethality in a model of graft-versus-host disease in mice.

    abstract::PI(3)Kγ is thought to mediate leukocyte migration to injured tissues and may be important in the pathogenesis of various T-lymphocyte-dependent pathologies, including autoimmune and inflammatory diseases. The present study evaluated the relevance of PI(3)Kγ in donor cells for the pathogenesis of acute GVHD using a mod...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Castor MG,Rezende BM,Bernardes PT,Vieira AT,Vieira EL,Arantes RM,Souza DG,Silva TA,Teixeira MM,Pinho V

    更新日期:2011-06-01 00:00:00

  • Differential expression of the chemokine receptors by the Th1- and Th2-type effector populations within circulating CD4+ T cells.

    abstract::The in vitro studies have proposed that human Th1 cells favor expression of CXCR3 or CCR5, whereas Th2 cells favor CCR3 and CCR4. In this study, the in vivo relevance of expression of these chemokine receptors on Th cells was investigated in patients with atopic dermatitis (AD) as the Th2-dominated disorder and nonato...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Yamamoto J,Adachi Y,Onoue Y,Adachi YS,Okabe Y,Itazawa T,Toyoda M,Seki T,Morohashi M,Matsushima K,Miyawaki T

    更新日期:2000-10-01 00:00:00

  • Controlling the Toll road to dendritic cell polarization.

    abstract::The activation of dendritic cells (DC) via Toll-like receptors (TLRs) plays a decisive role in shaping the outcome of primary immune responses. Following TLR engagement by microbial products, DC migrate from peripheral tissues to lymphoid organs and up-regulate major histocompatibility complex and costimulatory molecu...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审


    authors: Mazzoni A,Segal DM

    更新日期:2004-05-01 00:00:00

  • Effects of endotoxin on expression of VLA integrins by human bronchoalveolar lavage macrophages.

    abstract::Endotoxin (lipopolysaccharide, LPS) is known to induce inflammatory responses, such as monocyte/macrophage adherence, migration, and accumulation. Recruitment and accumulation of macrophages during infection and inflammation are regulated by integrin-mediated cell-extracellular matrix interactions. In the present repo...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Kang YH,Lee CH,Brummel SE,Newball HH,Forrester J

    更新日期:1995-04-01 00:00:00

  • Neutrophil accumulation and plasma leakage induced in vivo by neutrophil-activating peptide-1.

    abstract::Neutrophil accumulation and plasma leakage induced in rabbit skin by neutrophil-activating peptide-1 (NAP-1, a 72 amino acid peptide produced by monocytes and a variety of tissue cells), E. coli endotoxin, and interleukin-1 (IL-1) were compared. Neutrophil accumulation at sites injected with NAP-1 was intense, rapid, ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Colditz IG,Zwahlen RD,Baggiolini M

    更新日期:1990-08-01 00:00:00

  • Alpha-defensin expression during myelopoiesis: identification of cis and trans elements that regulate expression of NP-3 in rat promyelocytes.

    abstract::Alpha-defensins are antimicrobial peptides that contribute to innate-immune functions of neutrophils and intestinal Paneth cells. Transcription of alpha-defensin genes occurs early in neutrophilic myelopoeisis. To examine the mechanisms that regulate alpha-defensin gene expression, we analyzed transcription of rat neu...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Yamamoto CM,Banaiee N,Yount NY,Patel B,Selsted ME

    更新日期:2004-02-01 00:00:00

  • Differential effects of 15-deoxy-delta(12,14)-prostaglandin J2 and a peroxisome proliferator-activated receptor gamma agonist on macrophage activation.

    abstract::Prostaglandin J2 metabolite 15-deoxy-delta(12,14)-prostaglandin J2 (15-PGJ2) appears to possess anti-inflammatory properties. Unlike other prostaglandins, it has no known plasma membrane receptor. Its effects have been thought to occur through activation of the nuclear peroxisome proliferator-activated receptor gamma ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Guyton K,Bond R,Reilly C,Gilkeson G,Halushka P,Cook J

    更新日期:2001-04-01 00:00:00

  • Exposure of cultured murine peritoneal macrophages to low concentrations of beryllium induces increases in intracellular calcium concentrations and stimulates DNA synthesis.

    abstract::Exposure of humans to beryllium dusts can induce a specific form of chronic pneumonitis that consists mainly of noncaseating granulomas in the lungs. Multiple studies have documented both genetic and immune components of chronic berylliosis. Much work has focused on T cells and their reactivity in berylliosis, but les...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Misra UK,Gawdi G,Pizzo SV,Lewis JG

    更新日期:1999-06-01 00:00:00